-
範建華
（華東理工大學教授、博士生導師）
鎖定
1984年12月生，江蘇海門人，中共黨員，教授，博士生導師。
入選上海市“浦江人才”計劃（2018），上海市“晨光計劃”（2014），江蘇省“雙創人才”（2023），美國斯坦福大學卡內基科學研究所訪問學者（2016-2017）。獲上海海洋科學技術獎青年科技創新獎（2023）、上海市生物工程學會優秀青年科學家獎（2022）。獲華東理工大學青年五四獎章（2023）、青年英才培育計劃（2020）、優秀研究生指導老師（2022）、優秀研究生兼職輔導員（2019）、校園新星（2021）等榮譽稱號。擔任中國生物工程學會一碳生物技術專委會委員（2022-2026）、中國化工學會生物化工專業委員會青年學者工作委員會委員（2023-2027）、上海市生物工程學會一碳生物技術專委會委員（2023-2027）。
承擔國家自然科學基金、國家重點研發計劃合成生物學專項、973計劃子課題、中央高校基本科研業務費專項基金、上海市自然科學基金、山東省自然科學基金重大基礎研究項目等多個國家級/省部級項目。已在Biotechnology Advances、Trends in Food Science and Technology、Chemical Engineering Journal、Plant Physiology、Biotechnology for Biofuels、Bioresource Technology、Bioorganic Chemistry等專業領域Top期刊等雜誌上發表論文50多篇，Google Scholar總被引用超過1700次，單篇最高引用超300次，入選ESI高被引論文1篇、熱點論文1篇；申請發明專利26項，授權12項。
- 中文名
- 範建華
- 外文名
- Jianhua Fan
- 國 籍
- 中國
- 民 族
- 漢族
- 出生地
- 江蘇
- 出生日期
- 1984年12月
- 畢業院校
- 華東理工大學
- 職 業
- 大學教授
範建華人物經歷
2024/01-至今 | 華東理工大學生物工程學院 | 教授，博士生導師 |
2022/03-2023/07 | 石河子大學化學化工學院 | 黨委委員、副院長（援疆） |
2015/01-2023/12 | 華東理工大學生物工程學院 | 歷任講師、副教授，碩導/博導 |
2016/10-2017/10 | Stanford University，Carnegie Institution for Science | 訪問學者 |
2012/12-2014/12 | 華東理工大學生物反應器工程國家重點實驗室 | 師資博士後 |
2010/12-2012/06 | 中科院青島生物能源與過程研究所 | 聯合培養 |
2009/03-2010/02 | 中科院遺傳與發育生物學研究所 | 聯合培養 |
2007/09-2012/11 | 華東理工大學生物工程學院 | 生物化工，碩博連讀 |
2003/09-2007/07 | 華東理工大學生物工程學院 | 生物科學，本科 |
範建華研究方向
（1）生物轉化與綠色低碳技術
主要針對富含生物活性物質和高效環境修復的微藻優良種質，重點探索營養與環境因素對微藻生長及代謝作用機制、微藻光合自養和光暗發酵過程中碳氮磷高效生物轉化及優化調控技術，為微藻植物蛋白和生物活性物質生產（如藻膽蛋白、PUFAs、色素、多糖等）、環境治理（CO2減排和污染物降解）與生物質利用、生物餌料與飼料、生物能源的開發提供綠色低碳關鍵技術。
（2）合成生物系統構建與應用
主要以微藻及藍細菌等光合微生物為研究對象，基於功能基因組學、代謝途徑解析與組裝、合成生物技術等手段開發藻細胞底盤，建立成熟的表達系統/基因編輯體系（細胞核、葉綠體基因組），實現外源蛋白（如疫苗、工業酶、藥用蛋白、抗體、細胞因子等）在藻細胞內高效表達，藉此推動微藻綠色細胞工廠相關技術的發展（如重組微藻疫苗、活細胞光-酶催化等），實現高值化利用。
範建華學術兼職
1. Frontiers in Marine Science副主編（SCI收錄，Q1 Top期刊，2019-至今）
2. Bioresources and Bioprocessing青年編委（SCI收錄，Q2，2020-至今）
3. Frontiers in Bioengineering and Biotechnology客座副主編（SCI收錄，Q2），主持Novel insights into algal biology and biotechnology（2017）、Advanced technologies and perspectives on sustainable microalgae production（2020）、Microalgal production of omega fatty acids: present and future（2022）專刊
4. 中國生物工程學會一碳生物技術專委會委員（2022-2026）
5. 中國化工學會生物化工專業委員會青年學者工作委員會委員（2023-2027）
6. 上海市生物工程學會一碳生物技術專委會委員（2023-2027）
7. 美國植物生物學家學會（ASPB）會員（2015-）、中國藻業協會會員（2020-）
8. Nature Communications、New Phytologist、Biotechnology for Biofuels、Bioresource Technology、Journal of Agricultural and Food Chemistry、Biotechnology Journal、Biochemical Engineering Journal、Briefings in Bioinformatics、Algal Research、生物工程學報、微生物學報等20多個期刊審稿人
範建華教學情況
獲中國石油與化工教育教學優秀成果一等獎（2020，2022），華東理工大學本科教學成果二等獎（2019，2021），主持教育部產學合作協同育人項目（2019，2021）。指導本科生獲國際遺傳工程機器大賽iGEM金獎及生物製造單項最佳獎（2019）；指導本科生獲全國大學生生命科學競賽一等獎（2021，2項）；指導研究生獲中國“互聯網+”大學生創新創業大賽上海市金獎（2021）、“挑戰杯”中國大學生創業計劃競賽上海市銀獎等省部級獎勵（2022）。指導研究生獲國家獎學金（5人次）、上海市優秀畢業生（5人次）、成思危名譽校長獎學金和校高水平論文獎等榮譽；指導本科生承擔國家級/上海市級“大學生創新創業訓練計劃”十多項。
