-
李曉萌
(博士生導師)
鎖定
李曉萌,教授,博士生導師
[1]
。教育部新世紀人才獲得者
[2]
,吉林省遺傳學會常務理事等
[3]
。在美國和日本從事過博士後等科研工作。 研究領域(1)蛋白質SUMO化修飾與腫瘤(2)神經退行性疾病的藥物研發。
[1]
作為項目負責人主持國家和省市各級各類項目 30餘項,包括主持科技部國家重點研發計劃國際合作項目兩項,另外主持國家自然科學基金、教育部、吉林省團隊項目等科研項目多項,近五年主持科研經費 500 萬元以上
[1]
。在 J BiolChem、Cancer Res、Cancer Prev Res、Mol Endocrinol、Cell Death & Disease、Frontier in Aging Neuroschience 等雜誌發表 SCI 論文 30 餘篇;獲授權專利5 項
[1]
。參與編寫教材和專著 3 部,包括國際專著(INTECH)和《細胞生物學簡明教程》(高等教育出版社)的編寫
[1]
。獲得"教育部國家科學技術二等獎"、"中華醫學科技獎二等獎"和"吉林省科學技術進步獎二等獎/三等獎"科技獎勵 6 項
[1]
。獲得吉林省中青年科技創新帶頭人培育人選
[4]
吉林省拔尖創新人才
[5]
,和吉林省突出貢獻中青年專家等稱號
[6]
。
- 中文名
- 李曉萌
- 畢業院校
- 吉林大學
- 職 業
- 教師
- 主要成就
- 教育部新世紀優秀人才獲得者
- 職 稱
- 教授
- 研究方向
- 腫瘤信號轉導,AD藥物研發
- 性 別
- 女
李曉萌個人履歷
2011年12月 東北師範大學生命科學學院 教授
2008年9月 東北師範大學生命科學學院 博士生導師
2006年1月-2008年9月 東北師範大學生命科學學院 副教授
2003年1月-2005年12月 美國斯坦福大學醫學院 遺傳學泌尿外科學 博士後
2001年6月-2002年 6月 日本東北大學醫學部 JICA研究員
2001年9月-2003年1月 吉林大學基礎醫學院病理生理學教研室 講師
1999年7月-2001年9月 白求恩醫科大學基礎醫學院 助教
1999年9月-2002年 7月 博士,吉林大學 病理學與病理生理學
1996年9月-1999年7月 碩士,白求恩醫科大學 病理學與病理生理學
李曉萌科研方向
(1)腫瘤信號轉導
(2)甾體類激素受體轉錄調控與腫瘤發生
(3)轉錄因子的SUMO化修飾與腫瘤發生
李曉萌科研成果
李曉萌論文
(1)Xiaowan Wang, Runmin Song, Wenliang Lu, Ziyu Liu, Lichun Wang, Xiaojuan Zhu, Yanjun Liu, Zijie Sun, Jiang Li*, Xiaomeng Li*. YXQN Reduces Alzheimer's Disease-Like Pathology and Cognitive Decline in APPswePS1dE9 Transgenic Mice.Front Aging Neurosci.9:157:1-15., 2017
[7]
(2) Hui Qin, Azhar Rasual, Xin Li, Muqaddas Masood, Guang Yang, Na Wang, Wei Wei, Xi He, Nobumoto Watanabe, Jiang Li*, Xiaomeng Li*. CD147-induced cell proliferation is associated with Smad4 signal inhibition. Exp Cell Res.358(2):279-289. 2017
[8]
(3) Chunwa Jiang, Muqaddas Masood, Azhar Rasul, Wei Wei, Ya Wang, Muhammad Ali, Muhammad Mustaqeem, Jiang Li*, Xiaomeng Li*. Altholactone Inhibits NF-κB and STAT3 Activation and Induces Reactive Oxygen Species-Mediated Apoptosis in Prostate Cancer DU145 Cells.Molecules.22(2):1-13., 2017
[9]
(4) Chunwa Jiang, Juanjing Wang, Chen Dong, Wei Wei, Jiang Li*, Xiaomeng Li*. Membranous type matrix metalloproteinase 16 induces human prostate cancer metastasis.Oncol Lett.14(3):3096-3102., 2017
[10]
(5) Moussa Ide Nasser, Muqaddas Masood, Wei Wei, Xiaochun Li, Yifa Zhou, Bao Liu, Jiang Li*, Xiaomeng Li*. Cordycepin induces apoptosis in SGC7901 cells through mitochondrial extrinsic phosphorylation of PI3K/Akt by generating ROS. Int J Oncol.50(3):911-919., 2017
[11]
(6) Faya M. Millimouno, Jia Dong, Liu Yang, Jiang Li*, Xiaomeng Li*. Targeting apoptosis pathways in cancer and perspectives with natural compounds from Mother Nature. Cancer Prev Res.7(11):1081-1107., 2014
[12]
(7) N Yang, B Zhao, A Rasul, H Qin, J Li*, X Li*. PIAS1-modulated Smad2/4 complex activation is involved in zinc-induced cancer cell apoptosis. Cell Death Dis. 4:e811:1-16., 2013
[13]
(8) Bing Zhao, Xiaomeng Li*. Altholactone induces reactive oxygen species-mediated apoptosis in bladder cancer T24 cells through mitochondrial dysfunction, MAPK-p38 activation and Akt suppression. Oncol Rep. 31(6):2769-2775., 2014
[14]
(9) Liu He, Tingting Wang, Jiping A, Xiaomeng Li*, Lingyu Zhang, Lu Li, Guangzhe Li, Xiaotong Wu, Zhongmin Su*, Chungang Wan*. Carbon nanodots@zeolitic imidazolate framework-8 nanoparticles for simultaneous pH-responsive drug delivery and fluorescence imaging. Cryst Eng Comm. 16:3259-3263.,2014
