張冬梅

代謝綜合徵腎損傷的病理機制研究及中藥活性成分的保護作用

代謝重編程誘發足細胞損傷的作用機制 ^[1] 

2014年 江蘇省“六大人才高峯”高層次人才培養計劃 ^[1] 

發表科研文章

1. Gu, Ting-Ting#; Chen, Tian-Yu; Yang, Yan-Zi; Zhao, Xiao-Juan; Sun, Yang; Li, Tu-Shuai; Zhang, Dong-Mei*; Kong, Ling-Dong*. Pterostilbene alleviates fructose-induced renal fibrosis by suppressing TGF-beta1/TGF-beta type I receptor/Smads signaling in proximal tubular epithelial cells. European journal of pharmacology. 2018. 842: 70-78.

2. Minzan Zuo, Weirui Qian, Zuqiang Xu, Wei Shao, Xiao-Yu Hu,* Dongmei Zhang,* Juli Jiang,* Xiaoqiang Sun, and Leyong Wang. I Multi-Responsive Supramolecular Theranostic Nanoplatform Based on Pillar[5]arene and Diphenylboronic Acid Derivatives for Integrated Glucose Sensing and Insulin Delivery. Small. 2018 1801942(DOI: 10.1002/smll.201801942)

3. Yanjing Zheng#, Yumei Li, Hongyan Long, Xiaojuan Zhao, Keke Jia1, Juan Li, Leyong Wang, Ruiyong Wang, Xiancai Lu and Dongmei Zhang*. bifA Regulates Biofilm Development of Pseudomonas putida MnB1 as a Primary Response to H2O2 and Mn2+. Frontiers in Microbiology. 2018 9, 1490(DOI:10.3389/fmicb.2018.01490)

4. Lin, Xin#; Jia, Keke#; Wang, Yichen; Shao, Wei ; Yao, Chenhao ; Peng, Luming; Zhang, Dongmei*; Hu, Xiao-Yu*; Wang, Leyong. Dual-Responsive Bola-Type Supra-Amphiphile Constructed from Water-Soluble Pillar[5]arene and Naphthalimide-Containing Amphiphile for Intracellular Drug Delivery. ACS Applied Materials & Interfaces. 9: 4843-4850. 2017.1.18

5. Gao Lei #, Wang Tingting, Jia Keke, Wu Xuan, Yao Chenhao, Shao Wei, Zhang Dongmei, Hu XiaoYu *, and Wang Leyong *. Glucose-Responsive Supramolecular Vesicles Based on Water- Soluble Pillar[5]arene and Pyridylboronic Acid Derivatives for Controlled Insulin Delivery. Chemistry - A European Journal. 2017.5.11, 23, 6605–6614.

6. Zhang Dong-Mei#, Jiao Rui-Qing, Ling-Dong Kong*. High Dietary Fructose: Direct or Indirect Dangerous Factors Disturbing Tissue and Organ Functions. Nutrients. 2017.4, 9(4), 335; doi:10.3390/nu9040335.

7. Gu Ting-Ting#, Song Lin#, Chen Tian-Yu, Wang Xing, Zhao Xiao-Juan, Ding Xiao-Qin, Yang Yan-Zi, Pan Ying, Zhang Dong-Mei*, Kong Ling-Dong*. Fructose down-regulates miR-330 to induce renal inflammatory response and insulin signaling impairment: Attenuation by morin. Molecular Nutrition & Food Research. 2017.8;61(8). doi: 10.1002/mnfr.201600760.

8. Kang Lin-Lin#, Zhang Dong-Mei#, Ma Chun-Hua, Zhang Jian-Hua, Jia Ke-Ke, Liu Jia-Hui, Wang Rong, Kong Ling-Dong*. Cinnamaldehyde and allopurinol reduce fructose-induced cardiac inflammation and fibrosis by attenuating CD36-mediated TLR4/6-IRAK4/1 signaling to suppress NLRP3 inflammasome activation. Scientific Reports. 2016.6.8; 6:27460.

