張兵

2007年畢業於山東大學；

2015年獲得美國凱斯西儲大學生物化學博士學位；

2015-2020年在美國哈佛大學幹細胞與可再生生物學系任職博士後，從事哺乳動物皮膚幹細胞調控與皮膚和毛髮再生的研究。曾先後獲得哈佛大學傑出教學獎和Charles A. King Trust博士後獎金。 ^[1] 

成體幹細胞對維持身體組織器官的更新和修復起到核心作用。張兵博士的工作重點是利用哺乳動物皮膚幹細胞作為模型系統，研究組織器官內各類細胞之間的相互作用機制，以及這些機制如何控制器官發育，組織再生和傷口修復。主要學術成果包括：

1. 闡明瞭在毛囊再生過程中，不同細胞之間的協調生長機制（Zhang et al., Gene and Development 2016），對了解複雜器官的發育和再生具有重要意義。

2. 發現了交感神經系統對幹細胞活動的直接調控機制 (Zhang et al., Nature 2020)，對了解精神壓力對組織器官再生和修復的影響提供新的思路。

3. 發展測試各類基因組學和基因編輯方法在皮膚和毛囊組織再生中的應用。 ^[1] 

研究方向主要集中在以下三個方面：

1. 神經系統與成體幹細胞的相互作用機制和生理功能；

2. 身體的系統性因子（如精神壓力，衰老等）對幹細胞及組織器官再生的影響機制；

3. 哺乳動物皮膚和毛髮的再生機制。 ^[1] 

1. Sekyu Choi, Bing Zhang, Sai Ma, Meryem Gonzalez-Celeiro, Daniel Stein, Xin Jin, Seung Tea Kim, Yuan-Lin Kang, Antoine Besnard, Amelie Rezza, Laura Grisanti, Jason Buenrostro, Michael Rendl, Matthias Nahrendorf, Amar Sahay and Ya-Chieh Hsu (2021) The stress hormone corticosterone governs hair follicle stem cell quiescence by suppressing a dermal niche activator Gas6. Nature 593.

2. Bing Zhang^#, Megan He, Inbal Rachmin, Xiaoling Yu, Seungtea Kim, David E Fisher and Ya-Chieh Hsu^# (2021) Melanocortin 1 receptor is dispensable for acute stress induced hair graying in mice. Experimental Dermatology Apr;30(4):572-577. (# Corresponding authors)

3. Inbal Rachmin, Ju Hee Lee, Bing Zhang, James Sefton, Inhee Jung, Young In Lee, Ya-Chieh Hsu and David E. Fisher (2021) Stress-associated ectopic differentiation of melanocyte stem cells and ORS amelanotic melanocytes in an ex vivo human hair follicle model. Experimental Dermatology, Apr;30(4):578-587.

4. Sai Ma, Bing Zhang, Lindsay LaFave, Zachary Chiang, Yan Hu, Jiarui Ding, Alison Brack, Vinay K Kartha, Travis Law, Caleb Lareau, Ya-Chieh Hsu, Aviv Regev, Jason D Buenrostro (2020) Chromatin potential identified by shared single cell profiling of RNA and chromatin. Cell 183, 1103-1116.e20.

5. Yulia Shwartz, Meryem Gonzalez-Celeiro, Chih-Lung Chen, H. Amalia Pasolli, Shu-Hsien Sheu, Sabrina Mai-Yi Fan, Farnaz Shamsi, Steven Assaad, Edrick Tai-Yu Lin, Bing Zhang, Pai-Chi Tsai, Megan He, Yu-Hua Tseng, Sung-Jan Lin and Ya-Chieh Hsu (2020) Cell types promoting goosebumps form a niche to regulate hair follicle stem cells. Cell 182, 578-593.e19.

6. Bing Zhang, Sai Ma, Inbal Rachmin, Megan He, Pankaj Baral, Sekyu Choi, William A. Gonçalves, Yulia Shwartz, Eva M. Fast, Yiqun Su, Leonard I. Zon, Aviv Regev, Jason D. Buenrostro, Thiago M. Cunha, Isaac M. Chiu, David E. Fisher and Ya-Chieh Hsu (2020) Hyperactivation of Sympathetic Nerves Drives Melanocyte Stem Cell Depletion. Nature 577, 676–681.

7. Bing Zhang*, Megan He* and Ya-Chieh Hsu (2020) FACS Isolation of Melanocyte Stem Cells from Mouse Skin. Protocol Exchange: DOI 10.21203/rs.2.17987/v1 (*Co-first author).

8.Alex J. Gooding, Bing Zhang, Lalith Gunawardane, Abigail Beard, Saba Valadkhan and William P. Schiemann (2018) The lncRNA BORG Facilitates the Survival and Chemoresistance of Triple-Negative Breast Cancers. Oncogene 38: 2020-2041.

9. Alex J. Gooding, Bing Zhang, Fereshteh K. Jahanbani, Hannah L. Gilmore, Jenny C. Chang, Saba Valadkhan and William P. Schiemann (2017) The lncRNA BORG Drives Breast Cancer Metastasis and Disease Recurrence. Scientific Reports 7: 12698.

10. Bing Zhang and Ya-Chieh Hsu (2017) Emerging Roles of Transit-Amplifying Cells in Tissue Regeneration and Cancer. WIREs Developmental Biology 6: e282.

11. Bing Zhang*, Pai-Chi Tsai*, Meryem Gonzalez-Celeiro, Oliver Chung, Benjamin Boumard, Carolina N. Perdigoto, Elena Ezhkova and Ya-Chieh Hsu (2016) Hair Follicles’ Transit Amplifying Cells Govern Concurrent Dermal Adipocyte Production through Sonic Hedgehog. Genes and Development 30: 2325-2338 (*Co-first author).

12. Meryem Gonzalez-Celeiro*, Bing Zhang* and Ya-Chieh Hsu (2016) Fate by Chance, not by Choice: Epidermal Stem Cells Caught in Live. Cell Stem Cell 19: 8-10 (*Co-first author).

13. Hongmei Mou, Vladimir Vinarsky, Purushothama RaoTata, Karissa Brazauskas, Soon H.Choi, Adrianne K.Crooke, Bing Zhang, George M.Solomon, Brett Turner, Hermann Bihler, Jan Harrington, Allen Lapey, Colleen Channick, Colleen Keyes, Adam Freund, Steven Artandi, Martin Mense, Steven Rowe, John F.Engelhardt, Ya-Chieh Hsu and Jayaraj Rajagopal (2016) Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells. Cell Stem Cell 19, 217-231.

14. Bing Zhang, Lalith Gunawardane, Farshad Niazi, Fereshteh Jahanbani, Xin Chen and Saba Valadkhan (2014) A Novel RNA Motif Mediates the Nuclear Localization of a Long Non-Coding RNA. Molecular and Cell Biology 34: 2318-2329.

15. Yasaman Jaladat, Bing Zhang, Afshin Mohammadi and Saba Valadkhan (2011) Splicing of an intervening sequence by protein free human snRNAs. RNA Biology 8: 372-377. ^[1]