張世海

張世海，中國農業大學和北卡羅萊納州立大學聯合培養博士。現為華南農業大學動物科學學院副教授，碩士研究生導師，美國德州大學西南醫學中心客座副教授。主要研究方向包括母仔豬營養、脂肪酸營養、氨基酸營養等。主講《動物營養學》、《飼料學》等專業課課程。近年來，以第一或通訊作者在PloS Genetics，Nutrition Research Reviews等國內外期刊發表SCI論文45篇，其中TOP期刊10篇，論文總引用次數達2300餘次。先後主持/參與國家自然科學基金，十四五國家重點研發計劃青年科學家項目課題，十三五國家重點研發計劃重點專項子課題，廣東省自然科學基金，廣州市科技計劃等。入選華南農業大學“卓越青年教師百人計劃”，曾獲華南農業大學動物科學學院“青年教師教學觀摩比賽”一等獎、華南農業大學“青年教師教學優秀獎”一等獎、華南農業大學“本科課堂教學十佳教師”，在廣東省第六屆高校（本科）青年教師教學大賽中獲工科組一等獎（冠軍）。

2016-2019：華南農業大學，動物科學，首聘副教授

2020- ：華南農業大學，動物科學，副教授

2019-2020: 美國德州大學西南醫學中心，分子生物學，客座副教授

2018年 華南農業大學 “青年教師教學優秀獎” 一等獎

2018年 華南農業大學 動物科學學院 “教學十佳”

2019年 華南農業大學 動物科學學院“青年教師成長獎”

2021年 華南農業大學 動物科學學院“青教賽一等獎”

2021年 華南農業大學 動物科學學院“青年教師成長獎”

2022年 華南農業大學 “教學十佳”

2022年 廣東省第六屆高校（本科）青年教師教學大賽工科組一等獎（冠軍）

2022年 華南農業大學 卓越青年教師百人計劃

中國高科技產業化研究會飼料分會理事

Frontiers in Cell and Developmental Biology (SCI收錄)期刊 Review Editor

Antioxidants (SCI收錄)期刊 Guest Editor

Frontiers in Sustainable Food Systems (SCI收錄)期刊 Guest Associate Editor

Agriculture（SCI收錄）期刊 Guest Editor

主要主持項目

1. 腸道氨基酸感知受體介導支鏈氨基酸調控仔豬採食量的機制研(31802067) ，國家科學自然基金委， 2019.1-2021.12

2. 腸道和大腦氨基酸感知受體介導支鏈氨基酸調控仔豬採食量的機制研究 (2018A030310201) 廣東省自然科學基金，2018.5.1-2021.4.30

3. 胃腸道氨基酸感知受體影響仔豬採食量的作用機制，華南農業大學青年科技人才培育專項基金， 2017.1-2018.12

4. 飼糧中添加OxC-beta和硒對母豬繁殖性能的影響及其機制（2018YFD0500600），國家重點研發計劃2018.6-2021.6

5. FFAR2對母豬泌乳功能的調節作用及其機制研究 (202102020056), 廣州市科技計劃2021.4.1-2023.3.31

6. GPR43介導Gα信號通路調控母豬泌乳功能的機制研究 (2021A1515010440)，廣東省自然科學基金， 2021.01-2023.12

7.GPR120介導油酸調節母豬乳脂合成的機制研究，廣東省自然科學基金，2023.01-2025.12

主要參與項目

1. 母豬泌乳能力及初乳IgA含量提升的營養調控機制, 國家重點研發計劃青年科學家項目(2021YFD1300700), 2021.12-2026.11

2. 長鏈脂肪酸調節母豬乳脂合成的分子機制（31872364），國家科學自然基金，2019.1-2022.12

3. 不同種類和加工工藝的油脂對腸道穩態和腸道微生物菌羣定植的影響（2017YFD0500501），國家重點研發計劃項目， 2017.9-2020.1

44. Li, L., Wu, W., Deng, Z., Zhang, S.*, & Guan, W*. (2022). Improved thermostability of lipase Lip2 from Yarrowia lipolytica through disulfide bond design for preparation of medium-long-medium structured lipids. LWT, 166, 113786. （*通訊作者，IF 2021=6.1, 2022中科院分區一區）