承擔教學任務：
1. 上海市重點課程、專業必修課《分子生物學》（全英文，48學時，3學分）；
2. 專業選修課《進化生物學》（32學時，2學分）；
3. 專業必修課《生物化學實驗》（32學時，1學分）；
4. 公選課《國際遺傳工程機器競賽與合成生物技術》（16學時，1學分，團隊教學）；
5. 班導師，iGEM競賽指導老師，Biomaker創新俱樂部指導老師，大創指導老師；
範建華發表論文
[1] Ping Wu, Tianyouzi Hu, Liyun Sun, Jianhua Fan*. Efficient degradation of sulfadiazine by photosynthetic cyanobacteria Synechocystis sp. PCC 6803 coupling with recombinant laccase strategy. Chemical Engineering Journal, 2023, 474, 145974. IF15.10, 1區top
[2] Cheng Chen, Qianwen Shi, Akang Tong, Liyun Sun, Jianhua Fan*. Screening of microalgae strains for efficient biotransformation of small molecular organic acids from dark fermentation biohydrogen production wastewater. Bioresource Technology, 2023, 390, 129872. IF11.39, 1區top
[3] Qianwen Shi#, Zuodong Zhou#, Zhiwei Hong, Zhi Yang, Zhengquan Gao, Liyun Sun*, Jianhua Fan*.Transcriptomics reveal how circadian regulation contributes to starch hyperaccumulation in marine alga Tetraselmis helgolandica. GCB Bioenergy, 2023, 15:1477-1493. IF5.59, 3區
[4] Liang Ji#, Sheng Qiu#, Zhiheng Wang, Chenni Zhao, Bo Tang, Zhengquan Gao, Jianhua Fan*. Phycobiliproteins from algae: Current updates in sustainable production and applications in food and health. Food Research International, 2023,167:112737. IF8.10, 1區top
[5] Sheng Qiu, Yuchen Yuan, Xiaoyi Li, Chenni Zhao, Yulong He, Bo Tang, Wenda Wang, Jianhua Fan*. Peridinin-chlorophyll-protein complex industry from algae: A critical review of the current advancements, hurdles, and biotechnological potential. Algal Research, 2023, 72, 103118. IF5.10, 2區
[6] Cheng Chen, Tao Tang, Qianwen Shi, Zuodong Zhou, Jianhua Fan*. The potential and challenge of microalgae as promising future food sources. Trends in Food Science and Technology, 2022, 126:99-112. IF15.29, 1區top，ESI高被引、熱點論文
[7] Qianwen Shi, Cheng Chen, Tingwei He, Jianhua Fan*. Circadian rhythm promotes the biomass and amylose hyperaccumulation by mixotrophic cultivation of marine microalga Platymonas helgolandica. Biotechnology for Biofuels and Bioproducts, 2022, 15, 75. IF6.29, 2區
[8] Liang Ji, Yueling Liu, Jianquan Luo, Jianhua Fan*. Freeze-thaw-assisted aqueous two-phase system as a green and low-cost option for analytical grade B-phycoerythrin production from unicellular microalgae Porphyridium purpureum. Algal Research, 2022, 67, 102831. IF5.1, 2區
[9] Ke Ma, Lei Deng, Haizhen Wu*, Jianhua Fan*. Towards green biomanufacturing of high-value recombinant proteins using promising cell factory: Chlamydomonas reinhardtii chloroplast. Bioresources and Bioprocessing, 2022, 9, 83. IF4.60, 3區
[10] Dongqing Zhou, Yeling Luo, Yingqiu Zhang, Chenni Zhao, Hui Wu*, Jianhua Fan*. Perturbing electron carriers of green algae Chlamydomonas reinhardtii for efficient physiological and metabolic regulation. Food Bioengineering, 2022, 1:148-158.
