林靜

2004/09-2008/06：華中師範大學，化學學院，化學/生物學雙學位，學士

2008/09-2013/06：中山大學，藥學院，藥物化學，博士

2013/07-2016/09：暨南大學，藥學院，講師

2016/10-2023/09：暨南大學，藥學院，副教授

2017/08-2017/11：新加坡南洋理工大學，環境生命科學工程中心，訪問學者

2023/10-至今：暨南大學，藥學院，教授 ^[1] 

抗菌及抗細菌生物膜藥物的發現與機制研究

新型核酸靶向性抗感染藥物研究

《藥物化學》（本科生）

《藥物化學實驗》（本科生）

《創新藥物設計與研究綜合大實驗》（本科生）

《生物醫藥綜合實驗基本技能》（本科生）

《微生物藥物學》（研究生）

（1）國家自然科學基金面上項目（82273765），C-di-GMP G-四鏈體誘導劑偶聯NO供體的細菌生物膜抑制及分散雙功效藥物研究（2023/01-2026/12）

（2）國家自然科學基金青年基金項目（81402774），基於一葉鹼氨基酸軛合物設計合成靶向突變型IHD1抗膠質瘤藥物研究（2015/01-2017/12）

（3）廣州市珠江科技新星項目（201806010116），新型木豆素類廣譜抗菌劑的發現與靶點研究（2018/04-2021/03）

（4）廣東省自然科學基金面上項目（2019A1515011801），靶向細菌信號分子c-di-GMP的新型細菌生物膜抑制劑研究（2019/10-2022/09）

（5）暨南大學科研培育與創新基金面上項目（21617478），基於細菌生物膜耐藥的抗慢性感染藥物設計與合成（2017/01-2018/12） ^[1] 

(1) Hai-Tao Yu, Jie-Jiao Liu, Qian-Wen Lin, Jnu Liu, Si-Ming Yu*,Ping-Hua Sun*, Jing Lin*. Glutathione-Responsive SulfurDioxide-Releasing Dendronized Chitooligosaccharide Polymer for EffectiveTreatment of Multidrug-Resistant Bacterial Infection. Chemical Engineering Journal,2023, 474: 145316.

(2) ZhuoyingLiang¹, WenkangLiu¹, ZiqiangWang¹, PeilianZheng, WeiLiu, JianfuZhao, YunlongZhong, YanZhang, JingLin*, WeiXue*, SimingYu*, Near-infrared laser-controlled nitric oxide-releasing goldnanostar/hollow polydopamine Janus nanoparticles for synergistic elimination ofmethicillin-resistant Staphylococcus aureus and wound healing.Acta Biomaterialia, 2022, 143: 428-444.

(3) Chan Shan¹, Jing Lin ¹, Jin-QiangHou, Shuo-Bin Chen, Ai-Chun Chen, Tian-Miao Ou*, Jia-Heng Tan, Ding Li,Lian-Quan Gu, Zhi-Shu Huang*. Chemical Intervention of the NM23-H2Transcriptional Programme on c-MYC via a Novel Small Molecule. Nucleic Acids Research, 2015, 15(6): 744-754.

(4) Qian-Wen Lin¹, Jin-Qiang Lu¹, Ye-Si Huang, Jie-Jiao Liu, Wei-MinChen*, Jing Lin*.Cyclic Diguanylate G-Quadruplex Inducer-Nitric Oxide Donor Conjugate as aBifunctional Antibiofilm Agent and Antibacterial Synergistagainst Pseudomonas aeruginosa with a Hyperbiofilm Phenotype. Journal of Medicinal Chemistry, 2023,66(17):11927-11939.

(5) Teng-Fei Xuan¹, Zi-Qiang Wang¹, Jun Liu,Hai-Tao Yu, Qian-Wen Lin, Wei-Min Chen*, Jing Lin*. Design and Synthesisof Novel c-di-GMP G-Quadruplex Inducers as Bacterial Biofilm Inhibitors.Journal of Medicinal Chemistry, 2021, 64 (15): 11074-11089.

(6) Zhi-Ying Miao, Xiao-Yi Zhang, Ming-Han Yang, Yong-Jun Huang, Jing Lin*, Wei-Min Chen*.3-Hydroxypyridin-4(1H)-one Derivatives as Pqs Quorum Sensing InhibitorsAttenuate Virulence and Reduce Antibiotic Resistance in Pseudomonas aeruginosa.Journal of Medicinal Chemistry, 2023, 66(23): 15823-15846.

(7) Yuan-Yuan Wang, Xiao-Yi Zhang, Xiao-Lin Zhong, Yong-Jun Huang, Jing Lin*, and Wei-Min Chen*. Design and Synthesis of 3‑Hydroxy-pyridin-4(1H)‑ones−CiprofloxacinConjugates as Dual Antibacterial and Antibiofilm Agents against Pseudomonas aeruginosa. Journal of Medicinal Chemistry, 2023,66, 2169-2193.

(8) Jun Liu¹, Jin-Song Hou¹, Yi-QunChang, Li-Jun Peng, Xiao-Yi Zhang, Zhi-Ying Miao, Ping-HuaSun*, Jing Lin*, and Wei-MinChen*. New Pqs Quorum Sensing System Inhibitor as an Antibacterial Synergistagainst Multidrug-Resistant Pseudomonas aeruginosa. Journal of Medicinal Chemistry, 2022, 65(1): 688-709.

(9) Jun Liu, Jin-Song Hou, Yi-Bin Li, Zhi-Ying Miao, Ping-Hua Sun*, Jing Lin*, Wei-Min Chen*. Novel2-Substituted 3-Hydroxy-1,6-dimethylpyridin-4(1H)-ones as Dual-Acting BiofilmInhibitors of Pseudomonas aeruginosa. Journal of Medicinal Chemistry, 2020, 63(19):10921-10945.

(10) Tian-Miao Ou¹, Jing Lin ¹, Yu-Jing Lu, Jin-Qiang Hou, Jia-Heng Tan, Shu-Han Chen, Zeng Li,Yan-Ping Li, Ding Li, Lian-Quan Gu*, Zhi-Shu Huang*. Inhibition of Cell Proliferation by QuindolineDerivative SYUIQ-05 through its Preferential Interaction with c-myc PromoterG-Quadruplex. Journal of Medicinal Chemistry, 2011, 54: 5671-5679. ^[1] 

（1）苯並噻唑類化合物及其在製備細菌生物膜抑制劑中的應用，中國發明專利，已授權，專利號：ZL201910162777.0。

（2）含有苯並噻唑類化合物的熒光探針在檢測細菌信使分子c-di-GMP中的應用，中國發明專利，已授權，專利號：ZL 201910598487.0。

（3）木豆素結構類似物及其在製備抗菌藥物中的應用，中國發明專利，已授權，專利號：ZL201410570796.4。 ^[1]