王璞

1997-2007年先後於瀋陽藥科大學藥學院藥劑學系和生命科學與生物製藥學院微生物與生化藥學系獲得本科、碩士和博士學位。 ^[1] 

2008-2012年在美國約翰霍普金斯大學從事博士後研究工作。2012年8月作為國外引進人才回到東北大學生命科學與健康學院工作，繼續從事環氧合酶-2（Cycloloxygenase-2, COX-2）通過炎症機制調控退行性疾病發病機制領域的研究。 ^[1] 

主要從事環氧合酶-2（Cyclooxygenase-2, COX-2）代謝紊亂參與阿爾茨海默病（Alzheimer’s Disease, AD）和骨關節炎（Osteoarthritis, OA）發病機理的研究。應用體外細胞模型和體內小鼠模型相結合的方式，探討COX-2通過調控炎症因子的表達影響AD和OA發病的分子機制，試圖揭示非甾體抗炎藥（NSAIDs）作為COX-2抑制劑類藥物治療AD和OA發病的分子機理。進而對COX-2調控AD和OA發病的信號傳導通路進行闡述，發現AD和OA發病的分子靶點，為藥物開發提供新思路，新靶標。 ^[1] 

1. 國家自然科學基金面上項目：環氧合酶-2代謝紊亂促進b-澱粉樣蛋白在阿爾茨海默病中產生、傳播和沉積的神經病理學機制研究、項目負責人。

2. 國家自然科學基金青年科學基金項目：生理平流剪切應力通過COX-2/MMPs信號通路參與機械損傷誘發骨關節炎的作用機制研究、項目負責人。

3. 基本科研業務費“青年教師科研創新基金”項目：環氧合酶-2通過炎症機制調控tau蛋白磷酸化、傳播和沉積的分子機制研究、項目負責人。

4. 遼寧省教育廳“高校傑出青年學者成長計劃”項目：環氧合酶-2通過調控炎症因子的表達影響阿爾茨海默病發病的機理研究、項目負責人。

5. 基本科研業務費優秀科技人才培育基金項目：環氧合酶-2調控阿爾茨海默病發生、發展機制研究、項目負責人。 ^[1] 

1. Pu Wang, Pei-Pei Guan, Jing-Wen Guo, Long-Long Cao, Guo-Biao Xu, Xin Yu, Yue Wang, Zhan-You Wang*. Prostaglandin I2 upregulates the expression of anterior pharynx-defective-1a and -1b in amyloid precursor protein/presenilin1 transgenic mice. Aging cell, 2016, In press.

2. Pu Wang, Pei-Pei Guan, Xin Yu, Li-Chao Zhang, Ya-Nan Su, Zhan-You Wang*. Prostaglandin I2 attenuates prostaglandin E2-stimulated expression of interferon γ in a β-Amyloid Protein- and NF-κB-dependent mechanism. Scientific Reports, 2016, In press.

3. Pu Wang, Xin Yu, Pei-Pei Guan, Jing-Wen Guo, Yue Wang, Yan Zhang, Hang Zhao, Zhan-You Wang*. Magnesium ion influx reduces neuroinflammation in Aβ precursor protein/Presenilin 1 transgenic mice by suppressing the expression of interleukin-1β. Cellular & Molecular Immunology, 2015, In press.

4. Xin Yu, Pei-Pei Guan, Jing-Wen Guo, Yue Wang, Long-Long Cao, Guo-Biao Xu, Konstantinos Konstantopoulos, Zhan-You Wang*, Pu Wang*. By suppressing the expression of anterior pharynx-defective-1α and -1β and inhibiting the aggregation of β-amyloid protein, magnesium ions inhibit the cognitive decline of amyloid precursor protein/presenilin 1 transgenic mice. The FASEB Journal, 2015, 29: 5044-5058.

5. Pu Wang*, SH Chen, WC Hung, Colin Paul, Fei Zhu, Pei-Pei Guan, DL Huso, A Kontrogianni-Konstantopoulos, Konstantinos Konstantopoulos*. Fluid shear promotes chondrosarcoma cell invasion by activating matrix metalloproteinase 12 via IGF-2 and VEGF signaling pathways. Oncogene, 2015, 34: 4558-4569.

6. Pu Wang, Pei-Pei Guan, Tao Wang, Xin Yu, Jian-Jun Guo, Zhan-You Wang*. Aggravation of Alzheimer’s disease due to the COX-2-mediated reciprocal regulation of IL-1b and Ab between glial and neuron cells. Aging cell, 2014, 13, 605-615.

