張智

2001年畢業於安徽大學並獲生物化學學士學位，

2008年獲中國科學技術大學神經生物學博士學位，

2008-2012年在美國德克薩斯大學MD Anderson cancer center從事博士後工作。

2012年10月起任中國科學技術大學生命科學學院教授。 ^[1] 

1、疼痛與情緒疾病（抑鬱和焦慮等）相互作用的神經機制

2、中樞神經系統和外周器官相互作用的神經機制

3、調控疼痛和情緒神經環路的物理刺激方式（聲、光、電和磁刺激） ^[1] 

相關研究成果發表在Nature Medicine, Nature Neuroscience, Neuron，PNAS，Journal of Neuroscience, Cerebral Cortex和FASEB J等學術期刊上，其中兩篇論文分別被Nature Reviews Neuroscience和Nature Reviews Drug Discovery雜誌Highlight。 ^[1] 

1.Wenjie Zhou; Chonghuan Ye; Haitao Wang; Yu Mao; Weijia Zhang; An Liu; Chen-Ling Yang; Tianming Li; Lauren Hayashi; Wan Zhao; Lin Chen; Yuanyuan Liu*; Wenjuan Tao*; Zhi Zhang*; Sound induces analgesia via corticothalamic circuits, Science, 2022, 377, 198–204.

2.Peng Cao; An Liu; Changmao Chen; Qinghong Shan; Xia Zhu; Chunhui Jia; Xiaoqi Peng; Mingjun Zhang; Zahra Farzinpour; Wenjie Zhou; Haitao Wang; Jiang-Ning Zhou; Xiaoyuan Song; Liecheng Wang; Wenjuan Tao; Changjian Zheng; Yan Zhang; Yu-Qiang Ding; Yan Jin*; Lin Xu*; Zhi Zhang*; Early-life inflammation promotes depressive symptoms in adolescence via microglial engulfment of dendritic spines, Neuron, 2021.

3.Xia Zhu; Hao-Di Tang; Wan-Ying Dong; Fang Kang; An Liu; Yu Mao; Wen Xie; Xulai Zhang; Peng Cao; Wenjie Zhou; Haitao Wang; Zahra Farzinpou; Wenjuan Tao; Xiaoyuan Song; Yan Zhang; Tian Xue; Yan Jin*; Juan Li*; Zhi Zhang*; Distinct thalamocortical circuits underlie allodynia induced by tissue injury and by depression-like states, Nature Neuroscience, 2021, 24(4): 542-553.

4.Wenjuan Tao; Changmao Chen; Yuping Wang; Wenjie Zhou; Yan Jin; Yu Mao; Haitao Wang; Likui Wang; Wen Xie; Xulai Zhangd; Jie Li; Juan Li; Xiangyao Lie; Zhen-Quan Tang; Chenghua Zhoug; Zhizhong Z. Pang*; Zhi Zhang*; MeCP2 mediates transgenerational transmission of chronic pain, Progress in Neurobiology, 2020, 189:101790.

5.Yan Jin; Qian Meng; Lisheng Mei; Wenjie Zhou; Xia Zhu; Yu Mao; Wen Xie; Xulai Zhang; Min-Hua Luo; Wenjuan Tao; Haitao Wang; Jie Li; Juan Li; Xiangyao Li; Zhi Zhang*; A somatosensory cortex input to the caudal dorsolateral striatum controls comorbid anxiety in persistent pain, PAIN, 2020, 161(2): 416-428.

6.Weiwei Yin; Lisheng Mei; Tingting Sun; Yuping Wang; Jie Li; Changmao Chen; Zahra Farzinpour; Yu Mao; Wenjuan Tao; Juan Li; Wen Xie; Zhi Zhang*; A central amygdala–ventrolateral periaqueductal gray matter pathway for pain in a mouse model of depression-like behavior, Anesthesiology, 2020, Jan 27.