[11] Ping Wu, Zhaofei Zhang, Yeling Luo, Yunpeng Bai, Jianhua Fan*. Bioremediation of phenolic pollutants by algae - current status and challenges. Bioresource Technology, 2022, 350, 126930. IF11.39, 1區top
[12] Ke Ma, Siwei Chen, Yue Wu, Yiting Ma, Haochen Qiao, Jianhua Fan*, Haizhen Wu*. Dietary supplementation with microalgae enhances the zebrafish growth performance by modulating immune status and gut microbiota. Applied Microbiology and Biotechnology, 2022, 106: 773-788. IF5.00, 3區
[13] Jianhua Fan, Yinghui Zhang, Ping Wu, Xiaoyan Zhang, Yunpeng Bai*. Enhancing cofactor regeneration of cyanobacteria for the light-powered synthesis of chiral alcohols. Bioorganic Chemistry, 2022, 118, 105477. IF5.10, 2區top
[14] Jianhua Fan*, Qiuwen Bao, Ke Ma, Xiaofei Li, Jing Jia, Haizhen Wu*. Antioxidant and innate immunity of Danio rerio against Edwardsiella tarda in response to diets including three kinds of marine microalgae. Algal Research, 2022, 64, 102689. IF5.10, 2區
[15] Jianhua Fan, Dongqing Zhou, Cheng Chen, Ju Wu, Hui Wu*. Reprogramming the metabolism of Synechocystis PCC 6803 by regulating the plastoquinone biosynthesis. Synthetic and Systems Biotechnology, 2021, 4(6):351-359. IF4.80, 2區
[16] Liang Ji, Shaohua Li, Cheng Chen, Haojie Jin, Haizhen Wu, Jianhua Fan*. Physiological and transcriptome analysis elucidates the metabolic mechanism of versatile Porphyridium purpureum under nitrogen deprivation for exopolysaccharides accumulation. Bioresources and Bioprocessing, 2021, 8, 73. IF4.60, 3區
[17] Shaohua Li#, Jianke Huang#, Liang Ji, Cheng Chen, Ping Wu, Wei Zhang, Gaoyi Tan, Haizhen Wu, Jianhua Fan*. Assessment of light distribution model for marine red microalga Porphyridium purpureum for sustainable production in photobioreactor. Algal Research, 2021, 58, 102390. IF5.10, 2區
[18] Qianwen Shi, Cheng Chen, Wei Zhang, Ping Wu, Meng Sun, Hui Wu, Haizhen Wu, Pengcheng Fu*, Jianhua Fan*. Transgenic eukaryotic microalgae as green factories: providing new ideas for the production of biologically active substances. Journal of Applied Phycology, 2021, 33:705-728. IF3.30, 3區
[19] Ke Ma#, Qiuwen Bao#, Yue Wu, Siwei Chen, Shuxin Zhao, Haizhen Wu*, Jianhua Fan*. Evaluation of microalgae as immunostimulants and recombinant vaccines for disease prevention and control in aquaculture. Frontiers in Bioengineering and Biotechnology, 2020, 8, 590431. IF5.69, 3區
[20] Shaohua Li, Liang Ji, Cheng Chen, Shuxin Zhao, Meng Sun, Zhengquan Gao, Haizhen Wu, Jianhua Fan*.Efficient accumulation of high-value bioactive substances by carbon to nitrogen ratio regulation in marine microalgae Porphyridium purpureum. Bioresource Technology, 2020, 309, 123362. IF11.39, 1區top
[21] Shaohua Li#, Liang Ji#, Qianwen Shi#, Haizhen Wu, Jianhua Fan*. Advances in the production of bioactive substances from marine unicellular microalgae Porphyridium spp. Bioresource Technology, 2019, 292, 122048. IF11.39, 1區top
[22] Lili Xu, Jianhua Fan*, Quanxi Wang*.Omics application of bio-hydrogen production through green alga Chlamydomonas reinhardtii. Frontiers in Bioengineering and Biotechnology, 2019, 7, 201. IF5.69, 3區