[15]
(10) Azhar Rasul, Bin-Ji Zhao, Jun Liu, Bao Liu, Jia-Xin Sun, Jiang Li*, Xiao-Meng Li*. Molecular Mechanisms of Casticin Action: an Update on its Antitumor Functions. Asian Pac J Cancer Prev. 15(21):9049-9058., 2014
[16]
(11) Azhar Rasul, Jun D, Faya Martin Millimouno, Mahadev Malhi, Ichiro Tsuji, Muhammad Ali, Jiang Li*, Xiaomeng Li*. Reactive oxygen species mediate Isoalantolactone-induced apoptosis in human prostate cancer cells.Molecules. 18:9382-9396., 2013
[17]
(12) Azhar Rasul, Rui Bao, Mahadev Malhi, Bing Zhao, Ichiro Tsuji, Jiang Li*, Xiaomeng Li*. Induction of apoptosis by Costunolide in bladder cancer cells is mediated through ROS generation and mitochondrial dysfunction. Molecules. 18:1418-1433., 2013
[18]
(13) WU Jing, LIU Shu, SHEN Xiao-yan, YANG Nan-yang, LIU Ying, TSUJI Ichiro, YAMAMURA Takaki, LI Jiang*, LI Xiao-meng*. Phytoestrogens Inhibiting Androgen Receptor Signal and Prostate Cancer Cell Proliferation. Chem Res Chin Uni. 29(5): 911-916., 2013
[19]
(14) WU Jing, WEI Wei, YANG Nan-yang, SHEN Xiao-yan, TSUJI Ichiro, YAMAMURA Takaki, LI Jiang*, LI Xiao-meng*. Xeno-oestrogens Bisphenol A and Diethylstilbestrol Selectively Activating Androgen Receptor Mediated AREs-TATA Reporter System. Chem Res Chin Uni.29(3):512-518.,2013
[20]
(15) Zhenyu Chen, Azhar Rasul, Chaoyue Zhao, Faya Martin Millimouno, Ichiro Tsuji, Takaki Yamamura, Rehana Iqbal, Mahadev Malhi, Jiang Li*, Xiaomeng Li*. Dracorhodin perchlorate induces apoptosis in bladder cancer cells through Bcl-2, Bcl-XL, survivin down-regulation and caspase-3 activation. B J Pharmacol.8:276-282., 2013
[21]
(16) Wei Wei, Jun Di, Azhar Rasul, Chaoyue Zhao, Faya Martin Millimouno, Ichiro Tsuji, Furhan Iqal, Mahadev Malhi, Xiaomeng Li*, Jiang Li*. Antipro-liferative and apoptotic effects of pinocembrin in humanprostate cancer cells. BJ Pharmacol.8:255-262., 2013
[22]
(17) Azhar Rasul, Jinmei Liu, Ying Liu, Faya Martin Millimouno, Xiaowan Wang, Ichiro Tsuji, Takaki Yamamura, Jiang Li*, Xiaomeng Li*. Eriocalyxin B inhibits proliferation and induces apoptosis throughdownregulation of Bcl-2 and activation of caspase-3 in humanbladder cancer cells. B J Pharmacol. 8:116-123., 2013
[23]
(18) Azhar Rasul, Muhammad Khan, Muhammad Ali, Jiang Li*, Xiaomeng Li*. Targeting Apoptosis Pathways in Cancer with Alantolactone and Isoalantolactone. Scientifi World J, 248532:1-9.,2013
[24]
(19) Azhar Rasul, Faya Martin Millimouno, Wafa Ali Eltayb, Muhammad Ali, Jiang Li*, Xiaomeng Li*. Pinocembrin: a novel natural compound with versatile pharmacological and biological activities. BioMed Research International.2013:379850:1-9.,2013
[25]
(20) Hao Wang, Jiang Li*, Yang Gao, Ying Xu, Ying Pan, Ichiro Tsuji, Zi-Jie Sun, Xiaomeng Li*. Xeno-oestrogens and phyto-oestrogens are alternative ligands for the androgen receptor. Asian J Androl.12(4): 535-547., 2013
[26]
(21) AzharRasul, ChuanDing, XiaomengLi, MuhammadKhan, FeiYi, MuhammadAli, TonghuiMa*. Dracorhodin perchlorate inhibits PI3K/Akt and NF-κB activation, up-regulates the expression of p53, and enhances apoptosis.Apoptosis. 17(10):1104-19.,2012
[27]
