胡芳弟

2009～2010年美國University of South Alabama訪問學者，

2012～2014年在上海中醫藥大學中藥研究所從事博士後研究。

蘭州大學藥學院藥物分析學研究所所長，二級教授，博士生導師。 ^[1] 

（1）中藥（天然藥物）成分分離分析及中藥藥效物質基礎研究；

（2）體內藥物分析及藥代動力學研究；

（3）中藥多糖化學及生物學研究；

（4）中藥新藥及中藥保健品研發；

（5）天然藥物及生物活性分子生物電化學研究。 ^[1] 

《天然藥物化學》、《現代色譜》、《藥學概論》、《體內藥物分析》 ^[1] 

【1】Bolu Sun, Yuqiang Gou, Yuling Ma, Xiaoping Zheng, Ruibin Bai, Ahmed Attia Ahmed Abdelmoaty, Fangdi Hu*, In Investigate electrochemical immunosensor of cortisol based on gold nanoparticles/magnetic functionalized reduced grapheneoxide. Biosensors and Bioelectronics, 2017;88:52-62.

【2】Pei Zhang, Linhai Hu, Ruibin Bai, Xiaoping Zheng, Yuling Ma, Xia Gao, Bolu Sun, Fangdi Hu?, Structural characterization of a pectic polysaccharide from Codonopsispilosula and its immunomodulatory activities in vivo and in vitro. International Journal of Biological Macromolecules 2017;104:1359–1369.

【3】 Xiao?Ping Zheng, Fang?Di Hu*, Li Yang, Yu?Ling Ma, Bo?Lu Sun, Chang?Hong Wang Zheng?Tao Wang, The Effects of Different Compatibilities of Qing’e Formula on Scopolamine?induced Learning and Memory Impairment in the Mouse. World J Tradit Chin Med. 2017;(3)3:12-17.

【4】強思思，高霞，馬玉玲，鄭曉萍，胡芳弟*，李應東. 基於紋黨鮮藥材的產地加工炮製一體化技術研究, 中國中醫藥信息雜誌. 2017;23 (1)14-17.

【5】Bolu Sun, Xiaodan Gou, Ruibin Bai, Ahmed Attia Ahmed Abdelmoaty, Yuling Ma, Xiaoping Zheng, Fangdi Hu*, Direct electrochemistry and electrocatalysis of lobetyolin via magnetic functionalized reduced graphene oxide film fabricated electrochemical sensor. Materials Science and Engineering C. 2017,74: 515–524.

【6】Xia Gao, Yu-Ling Ma, Pei Zhang, Xiao-Ping Zheng, Bo-Lu Sun and Fang-Di Hu*,Chemical Characteristics Combined with Bioactivity for Comprehensive Evaluation of Tumuxiang Based on HPLC-DAD and Multivariate Statistical Methods, Modern Research on Chinese Materia Medica,2016;2(2):36-47.

【7】孫伯祿, 苟於強, 馬玉玲, 鄭曉萍, 胡芳弟* , 基於DNA / Nafion-聚二烯丙基二甲基氯化銨功能化的石墨烯電化學傳感器評價阿魏酸及當歸水提物抗氧化活性, 分析化學, 2016;44(10):1575-1583.

【8】Jing An, Fangdi Hu*, Changhong Wang, Zijia Zhang, Li Yang, and Zhengtao Wang Pharmacokinetics and tissue distribution of five active ingredients of Eucommiae cortex in normal and ovariectomized mice by UHPLC-MS/MS, Xenobiotica. 2016:1-12.

【9】Pei Zhang, Yu-QiangGou, Xia Gao, Rui-Bin Bai, Wen-Xia Chen, Bo-Lu Sun, Fang-Di Hu, Wang-Hong Zhao. The pharmacokinetic study of rutin in rat plasma based on an electrochemically reduced grapheneoxide modified sensor, Journal of Pharmaceutical Analysis. 2016;6(2):80-86.

【10】張 培，鄭曉萍，馬玉玲，白瑞斌，胡芳弟*, 黨蔘多糖單糖組成與其對HepG2 細胞毒活性的相關分析,中草藥. 2016; 47(15):2684-2692.

【11】高霞，張培，強思思，胡林海，胡芳弟*，李應東. 蜜炙紋黨的炮製新工藝研究，中國現代應用藥.2016;33（5）:262-268.

【12】高霞， 強思思， 鄭曉萍， 胡林海， 胡芳弟*， 李應東. 紋黨產地初加工工藝的優化，中成藥，2016;8（6）:1330-1337. 11.

