李棟

2002-09--2006-06 浙江大學 學士，光電信息工程學系

2006-08--2011-08 香港科技大學 博士，電子與計算機學系

2011-12~2015-12,霍華德休斯醫學研究所，Janelia研究園, 博士後

2016-01~現在, 中國科學院生物物理研究所, 研究員，博導 ^[2] 

生物光學成像技術開發與應用 ^[3] 

主要從事超分辨顯微成像技術研製及其生物學應用研究，系統掌握了超分辨顯微鏡的關鍵技術，提出了新的成像方法，關鍵指標達到國際領先水平。 ^[1] 

2015年，PicoQuant青年研究員獎, 一等獎, 其他 ^[2] 

2021年，國家傑出青年科學基金 ^[3] 

研究成果“掠入射結構光超分辨成像技術發展與應用”入選2018年度中國科學十大進展。 ^[1] 

2023年，新基石研究員項目。 ^[4] 

[1] Di Li, Huw ColinYork, Liliana Barbieri, Yousef Javanmardi, Yuting Guo, Kseniya Korobchevskaya, Emad Moeendarbary, Dong Li, Marco Fritzsche. Astigmatic traction force microscopy (aTFM). NATURE COMMUNICATIONS[J]. 2021, 12(1): https://doaj.org/article/cc4958160dce4580b716a2a465783980.

[2] Xu, Guangju, Liu, Chong, Zhou, Sheng, Li, Quanjin, Feng, Yun, Sun, Panpan, Feng, Han, Gao, Yina, Zhu, Jingpeng, Luo, Xiu, Zhan, Qi, Liu, Songqing, Zhu, Shu, Deng, Hongyu, Li, Dong, Gao, Pu. Viral tegument proteins restrict cGAS-DNA phase separation to mediate immune evasion. MOLECULAR CELL[J]. 2021, 81(13): 2823-+, http://dx.doi.org/10.1016/j.molcel.2021.05.002.

[3] Liliana Barbieri, Huw ColinYork, Kseniya Korobchevskaya, Di Li, Deanna L Wolfson, Narain Karedla, Falk Schneider, Balpreet S Ahluwalia, Tore Seternes, Roy A Dalmo, Michael L Dustin, Dong Li, Marco Fritzsche. Two-dimensional TIRF-SIM-traction force microscopy (2D TIRF-SIM-TFM). NATURE COMMUNICATIONS[J]. 2021, 12(1): https://doaj.org/article/2749e6a50094452587f5c8033adf28f0.

[4] Qiao, Chang, Li, Di, Guo, Yuting, Liu, Chong, Jiang, Tao, Dai, Qionghai, Li, Dong. Evaluation and development of deep neural networks for image super-resolution in optical microscopy. NATURE METHODS[J]. 2021, 18(2): 194-+, https://www.webofscience.com/wos/woscc/full-record/WOS:000609345700001.

[5] Gong, Bo, Guo, Yuting, Ding, Shihui, Liu, Xiaohui, Meng, Anming, Li, Dong, Jia, Shunji. A Golgi-derived vesicle potentiates PtdIns4P to PtdIns3P conversion for endosome fission. NATURE CELL BIOLOGY[J]. 2021, 23(7): 782-+, http://dx.doi.org/10.1038/s41556-021-00704-y.

[6] Wang, Xinyu, Liu, Chong, Zhang, Siwei, Yan, Huiwen, Zhang, Liwen, Jiang, Amin, Liu, Yong, Feng, Yun, Li, Di, Guo, Yuting, Hu, Xinyao, Lin, Yajing, Bu, Pengcheng, Li, Dong. N-6-methyladenosine modification of MALAT1 promotes metastasis via reshaping nuclear speckles. DEVELOPMENTAL CELL[J]. 2021, 56(5): 702-+, http://dx.doi.org/10.1016/j.devcel.2021.01.015.

[7] Dong Li. 3D Structured Illumination Microscopy via Channel Attention Generative Adversarial Network. 2021, [8] Jinshan Qin, Yuting Guo, Boxin Xue, Peng Shi, Yang Chen, Qian Peter Su, Huiwen Hao, Shujuan Zhao, Congying Wu, Li Yu, Dong Li, Yujie Sun. ER-mitochondria contacts promote mtDNA nucleoids active transportation via mitochondrial dynamic tubulation. NATURE COMMUNICATIONS[J]. 2020, 11(1): http://dx.doi.org/10.1038/s41467-020-18202-4.

[9] 李棟. 時空超分辨率三維力示蹤顯微鏡. 2019, [10] Li, Dongfang, Zhao, Yan G, Li, Di, Zhao, Hongyu, Huang, Jie, Miao, Guangyan, Feng, Du, Liu, Pingsheng, Li, Dong, Zhang, Hong. The ER-Localized Protein DFCP1 Modulates ER-Lipid Droplet Contact Formation. CELL REPORTS[J]. 2019, 27(2): 343-+, http://dx.doi.org/10.1016/j.celrep.2019.03.025.

[11] Guo, Yuting, Li, Di, Zhang, Siwei, Yang, Yanrui, Liu, JiaJia, Wang, Xinyu, Liu, Chong, Milkie, Daniel E, Moore, Regan P, Tulu, U Serdar, Kiehart, Daniel P, Hu, Junjie, LippincottSchwartz, Jennifer, Betzig, Eric, Li, Dong. Visualizing Intracellular Organelle and Cytoskeletal Interactions at Nanoscale Resolution on Millisecond Timescales. CELL[J]. 2018, 175(5): 1430-+, http://dx.doi.org/10.1016/j.cell.2018.09.057.