43. Zhang, S., Xiong, L., Cui, C., Zhao, H., Zhang, Y., Tian, Z., Guan, W.*, & Chen, F*. (2022). Maternal supplementation with Artemisia annua L. ameliorates intestinal inflammation via inhibiting the TLR4/NF-κB and MAPK pathways and improves the oxidative stability of offspring. Food & function, 13(18), 9311–9323. （第一作者，IF 2021=6.3，2022中科院分區一區）

42. Cui, C., Wu, C., Wang, J., Zheng, X., Ma, Z., Zhu, P., Guan, W., Zhang, S.*, & Chen, F. *(2022). Leucine supplementation during late gestation globally alters placental metabolism and nutrient transport via modulation of the PI3K/AKT/mTOR signaling pathway in sows. Food & function, 13(4), 2083–2097. （*通訊作者，IF 2021=6.3，2022中科院分區一區）

41. Xiong, L., Zhang, W., Zhao, H., Tian, Z., Ren, M., Chen, F., Guan, W.*, & Zhang, S*. (2022). Dietary Supplementation of Enzymatically Treated Artemisia annua L. Improves Lactation Performance, Alleviates Inflammatory Response of Sows Reared Under Heat Stress, and Promotes Gut Development in Preweaning Offspring. Frontiers in veterinary science, 9, 843673. （*通訊作者，IF 2021=3.4, 2022中科院分區二區）

40. Tian, M., Li, L., Tian, Z., Zhao, H., Chen, F., Guan, W., & Zhang, S. (2022). Glyceryl butyrate attenuates enterotoxigenic Escherichia coli-induced intestinal inflammation in piglets by inhibiting the NF-κB/MAPK pathways and modulating the gut microbiota. Food & function, 13(11), 6282–6292. （*通訊作者，IF 2021=6.3， 2022中科院分區一區）

39. Wu, Z., Li, Q., Yang, S., Zheng, T., Shao, J., Guan, W., Chen, F., & Zhang, S. (2022). Energy deprivation-induced AMPK activation inhibits milk synthesis by targeting PrlR and PGC-1α. Cell communication and signaling, 20(1), 25. （*通訊作者，IF 2021=7.5，2022中科院分區二區）

38. Wu, Z., Xu, C., Zheng, T., Li, Q., Yang, S., Shao, J., Guan, W., & Zhang, S. (2022). A critical role of AMP-activated protein kinase in regulating intestinal nutrient absorption, barrier function, and intestinal diseases. Journal of cellular physiology, 237(10), 3705–3716. （*通訊作者，IF 2021=6.5，2022中科院分區二區）

37. Li, Q., Yang, S., Zhang, X., Liu, X., Wu, Z., Qi, Y., Guan, W., Ren, M., & Zhang, S. (2022). Maternal Nutrition During Late Gestation and Lactation: Association With Immunity and the Inflammatory Response in the Offspring. Frontiers in immunology, 12, 758525. （*通訊作者，IF 2021=8.7，2022中科院分區二區）

36. Tian, M., Wu, Z., Heng, J., Chen, F., Guan, W.,* & Zhang, S.* (2022). Novel advances in understanding fatty acid–binding G protein–coupled receptors and their roles in controlling energy balance. Nutrition Reviews, 2022;80(2):187-199. （*通訊作者，IF 2020=7.1，2022中科院分區二區）

34. Li, Q., Yang, S., Chen, F., Guan, W.*, & Zhang, S*. (2022). Nutritional strategies to alleviate oxidative stress in sows. Animal Nutrition. 9, 60–73. （*通訊作者，IF 2021=6.3，2022中科院分區一區）

35. Zhang, S., Wang, H., Melick, C. H., Jeong, M. H., Curukovic, A., Tiwary, S., ... & Jewell, J. L. (2021). AKAP13 couples GPCR signaling to mTORC1 inhibition. PLoS Genetics, 17(10), e1009832.（第一作者，IF 2020=5.9，自然指數期刊）

33. Qi, Y., Zhang, X., Wu, Z., Tian, M., Chen, F., Guan, W., & Zhang, S. (2022). Ferroptosis Regulation by Nutrient Signalling. Nutrition research reviews, 35(2), 282–294. （*通訊作者，IF 2021=8.1，2021中科院分區二區）

