張新剛

1994.09-1998.07, 四川大學應用化學系， 本科學生

1998.09-2003.07, 中國科學院上海有機化學研究所， 博士

2003.08-2008.03, 美國伊利諾伊大學香檳分校，博士後研究助理

2008.05-2011.12, 中國科學院上海有機化學研究所，副研究員，課題組長

2012.01-至今 中國科學院上海有機化學研究所，研究員，課題組長

2020.04-至今 中國科學院上海有機化學研究所，研究員，院重實驗室主任 ^[13] 

1.金屬有機氟化學 以過渡金屬催化為手段，研究廉價易得的含氟工業原料和工業廢棄物的高效轉化，使之具有工業應用前景，建立高效廉價金屬催化體系，發展高效温和的氟化新策略、新反應、新方法以及相關理論；

2.化學生物學相關研究 應用化學生物學手段研究和發現新的含氟生物活性分子，探索氟原子對相關生物活性分子影響的內在本質規律；利用氟原子的特性發展對多肽、蛋白，核酸進行選擇性修飾的方法，並進一步應用到化學生物學中；

3.能源相關含氟材料的研究 基於所發展方法研究含氟化合物在光伏和電池材料方面的應用。 ^[12] 

張新剛研究員長期從事有機氟化學研究。研究工作基於含氟有機化合物對醫藥、農藥和材料等領域的不可替代性，以過渡金屬催化為手段，建立了廉價含氟資源導向的催化偶聯氟烷基化和氟芳基化研究新體系，併成功應用於藥物化學和光電材料等領域；發現了基於金屬二氟卡賓的催化偶聯新反應，提出了零價鈀二氟卡賓親核質子化歷程，被國際同行稱為“金屬二氟卡賓反應”（Metal Difluorocarbene Reaction）；應用該反應，首次實現了廉價大宗工業原料氟利昂（ClCF2H）的高效催化轉化，為發現新的醫藥和農藥分子提供了新的機遇。發展了鎳催化下螯合基團輔助的烯烴雙碳化新型反應策略，成功應用於含氟多肽等生物活性分子的合成中，並被國內外同行用於非氟化合物的高效合成中，在國際上引領了該領域；首次提出了對映發散式不對稱接力偶聯（Enantiodivergent Relay Coupling, EDRC）的概念，為過渡金屬催化的不對稱偶聯反應提供了新思路。 ^[13] 

2017 年 科技部萬人計劃 ^[6] 

2016 年 科技部中青年科技創新領軍人才 ^[7] 

2015 年 英國皇家化學會氟化學獎(RSC Fluorine Chemistry Prize) ^[8] 

2015 年 第五屆中國化學會—英國皇家化學會青年化學家獎 ^[9] 

2014 年 國家“傑出青年科學基金” ^[10] 

2009 年 上海市啓明星計劃 ^[11] 

1.Chang Xu,Wen-Hao Guo,Xu He, Ying-Long Guo, Xue-Ying Zhang, and Xingang Zhang*, “Difluoromethylation of (Hetero)Aryl Chlorides with Chlorodifluoromethane Catalyzed by Nickel”, Nat. Commun. 2018, Accepted.

2.Xing Gao, Yu-Lan Xiao, and Xingang Zhang*, “Copper-Catalyzed Highly Stereospecific Trifluoromethylation and Difluoroalkylation of Secondary Propargyl Sulfonates” Angew. Chem. Int. Ed. 2018, DOI: 10.1002/anie.2017114673.

3.Zhang Feng,? Qiao-Qiao Min,? Xia-Ping Fu,? Lun An, and Xingang Zhang,* “Chlorodifluoromethane-Triggered Formation of Difluoromethylated Arenes Catalysed by Palladium”, Nature Chemistry, 2017, 9, 918 (This paper was highlighted by Chemical & Engineering News 2017, 95, 7; ACS Molecule of the week June 19, 2017; Synfacts 2017, 13, 1126).

4.Ji-Wei Gu, Qiao-Qiao Min, Ling-Chao Yu, and Xingang Zhang,* “Tandem Difluoroalkylation-Arylation of Enamides Catalyzed by Nickel” Angew. Chem. Int. Ed. 2016, 55, 12270-12274.