[12] Dong Li. Structured illumination microscopy with inter-leaved reconstruction (SIMILR). 2017, [13] Xiaofan Han, Pin Li, Zhenghao Yang, Xiaoshuai Huang, Guoqin Wei, Yujie Sun, Xuya Kang, Xueting Hu, Qiuping Deng, Liangyi Chen, Aibin He, Yingqing Huo, Dong Li, Eric Betzig, Jincai Luo. Zyxin regulates endothelial von Willebrand factor secretion by reorganizing actin filaments around exocytic granules. NATURE COMMUNICATIONS[J]. 2017, 8(1): https://doaj.org/article/76945a8838754779baa5979b1b9c124a.

[14] NixonAbell, Jonathon, Obara, Christopher J, Weigel, Aubrey V, Li, Dong, Legant, Wesley R, Xu, C Shan, Pasolli, H Amalia, Harvey, Kirsten, Hess, Harald F, Betzig, Eric, Blackstone, Craig, LippincottSchwartz, Jennifer. Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER. SCIENCE[J]. 2016, 354(6311): 433-+, [15] Zhang, Xi, Zhang, Mingshu, Li, Dong, He, Wenting, Peng, Jianxin, Betzig, Eric, Xu, Pingyong. Highly photostable, reversibly photoswitchable fluorescent protein with high contrast ratio for live-cell superresolution microscopy. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2016, 113(37): 10364-10369, http://www.corc.org.cn/handle/1471x/2376269.

[16] Li, Dong, Betzig, Eric. Response to Comment on "Extended-resolution structured illumination imaging of endocytic and cytoskeletal dynamics". SCIENCEnull. 2016, 352(6285): https://www.webofscience.com/wos/woscc/full-record/WOS:000374998600029.

[17] Li, Dong, Shao, Lin, Chen, BiChang, Zhang, Xi, Zhang, Mingshu, Moses, Brian, Milkie, Daniel E, Beach, Jordan R, Hammer, John A, III, Pasham, Mithun, Kirchhausen, Tomas, Baird, Michelle A, Davidson, Michael W, Xu, Pingyong, Betzig, Eric. Extended-resolution structured illumination imaging of endocytic and cytoskeletal dynamics. SCIENCE[J]. 2015, 349(6251): https://www.webofscience.com/wos/woscc/full-record/WOS:000360646800044.

[18] Beach, Jordan R, Shao, Lin, Remmert, Kirsten, Li, Dong, Betzig, Eric, Hammer, John A, III. Nonmuscle Myosin II Isoforms Coassemble in Living Cells. CURRENT BIOLOGY[J]. 2014, 24(10): 1160-1166, http://dx.doi.org/10.1016/j.cub.2014.03.071.

[19] Dong Li. Time-resolved detection enables standard two-photon fluorescence microscope for in vivo label-free imaging of microvasculature in tissue. 2011, [20] Zheng, Wei, Li, Dong, Zeng, Yan, Luo, Yi, Qu, Jianan Y. Two-photon excited hemoglobin fluorescence. BIOMEDICAL OPTICS EXPRESS[J]. 2011, 2(1): 71-79, https://www.webofscience.com/wos/woscc/full-record/WOS:000299872300007.

[21] Li, Dong, Zheng, Wei, Zeng, Yan, Luo, Yi, Qu, Jianan Y. Two-photon excited hemoglobin fluorescence provides contrast mechanism for label-free imaging of microvasculature in vivo. OPTICS LETTERS[J]. 2011, 36(6): 834-836, https://www.webofscience.com/wos/woscc/full-record/WOS:000288322800020.

[22] Dong Li. In vivo and simultaneous multimodal imaging: integrated multiplex CARS and two-photon microscopy. 2010, [23] Li, Dong, Zheng, Wei, Qu, Jianan Y. Two-photon autofluorescence microscopy of multicolor excitation. OPTICS LETTERS[J]. 2009, 34(2): 202-204, https://www.webofscience.com/wos/woscc/full-record/WOS:000263217600029.

[24] Li, Dong, Zheng, Wei, Qu, Jianan Y. Imaging of epithelial tissue in vivo based on excitation of multiple endogenous nonlinear optical signals. OPTICS LETTERS[J]. 2009, 34(18): 2853-2855, https://www.webofscience.com/wos/woscc/full-record/WOS:000270114800052.

[25] Li, Dong, Zheng, Wei, Qu, Jianan Y. Time-resolved spectroscopic imaging reveals the fundamentals of cellular NADH fluorescence. OPTICS LETTERS[J]. 2008, 33(20): 2365-2367, http://dx.doi.org/10.1364/OL.33.002365. ^[2] 

（ 1 ） 細胞分泌和降解相關膜行為的蛋白質機器, 參與, 國家級, 2016-07--2021-06 ^[2] 

（1）Pushing the envelope of super-resolution live imaging Dong Li 2015-05-12

（2）Introduction to structured illumination microscopy and comparison between super resolution techniques Dong Li 2015-05-08

（3）Extended resolution structured illumination imaging of dynamic process in living cells Dong Li, Eric Betzig 2015-01-20

（4）Live cell SIM imaging and comparison between super-resolution techniques Dong Li 2014-11-06

（5）Live cell structured illumination microscopy with enhanced resolution Dong Li, Eric Betzig 2014-10-10

（6）Integrated multiplex CARS and two-photon fluorescence microscopy for imaging biological systems Dong Li, Wei Zheng, Jianan Qu 2011-01-20

（7）Multicolor excitation two-photon microscopy: In vivo imaging of cells and tissues Dong Li, Wei Zheng, Jianan Qu 2010-01-20 ^[2] 

（ 1 ） A system and method for dispersion compensation in optical coherence tomography, 發明, 2008, 第 2 作者, 專利號: CN1887220

（ 2 ） Patterned activation structured illumination microscopy, 發明, 2015, 第 2 作者, 專利號: 62057220

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