7.Wenjie Zhou; Yan Jin; Qian Meng; Xia Zhu; Tongjian Bai; Yanghua Tian; Yu Mao; Likui Wang; Wen Xie; Hui Zhong; Na Zhang; Min-Hua Luo; Wenjuan Tao; Haitao Wang; Jie Li; Juan Li; Ben-Sheng Qiu; Jiang-Ning Zhou; Xiangyao Li; Han Xu; Kai Wang; Xiaochu Zhang; Yong Liu; Gal Richter-Levin; Lin Xu; Zhi Zhang*; A neural circuit for comorbid depressive symptoms in chronic pain, Nature Neuroscience, 2019, 22(10): 1649-1658.

8.Tingting Sun; Zihua Song; Yanghua Tian; Wenbo Tian; Chunyan Zhu; Gongjun Ji; Yudan Luo; Shi Chen; Likui Wang; Yu Mao; Wen Xie; Hui Zhong; Fei Zhao; Min-Hua Luo; Wenjuan Tao; Haitao Wang; Jie Li; Juan Li; Jiang-Ning Zhou; Kai Wang*; Zhi Zhang*; Basolateral amygdala input to the medial prefrontal cortex controls obsessive-compulsive disorder-like checking behavior, PNAS, 2019, 116(9): 3799-3804.

9.Xia Zhu; Wenjie Zhou; Yan Jin; Haodi Tang; Peng Cao; Yu Mao; Wen Xie; Xulai Zhang; Fei Zhao; Min-Hua Luo; Haitao Wang; Jie Li; Wenjuan Tao; Zahra Farzinpour; Likui Wang; Xiangyao Li; Juan Li; Zheng-Quan Tang; Chenghua Zhou; Zhizhong Z. Pan*; Zhi Zhang*; A central amygdala input to the parafascicular nucleus controls comorbid pain in depression, Cell Reports, 2019, 29(12): 3847-3858.

10.Haitao Wang; Jiahui Chen; Xiaotong Xu; Wen-Jian Sun; Xi Chen; Fei Zhao; Min-Hua Luo; Chunhua Liu; Yiping Guo; Wen Xie; Hui Zhong; Tongjian Bai; Yanghua Tian; Yu Mao; Chonghuan Ye; Wenjuan Tao; Jie Li; Zahra Farzinpour; Juan Li; Jiang-Ning Zhou; Kai Wang; Jufang He; Lin Chen*; Zhi Zhang*; Direct auditory cortical input to the lateral periaqueductal gray controls sound-driven defensive behavior, PLoS Biology, 2019, 17(8): e3000417.

11.Persistent inflammation-induced upregulation of BDNF promotes synaptic delivery of α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptor GluA1 subunits in descending pain modulatory circuits - J. Biol. Chem. - 2014 -

12.MeCP2 repression of G9a in regulation of pain and morphine reward - The Journal of Neuroscience - 2014 -

13.Persistent Pain Facilitates Response to Morphine Reward by Downregulation of Central Amygdala GABAergic Function - Neuropsychopharmacology - 2014 -

14.Epigenetic suppression of GAD65 expression mediates persistent pain - Nature Medicine - 2011 -

15.Brain-derived neurotrophic factor-mediated downregulation of brainstem K+-Cl- cotransporter and cell-type-specific GABA impairment for activation of descending pain facilitation - Molecular Pharmacology - 2013 -

16.Signaling cascades for δ-opioid receptor-mediated inhibition of GABA synaptic transmission and behavioral antinociception - Molecular Pharmacology - 2012 -

17.Bell-shaped D-serine actions on hippocampal long-term depression and spatial memory retrieval - Cerebral Cortex - 2008 -

18.Synaptic mechanism for functional synergism between delta- and mu-opioid receptors - Journal of Neuroscience - 2010 -

19.Nerve growth factor-regulated emergence of functional delta-opioid receptors - Journal of Neuroscience - 2010 -

20.Central Amygdala GluA1 Facilitates Associative Learning of Opioid Reward - Journal of Neuroscience - 2013 - ^[1] 

2020年8月，入選2020年度國家傑出青年科學基金建議資助項目申請人名單。 ^[2]