【13】吳紅梅，苟於強，胡林海，胡芳弟*，陳嘉嶼，楊春霞，白瑞斌. 紋黨蔘多糖聯合環磷酰胺對S180 荷瘤小鼠抗腫瘤增效機制的研究, 2016;29(4):17-21.

【14】 Bolu Sun, Yuqiang Gou, Zhiyuan Xu, Xiaoping Zheng, Yuling Ma, Fangdi Hu*, Wanghong Zhao. Protections of bovine serum albumin protein from damage on functionalized graphene-based electrodes by flavonoids. Materials Science and Engineering C, 2016; 62: 197-205.

【15】Jing An, Fangdi Hu, Changhong Wang, Zijia Zhang, Li Yang, and Zhengtao Wang*. Pharmacokinetics and tissue distribution of five active ingredients of Eucommia cortex in normal and ovariectomized mice by UHPLC-MS/MS. Xenobiotica, 2016 Early Online: 1-12.

【16】Wenxia Chen, Yuqiang Gou, Jiayu Chen, Hongmei Wu, Fangdi Hu*, Activation of intrinsic apoptotic signaling pathway in A549 cell by a pectin polysaccharide isolated from codonopsis pilosula and its selenized derivative. Journal of carbohydrate Chemistry.

【17】Fangdi Hu, JingAn, WenLi, Zijia Zhang, Wenxia Chen, Changhong Wang, Zhengtao Wang. UPLC-MS/MS determination and gender-related pharmacokinetic study of five active ingredients in rat plasma after oral administration of Eucommia cortex extract. Journal of Ethnopharmacology. 2015,169:145–155.

【18】陳嘉嶼，胡林海，吳紅梅，邊向聰，張培，高霞，陳文霞，胡芳弟*，黨蔘多糖對荷瘤小鼠免疫應答及抑瘤作用研究[J]. 中華腫瘤防治雜誌，2015;22(17):1357-1362.

【19】陳文霞，張培，高霞，白瑞斌，胡芳弟*，基於抗腫瘤活性的紋黨蔘多糖硒化工藝研究[J].中成藥，2015;37(11):2408-2415.

【20】Wenxia Chen, Jiayu Chen, Hongmei Wu, Yuqiang Gou, Fangdi Hu*, Optimization of selenylation conditions for a pectic polysaccharideand its structural characteristic. International Journal of Biological Macromolecules.2014;69:244-251.

【21】Wenxia Chen, Hongmei Wu, Linjie Liu, Pei Zhang, Xia GaO, Fangdi Hu*, Fingerprint Analysis and Peak Pattern Matching of Xiaochaihu Granules at Multi-Wavelength Latin American Journal of Pharmacy. Lat. Am. J. Pharm. 2014;33 (3): 382-91.

【22】Linjie Liu, Yuqiang Gou, Xia Gao, Pei Zhang, Fangdi Hu*, .Electrochemically reduced graphene oxide-based electrochemical sensor for the sensitive determination of ferulic acid in A. sinensis and biological samples. Materials Science and Engineering C. (2014),42:227-233.

【23】 Linjie Liu, Xia Gao, Pei Zhang, Fangdi Hu*, Ultrasensitive Detection of Ferulic Acid Using Poly(diallyldimethylammonium chloride) Functionalized Graphene-Based Electrochemical Sensor. Journal of Analytical Methods in Chemistry. Volume 2014;9 pages.

【24】Jing An, Yuqiang Gou, Chunxia Yang, Fangdi Hu*, Chunming Wang，Synthesis of a biocompatible gelatin functionalized graphene nanosheets and its application for drug delivery. Materials Science and Engineering C. 2013;33: 2827–2837.

【25】Jing An, Jiping Li, Wenxia Chen, Chunxia Yang, Fangdi Hu * and Chunming Wang. Electrochemical study and application on shikonin at poly(diallyldimethylammonium chloride) functionalized graphene sheets modified glass carbon electrode. Chem. Res. Chin. Univ. 2013;4:798-805

【26】Jing An, Yingyan Bi, ChunxiaYang, Fangdi Hu*, ChunmingWang Electrochemical study and application on rutin at chitosan/graphene films modified glassy carbon electrode. Journal of pharmaceutical analysis. 2013;3(2):106-108.

【27】Qingliang Feng, Yongling Du, Chao Zhang, Zhixiang Zheng, Fangdi Hu, Zaihua Wang, Chunming Wanga Synthesis of the multi-walled carbon nanotubes-COOH/graphene/goldnanoparticles nanocomposite for simple determination of Bilirubin in humanblood serum. Sensors and Actuators B: Chemical. 2013;185:337-344.