9. Ma Chun-Hua#, Kang Lin-Lin, Ren Hong-Mei，Zhang Dong-Mei，Kong Ling-Dong*. Simiao pill ameliorates renal glomerular injury via increasing Sirt1 expression and suppressing NF-kappaB/NLRP3 inflammasome activation in high fructose-fed rats. Journal of Ethnopharmacology. 2015.8.22;172:108-117.

10. Yang Ying#，Zhang Dong-Mei，Liu Jia-Hui，Hu Lin-Shui，Xue Qiao-Chu，Ding Xiao-Qin，Kong Ling-Dong*. Wuling San protects kidneydysfunction by inhibiting renal TLR4/MyD88 signaling and NLRP3 inflammasomeactivation in high fructose-induced hyperuricemic mice. Journal of Ethnopharmacology. 2015.7.1; 169:49-59.

11. Liu Lei#, Zhang Dong-Mei#, Wang Ming-Xin, Fan Chen-Yu, Zhou Fan, Wang Shui-Juan, Kong Ling-Dong*. The adverse effects of long-term l-carnitine supplementation on liver and kidney function in rats. Human & experimental toxicology. 2015.11; 34(11):1148-1161.

12. Wang Ming-Xing#, Liu Yang-Liu, Yang Ying, Zhang Dong-Mei, Kong Ling-Dong*. Nuciferine restores potassium oxonate-induced hyperuricemia and kidney inflammation in mice. European journal of pharmacology. 2015.1.15;15(747):59-70.

13. Hu Xiao-Yu#, Jia Ke-Ke, Cao Yu, Li Yan, Qin Shan, Zhou Fan, Lin Chen, Zhang Dong-Mei, Wang Leyong*. Dual photo- and pH-responsive supramolecular nanocarriers based on water-soluble pillar[6]arene and different azobenzene derivatives for intracellular anticancer drug delivery. Chemistry-A European Journal. 2015.1.12;21(3):1208-1220.

14. Wang Xing#, Zhang Dong-Mei#, Gu Ting-Ting, Ding Xiao-Qin, Fan Chen-Yu, Zhu Qin, Shi Yun-Wei, Hong Ye, Kong Ling-Dong*. Morin reduces hepatic inflammation-associated lipid accumulation in high fructose-fed rats via inhibiting sphingosine kinase 1/sphingosine phosphate signaling pathway. Biochemical Pharmacology. 2013.12.15.86(12):1791-1804.

15. Guan Fu-Qin#, Wang Hai-Ting, Shan Yu, Zhang Dong-Mei, Zhao You-Yi, Chen Yu, Wang Qi-Zhi, Wang Ming, Feng Xu*. Bigelovii A induces apoptosis of HL ‑60 human acute promyelocytic leukaemia cells. Molecular Medicine Reports. 2013.5;7(5):1585-1590.

16. Zhang Dong-Mei#, Li Yu-Cheng#, Xu De, Ding Xiao-Qin, Kong Ling-Dong*. Protection of curcumin against fructose-induced hyperuricaemia and renal endothelial dysfunction involves NO-mediated JAK-STAT signalling in rats. Food Chemistry. 2012.10.15;134(4):2184-2193.

17. Yang Jing-Hua#, Zhao Jing, Xiao Han, Zhang Dong-Mei, Li Gen-Xi*. Study of Hemoglobin and Human Serum Albumin Glycation with Electrochemical Techniques. Electroanalysis. 2011.2 .23(2):463-468.

18. Pan Ying#, Wang Fu-Meng, Qiang Li-Qin, Zhang Dong-Mei, Kong Ling-Dong*. Icariin attenuates chronic mild stress-induced dysregulation of the LHPA stress circuit in rats. Psychoneuroendocrinology. 2010.2; 35(2): 272-283.

19. Sun Xue-Song#, Ge Rui-Guang, Zhang Dong-Mei, Sun Hong-Zhe, He Qing-Yu*. Iron-containing lipoprotein SiaA in SiaABC, the primary heme transporter of Streptococcus pyogenes. Journal of Biological Inogranic Chemistry. 2010.11;15: 1265-1273.

