李新明

1998年6月畢業於北京化工大學高分子系，獲工學學士學位；2003年6月畢業於北京化工大學材料科學與工程學院，獲工學碩士學位； 2005年1月至2008年6月，就讀於新加坡國立大學化學專業；獲理學博士學位。2008年7月-2009年2月和2009年3月-2012年6月，分別在新加坡南洋理工大學的化學與化學生物學系和美國布蘭迪斯大學化學系從事博士後研究工作。2012年8月受聘於蘇州大學材料化學與化工學部教授。

(1) 超分子自組裝納米材料

(2) 生物醫用凝膠材料

主要從事構建具有良好生物醫學應用潛力的多肽超分子自組裝納米凝膠材料。主持科技部國家重點研發計劃子課題項目，國家自然科學基金面上項目，江蘇省自然科學基金面上項目，教育部留學回國人員科研啓動基金，蘇州市科技創新政策性資助。 2015年獲得蘇州大學“東吳學者計劃”資助。已在J. Am. Chem. Soc., Angew. Chem. Int. Ed., Biomaterials, Chem. Sci., Chem. Commun., J. Mater. Chem. B, ACS Appl. Mater. Interfaces, Adv. Healthcare Mater.等國際核心研究期刊上發表論文60餘篇。

[63] Zhijie Chen,, Lianlian Wang, Changjun Guo, Minglong Qiu, LiangCheng, Kaizhe Chen, Jin Qi, Lianfu Deng, Chuan He,*, Xinming Li,* Yufei Yan,* Vascularized polypeptide hydrogelmodulates macrophage polarization for wound healing, Acta Biomaterialia, 2023, 155, 218–234.

[62] Na Liu, Shunjie Wu, Xin Tian* and Xinming Li*, Fabricationof Injectable Hydrogels from an Anticancer Peptide for Local TherapeuticDelivery and Synergistic Photothermal-Chemotherapy, J. Mater. Chem. B, 2022, 10, 5165-5173.

[61] Jie Li, Shunjie Wu, Xin Tian* and Xinming Li*, Fabricationof a multifunctional nanomaterial from a mussel-derived peptide for multimodalsynergistic cancer therapy, ChemicalEngineering Journal, 2022, 446, 136837.

[60] Yue Zhang, Xin Tian*and Xinming Li*, Supramolecularassemblies of histidine-containing peptides with switchable hydrolase andperoxidase activities through Cu(ii) binding and co-assembling, J. Mater. Chem. B, 2022, 10, 3716-3722.

[59] Xiao Zhu, Binggang Guan, Ziling Sun, Xin Tian* and Xinming Li*, Fabrication of an injectable hydrogel with inherentphotothermal effects from tannic acid for synergistic photothermal-chemotherapy, J. Mater. Chem. B, 2021, 9, 6084–6091.

[58] Lianlian Wang, Zhijie Chen, Yufei Yan, Chuan He* and Xinming Li*, Fabrication of injectable hydrogels from silk fibroinand angiogenic peptides for vascular growth and tissue regeneration, Chemical Engineering Journal, 2021, 418,129308.

[57] Hang Li, Jikun Zhang, Shengnan Liu, Yufei Yan* and Xinming Li*, Consecutivedephosphorylation by alkaline phosphatase-directed in situ formation of poroushydrogels of SF with nanocrystalline calcium phosphate ceramics for boneregeneration, J. Mater. Chem. B,2020, 8, 9043-9051.

[56] Shengnan Liu, Hang Li, Jikun Zhang, Xin Tian* and Xinming Li*, A biocompatiblesupramolecular hydrogel with multivalent galactose ligands inhibiting Pseudomonas aeruginosa virulence andgrowth, RSC Adv., 2020, 10, 33642.

[55] Jikun Zhang, Shengnan Liu, Hang Li, Xin Tian*, and Xinming Li*, Tryptophan-BasedSelf-Assembling Peptides with Bacterial Flocculation and AntimicrobialProperties, Langmuir 2020, 36,11316–11323.

[54] Ya Yang, Hui Wang*, Jia-Chen Zhu, Yun-Fei Shao, Feng-JiaoBai, Xiao-Min Chen, Xinming Li,Mingyu Guo, Zengwu Shao, and Ke-Qin Zhang,* Silk-Fibroin-Assisted CathodicElectrolytic Deposition of Calcium Phosphate for Biomedical Applications, ACS Biomater. Sci. Eng. 2019, 5, 9,4302–4310.

