紀洪芳

2022年7月，擔任魯東大學副校長。 ^[2] 

近年來採用理論和實驗研究結合的方法從事神經退行性疾病（如阿爾茨海默氏症，朊病毒病等）的致病機理及多靶點藥物設計、天然產物的藥理及耐藥機理等等方向的研究。取得的系列成果先後發表於Genome Biol. (IF: 11.3 ), Trends Biochem. Sci. (IF: 12.8), EMBO Rep. (IF: 7.7), Trends Mol. Med. (IF: 9.3), Sci. Rep. (IF: 5.2)等本領域國際權威期刊，論文被引用1000餘次。主持國家自然科學基金和山東省自然科學傑出青年基金等課題。先後獲山東省自然科學獎二等獎、教育部自然科學獎二等獎、山東省青年科技獎、山東省高校自然科學類一等獎等科研獎項。 ^[1] 

現擔任生命科學學院副院長、山東省生物信息工程技術研究中心負責人、'生物化學工程'二級博士點授權學科帶頭人、山東省生物物理專業委員會副主任、山東省生物化學與分子生物學常務理事。

主講本科生和研究生《生物信息學》、《生命科學前沿》、《理論生物學》等課程。

(1) 神經退行性疾病的致病機理及藥物設計研究

(2) 藥物活性、藥理及耐藥機理研究

(3) 計算機輔助藥物設計研究

(4) 複雜疾病的生物信息學研究

1. L. Shen, C.-C. Liu, C.-Y. An, H.-F. Ji How does curcumin work with poor bioavailability? Clues from experimental and theoretical studies. Sci. Rep. 2016, 6:20872.

2. L. Gao, Z. Cui, L. Shen, H.-F. Ji Shared Genetic Etiology between Type 2 Diabetes and Alzheimer's Disease Identified by Bioinformatics Analysis. J. Alzheimers Dis. 2015, 50:13-17.

3. H.-F. Ji, D.-X. Kong, L. Shen, L.-L. Chen, B.-G. Ma, H.-Y. Zhang. Distribution patterns of small-molecule ligands in the protein universe and implications for origin of life and drug discovery. Genome Biol. 2007, 8: R176.

4. L. Shen, H.-F. Ji. The pharmacology of curcumin: is it the degradation products? Trends Mol. Med. 2012, 18: 138-144.

5. H.-F. Ji, X.-J. Li, H.-Y. Zhang, Natural products and drug discovery. EMBO Rep. 2009, 10: 194-200.

6. H.-F. Ji*, H.-Y. Zhang. β-sheet constitution of prion protein. Trends Biochem. Sci. 2010, 35: 129-134.

7. L. Shen, H.-F. Ji, H.-Y. Zhang. Why Is the C-terminus of Abeta(1-42) more unfolded than that of Abeta(1-40)? Clues from hydrophobic interaction. J. Phys. Chem. B. 2008, 112:3164-3167.

8. L. Shen, H.-F. Ji, Vitamin E: supplement versus diet in neurodegenerative diseases. Trends Mol. Med. 2012, 18, 443-445.

9. H.-F. Ji, L. Chen, H.-Y. Zhang, Organic cofactors participated more frequently than transition metals in redox reactions of primitive proteins. BioEssays 2008, 30: 766-771.

10. L. Shen, H.-F. Ji, Small cofactors may assist protein emergence from RNA world: clues from RNA-protein complexes. PLoS One 2011; 6: e22494.