20. Liu Tao#, Zhao Jing, Zhang Dong-Mei, Li Gen-Xi*. Novel Method to Detect DNA Methylation Using Gold Nanoparticles Coupled with Enzyme-Linkage Reactions. Analytical Chemistry. 2010.1.1;82(1): 229-233.

21. Hu Qing-Hua#, Wang Chuang, Li Jian-Mei, Zhang Dong-Mei, Kong Ling-Dong*. Allopurinol, rutin and quercetin attenuate hyperuricemia and renal dysfunction in rats induced by fructose intake: renal organic ion transporter involvement. American Journal of Physiology-Renal Physiology. 2009.10; 297(4): F1080-1091.

22. Lu Hua#, Shi Ji-Xin, Zhang Dong-Mei, Shen Jie, Lin Yi-Xing, Hang Chun-Hua, Yin Hong-Xia*. Hemolysate-induced Expression of Intercellular Adhesion Molecule-1 and Monocyte Chemoattractant Protein-1 Expression in Cultured Brain Microvascular Endothelial Cells via Through ROS-dependent NF-κB Pathways. Cellular and Molecular Neurobiology. 2009.2; 29:87-95.

23. Zhang Dong-Mei#, Shen Jie, Wang Cui-Cui, Zhang Xin, Chen Jun-Hui*. GSH-dependent iNOS and HO-1 Mediated Apoptosis of Human Jurkat Cells Induced by Nickel(II). Environmental Toxicology. 2009.8; 24(4): 404-414.

24. Zhang Dong-Mei#, Zhao Jing, Li Gen-Xi*. Protein-based voltammetric biosensors fabricated with nanomaterials. Protein and Peptide Letters. 2008;15(8):764-771.

25. Zhou Nan-Di#, Chen Zhen-Yu, Zhang Dong-Mei, Li Gen-Xi*. Electrochemical Assay of Human Islet Amyloid Polypeptide and Its Aggregation. Sensors. 2008.9; 8:5987-5995.

26. Huang Jun-Yi#, Zhang Dong-Mei, Xing Wei, Ma Xiang, Yin Yan-Xia, Wei Qun, Li Gen-Xi*. An approach to assay the enzymatic activity of calcineurin and the inhibitory effect of zinc ion. Analytical Biochemistry. 2008.4.15; 375(2):385-387.

27. Zeng Yi-Bo#, Zhang Dong-Mei, Li Hong-Yan, Sun Hong-Zhe*. Binding of Ni2+ to a histidine- and glutamine-rich protein, Hpn-like. Journal of Biological Inorganic Chemistry. 2008.9;13(7): 1121-1131.

28. Zhang Dong-Mei#; Zhou Nan-Di; Zhou Hhui; Chen Ting; Li Gen-Xi*. Electrochemical study of the inhibitory effect of sinapic acid and its derivatives on tyrosinase reactivity. Chemical Journal of Chinese Universities-Chinese 2008.2.10;29(2):273-276.

29. Guan Fu-Qin#, Zhang Dong-Mei#, Wang Xin-Chang, Chen Jun-Hui*. Nitric Oxide and Bcl-2 Mediated the Apoptosis Induced by Nickel(II) in Human T Hybridoma Cells. Toxicology and Applied Pharmacology. 2007.5.15;211(1):86-94.

30. Liu Lei#, Zhu Xiao-Li, Zhang Dong-Mei, Huang Jun-Yi, Li Gen-Xi*. An electrochemical method to detect folate receptor positive tumor cells. Electrochemistry communication. 2007.10;9(10): 2547-2550.

31. Mo Shi-Fu#, Zhou Feng, Lv Yao-Zhong, Hu Qing-Hua, Zhang Dong-Mei, Kong Ling-Dong*. Hypouricemic action of selected flavonoids in mice structure-activity relationships. Biological & Pharmaceutical Bulletin 2007.8; 30(8):1551-1556. ^[1]