[53] Juan Jing, Shufeng Liang, Yufei Yan, Xin Tian and Xinming Li,* Fabrication of HybridHydrogels from Silk Fibroin and Tannic Acid with Enhanced Gelation and AntibacterialActivities, ACS Biomater. Sci. Eng. 2019,5, 4601–4611.

[52] Jing Li, Shufeng Liang, Yufei Yan, Xin Tian, Xinming Li,* O-Mannosylation Affords aGlycopeptide Hydrogel with Inherent Antibacterial Activities against E. colivia Multivalent Interactions between Lectins and Supramolecular Assemblies, Macromol. Biosci. 2019, 19, 1900124.

[51] Yufei Yan, Baochang Cheng, Kaizhe Chen, Wenguo Cui, Jin Qi,* Xinming Li,* and Lianfu Deng “EnhancedOsteogenesis of Bone Marrow-Derived Mesenchymal Stem Cells by a FunctionalizedSilk Fibroin Hydrogel for Bone Defect Repair” Adv. Healthcare Mater. 2018, 1801043. (研究內容被選為該期封面)

[50] Baochang Cheng, Yufei Yan, Jingjing Qi, Lianfu Deng, Zeng-WuShao, Ke-Qin Zhang, Bin Li, Ziling Sun, and Xinming Li*, “Cooperative Assembly of a Peptide Gelator and SilkFibroin Afford an Injectable Hydrogel for Tissue Engineering” ACS Appl. Mater. Interfaces, 2018, 10, 12474–12484.

[49] Jingjing Qi, Yufei Yan, Baochang Cheng, Lianfu Deng, ZengwuShao, Ziling Sun, and Xinming Li*, “Enzymatic Formation of an InjectableHydrogel from a Glycopeptide as a Biomimetic Scaffold for Vascularization” ACS Appl. Mater. Interfaces, 2018, 10, 6180–6189.

[48] Qingxin Yao, Qiang Bao, XinmingLi, Hui Wang, Zhenyu Yang, Xinghua Shi*, Yuan Gao* and Bing Xu, “Determinationof the packing model of a supramolecular nanofiber via mass-per-length measurementand de novo simulation” Nanoscale, 2018, 10, 3990-3996.

[47] Fengyang Xu, Jie Liu, Jian Tian, Linfeng Gao, Yue Pan, ZilingSun* and Xinming Li,* “SupramolecularSelf-assemblies with nanoscale RGD clusters promote cell growth andintracellular drug delivery” ACS Appl.Mater. Interfaces, 2016, 8,29906–29914.

[46] Jie Liu, Ziling Sun, Yuqi Yuan, Xin Tian, Xi Liu, GuangxinDuan, Yonggang Yang, Lin Yuan,* Hsin-Chieh Lin,* and Xinming Li* “PeptideGlycosylation Generates Supramolecular Assemblies from Glycopeptides asBiomimetic Scaffolds for Cell Adhesion and Proliferation” ACS Appl. Mater. Interfaces, 2016, 8, 6917–6924.

[45] Jie Liu, Fengyang Xu, Ziling Sun,* Yue Pan, Jian Tian,Hsin-Chieh Lin, Xinming Li,* “Asupramolecular gel based on a glycosylated amino acid derivative with theproperty of gel to crystal transition” SoftMatter, 2016, 12, 141-148.

[44] Jiaqing Wang, Hongbo Geng, Xinming Li, Yue Pan and Hongwei Gu,* “Novel Ultra-thin PlatinumNanowires and Their Catalytic Applications” CurrentOrganic Chemistry, 2015, 19, 2142-2155.

[43] Jingwen Li, Zhonglin Lv, Yanli Li, Huan Liu, Jinkui Wang,Hong Chen*, Huabing Chen* and Xinming Li,*“A theranostic prodrug delivery system based on Pt(IV) conjugatednano-graphene oxide with synergistic effect to enhance the therapeutic efficacyof Pt drug” Biomaterials, 2015, 51, 12-21.

[42] Hongmei Zhang, Chenglong Xu, Jie Liu, Xiaohong Li, Lin Guo*and Xinming Li,* “Anenzyme-activatable probe with a self-immolative linker for rapid and sensitivealkaline phosphatase detection and cell imaging through a cascade reaction” Chemical Communications, 2015, 51, 7031-7034.