5.Wen-Hao Guo, Qiao-Qiao Min, Ji-Wei Gu, and Xingang Zhang,* “Rhodium-Catalyzed ortho-Selective C-F Bond Borylation of Polyfluoroarenes with Bpin-Bpin” Angew. Chem.Int. Ed. 2015, 54, 9075.

6.Yu-Lan Xiao, Wen-Hao Guo, Guo-Zhen He, Qiang Pan, and Xingang Zhang,* “Nickel-Catalyzed Cross-Coupling of Functionalized Difluoromethyl Bromides and Chlorides with Aryl Boronic Acids: A General Method for Difluoroalkylated Arenes” Angew. Chem. Int. Ed. 2014, 53, 9909 (This paper was highlighted by Chemical & Engineering News 2014, 92, 25).

7.Zhang Feng, Qiao-Qiao Min, Yu-Lan Xiao, Bo Zhang, and Xingang Zhang,* “Pd-Catalyzed Difluoroalkylation of Arylboronic Acids: A New Method for Aryldifluoromethylated Phosphonates and Carboxylic Acid Derivatives” Angew. Chem., Int. Ed. 2014, 53, 1669 (This paper was highlighted by Chemical & Engineering News 2014, 92, 25)

8.Qiao-Qiao Min, Zengsheng Yin, Zhang Feng, Wen-Hao Guo, and Xingang Zhang,* “Highly Selective gem-Difluoroallylation of Organoborons with Bromodifluoromethylated Alkenes Catalyzed by Palladium” J. Am. Chem. Soc. 2014, 136, 1230.

9.Xingang Zhang*, Shilu Fan, Chun-Yang He, Xiaolong Wan, Qiao-Qiao Min, Jie Yang and Zhong-Xing Jiang, “Pd(OAc)2 Catalyzed Olefination of Highly Electron-deficient Perfluoroarenes” J. Am. Chem. Soc. 2010, 132, 4506. (This paper was highlighted in Synfacts, 2010, 6, 0652)

10.Chun-Yang He, Shilu Fan, and Xingang Zhang,* “Pd-Catalyzed Oxidative Cross-Coupling of Perfluoroarenes with Aromatic Heterocycles” J. Am. Chem. Soc. 2010, 132, 12850. ^[14] 

1. Xing Gao, Ran Cheng, Yu-Lan Xiao, Xiao-Long Wan, and Xingang Zhang,* "Copper-Catalyzed Highly Enantioselective Difluoroalkylation of Secondary Propargyl Sulfonates with Difluoroenoxysilanes", Chem. 2019, 5, 2987-2999.

2. Xia-Ping Fu, Xiao-Song Xue, Xue-Ying Zhang, Yu-Lan Xiao, Shu Zhang, Yin-Long Guo, Xuebing Leng, Kendall N. Houk * and Xingang Zhang *, "Controllable catalytic difluorocarbene transfer enables access to diversified fluoroalkylated arenes", Nat. Chem. 2019, 11, 948–956. (A story behind this paper)

3. Zhang Feng, Yu-Lan Xiao and Xingang Zhang*, "Transition-Metal (Cu, Pd, Ni)-Catalyzed Difluoroalkylation via Cross-Coupling with Difluoroalkyl Halides", Acc. Chem. Res., 2018 ,51, 2264-2278

4. Zhang Feng, Qiao-Qiao Min, Xia-Ping Fu, Lun An and Xingang Zhang,* "Chlorodifluoromethane-Triggered Formation of Difluoromethylated Arenes Catalysed by Palladium", Nat. Chem. 2017, 9, 918-923 (This paper was highlighted by Chemical & Engineering News 2017, 95, 7; ACS Molecule of the Week, 2017, June 19)

5. Ji-Wei Gu, Qiao-Qiao Min, Ling-Chao Yu, and Xingang Zhang,* "Tandem Difluoroalkylation-Arylation of Enamides Catalyzed by Nickel" Angew. Chem. Int. Ed. 2016, 55, 12270-12274. ^[1]