彭博

細菌耐藥性及其代謝調控 ^[1] 

長期以來從事細菌耐藥及其代謝調控方面的研究。近年來，通過功能代謝組學發現，耐藥菌的代謝狀態決定耐藥性。通過關鍵代謝物將細菌的耐藥代謝狀態逆轉為敏感代謝狀態，從而提高耐藥菌對抗生素的敏感性，促進胞外抗生素進入胞內，提高胞內抗生素濃度，高效殺死細菌。細菌耐藥代謝組的發現和關鍵代謝物逆轉耐藥性新概念的提出，對建立控制細菌耐藥的新策略具有十分重要的價值。此外，從宿主中發現抗耐藥菌代謝狀態生物標誌物作為調節物，使宿主從對病原菌敏感代謝狀態轉為對病原菌抵抗狀態，增強宿主抗感染能力，減輕和消除病原菌對宿主的侵染作用。並在研究細菌耐藥性的過程中，發現在一個新的產能循環，丙酮酸循環而不是三羧酸循環為細菌提供能量。 ^[1] 

1. 優秀青年科學基金，2019

2.面上項目兩項（2016，2018）

3. 重點研發子課題一項（2016） ^[1] 

1.Peng B, Su YB, Li H, Han Y, Guo C, Tian YM, Peng XX. Exogenous alanine and or/glucose plus kanamycin kills antibiotic-resistant bacteria. Cell Metabolism, 2015, 21(2):249-261

2. Su YB,Peng B, Li H, Cheng ZX, Zhang TT, Zhu JX, Li D, Li MY, Ye JZ, Du CC, Zhang S, Zhao XL, Yang MJ, Peng XX. Pyruvate cycle increases aminoglycoside efficacy and provides respiratory energy in bacteria. Proc. Natl. Acad. Sci, 2018, 115 (7) E1578-E1587（co-corresponding author）

3. Ye JZ, Su YB, Lin XM, Lai SS, Li WX, Ali F, Zheng J,Peng B. Alanine enhances aminoglycosides-induced ROS production as revealed by proteomic analysis. Frontiers in Microbiology, 2018, 9：29(corresponding author)

4. Xie RQ, Zhang XH, Zhao Q, Peng B, Zheng J. Analysis of global prevalence of antibiotic resistance in Acinetobacter baumannii infections disclosed a faster increase in OECD countries. Emerging Microbes & Infections, 2018, 7:31

5. Ye JZ, Lin XM, Cheng ZX, Su YB, Li WX, Ali F, Zheng J,Peng B. Identification and efficacy of glycine serine and threonine metabolism in potentiating kanamycin-mediated killing of Edwardsiella piscicida Journal of Proteomics, 2018, 183:34-44 (corresponding author)

6. Cheng ZX, Gong QY, Wang Z, Chen ZG, Ye JZ, Li J, Wang J, Yang MJ, Ling XP,Peng B. Edwardsiella tarda tunes tricarboxylic acid cycle to evade complement-mediated killing, Frontiers in Immunology, 2017, 8:1706 (corresponding author)

7. Li H, Zhu QF, Peng XX,Peng B. (2017) Interactome of E.piscicida and grouper liver proteins reveals strategies of bacterial infection and host immune response. Scientific reports, 7, 39284 (corresponding author)

8. Zeng ZH, Du CC, Liu SR, Li H, Peng XX,Peng B. (2017) Glucose enhances tilapia againstEdwardsiella tardainfection through metabolome reprogramming. Fish & Shellfish Immunology, 61, 34-43 (corresponding author)

9. Peng B, Wang C, Li H, Su YB, Ye JZ, Yang MJ, Jiang M, Peng XX. (2017) Outer membrane proteins form specific patterns in antibiotic-resistant Edwardsiella tarda. Front. Microbiol, 8, 69

10. Zhang YL,Peng B, Li H, Yan F, Wu HK, Zhao XL, Lin XM, Min SY, Gao YY, Wang SY, Li YY, Peng XX (2017) C-terminal domain of hemocyanin, a major antimicrobial protein from Litopenaeus vannamei: structural homology with immunoglobulins and molecular diversity. Front. Immunol, 8, 611

11. Chen XH, Liu SR,Peng B, Li D, Cheng ZX, Zhu JX, Zhang S, Peng YM, Li H, Zhang TT, Peng XX. (2017) Exogenous L-valine promotes phagocytosis to kill multidrug-resistant bacterial pathogens. Frontiers in Immunol, 2017, 8:207

12. Du CC, Yang MJ, Li MY, Yang J,Peng B, Li H, Peng XX. (2017) Metabolic mechanism for L-Leucine-induced metabolome to eliminate Streptococcus iniae. J Proteome Res.16(5):1880-1889

13. Li H, Chu X,Peng B, Peng XX (2016) DNA shuffling approach for recombinant polyvalent OmpAs against V. alginolyticus and E.tarda infections. Fish Shellfish Immunol. 58:508-513

14. Wu CW, Wu X, Wen C,Peng B, Peng XX, Chen XH, Li H. (2016) Fructose promotes growth and antifugal activity of Penicillium citrinum. Protein Cell. 7, (7), 527-533

15. Wang Z, Li MY,Peng B, Cheng ZX, Li H, Peng XX. (2016) GC-MS-based metabolome and metabolite regulation in serum-resistant Streptococcus agalactiae. J Proteome Res. 15, (7), 2246-2253.

16. Peng B, Ye JZ, Han Y, Zeng L, Zhang JY, Li H. (2016) Identification of polyvalent protective immunogens from outer membrane proteins in Vibrio paraheamolyticus to protect fish against bacterial infection. Fish & Shellfish Immunology, 54, 204-210

17. Li H, Huang X, Zeng Z, Peng XX,Peng B.(2016) Identification of the interactome between fish plasma proteins andEdwardsiella tardareveals tissue-specific strategies against bacterial infection.International Journal of Biochemistry and Cell Biology. 78: 260-267 (corresponding author)

18. Wang C,Peng B, Li H, Peng XX. (2016) TolC plays a crucial role in immune protection conferred by Edwardsiella tarda whole-cell vaccines. Scientific Report, 6 : 29488

19.Peng B, Liu F, Han R, Luo G, Cathopoulis T, Lu K, Li X, Yang L, Liu GY, Cai JC, Shi SL. (2015) Dyanmic metabolic change is indicative of inflammation-induced transformation of hepatic cells.International Journal of Biochemistry & Cell Biology. 66: 45-58

20.Peng B,Li H, Peng XX. (2015) Functional metabolomics: from biomarker discovery to metabolome reprogramming.Protein & Cell6(9), 628-637.

21.Peng B,Ma YM, Zhang JY, Li H. (2015) Metabolome strategy againstEdwardesiella tardainfection through glucose-enhanced metabolic modulation in talapias.Fish & Shellfish Immunology45 (2),869-876

22. Su YB*,Peng B*, Han Y, Li H, Peng XX. (2015) Fructose restores susceptibility of multidrug-resistantEdwardesilla tardato kanamycin.Journal of Proteome Research.14, 1612-1620. (*Co-first author)

23. Guo C*,Peng B*, Song M, Wu CW, Yang MJ, Zhang JY. Li H. (2015) Live Edwardsiella tarda vaccine enhances innate immunity by metabolic modulation in Zebrafish.Fish & Shellfish Immunology ^[1]