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王迪

（浙江大學求是特聘教授）

鎖定
王迪，浙江大學求是特聘教授，博士生導師。
2003年畢業於武漢大學生命科學學院獲得學士學位；2008年畢業於武漢大學生命科學學院病毒學國家重點實驗室獲得博士學位。2008年進入浙江大學醫學院免疫學研究所任講師、副教授。2012年底公派進入哈佛大學醫學院免疫學系從事博士後研究工作。2014年底任浙江大學醫學院免疫學系教授，組建免疫代謝研究組 [1]  。近些年以通訊作者在Immunity，Science Immunology，Cell Metabolism，Molecular Cell，Developmental Cell，Nature Communications，Gut 等學術雜誌上發表研究論文多篇 [1]  。獲得國家傑出青年基金，優秀青年基金，重點項目資助，教育部青年長江學者，浙江省萬人計劃科技創新領軍人才，浙江省傑出青年基金 ，浙江省有突出貢獻青年科技人才，浙江省優秀博士論文導師，藥明康德生命化學研究學者獎 [1]  ，中國免疫學青年學者獎等。
中文名
王迪
國    籍
中國
民    族
漢
畢業院校
武漢大學 [1] 
職    業
高校教師 [1] 
職    稱
教授 [1] 

目錄

  1. 1 教育和工作經歷
  2. 2 代表性論文
  3. 3 研究方向

王迪教育和工作經歷

2003年畢業於武漢大學生命科學學院獲得學士學位；2008年畢業於武漢大學生命科學學院病毒學國家重點實驗室獲得博士學位。攻讀博士期間進入法國巴黎第十一大學聯合培養，並於芬蘭赫爾辛基大學、日本理化學研究所交流學習。2008年進入浙江大學醫學院免疫學研究所任講師、副教授。2012年底公派進入哈佛大學醫學院免疫學系從事博士後研究工作，跟隨美國科學院院士Diane Mathis從事免疫代謝學研究。2014年底，任浙江大學醫學院免疫學系教授，組建免疫代謝研究組。 [1] 

