許悦

2012年本科畢業於中國農業大學生物學院，2018年底在北京生命科學研究所獲得博士學位。隨後繼續在北京生命科學研究所邵峯實驗室從事博士後研究。

2021年3月加入上海交通大學醫學院基礎醫學院病理生理系，擔任課題組組長。

研究工作主要聚焦病原細菌感染的致病機理和宿主先天免疫識別機制。

國家自然科學基金面上項目，V-ATPase-ATG16L1介導的選擇性自噬在內膜損傷修復中的作用研究，在研，主持

上海市自然科學基金面上項目，紫色色桿菌抑制細胞凋亡通路的機制研究，在研，主持

上海市青年科技啓明星項目，生物膜完整性監控及修復過程的分子調控機制研究，在研，主持 ^[1] 

研究成果發表在Cell, Nature Structural & Molecular Biology，Autophagy，mBio等期刊。入選中國科協青年人才託舉工程，上海市青年科技啓明星，藥明康德生命化學研究學者獎。

Liu, Y., Zeng, H., Hou, Y., Li, Z., Li, L., Song, X., Ding, J., Shao, F., Xu, Y. (2022). Calmodulin Binding Activates Chromobacterium CopC Effector to ADP-Riboxanate Host Apoptotic Caspases. mBio, e00690-22

Xu, Y., Ding, J. (2022). Endomembrane damage sensing by V-ATPase recruits ATG16L1 for LC3 lipidation in situ. Autophagy, 1-3

Xu, Y., Cheng, S., Zeng, H., Zhou, P., Ma, Y., Li, L., Liu, X., Shao, F., Ding, J. (2022). ARF GTPases activate Salmonella effector SopF to ADP-ribosylate host V-ATPase and inhibit endomembrane damage-induced autophagy. Nature Structural & Molecular Biology 29 (1), 67-77

Li, Z., Liu, W., Fu, J., Cheng, S., Xu Y., Wang, Z., Liu, X., Shi, X., Liu, Y., Qi X., Liu, X., Ding, J., Shao, F. (2021) Shigella evades pyroptosis by arginine ADP-riboxanation of caspase-11. Nature 599 (7884), 290-295

Schubert, K.A., Xu, Y., Shao, F., and Auerbuch, V. (2020). The Yersinia type III secretion system as a tool for studying cytosolic innate immune surveillance. Annual review of microbiology 74:221-245

Xu, Y., Zhou, P., Cheng, S., Lu, Q., Nowak, K., Hopp, A.K., Li, L., Shi, X., Zhou, Z., Gao, W., Li, D., He, H., Liu, X., Ding, J., Hottiger, M. O., Shao, F. (2019). A bacterial effector reveals the V-ATPase-ATG16L1 axis that initiates xenophagy. Cell 178, 552-566 e520.

Zhou, P., She, Y., Dong, N., Li, P., He, H., Borio, A., Wu, Q., Lu, S., Ding, X., Cao, Y., Xu, Y., Gao, W., Dong, M., Ding, J., Wang, D. C., Zamyatina, A., Shao, F. (2018). Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose. Nature 561, 122-126.

Liu, W.*, Zhou, Y.*, Peng, T.*, Zhou, P., Ding, X., Li, Z., Zhong, H., Xu, Y., Chen, S., Hang, H.C., Shao, F. (2018). Nε-fatty acylation of multiple membrane-associated proteins by Shigella IcsB effector to modulate host function. Nature microbiology 3, 996-1009.

Lu, Q., Xu, Y., Yao, Q., Niu, M., and Shao, F. (2015). A polar-localized iron-binding protein determines the polar targeting of Burkholderia BimA autotransporter and actin tail formation. Cellular microbiology 17, 408-424.

Lu, Q.*, Yao, Q.*, Xu, Y.*, Li, L., Li, S., Liu, Y., Gao, W., Niu, M., Sharon, M., Ben-Nissan, G., Zamyatina, A., Liu, X., Chen, S., Shao, F. (2014). An iron-containing dodecameric heptosyltransferase family modifies bacterial autotransporters in pathogenesis. Cell host & microbe 16, 351-363. (* co-first author)

Yao, Q. *, Lu, Q. *, Wan, X., Song, F., Xu, Y., Hu, M., Zamyatina, A., Liu, X., Huang, N., Zhu, P., Shao, F. (2014). A structural mechanism for bacterial autotransporter glycosylation by a dodecameric heptosyltransferase family. eLife 3. ^[1]