Zhang, W., Xiong, L., Chen, J., Tian, Z., Liu, J., Chen, F., Guan, W.* & Zhang, S*. (2021). Artemisinin Protects Porcine Mammary Epithelial Cells against Lipopolysaccharide-Induced Inflammatory Injury by Regulating the NF-κB and MAPK Signaling Pathways. Animals, 11(6), 1528.（*通訊作者，IF 2020=2.8）

32. Song, H., Chai, W., Yang, F., Ren, M., Chen, F., Guan, W.,* & Zhang, S.* (2021). Effects of Dietary Monoglyceride and Diglyceride Supplementation on the Performance, Milk Composition, and Immune Status of Sows During Late Gestation and Lactation. Frontiers in Veterinary Science, 8. (*通訊作者，IF 2020=3.4)

31. Yi, Q., Liu, J., Zhang, Y., Qiao, H., Chen, F., Zhang, S.,* & Guan, W*. (2021). Anethole attenuates enterotoxigenic Escherichia coli-induced intestinal barrier disruption and intestinal inflammation via modification of TLR signaling and intestinal microbiota. Frontiers in microbiology, 12. (*通訊作者，IF 2020=5.6)

30. Tian M, Chen J, Wu Z, Chen, F., Zhang, S.,* & Guan, W*. Fat encapsulation reduces diarrhea in piglets partially by repairing the intestinal barrier and improving fatty acid transport[J]. Animals, 2021, 11(1): 28. （*通訊作者，IF 2020=2.8）

29. Zhang, W. F., Tian, M., Song, J. S., Chen, F., Lin, G., Zhang, S. H.*, & Guan, W. T*. (2021). Effect of replacing inorganic trace minerals at lower organic levels on growth performance, blood parameters, antioxidant status, immune indexes, and fecal mineral excretion in weaned piglets. Tropical Animal Health and Production, 53(1), 1-8. (IF: 2.7) （*通訊作者，IF 2020=1.6）

28．Wu, Z., Heng, J., Tian, M., Song, H., Chen, F., Guan, W*., & Zhang, S*. (2020). Amino acid transportation, sensing and signal transduction in the mammary gland: key molecular signalling pathways in the regulation of milk synthesis. Nutrition research reviews, 33(2), 287–297. （*通訊作者，IF 2019 = 7.641，2020中科院分區一區）

27. Heng, J., Wu, Z., Tian, M., Chen, J., Song, H., Chen, F., Guan, W*., & Zhang, S*. (2020). Excessive BCAA regulates fat metabolism partially through the modification of m6A RNA methylation in weanling piglets. Nutrition & metabolism, 17, 10. （*通訊作者，IF 2019 =3.211）

26. Zhang, W., Heng, J., Kim, S.W., Chen, F., Deng, Z., Zhang, S*, Guan, W*. Dietary enzymatically-treated Artemisia annua L. supplementation could alleviate oxidative injury and improve reproductive performance of sows reared under high ambient temperature[J]. Journal of Thermal Biology, 2020, 94: 102751. （*通訊作者，IF 2019=2.361）

25. Tian, M., Chen, J., Liu, J., Chen, F., Guan, W*, Zhang, S*, Dietary fiber and microbiota interaction regulates sow metabolism and reproductive performance[J]. Animal Nutrition, 2020. （*通訊作者, IF 2019=4.492，2020中科院分區一區）

24. Tian, M., Qi, Y., Zhang, X., Wu, Z., Chen, J., Chen, F., Guan, W*, Zhang, S*. Regulation of the JAK2-STAT5 pathway by signaling molecules in the mammary gland[J]. Frontiers in Cell and Developmental Biology, 2020, 8: 1382. （*通訊作者, IF 2019=5.201）

23. Wu, Z., Tian, M., Heng, J., Chen, J., Chen, F., Guan, W*., & Zhang, S*. (2020). Current Evidences and Future Perspectives for AMPK in the Regulation of Milk Production and Mammary Gland Biology. Frontiers in cell and developmental biology, 8, 530. （*通訊作者, IF 2019=5.201）

