蔡勇

人Ino80染色質重塑酶複合物的結構及其生物學功能。

染色質修飾酶之間的相互作用及其協同關係。

癌症發生發展的表觀遺傳學調控機制及其診斷的生物標記物和靶向治療藥物的篩選和研發。

胚胎幹細胞的自我更新和分化，以及體細胞重編程（iPS）時表觀遺傳學調控機制。

吉林大學唐敖慶特聘教授啓動資金（2009年）。

中國科學學院北京生物物理所生物大分子研究室開放課題（2010年）。

國家自然科學基金，面上項目（2011-2014年），項目號（31071131）。

吉林省人才開發資金資助項目（2011年）。

國家自然科學基金，面上項目（2012-2016年），項目號（31171245）。

Ning Liu, Rui Zhang, Xiaoming Zhao, Jiaming Su, Xiaolei Bian, Jinsong Ni, Ying Yue, Yong Cai and Jingji Jin. A potential diagnostic marker for ovarian cancer:Involvement of the histoneacetyltransferase,human males absent on the first. Oncology Letters, 2013

Wu D, Zhang R, Zhao R, Chen G, Yong Cai, Jin J. A Novel Function of Novobiocin: Disrupting the Interaction of HIF 1α and p300/CBP through Direct Binding to the HIF1α C-Terminal Activation Domain. PLoS One. 2013, 6;8(5):e62014.

Yong Wang, Rui Zhang, Donglu Wu, Zhihua Lu, Wentao Sun, Yong Cai, Chunxi Wang, and Jingji Jin .Epigenetic change in kidney tumor: downregulation of histone acetyltransferase MYST1 in human renal cell carcinoma. J Exp Clin Cancer Res. 2013, 32(1): 8.

Chen L, Yong Cai, Jin, J.,Florens L, Swanson SK, Washburn MP, Conaway JW, and Conaway RC. Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. Journal of Biological Chemistry, 2011, 1;286(13):11283-9.

Capotosti F, Guernier S, Lammers F, Waridel P, Yong Cai, Jin, J.,Conaway JW, Conaway RC, and Herr W. O-GlcNAc transferase catalyzes site-specific proteolysis of HCF-1. Cell, 2011, 144: 376-88.

Yong Cai, Jin, J., Swanson SK, Cole MD, Choi SH, Florens LF, Warshburn MP, Conaway JW, and Conaway RC. Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. Journal of Biological Chemistry, 2010, 285: 4268-72.

Gottschalk AJ, Timinszky G, Kong SE, Jin J, Yong Cai, Swanson SK, Washburn MP, Ladurner AG, Conaway JW, Conaway RC. Poly (ADP-ribosyl) ation directs recruitment and activation of an ATP_dependent chromatin remodeler. Proc Natl Acad Sci., 2009, 106, 13770-4.

Yao, T., Song, L., Jin, J., Yong Cai, Takahashi, H., Swanson, S.K., Washburn, M.P., Florens, L., Conaway, R.C., Cohen, R.E., and Conaway, J.W. (2008) Distinct modes of regulation of the Uch37 deubiquitinating enzyme in the proteasome and in the Ino80 chromatin remodeling complex. Molecular Cell, 31, 909-17.

Sardiu, M.E., Yong Cai, Jin, J., Swanson, S.K., Conaway, R.C., Conaway J.W., Florens, L., and Washburn, M.P.. (2008) Probabilistic assembly of human protein interaction networks from label-free quantitative proteomics. Proceedings of the National Academy of Sciences, 105, 1454–59.

Yong Cai, Jin, J., Yao, T., Gottschalk, A.J., Swanson, S.K., Wu, S., Shi, Y., Washburn, M.P., Florens, L., Conaway, R.C., and Conaway, J.W. (2007) YY1 functions with INO80 to activate transcription. Nature Structural & Molecular Biology, 14, 872 – 74. (co-first author)

Donald D. Ruhl, Jingji Jin, Yong Cai, Selene Swanson, Laurence Florens, Michael P. Washburn, Ronald C. Conaway, Joan W. Conaway and John C. Chrivia (2006) Purification of human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes. Biochemistry, 45, 5671-77.

Yong Cai, Jingji Jin, Aaron J. Gottschalk, Tingting Yao, Joan W. Conaway and Ronald C. Conaway (2006) Purification and assay of the human INO80 and SRCAP chromatin remodeling complexes. Methods, 40, 312-17.

Jin, J., Yong Cai, Li, B., Conaway, RC., Conaway, JW., Workman, JL. and Kusch, T (2005) In and out: Histone variant exchange in chromatin. Trends in Biochemical Sciences, 30, 680-87.

Jin, J., Yong Cai, Yao, T., Gottschalk, A., Florence, F., Swanson, SK., Gutierrez, J., Coleman, MK., Workman, JL., Mushegian, A., Washburn, MP., Conaway, RC and Conaway, JW (2005) A mammalian chromatin remodeling complex with similarities to the yeast Ino80 complex. Journal of Biological Chemistry, 280, 41207-12. (co-first author)

Yong Cai, Jin, J., Florens, L., Swanson, SK., Kusch, T., Li, B., Workman, JL., Washburn, MP., Conaway, RC., and Conaway, JW (2005) The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes. Journal of Biological Chemistry, 280, 13665-70. (co-first author)

Yan, Q., Kamura, T., Yong Cai, Jin, J., Ivan, M., Mushegian, A., Conaway, R.C. and Conaway, J.W. (2004) Identification of elongin C and Skp1 sequences that determine cullin selection. Journal of Biological Chemistry, 279, 43019-26.

Sato, S., Tomomori-Sato, C., Parmely, T.J., Florens, L., Zybailov, B., Swanson, S.K., Banks, C.A., Jin, J., Yong Cai, Washburn, M.P., Conaway, J.W. and Conaway, R.C. (2004) A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. Molecular Cell, 14, 685-91.

Yong Cai, Jin, J., Tomomori-Sato, C., Sato, S., Sorokin, I., Parmely, TJ., Conaway, RC. and Conaway, JW (2003) Identification of new subunits of the multiprotein mammalian TRRAP/TIP60-containing histone acetyltransferase complex. Journal of Biological Chemistry, 278, 42733-6. (co-first author)

Zhang, C., Yong Cai, Adachi, MT., Oshiro, S., Aso, T., Kaufman, RJ., Kitajima, S (2001) Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response. Journal of Biological Chemistry, 276, 35867-74.

Yong Cai, Zhang, C., Nawa, T., Aso, T., Tanaka, M., Oshiro, S., Ichijo, H., Kitajima, S (2000) Homocysteine-responsive ATF3 gene expression in human vascular endothelial cells: activation of c-Jun NH2-terminal kinase and promoter response element. Blood, 96, 2140-8.