王靜

2004/09-2008/07 中央民族大學生命與環境科學學院 本科

2008/09-2013/07 北京協和醫學院基礎醫學研究所 生物化學與分子生物學系 碩博連讀

2013/09-2019/09 中國醫學科學院醫藥生物技術研究所 助理研究員

2019/10-至今 中國醫學科學院醫藥生物技術研究所 副研究員

病毒學基礎研究和抗病毒藥物應用研究

主要從事病毒與宿主的相互作用研究，及新型抗病毒藥物靶點的發現。近年來致力於宿主長鏈非編碼RNA（lncRNAs）在流感病毒複製過程中的功能及機制探討。首次利用loss-of-function策略，篩選獲得了一系列功能性lncRNAs，並首次揭示了候選lncRNAs在病毒感染中的新功能及作用機制，以期後續構建完整的流感病毒-lncRNA調控網絡，為新抗病毒療法的發展提供新思路。以第一/通訊作者身份，將該部分成果分別發表於Cell子刊Cell Reports、Viruses及Emerging Microbes & Infections等國際學術期刊，並授權專利1項。同時還參與了多個課題研究，在J Virol.，BBAR:MCR，Acta Pharm Sin B，Sci Rep.，Antiviral Res.，BMC Cancer，Retrovirology等專業刊物上發表SCI論文10餘篇，國家發明專利2項。先後主持承擔協和青年基金及滾動項目、北京市重點實驗室、國家自然科學基金青年和麪上項目，並參與國家重點研發計劃、傳染病防治重大專項及中國醫學科學院協同創新團隊項目等。

1. Jing Wang#, Yongxin Zhang#, Quanjie Li, Jianyuan Zhao, Dongrong Yi, Jiwei Ding, Fei Zhao, Siqi Hu, Jinming Zhou, Tao Deng, Xiaoyu Li*, Fei Guo, Chen Liang, and Shan Cen*, Influenza virus exploits an interferon-independent lncRNA to preserve viral RNA synthesis through stabilizing viral RNA polymerase PB1. Cell Reports, 2019, 27, 3295–3304.

2. Jing Wang* and Shan Cen*. Roles of lncRNAs in influenza virus infection. Emerg Microbes Infect. 2020, 9 (1):1407-1414.

3. Jing Wang, Yujia Wang, Rui Zhou, Jianyuan Zhao, Yongxin Zhang, Dongrong Yi, Quanjie Li, Jinming Zhou, Fei Guo, Chen Liang, Xiaoyu Li and Shan Cen*, Host long noncoding RNA lncRNA-PAAN regulates the replication of Influenza A Virus. Viruses, 2018, 10, 330.

4. Ling-xia Wang#, Jing Wang#, Ting-ting Qu, Ye Zhang*, Yu-fei Shen*, Reversible acetylation of Lin28 mediated by PCAF and SIRT1. Biochimica et Biophysica Acta: Molecular Cell Research, 2014, 1843(6): 1188-1195.

5. Jianyuan, Saisai Guo, Dongrong Yi, Quanjie Li, Ling Ma, Yongxin Zhang, Jing Wang, Xiaoyu Li, Fei Guo, Rongtuan Lin, Chen Liang, Zhenlong Liu*, Shan Cen*, A cell-based assay to discover inhibitors of SARS-CoV-2 RNA dependent RNA polymerase. Antiviral Research.

6. Dong-Rong Yi#, Ni An#, Zhen-Long Liu, Feng-Wen Xu, Kavita Raniga, Quan-Jie Li, Rui Zhou, Jing Wang, Yong-Xin Zhang, Jin-Ming Zhou, Lei-Liang Zhang, Jing An, Cheng-Feng Qin, Fei Guo, Xiao-Yu Li, Chen Liang, Shan Cen*, Human MxB inhibits the replication of hepatitis C virus. J Virol, 2019, 93:e01285-18.

7. Quanjie Li#, Ling Ma#, Dongrong Yi#, Han Wang, Jing Wang, Yongxin Zhang, Ying Guo, Xiaoyu Li, Jinming Zhou*, Yi Shi*, George F. Gao, Shan Cen*, Novel cyclo-peptides inhibit Ebola pseudotyped virus entry by targeting primed GP protein. Antiviral Res., 2018, 155:1-11.

8. Ling Ma, Zhixin Zhang, Zhenlong Liu, Qinghua Pan, Jing Wang, Xiaoyu Li, Fei Guo, Chen Liang, HuLaixing Hu, Jinming Zhou*, Shan Cen*, Identification of small molecule compounds targeting the interaction of HIV-1 Vif and human APOBEC3G by virtual screening and biological evaluation. Sci Rep., 2018, 8(1):8067.

9. Ting-ting Qu#, Fei Chen#, Jing Wang, Yan-jun Zhang, Mo-bin Cheng, Wen-zheng Sun, Yu-fei Shen and Ye Zhang*, PCAF-mediated acetylation of Lin28B increases let-7 biogenesis in lung adenocarcinoma H1299 cells. BMC Cancer, 2018, 18: 27.

10. Congjie Zhai, Ling Ma, Zhixin Zhang, Jiwei Ding, Jing Wang, Yongxin Zhang, Xiaoyu Li, Fei Guo, Liyan Yu, Jinming Zhou, Shan Cen*, Identification and characterization of loop7 motif and its role in regulating biological function of human APOBEC3G through molecular modeling and biological assay. Acta Pharm Sin B, 2017,7(5):571-582.

11. Quan Zhang#, Zeyun Mi#, Yuming Huang#, Ling Ma, Jiwei Ding, Jing Wang, Yongxin Zhang, Yang chen, Jinming Zhou, Fei Guo, Xiaoyu Li and Shan Cen*, 2-thio-6-azauridine inhibits Vpu mediated BST-2 degradation. Retrovirology, 2016, 13:13.

1. 岑山、王靜、張永欣、衣崬戎、李泉潔。以IPAN或其編碼基因為靶點的物質在製備流感病毒抑制劑中的應用，ZL201910276034.6，授權日：2021-03-12

2. 岑山、李泉潔、馬鈴、衣崬戎、王靜、張永欣。與埃博拉病毒激活態包膜糖蛋白特異性結合的多肽及其在抗病毒中的應用，ZL201810087839.1，授權日：2020-06-16　

3. 岑山，李泉潔，馬鈴，衣崬戎，王靜，張永欣，多肽及其在抗埃博拉病毒中的應用，中國發明專利申請：202010460222.7，申請日：2020-05-02