朱磊

長期從事細菌脂肪酸合成系統（FASII）及其調控機制的相關研究。

主要研究細菌脂肪酸及相關脂質小分子活性物質的合成、調控過程，對相關的微生物耐藥性、致病性機制進行探索。研究範圍涉及糞腸球菌、銅綠假單胞菌、多黏芽孢桿菌等多種模式細菌和生產應用菌株。

在農業微生物中，主要研究根際促生細菌與植物相互作用機制、土壤生物活性小分子的合成代謝過程與生物合成。 ^[1] 

從事《微生物學》、《微生物遺傳育種學》、《農業與環境微生物技術》、《微生物學實驗》、《微生物遺傳育種實驗》的教學工作。 ^[2] 

1.細菌脂肪酸合成代謝

2.土壤細菌與農作物互作分子機制

3.農業病害菌致病機制與防治 ^[1] 

4.土壤微生物資源利用 ^[2] 

1.山東農業大學人才引進啓動基金 ^[1] 

2. 山東省重要土傳病害生防微生態製劑的研製與應用山東省農業重大應用技術創新項目2019.7-2021.12子項目主持10萬元

3. 國家自然科學基金 2022.01-2025.12多粘類芽孢桿菌SC2殺鐮孢菌素GHPD基團合成途徑解析；

4. 山東省自然科學基金 2021.01-2023.12銅綠假單胞菌 pafabF1 和 pafabF2 基因調控羣體感應機制研究。 ^[2] 

1.Cao X, Hong Y, Zhu L, Hu Y, Cronan JE: Development and retention of a primordial moonlighting pathway of protein modification in the absence of selection presents a puzzle. Proc Natl Acad Sci U S A 2018, 115(4):647-655.

2.Cao X, Zhu L, Hu Z, Cronan JE: Expression and Activity of the BioH Esterase of Biotin Synthesis is Independent of Genome Context. Sci Rep 2017, 7(1):2141.

3.Bi H, Zhu L, Jia J, Zeng L, Cronan JE: Unsaturated Fatty Acid Synthesis in the Gastric Pathogen Helicobacter pylori Proceeds via a Backtracking Mechanism. Cell Chem Biol 2016, 23(12):1480-1489.

4.Bi H, Zhu L, Jia J, Cronan JE: A Biotin Biosynthesis Gene Restricted to Helicobacter. Sci Rep 2016, 6:21162.

5.Zhu L, Cronan JE: The Conserved Modular Elements of the Acyl Carrier Proteins of Lipid Synthesis are Only Partially Interchangeable. J Biol Chem 2015.

6.馬金成, 鄧麗婷, 童文華, 朱磊, 王海洪: 五個3-酮脂酰ACP合成酶同源蛋白的功能鑑定. 生物化學與生物物 理進展 2014, 41(09):887-895.

7.Bi H, Zhu L, Wang H, Cronan JE: Inefficient Translation Renders the Enterococcus faecalis fabK Enoyl-Acyl Carrier Protein Reductase Phenotypically Cryptic. J Bacteriol 2014, 196(1):170-179.

8.Zhu L, Bi H, Ma J, Hu Z, Zhang W, Cronan JE, Wang H: The Two Functional Enoyl-Acyl Carrier Protein Reductases of Enterococcus faecalis Do Not Mediate Triclosan Resistance. MBio 2013, 4(5).

9.Zhu L, Lin J, Ma J, Cronan JE, Wang H: Triclosan resistance of Pseudomonas aeruginosa PAO1 is due to FabV, a triclosan-resistant enoyl-acyl carrier protein reductase. Antimicrob Agents Chemother 2010, 54(2):689-698.

10.Zhu L, Cheng J, Luo B, Feng S, Lin J, Wang S, Cronan JE, Wang H: Functions of the Clostridium acetobutylicium FabF and FabZ proteins in unsaturated fatty acid biosynthesis. BMC Microbiol 2009, 9:119.

11.馮賽祥, 朱磊, 羅彪, 孫益嶸, 王海洪: 大腸桿菌體外脂肪酸合成反應的重建. 生物化學與生物物理進展 2008, 35(8):10.

12.Wang Y, Wang L, Sun Y, Chen Y, Zhu L, Guo L, Luo B, Wang H: Disrupted ompC Causes Osmosis Sensitivity of Escherichia coli in Alkaline Medium. Journal of Genetics and Genomics 2007, 34(12):8.

13.張東方, 初志戰, 黃卓烈, 何勇虎, 朱磊: 反膠束體系的光密度與酶活性測定. 華南農業大學學報 2005, 26(4):4. ^[1] 

14.Zou, Q., H. Dong, L. Zhu and J. E. Cronan: "The Enterococcus faecalis FabT Transcription Factor Regulates Fatty Acid Biosynthesis in Response to Exogeneous Fatty Acids." Front Microbiol 2022, 13: 877582.

15.Hu, Z., J. Ma, W. Tong, L. Zhu, H. Wang and J. E. Cronan: "Escherichia coli FabG 3-ketoacyl-ACP reductase proteins lacking the assigned catalytic triad residues are active enzymes." J Biol Chem: 2021,100365.

16.Zhu, L., Q. Zou, X. Cao and J. E. Cronan: "Enterococcus faecalis Encodes an Atypical Auxiliary Acyl Carrier Protein Required for Efficient Regulation of Fatty Acid Synthesis by Exogenous Fatty Acids." MBio 2019, 10(3).

17.Cao, X., L. Zhu, X. Song, Z. Hu and J. E. Cronan: "Protein moonlighting elucidates the essential human pathway catalyzing lipoic acid assembly on its cognate enzymes." Proc Natl Acad Sci U S A 2018，115(30): E7063-E7072. ^[2]