王迪代表性論文

12. Mobai Li, Dehang Yang, Huige Yan, Zhibin Tang, Danlu Jiang, Jian Zhang, Zhexu Chi, Wanyun Nie, Wenxuan Zhen, Weiwei Yu, Sheng Chen, Zhen Wang, Qianzhou Yu, Xue Zhang, Fan Yang, Shunwu Fan*, Xianfeng Lin*, and Di Wang*. Gasdermin D maintains bone mass by rewiring the endo-lysosomal pathway of osteoclastic bone resorption. Developmental Cell. 2022, DOI:10.1016/j.devcel.2022.09.013
11. Sheng Chen, Wenyu Cui, Zhexu Chi, Qian Xiao, Tianyi Hu, Qizhen Ye, Kaixiang Zhu, Weiwei Yu, Zhen Wang, Chengxuan Yu, Xiang Pan, Siqi Dai, Qi Yang, Jiacheng Jin, Jian Zhang, Mobai Li, Dehang Yang, Qianzhou Yu, Quanquan Wang, Xiafei Yu, Wei Yang, Xue Zhang, Junbin Qian, Kefeng Ding*, and Di Wang*. Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1. Cell Metabolism. 2022, DOI:10.1016/j.cmet.2022.08.016
10. Weiwei Yu, Zhen Wang, Xiafei Yu, Yonghui Zhao, Zili Xie, Kailian Zhang, Zhexu Chi, Sheng Chen, Ting Xu, Danlu Jiang, Xingchen Guo, Mobai Li, Jian Zhang, Hui Fang, Dehang Yang, Yuxian Guo, Xuyan Yang, Xue Zhang, Yingliang Wu, Wei Yang*, and Di Wang*. Kir2.1-mediated membrane potential promotes nutrient acquisition and inflammation through regulation of nutrient transporters. Nature Communications. 2022, DOI:10.1038/s41467-022-31149-y
9. Jian Zhang, Qianzhou Yu, Danlu Jiang, Kang Yu, Weiwei Yu, Zhexu Chi, Sheng Chen, Mobai Li, Dehang Yang, Zhen Wang, Ting Xu, Xingchen Guo, Kailian Zhang, Hui Fang, Qizhen Ye, Yong He, Xue Zhang, and Di Wang*. Epithelial Gasdermin D shapes the host-microbial interface by driving mucus layer formation. Science Immunology. 2022, DOI: 10.1126/sciimmunol.abk2092
8. Sheng Chen and Di Wang*. Intestinal-derived HDL: The portal guardian of the liver. Immunity. 2021, 54:1903-1905
7. Zhexu Chi, Sheng Chen, Ting Xu, Wenxuan Zhen, Weiwei Yu, Danlu Jiang, Xingchen Guo, Zhen Wang, Kailian Zhang, Mobai Li, Jian Zhang, Hui Fang, Dehang Yang, Qizhen Ye, Xuyan Yang, Hui Lin, Fan Yang, Xue Zhang, and Di Wang*. Histone deacetylase 3 couples mitochondria to drive IL-1β-dependent inflammation by configuring fatty acid oxidation. Molecular Cell. 2020, 80:43-58
6. Weiwei Yu, Zhen Wang, Kailian Zhang, Zhexu Chi, Ting Xu, Danlu Jiang, Sheng Chen, Wenxin Li, Xuyan Yang, Xue Zhang, Yingliang Wu*, and Di Wang*. One-carbon metabolism supports S-adenosylmethionine and histone methylation to drive inflammatory macrophages. Molecular Cell. 2019, 75:1147-1160
5. Chuansheng Guo, Zhexu Chi, Danlu Jiang, Ting Xu, Weiwei Yu, Zhen Wang, Sheng Chen, Li Zhang, Qianyun Liu, Xingchen Guo, Xue Zhang, Wenxin Li, Linrong Lu, Yingliang Wu, Bao-Liang Song, and Di Wang*. Cholesterol homeostatic regulator SCAP-SREBP2 integrates NLRP3 inflammasome activation and cholesterol biosynthetic signaling in macrophages. Immunity.2018, 49:1-15
4. Chuansheng Guo, Shujun Xie, Zhexu Chi, Jinhua Zhang, Yangyang Liu, Li Zhang, Mingzhu Zheng, Xue Zhang, Dajing Xia, Yuehai Ke, Linrong Lu, and Di Wang*. Bile acids control inflammation and metabolic disorder through inhibition of NLRP3 inflammasome. Immunity. 2016, 45:802-816
3. Di Wang*, Mingzhu Zheng, Yuanjun Qiu, Chuansheng Guo, Jian Ji, Lei Lei, Xue Zhang, Xuetao Cao, Yi Ting Zhou, and Linrong Lu*. Tespa1 negatively regulates FceRI-mediated signaling and the mast cell-mediated allergic response. Journal of Experimental Medicine. 2014, 211(13):2635-2649
2. Di Wang, Mingzhu Zheng, Lei Lei, Jian Ji, Yunliang Yao, Yuanjun Qiu, Lie Ma, Jun Lou, Chuan Ouyang, Xue Zhang, Yuewei He, Jun Chi, Lie Wang, Ying Kuang, Jianli Wang, Xuetao Cao, and Linrong Lu*. Tespa1 is involved in late thymocyte development through the regulation of TCR-mediated signaling.Nature Immunology. 2012, 13:560-568
1. Di Wang, Jun Lou, Chuan Ouyang, Weilin Chen, Yiqi Liu, Xinyuan Liu, Xuetao Cao, Jianli Wang, and Linrong Lu*. Ras-related protein Rab10 facilitates TLR4 signaling by promoting replenishment of TLR4 onto the plasma membrane. PNAS. 2010, 107 (31):13806-13811

王迪研究方向

免疫代謝學、細胞免疫學、分子免疫學、細胞生物學 [1] 
參考資料