22. Ren, C., Wang, Y., Lin, X., Song, H., Zhou, Q., Xu, W., Shi, K., Chen, J., Song, J., Chen, F., Zhang, S.*, & Guan, W*. (2020). A Combination of Formic Acid and Monolaurin Attenuates Enterotoxigenic Escherichia coli Induced Intestinal Inflammation in Piglets by Inhibiting the NF-κB/MAPK Pathways with Modulation of Gut Microbiota. Journal of agricultural and food chemistry, 68(14), 4155–4165. （*通訊作者, IF 2019=4.192，2020中科院分區一區）

21. Zhang, S., Wu, Z., Heng, J., Song, H., Tian, M., Chen, F., & Guan, W*. (2020). Combined yeast culture and organic selenium supplementation during late gestation and lactation improve preweaning piglet performance by enhancing the antioxidant capacity and milk content in nutrient-restricted sows. Animal nutrition, 6(2), 160–167. （第一作者，IF 2019=4.492，2020中科院分區一區）

20. Yang, F.#, Zhang, S.#, Tian, M., Chen, J., Chen, F., & Guan, W*. (2020). Different Sources of High Fat Diet Induces Marked Changes in Gut Microbiota of Nursery Pigs. Frontiers in microbiology, 11, 859. （#第一作者，IF 2019=4.235）

19. Zhang, S., Wu, Z., Heng, J., Tian, M., Chen, J., Chen, F., & Guan, W*. (2020). L-carnitine increases cell proliferation and amino acid transporter expression via the activation of insulin-like growth factor I signaling pathway in rat trophoblast cells. Food science & nutrition, 8(7), 3298–3307. （第一作者, IF 2019=1.797）

18. Heng, J., Tian, M., Zhang, W., Chen, F., Guan, W.*, & Zhang, S*. (2019). Maternal heat stress regulates the early fat deposition partly through modification of m6A RNA methylation in neonatal piglets. Cell stress & chaperones, 24(3), 635–645. （*通訊作者, IF 2019=2.892）

17. Tian, M., Heng, J., Song, H., Shi, K., Lin, X., Chen, F., Guan, W., & Zhang, S*. (2019). Dietary Branched-Chain Amino Acids Regulate Food Intake Partly through Intestinal and Hypothalamic Amino Acid Receptors in Piglets. Journal of agricultural and food chemistry, 67(24), 6809–6818. （*通訊作者, IF 2019=4.192，2019中科院分區一區）

16. Tian, M., Heng, J., Song, H., Zhang, Y., Chen, F., Guan, W., & Zhang, S*. (2019). Branched chain amino acids stimulate gut satiety hormone cholecystokinin secretion through activation of the umami taste receptor T1R1/T1R3 using an in vitro porcine jejunum model. Food & function, 10(6), 3356–3367. （*通訊作者, IF 2019=4.171，2019中科院分區一區）

15. Li, L.#, Zhang, S.#, Wu, W., Guan, W., Deng, Z., & Qiao, H. (2019). Enhancing thermostability of Yarrowia lipolytica lipase 2 through engineering multiple disulfide bonds and mitigating reduced lipase production associated with disulfide bonds. Enzyme and microbial technology, 126, 41-49. （#第一作者, IF 2019=3.448）

14. Zhang, S., Heng, J., Song, H., Zhang, Y., Lin, X., Tian, M., Chen, F., & Guan, W. (2019). Role of Maternal Dietary Protein and Amino Acids on Fetal Programming, Early Neonatal Development, and Lactation in Swine. Animals : an open access journal from MDPI, 9(1), 19. （第一作者, IF 2019=2.323）

13. Zhang, S., Chen, F., Zhang, Y., Lv, Y., Heng, J., Min, T., Li, L., & Guan, W. (2018). Recent progress of porcine milk components and mammary gland function. Journal of animal science and biotechnology, 9, 77. （第一作者, IF 2018=3.441，中科院分區2020一區）

12. Zhang, S., Tian, M., Song, H., Shi, K., Wang, Y., & Guan, W. (2018). Effects of L-carnitine on reproductive performance, milk composition, placental development and IGF concentrations in blood plasma and placental chorions in sows. Archives of animal nutrition, 1-14. （第一作者, IF 2018=1.786）