(22) Xiaomeng Li*, Chunfang Zhu, William H. Tu, Nanyang Yang, Hui Qin, Zijie Sun*. ZMIZ1 preferably enhances the transcriptional activity of androgen receptor with short polyglutamine tract. PLoS One,6(9): e25040.1-12., 2011
[28]
(23) ZHANG Ai-li, LI Jiang, WANG Yan-qing, ZAKNROU Zohra, MA Tong-hui , LI Xiao-meng*. Aquaporin 1 Facilitated Hepatocellular Carcinoma SMMC7221 Cell Migration Associated with Water Permeability.Chem Res Chin Uni.27(1):99-103., 2011
[29]
(24) Tingting Wang,Xuli Zhang,Ying Pan,Xiumin Miao,Zhongmin Su,Chungang Wang*, Xiaomeng Li*. Fabrication of doxorubicin functionalized gold nanorod probes for combined cancer imaging and drug delivery. Dalton Trans, 40 (38): 9789-9794., 2011
[30]
(25) LI Jiang, ZHANG Ai-li, TONG Qian, ZHANG Jun-fang, LI Hai-jing, ZHAO Bing, MA Tong-hui, LI Xiao-meng1*. Expression and Emmprin Regulated Function of Aquaporin1 in SMMC7221 Cells. Chem Res Chin Uni. 26(4):578-582.,2010
[31]
(26) LI Jiang*, YANG Nan-yang, GUAN Xin-gang, ZHANG Shu-zhi, ZHANG Yan, QIN Mei-ling, MA Tong-hui, LI Xiao-meng*. GST Fusion Protein Based Specific Polyclonal Antibody Preparation of Mouse Aquaporin 1.Chem Res Chin Uni.25(4):500-505., 2009
[32]
(27) Xiao-Meng Li*, Jiang Li, Ichiro Tsuji, Naoki Nakaya, Yoshikazu Nishino, Xue-Jian Zhao*. Mass screening-based case-control study of diet and prostate cancer in Changchun, China. Asian J Androl. 10(4):551-60., 2008
[33]
(28) Xiaomeng Li, Gregory Thyssen, Jason Beliakoff and Zijie Sun*.The novel PIAS-like protein HZIMP10 enhances Smad transcriptional activity. J Biol Chem, 281(33):23748-23756., 2006
[34]
(29) Xiao-Meng Li, Ling Zhang, Jiang Li, Yang Li, Hong-Liang Wang, Guo-Yi Ji, Masaaki Kuwahara and Xue-Jian Zhao*. Measurement of serum zinc improves prostate cancer detection efficiency in patients with PSA levels between 4 ng/mL and 10 ng/mL. Asian J Androl.7(3): 323-328., 2005
[35]
(30) Chun-Yin Huang,Jason Beliakoff , Xiaoyu Li,Jane Lee,Xiaomeng Li,Manju Sharma,Bing Lim,Zijie Sun*. hZimp7, a novel PIAS-like protein, enhances androgen receptor-mediated transcription and interacts with SWI/SNF-like BAF complexes. Mol Endocrinol.19(12):2915-2929.,2005
[36]
(31) XiaomengLi*, ItiroTsuji, MasaakiKuwahara, HaifengZhang, HongliangWang, LingZhang, GuoyiJi, XuejianZhao. Mass screening of prostate cancer in Changchun City of China. Int Urol Nephrol. 36(4): 541-548., 2004
[37]
(32) Meletios Verras, Jeffrey Brown, Xiaomeng Li, Roel Nusse and Zijie Sun*. Wnt3a growth factor induces androgen receptor-mediated transcription and enhances cell growth in human prostate cancer cells.Cancer Res. 64(24):8860-8866.,2004
(33)Masaaki Kuwahara*, Tatsuo Tochigi, Sadafumi Kawamura, Yukihiko Ogata, Ning Xu, Hongliang Wang, Haifeng Zhang, Shengwen Li, Xiaomeng Li, Xuejian Zhao. Mass screening for prostate cancer: a comparative study in Natori, Japan and Changchun,China. Urology. 61(1): 137-141., 2003
[38]
李曉萌論著
參編國際專著:“Soybean and Prostate Cancer”in Soybean - Bio-Active Compounds, ISBN 978-953-51-0977-8, Croatia,2013
[39]
參編教材:細胞生物學簡明教程,高等教育出版社,2010年4月
[40]
李曉萌學術獎勵
李曉萌科研項目
國家重點研發計劃(政府間國際科技創新合作專項):
科技部國際合作項目:
- 參考資料
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- 9. Altholactone Inhibits NF-κB and STAT3 Activation and Induces Reactive Oxygen Species-Mediated Apoptosis in Prostate Cancer DU145 Cells .Molecules[引用日期2018-02-05]