[41] CongZhi, Jiaqing Wang, Bin Luo, Xinming Li,Xueqin Cao, Yue Pan, Hongwei Gu,* “The Synthesis of Cyclohexenone UsingL-Proline Immobilized on a Silica Gel Catalyst by a Continuous-Flow Approach” RSC Adv., 2014, 4, 15036-15039.

[40] Jiaqing Wang,Jing He,Cong Zhi,Bin Luo,Xinming Li, Yue Pan,Xueqin Cao,Hongwei Gu,*”Highly Efficient Synthesis of Azos Catalyzed by the Common Metal Copper (0)Through Oxidative Coupling Reactions” RSCAdv., 2014, 4, 16607-16611.

[39] DanhuaGe, Jiaqing Wang, Hongbo Geng, Shuanglong Lu, Dongtao Wang, Xinming Li, Xianli Zhao, Xueqin Cao,*and Hongwei Gu,* “Facile Synthesisof Copper-Based Metal Oxide Nanoparticles with Exceptional Catalytic Activityfor the Selective Oxidation of Styrenes into Benzaldehydes” ChemPlusChem, 2015, 80, 511-515.

[38]Huan Liu, Yanli Li, Zhonglin Lyu, Yingbo Wan, Xiaohong Li, Huabing Chen, HongChen and Xinming Li,* ” Enzyme-triggered supramolecularself-assemblies of platinum prodrug with enhanced tumor-selective accumulationand reduced systemic toxicity” J. Mater.Chem. B, 2014, 2, 8303-8309.

[37] BinLuo, Jiaqing Wang, Danhua Ge, Xinming Li, Xueqin Cao, Yue Pan, Hongwei Gu,* “Efficientand ligand free palladium catalyst for Suzuki and Heck cross-couplingreactions” Science China Chemistry 2014, 57, 1310-1314.

[36] Lei Wang, Lin Yuan, Hongwei Wang,* Xiaoli Liu,Xinming Li and Hong Chen,* “A newstrategy for reversible modulation of protein activity through site-specificconjugation of small molecule and polymer” Bioconjugate Chemistry, 2014, 25,1252–1260.

[35] Dan Yuan, Rong Zhou, Junfeng Shi,Xuewen Du, Xinming Li and Bing Xu,* ” Enzyme-instructed self-assembly of thehydrogelators consisting of nucleobase, amino acids, and saccharide” RSC Adv., 2014, 4, 26487-26490.

[34]Xuewen Du, Jie Zhou, Olgun Guvench, Frank O. Sangiorgi, Xinming Li, Ning Zhou, and Bing Xu,* “Supramolecular Assemblies ofA Conjugate of Nucleobase, Amino Acids, and Saccharide Act as Agonists forProliferation of Embryonic Stem Cells and Development of Zygotes” Bioconjugate Chemistry, 2014, 25, 1031–1035.

[33] ShuanglongLu, Jiaqing Wang, Xueqin Cao, Xinming Li,Hongwei Gu,* “Selective synthesis of secondary amines from nitriles using Ptnanowires as a catalyst” Chemical Communications, 2014, 50,3512-3515.

[32] XiaojingWang, Huan Liu, Jingwen Li, Kaiguo Ding, Zhonglin Lv, Yonggang Yang, Hong Chen*,Xinming Li,* “A Fluorogenic Probewith Aggregation-Induced Emission Characteristics for Carboxylesterase Assaythrough Formation of Supramolecular Microfibers” Chemistry –Asian J., 2014,3, 784-789.

[31] HaichaoXu, Yafei Luan, Zhaoqiang Wu, Xinming Li,Yuling Yuan, Xiaoli Liu, Lin Yuan, Dan Li*, Hong Chen,* “Incorporation ofLysine-Containing Copolymer with Polyurethane Affording Biomaterial withSpecific Adsorption of Plasminogen” ChineseJournal of Chemistry, 2013, 32, 40-50.

[30] XinWang, Jiaqing Wang, Fenqiang Qi, Lei Hu, XinmingLi, Xueqin Cao, Hongwei Gu,* “Synthesis of in-situ surfactant-free Pdnanoparticle catalysts for the synthesis of aromatic azo compounds and forunsaturated bond hydrogenation by hydrogen transfer” Chinese Journal of Catalysis, 2013,34, 2084–2088

[29] JiaqingWang, Lei Hu, Xueqin Cao, Jianmei Lu, Xinming Li* and Hongwei Gu,*“Catalysis by Pd nanoclusters generated in situ of high-efficiency synthesis ofaromatic azo compounds from nitroaromatics under H2 atmosphere” RSC Adv., 2013, 3, 4899-4902.