7. Pu Wang, Pei-Pei Guan, Tao Wang, Xin Yu, Jian-Jun Guo, Konstantinos Konstantopoulos, Zhan-You Wang*. Interleukin-1β and cyclic AMP mediate the invasion of sheared chondrosarcoma cells via a matrix metalloproteinase-1-dependent mechanism. Biochim Biophys Acta-Molecular Cell Research, 2014, 1843, 923-933.

8. Pu Wang, Pei-Pei Guan, Chuang Guo, Fei Zhu, Konstantinos Konstantopoulos*, Zhan-You Wang*. Fluid shear stress-induced osteoarthritis: roles of cyclooxygenase-2 and its metabolic products in inducing the expression of proinflammatory cytokines and matrix metalloproteinases. The FASEB Journal, 2013, 27, 4664-4677.

9. Pu Wang, Fei Zhu, Konstantinos Konstantopoulos*. The antagonistic actions of endogenous interleukin-1β and 15-deoxy-Δ12,14-prostaglandin J2 regulate the temporal synthesis of matrix metalloproteinase-9 in sheared chondrocytes. Journal of Biological Chemistry, 2012, 287, 31877-31893.

10. Pu Wang, Fei Zhu, Konstantinos Konstantopoulos*. Interleukin-6 synthesis in human chondrocytes is regulated via the antagonistic actions of prostaglandin (PG)E2 and 15-deoxy-Δ12,14-PGJ2. PLoSONE, 2011, e27630.

11. Pu Wang, Fei Zhu, Zi-Qiu Tong, Konstantinos Konstantopoulos*. Response of chondrocytes

to shear stress:antagonistic effects of the binding partners Toll-like Receptor 4 and caveolin-1. The FASEB Journal, 2011, 25, 3401-3415.

12. Pu Wang, Su Xu, Pei-Xing Wu, Jing-Hai Zhang, Toshinori Sato, Sadako Yamagata, Tatsuya Yamagata*. GM3 suppresses anchorage-independent growth via Rho GDP dissociation inhibitor (GDI) beta in melanoma B16 cells. Cancer Science, 2011, 162, 1476-1485.

13. Pu Wang, Fei Zhu, Konstantinos Konstantopoulos*. Shear-induced interleukin-6 synthesis in chondrocytes: The distinct roles of EP2 and EP3 receptors in cAMP/protein kinase A- and PI3-K/Akt-dependent NF-kB activation. Journal of Biological Chemistry, 2010, 285, 24793-24804.

14. Pu Wang, Fei Zhu, Konstantinos Konstantopoulos*. Prostaglandin E2 Induces Interleukin-6 Expression in Human Chondrocytes via cAMP/Protein Kinase A- and Phosphatidylinositol 3-Kinase-dependent NF-kB Activation. American Journal of Physiology-Cell Physiology, 2010, 298, 1445-1456.

15. Pu Wang, Pei-Pei Guan, Su Xu, Zhan-You Wang, Sadako Yamagata, and Tatsuya Yamagata. Emerging GM3 Regulated Biomarkers in Malignant Melanoma. Recent Advances in the Biology, Therapy and Management of Melanoma, Dr. Lester Davids (Ed.), 2013, ISBN: 978-953-51-0976-1, InTech, DOI: 10.5772/54941.

16. Pu Wang, Sadako Yamagata, Tatsuya Yamagata. Changing the nature of melanoma cells by manipulation of ganglioside expression. Breakthroughs in Melanoma Research, Dr. Yohei Tanaka (Ed.), 2011, ISBN: 978-953-307-291-3, InTech, DOI: 10. 5772/21566.

17. Pu Wang, Xiao-Dong Wang, Pei-Xing Wu, Jing-Hai Zhang, Toshinori Sato, Sadako Yamagata, Tatsuya Yamagata. GM3 upregulation of matrix metalloproteinase-9 possibly through PI3K, Akt, Rictor, RhoGDI-2 and TNF-a pathways in mouse melanoma B16 cells. Advances in Experimental Medicine and Biology, 2011,705, 335-348. ^[1] 

1. 王璞、郭靜文、關佩沛、王佔友，一種腦靶向的塞來昔布量子點脂質體混懸液及其製備方法，中國.

2. 高慧玲、郭靜文、王佔友、王璞，一種青黴胺鼻凝膠劑及其製備方法，中國. ^[1]