- 10. Membranous type matrix metalloproteinase 16 induces human prostate cancer metastasis .Oncol Lett.[引用日期2018-02-05]
- 11. Cordycepin induces apoptosis in SGC‑7901 cells through mitochondrial extrinsic phosphorylation of PI3K/Akt by generating ROS .International Journal of Oncology[引用日期2018-02-05]
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- 13. 作者姓名在第一頁下方倒數第九行:Corresponding authors: Xiaomeng Li .Cell Death & Disease [引用日期2018-02-05]
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- 15. Carbon nanodots@zeolitic imidazolate framework-8 nanoparticles for simultaneous pH-responsive drug delivery and fluorescence imaging .CrystEngComm[引用日期2018-02-05]
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- 17. Reactive Oxygen Species Mediate Isoalantolactone-Induced Apoptosis in Human Prostate Cancer Cells .Molecules[引用日期2018-02-05]
- 18. Induction of Apoptosis by Costunolide in Bladder Cancer Cells is Mediated through ROS Generation and Mitochondrial Dysfunction .Molecules[引用日期2018-02-05]
- 19. Phytoestrogens Inhibiting Androgen Receptor Signal and Prostate Cancer Cell Proliferation .CHEMICAL RESEARCH IN CHINESE UNIVERSITES[引用日期2018-02-05]
- 20. Xeno-oestrogens Bisphenol A and Diethylstilbestrol Selectively Activating Androgen Receptor Mediated AREs-TATA Reporter System .CHEMICAL RESEARCH IN CHINESE UNIVERSITES [引用日期2018-02-05]
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- 23. Eriocalyxin B inhibits proliferation and induces apoptosis through downregulation of Bcl-2 and activation of caspase-3 in human bladder cancer cells .Bangladesh Journal of Pharmacology[引用日期2018-02-05]
- 24. Targeting Apoptosis Pathways in Cancer with Alantolactone and Isoalantolactone .The Scientific World Journal[引用日期2018-02-05]
- 25. Pinocembrin: a novel natural compound with versatile pharmacological and biological activities. .BioMed Research International[引用日期2018-02-05]
- 26. Xeno-oestrogens and phyto-oestrogens are alternative ligands for the androgen receptor .Asia Journal of Andrology[引用日期2018-02-05]
- 27. Dracorhodin perchlorate inhibits PI3K/Akt and NF-κB activation, up-regulates the expression of p53, and enhances apoptosis .Springer link-Apoptosis[引用日期2018-02-05]
- 28. ZMIZ1 Preferably Enhances the Transcriptional Activity of Androgen Receptor with Short Polyglutamine Tract .Plos One[引用日期2018-02-05]
- 29. Aquaporin 1 Facilitated Hepatocellular Carcinoma SMMC7221 Cell Migration Associated with Water Permeability .CHEMICAL RESEARCH IN CHINESE UNIVERSITES [引用日期2018-02-05]
- 30. Fabrication of doxorubicin functionalized gold nanorod probes for combined cancer imaging and drug delivery .Dalton Transactions[引用日期2018-02-05]
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- 32. GST Fusion Protein Based Specific Polyclonal Antibody Preparation of Mouse Aquaporin 1 .CHEMICAL RESEARCH IN CHINESE UNIVERSITES[引用日期2018-02-05]
- 33. Mass screening-based case-control study of diet and prostate cancer in Changchun, China .Asian Journal of Andrology[引用日期2018-02-05]
- 34. The Novel PIAS-like Protein hZimp10 Enhances Smad Transcriptional Activity .Journal of Biological Chemistry[引用日期2018-02-05]
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