[28] HuanLiu, Zhonglin Lv, Kaiguo Ding, Xiaoli Liu, Lin Yuan, Hong Chen* and Xinming Li,* ” Incorporation of tyrosine phosphate into tetraphenylethyleneaffords an amphiphilic molecule for alkaline phosphatase detection,hydrogelation and calcium mineralization” J.Mater. Chem. B, 2013, 1, 5550-5556. (研究內容被選為該期內封面)

[27] TingtingYu, Jiaqing Wang, Xinming Li, XueqinCao, Hongwei Gu,* “An Improved Method for the Complete Hydrogenation ofAromatic Compounds under 1 Bar H₂ with Platinum Nanowires” ChemCatChem, 2013, 5, 2852-2855.

[26]Danhua Ge, Lei Hu, Jiaqing Wang, XinmingLi, Fenqiang Qi, Jianmei Lu, Xueqin Cao*, Hongwei Gu,* “Reversible Hydrogenation–OxidativeDehydrogenation of Quinolines over a Highly Active Pt Nanowire Catalyst underMild Conditions” ChemCatChem, 2013, 5, 2183-2186.

[25] JiaqingWang, Xinming Li*, Hongwei Gu,*“Understanding the Atomic-scale Process of Catalytic Assembly of Si Nanowiresthrough Al Injection” ChemCatChem, 2013, 5, 2802-2804.

[24] JingwenLi, Xinming Li*, Xiujuan Shi, XuewenHe, Wei Wei, Nan Ma* and Hong Chen, “Highly Sensitive Detection of Caspase-3Activities via a Nonconjugated Gold Nanoparticle-Quantum Dot Pair Mediated byan Inner-Filter Effect” ACS Applied Materials& Interfaces, 2013, 5, 9798-9802.

[23] Xin Wang, Jiaqing Wang, Fenqiang Qi, Lei Hu, Xinming Li, Xueqin Cao, Hongwei Gu,* “Synthesis of in‐situ surfactant‐free Pd nanoparticle catalysts for thesynthesis of aromatic azo compounds and for unsaturated bond hydrogenation byhydrogen transfer” Chinese Journal ofCatalysis, 2013, 34, 2084-2088.

[22] Hong Yang, Huajian Mao, ZhihuiWan, Aijun Zhu, Miao Guo, YanliLi, Xinming Li, Jiangling Wan,Xiangliang Yang, Xintao Shuai, Huabing Chen,* “Micelles assembled withcarbocyanine dyes for theranostic near-infrared fluorescent cancer imaging andphotothermal therapy” Biomaterials, 2013, 34, 9124-9133.

[21] Jiayang Li, Xinming Li, Yi Kuang, Yuan Gao, Xuewen Du,Junfeng Shi, Bing Xu,* “Self-delivery Multifunctional Anti-HIV Hydrogels forSustained Release” Adv. Healthcare Mater.,2013, 2, 1586-1590.

[20] Xinming Li, Xuewen Du, Jiayang Li, Yuan Gao, Yue Pan,Junfeng Shi, Ning Zhou and Bing Xu,* “Introducing a D-amino acid or a simpleglycoside into small peptides to enable supramolecular hydrogelators to resistproteolysis” Langmuir, 2012, 28, 13512–13517.

[19] Zhimou Yang, YiKuang, Xinming Li, Ning Zhou, Ye Zhang, Bing Xu,* “Supramolecularhydrogel of kanamycin selectively sequesters 16s rRNA” ChemicalCommunications, 2012, 48, 9257-9259.

[18] Xinming Li, XuewenDu, Yuan Gao, Junfeng Shi, Yi Kuang, Bing Xu,* “Supramolecular hydrogels formedby the conjugates of nucleobases, Arg-Gly-Asp (RGD) peptides, and glucosamine” Soft Matter, 2012, 8, 7402– 7407.

[17] Xinming Li, Yi-Kuang, Bing Xu,* “Molecular trinity for soft materials: Integratingnucleobases, amino acids, and glycosides, to construct multifunctionalhydrogelators” Soft Matter, 2012, 8, 2801-2806.

[16] Xinming Li, Yi-Kuang,Hsin-Chieh Lin, Junfeng Shi, Yuan Gao, Bing Xu,* “Multifunctional, biocompatible supramolecular hydrogelators onlyconsist of nucleobase, amino acid, and glycoside” Journal of the American Chemical Society, 2011, 133, 17513-17518.

