林欣

上海科技大學，學士

德克薩斯大學休斯敦醫學院，博士

加州大學舊金山分校，Gladstone病毒和免疫學研究所， 博士後

紐約州立大學布法羅分校醫學院，微生物和免疫學系，助理教授

德克薩斯大學安德森癌症中心，分子和細胞腫瘤學系，副教授，教授，冠名講席教授

德克薩斯大學安德森癌症中心，炎症與癌症研究中心，副主任

德克薩斯大學生物醫學研究生院，腫瘤生物學項目主任

清華大學醫學院，教授，基礎醫學系主任 ^[1] 

林欣教授的研究興趣涵蓋免疫學的幾個方面，前期主要研究轉錄因子NF-B活化過程的相關信號通路，探討其在T淋巴細胞活化、炎症反應、以及腫瘤發生中的作用及其機理，系統地研究了T 淋巴細胞受體激活途徑及調節T淋巴細胞激活的信號通路。近年來關注於固有免疫應答的相關信號通路研究，以及腫瘤免疫治療的應用研究，共發表學術論文100多篇。

研究內容:

1.T淋巴細胞激活的調控機制 ^[1] 

2.固有免疫應答的分子機制 ^[1] 

3.腫瘤的細胞免疫治療研究 ^[1] 

1.德克薩斯大學安德森癌症醫院冠名講席教授

2.德克薩斯大學安德森癌症醫院學者獎

3.美國白血病與淋巴瘤協會學者獎

4.美國Cancer Research Institute研究者獎

1.Wang, D.; You, Y.; Case, S.M.; Wang, L.; DiStefano, P.S., Nunez, G.; Bertin, J.;Lin, X.(2002)A requirement of CARMA1 in T cell receptor-induced NF-kB activation.Nature Immunology. 3(9): 830-5.

2. Matsumoto, R.; Wang, D.; Blonska, M.; Li, H.; Kobayashi, M.; Pappu, B.; Chen, Y.; Wang, D.;Lin, X. (2005) Phosphorylation of CARMA1 plays a critical role in T cell receptor-induced NF-kB activation.Immunity,23, 1-11, 2005.

3.Blonska, M.; Pappu, B.; Li, H.; Matsumoto R.; Su, B.; Wang, D.;Lin, X. (2007) The CARMA1-Bcl10 complex selectively regulates JNK2 in the T cell receptor signaling pathway.Immunity, 26(1): 55-66.

4.Hsu, MY, Zhang, Y.; You, Y.; Wang, D.; Li, H.; Duramad, O, Qin, X; Dong, C;Lin, X.(2007) CARD9 is required for innate immune responses against intracellular pathogens.Nature Immunology, 8(2): 198-205.

5.Wu W, Hsu YM, Bi L, Songyang Z,Lin X.(2009)CARD9 facilitates microbe-elicited production of reactive oxygen species by regulating the LyGDI-Rac1 complex.Nature Immunology. Nov; 10(11):1208-14.

6.Zhu LL, Zhao XQ, Jiang CY, You Y, Chen XP, Jiang YY, Jia XM,Lin X(2013) C-type lectin receptors Dectin-3 (CLECSF8) and Dectin-2 form a heterodimeric pattern recognition receptor for host defense against fungal infection.Immunity,2013 Aug 22; 39(2):324-34.

7.Zhao X, Guo Y, Jiang C, Chang Q, Zhang S, Luo T, Zhang B, Jia X, Hung MC, Dong C,Lin X(2017) JNK1 negatively controls antifungal innate immunity by suppressing CD23 expression.NatureMedicine. 2017 Mar;23(3):337-346..

8.Xu X, Xu J, Zheng G, Lu H, Rui W, Guan J, Cheng L, Yang D, Wang M, Duan J, Lv Q, Li J, Zhao X, Chen C, Shi P, Jia X*,Lin X*.(2018). CARD9mutation converts alveolar macrophages into IL-5-producing cells and facilitates type 2 immune responses.Nature Immunology,2018 Jun;19(6):547-560.

9. Wang M, Zhang S, Zheng G, Huang J, Songyang Z, Zhao X,Lin X. (2018). Gain-of-Function Mutation of Card14 Leads to Spontaneous Psoriasis-like Skin Inflammation through Enhanced Keratinocyte Response to IL-17A. Immunity. 2018 Jul 17;49(1):66-79

10.Wang T, Fan C, Yao A, Xu X, Zheng G, You Y, Jiang C, Zhao X, Hung MC,Lin X.(2018). The adaptor protein CARD9 protects against colitis-associated colon cancer by restricting mycobiota-mediated expansion of myeloid-derived suppressor cells.Immunity,2018 Sep 18;49(3):504-514