11. Zhang, S., Zhang, X., Qiao, H., Chen, J., Fang, C., Deng, Z., & Guan, W. (2018). Effect of timing of post-weaning supplementation of soybean oil and exogenous lipase on growth performance, blood biochemical profiles, intestinal morphology and caecal microbial composition in weaning pigs. Italian Journal of Animal Science, 1-9. （第一作者, IF 2018=1.265）

10. Zhang, Y.#, Zhang, S.#, Guan, W., Chen, F., Cheng, L., Lv, Y., & Chen, J. (2018). GLUT1 and lactose synthetase are critical genes for lactose synthesis in lactating sows. Nutrition & metabolism, 15, 40. （#第一作者, IF 2018=3.599）

9. Yang, F.#, Zhang, S.#, Kim, S. W., Ren, C., Tian, M., Cheng, L., Song, J., Chen, J., Chen, F., & Guan, W. (2018). Fat encapsulation enhances dietary nutrients utilization and growth performance of nursery pigs. Journal of animal science, 96(8), 3337–3347. （#第一作者, IF 2018=1.697）

8. Zhang, S., Song, J., Deng, Z., Cheng, L., Tian, M., & Guan, W. (2017). Effects of combined α-galactosidase and xylanase supplementation on nutrient digestibility and growth performance in growing pigs. Archives of animal nutrition, 71(6), 441-454. （第一作者, IF 2017=1.887）

7. Zhang, S., Zeng, X., Ren, M., Mao, X., & Qiao, S. (2017). Novel metabolic and physiological functions of branched chain amino acids: a review. Journal of animal science and biotechnology, 8, 10. （第一作者, IF 2017=3.205）

6. Zhang, S., Chu, L., Qiao, S., Mao, X., & Zeng, X. (2016). Effects of dietary leucine supplementation in low crude protein diets on performance, nitrogen balance, whole-body protein turnover, carcass characteristics and meat quality of finishing pigs. Animal science journal = Nihon chikusan Gakkaiho, 87(7), 911–920. （第一作者, IF 2016=1.325）

5. Ren, M.#, Zhang, S.#, Liu, X., Li, S., Mao, X., Zeng, X., & Qiao, S. (2016). Different Lipopolysaccharide Branched-Chain Amino Acids Modulate Porcine Intestinal Endogenous β-Defensin Expression through the Sirt1/ERK/90RSK Pathway. Journal of agricultural and food chemistry, 64(17), 3371–3379. （#第一作者, IF 2016=3.154）

4. Zhang, S., Yang, Q., Ren, M., Qiao, S., He, P., Li, D., & Zeng, X. (2016). Effects of isoleucine on glucose uptake through the enhancement of muscular membrane concentrations of GLUT1 and GLUT4 and intestinal membrane concentrations of Na+/glucose co-transporter 1 (SGLT-1) and GLUT2. The British journal of nutrition, 116(4), 593–602. （第一作者）

3. Ma, W. F.#, Zhang, S. H.#, Zeng, X. F., Liu, X. T., Xie, C. Y., Zhang, G. J., & Qiao, S. Y. (2015). The appropriate standardized ileal digestible tryptophan to lysine ratio improves pig performance and regulates hormones and muscular amino acid transporters in late finishing gilts fed low-protein diets. Journal of animal science, 93(3), 1052–1060.（#第一作者, IF 2015=2.014）

2. Zhang, S., Ren, M., Zeng, X., He, P., Ma, X., & Qiao, S. (2014). Leucine stimulates ASCT2 amino acid transporter expression in porcine jejunal epithelial cell line (IPEC-J2) through PI3K/Akt/mTOR and ERK signaling pathways. Amino acids, 46(12), 2633–2642. （第一作者）

1. Zhang, S., Qiao, S., Ren, M., Zeng, X., Ma, X., Wu, Z., Thacker, P., & Wu, G. (2013). Supplementation with branched-chain amino acids to a low-protein diet regulates intestinal expression of amino acid and peptide transporters in weanling pigs. Amino acids, 45(5), 1191–1205. （第一作者）