[23] Lili Xu, Huawei Yong, Xiaomeng Tu, Quanxi Wang*, Jianhua Fan*. Physiological and proteomic analysis of Nostoc flagelliforme in response to alkaline pH shift for polysaccharide accumulation.Algal Research, 2019, 39, 101444. IF5.10, 2區
[24] Pengfei Cheng, Chengxu Zhou, et al, Xiaojun Yan*, Jianhua Fan*. Comparative transcriptome analyses of oleaginous Botryococcus braunii race A reveal significant differences in gene expression upon cobalt enrichment. Biotechnology for Biofuels, 2018, 11, 333. IF6.29, 1區top
[25] Lvhong Zheng, Xiaoyan Zhang, Yunpeng Bai*, Jianhua Fan*. Using algae cells to drive cofactor regeneration and asymmetric reduction for the synthesis of chiral chemicals.Algal Research, 2018, 35:432-438. IF5.10, 2區
[26] Jianhua Fan*, Lvhong Zheng, Yunpeng Bai, Shai Saroussi, Arthur Grossman. Flocculation of Chlamydomonas reinhardtii with different phenotypic traits by metal cations and high pH. Frontiers in Plant Science, 2017, 8, 1997. IF5.59, 2區top
[27] Jianhua Fan*, Lvhong Zheng. Acclimation to NaCl and light stress of heterotrophic Chlamydomonas reinhardtii for lipid accumulation. Journal of Bioscience and Bioengineering, 2017, 124(3):302-308. IF2.80, 3區
[28] Conglin Run, Lei Fang, Jianhua Fan*, et al. Stable nuclear transformation of the industrial alga Chlorella pyrenoidosa. Algal Research, 2016, 17:196-201. IF5.10, 2區
[29] Jianhua Fan*, Hui Xu, Yuanguang Li*. Transcriptome-based global analysis of gene expression in response to carbon dioxide deprivation in the green algae Chlorella pyrenoidosa. Algal Research, 2016, 16:12-19. IF5.10, 2區
[30] Jianhua Fan, Kang Ning, Xiaowei Zeng, et al, Jian Xu*, Yuanguang Li*. Genomic foundation of starch-to-lipid switch in oleaginous Chlorella spp. Plant Physiology, 2015, 169(4):2444-2461. IF7.40, 1區top
[31] Jianhua Fan, Hui Xu, Yuanchan Luo, Minxi Wan, Jianke Huang, Weiliang Wang, Yuanguang Li*. Impacts of CO2 concentration on growth, lipid accumulation and carbon concentrating mechanism related genes expression in oleaginous Chlorella. Applied Microbiology and Biotechnology, 2015, 99(5):2451-2462. IF5.00, 3區
[32] Jianhua Fan#, Yanbin Cui#, Minxi Wan, Weiliang Wang, Yuanguang Li*. Lipid accumulation and biosynthesis genes response of the oleaginous Chlorella pyrenoidosa under three nutrition stressors. Biotechnology for Biofuels, 2014, 7, 17. IF6.29, 1區top
[33] Jianhua Fan, Yanbin Cui, Yang Zhou, Minxi Wan, Weiliang Wang, Jingli Xie, Yuanguang Li*. The effect of nutrition pattern alteration on Chlorella pyrenoidosa growth, lipid biosynthesis-related gene transcription. Bioresource Technology, 2014, 164:214-220. IF11.39, 1區top
[34] Jianhua Fan#, Yanbin Cui#, Jianke Huang, Weiliang Wang, Weibo Yin, Zanmin Hu*, Yuanguang Li*. Suppression subtractive hybridization reveals transcript profiling of Chlorella under heterotrophy to photoautotrophy transition. PLoS One, 2012, 7:1-15. IF3.70, 3區
[35] Jianhua Fan, Jianke Huang, Yuanguang Li*, Feifei Han, Jun Wang, Xinwu Li, Weiliang Wang, Shulan Li. Sequential heterotrophy-dilution-photoinduction cultivation for efficient microalgal biomass and lipid production. Bioresource Technology, 2012, 112:206-211. IF11.39, 1區top
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- 參考資料
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- 1. 範建華 ．華東理工大學生物工程學院導師風采[引用日期2021-07-16]