[15] Xinming Li,Yi-Kuang, Hsin-Chieh Lin, Yuan Gao, Junfeng Shi, and Bing Xu,* “Supramolecularnanofibers and hydrogels of nucleopeptides”Angewandte Chemie International Edition, 2011, 50, 9365-9369.

[14] Yue Pan, Marcus J. C. Long, Xinming Li, Junfeng Shi, Lizbeth Hedstrom, Bing Xu,* “Glutathione (GSH)-decorated magneticnanoparticles for binding glutathione-S-transferase (GST) fusion protein andmanipulating live cells” Chemical Science, 2011, 2, 945-948.

[13] Xinming Li, Jiayang Li, Yuan Gao,Yi-Kuang, Junfeng Shi and Bing Xu,* “Molecular nanofibers of olsalazine formsupramolecular hydrogels for reductive release of an anti-inflammatory agent” Journal of the American Chemical Society, 2010, 132, 17707-17709.

[12] Xinming Li, Yuan Gao, Yi-Kuang and BingXu,* “Enzymatic formation of a photoresponsive supramolecular hydrogel” Chemical Communications, 2010, 46, 5364-5366.

[11] Magdeline Tao Tao Ng,Xinming Li (Co-first Author), Yifan Wang, Tianyan Zhou, Sock Teng Chua,WeixinYuan and Tianhu Li, “Site-specific self-cleavage of G-quadruplexes formedby Oxytricha telemetric repeats” Australian Journal of Chemistry, 2009, 62, 1189-1193.

[10]Tianyan Zhou, Xinming Li*, YifanWang, Magdeline Tao Tao Ng, Sock Teng Chua, Ngee Mien Quek, Zhaoqi Yang, JiLuo, Weixing Yuan and Tianhu Li, “Synthesis and characterization of circular structures of i-motif tagged withfluoresceins” Bioconjugate Chemistry,2009, 20, 644-647.

[9] Xinming Li, Magdeline Tao Tao Ng, YifanWang, Tianyan Zhou, Sock Teng Chua, Weixing Yuan and Tianhu Li,* “Site-specificself-cleavage of G-quadruplexes formed by human telometric repeats” Bioorganic & Medicinal Chemistry Letters,2008, 18, 5576-5580.

[8] Xinming Li, Magdeline Tao Tao Ng, YifanWang, Xiaoqian Liu and Tianhu Li,* “Dumbbell-shaped circular oligonucleotidesas human topoisomerase I inhibitors”, Bioorganic & Medicinal Chemistry Letters, 2007, 17, 4967-4971.

[7]Yifan Wang, Xinming Li, XiaoqianLiu, Tianhu Li,* “An i-motif-containing DNA device that breaks certain forms ofWatson–Crick interactions”, ChemicalCommunications, 2007, 42, 4369-4371.

[6]Xiaoqian Liu, Xinming Li, TianyanZhou, Yifan Wang, Magdeline Tao Tao Ng, Wei Xu and Tianhu Li,* “Site specific self-cleavageof certain assemblies of G-quadruplex”, Chemical Communications, 2008, 3, 380-382. (Highlightby Chemical Biology of Royal SocietyChemistry)

[5] YifanWang, Magdeline Tao Tao Ng, Tianyan Zhou, XinmingLi, Choon Hong Tan, Tianhu Li,* “C3-Spacer-containing circular oligonucleotides as inhibitors ofhuman topoisomerase I”, Bioorganic & Medicinal ChemistryLetters, 2008, 18, 3597-3602.

[4] Zhou, Tianyan,Wang, Yifan, Li, Xinming, Zhang,Qiang, Li, Tianhu,* “Synthesis and characterization of afluorescein-labeled circular G-quadruplex”, Bulletin of the Chemical Societyof Japan, 2006, 79, 1300-1302.

[3]Xiaolin Li, Xinming Li, Yang Zhang,*“Study of phenolic resin toughened by grafting with NBR”, China Synthetic Rubber Industry, 2002, 25, 115.

[2] Xinming Li, Xiaolin Li, Daming Wu,* “Synthesis of resole/montmorillonite nanocomposite by intercalation polymerization”, China Synthetic Rubber Industry, 2002, 25, 173.

[1] Xinming Li, Xiaolin Li, Zhiqiang Su,Yang Zhang*, “Phenolic resin modified by copolymerization with nitrilebutadiene rubber”, Thermosetting Resin,2002, 17, 11.