【28】Zilong Dang, Demei Feng, Xiaohua Liu, Tao Yang, Long Guo, Jin Liang, Jiandi Liang, Fangdi Hu, Fang Cui, Shilan Feng, Structure and antioxidant activity study of sulfated acetamidopolysaccharide from Radix Hedysari. Fitoterapia. 2013;89: 20-32.

【29】 Chunxia Yang, Yuqiang Gou, Jiayu Chen, Jing An, Wenxia Chen, Fangdi Hu? Structural characterization and antitumor activity of a pecticpolysaccharide from Codonopsis pilosula. Carbohydrate Polymers.2013;98 886-895.

【30】陳文霞，武靜蓮，馬 東，張 培，高 霞，胡芳弟*, 小柴胡顆粒製劑-藥材譜峯匹配指紋圖譜研究[J]，中草藥 Chinese Traditional and Herbal Drugs. 2013;44(22): 3154-3161.

【31】 楊春霞,胡林海,吳紅梅,王東,安婧,胡芳弟*,中心組合設計優化提取文黨蔘多糖及其硒含量的測定[J].西北師範大學學報（自然科學版）2013;49(1):66-71.

【32】韓菁, 劉新榮, 劉小花,吳紅梅, 楊春霞, 安婧, 崔方, 胡芳弟*.丹酚酸B的電化學行為及其測定[J].蘭州大學學報（自然科學版），2012;48(1):123-126.

【33】楊雪梅，楊海紅，楊春霞，安　婧，安美霖，胡芳弟*.當歸活性成分提取及其複合物栓劑抗炎活性研究[J].　西北師範大學學報（自然科學版），2012;48(4):71-75.

【34】 馬玉鳳，李文，胡芳弟，石義凱，畢映燕，封士蘭, LC-MS /MS 測定大鼠血漿中香柑內酯及其藥代動力學研究,中國中藥雜誌，2012;37（3）:381-383.

【35】Yikai Shi, Lianggong Zhao, Xiaohua Liu, Fangdi Hu, Fang Cui, Yingyan Bi, Yufeng Ma,Shilan Feng，Structural characterization of a sulfated glucan isolated from the aqueous extract of Hedysarum polybotrys Hand.-Mazz. Carbohydrate Polymers. 2012;87:160-169.

【36】 Fangdi Hu, Shilan Feng, Yuqiong Wu,Yingyan Bi, Chunming Wang*. Quantitative analysis of costunolide and dehydrocostuslactone in rat pLasma by ultraperformance liquid chromatography–electrospray ionization–mass spectrometry. Biomed. Chromatogr. 2011;25: 547-554. ^[1] 

【1】中藥新藥骨健顆粒的提取工藝優化及質量標準研究，橫向項目，負責人。

【2】黨蔘增免口服液的工業化研究，蘭州市科技局專利轉化項目，負責人。

【3】甘肅省地方習用藥材質量標準提升及產業化應用，甘肅省科技重大專項，蘭州大學項目負責人。

【4】百合鱗莖凍乾片及相關健康產品開發研究，橫向項目，負責人。

【5】甘肅黨蔘資源綜合開發利用知識產權創造力提升及對策研究，甘肅省科技計劃項目，負責人。

【6】甘肅特色藥材新型飲片研發中心，蘭州市成果轉化基地項目，負責人。

【7】大黃等六種藥材質量標準研究項目，國家中醫藥管理局，蘭州大學項目負責人。

【8】甘肅優質道地藥材產地加工炮製一體化關鍵技術研究，蘭州市人才創新創業項目，負責人。

【9】黨蔘山楂健脾養胃咀嚼片的研製，蘭州市重大科技計劃專項目，2015-3-3，主持。

甘肅省中醫藥管理局科研課題“甘肅黨蔘藥材道地性評價方法研究”GZK-2015-19。

【10】紋黨蔘鮮藥材產地加工炮製一體化關鍵技術研究，甘肅省科技支撐計劃項目，蘭州大學負責人。

【11】“基於藥物代謝動力學的青娥方配伍規律研究”，中國博中國博士後基金，上海市博士後基金：負責人。 ^[1] 

（1）蘭州大學巾幗標兵（2017）；

（2）甘肅省飛天學者（2016）；

（3）甘肅省科技進步二等獎（排名第一，2016）；

（4）甘肅省專利三等獎（排名第一，2015）；

（5）蘭州市科技發明一等獎（排名第一，2015）；

（6）城關區科技進步一等獎（排名第一，2015）；

（7）蘭州大學隆基教學骨幹獎（2013）；

（8）甘肅省科技進步二等獎（排名第二，2012）；

（9）蘭州市科技進步一等獎（排名第二，2012）。 ^[1]