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巨勇

鎖定
巨勇,清華大學生命有機磷化學及化學生物學教育部重點實驗室副主任。清華大學化學系副教授(1995-2003),教授(2003-)。 [1] 
中文名
巨勇
國    籍
中國
民    族
漢族
職    業
副主任

巨勇人物經歷

巨勇教育背景

1982年,理學學士,蘭州大學化學系
1987年,理學碩士,蘭州大學化學系
1992年,理學博士,蘭州大學化學系

巨勇工作經歷

1982-1993蘭州大學化學系,助教,講師。
1993-1995清華大學化學系從事博士後研究。
1996-1998美國Rutgers大學植物系,訪問學者。
2001-2002美國Ohio州立大學化學系,高級訪問學者。
2005-2006美國South Carolina大學化學與生物化學系,訪問教授。

巨勇社會任職

第十屆北京市政協委員。
《Pharmazie》編委(2006-)。

巨勇研究方向

天然產物化學,有機合成化學,化學生物學
主要研究領域
生物活性天然產物的結構,化學修飾,生物轉化和構效關係
生物小分子的化學進化及其仿生機理
糖生物綴合物、磷酰化肽、肽庫等的化學合成及其生物學功能
主講課程
本科生:有機化學,有機合成設計,天然產物化學。
研究生:立體有機化學,天然有機化學。
研究成果和獲得獎勵
作為課題負責人和主要工作者,先後承擔完成國家自然科學基金“七.五”重大項目和“八.五”重點項目各1項,主持國家自然科學基金項目3項。
榮獲教育部自然科學獎二等獎1項(2003),國家教委科技進步獎二等獎(1995),三等獎(1997)各1項,甘肅省科技進步獎二等獎1項(1993)。
主編出版《有機合成化學與路線設計》(清華大學出版社,2002)。《磷與生命化學》(清華大學出版社,第8章,2005)。《現代有機合成試劑》(化學工業出版社,2006)。
在國內外重要學術刊物上發表研究論文90餘篇。

巨勇合作單位

美國 New Jersey State Rutgers University 植物系
美國 Ohio State University 化學系
美國 University of South Carolina 化學與生物化學系
蘭州大學功能有機分子化學國家重點實驗室
國際學術交流
第四屆國際雜原子學術大會(口頭報告,韓國:漢城,1995.8.4-8.7)。
美國 Rutgers 大學植物系合作研究 (1996.9-1998.3)。
美國 Ohio 州立大學化學系合作研究 (2001.7-2002.7)。
第225屆美國化學會年會、順訪(口頭報告,美國:新奧爾良;Ohio州立大學,2003.3.22-4.5)。

巨勇發表論文

1. Ji SH,Xiao Q,Ju Y(巨勇),Zhao YF,Synthesis of novel dimeric steroidal nucleoside phosphoramidates,Chemistry Letters,2005,34⑺,944-945.
2. Liu MJ,Wang Z,Ju Y(巨勇),Wong RNS,Wu QY. Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells with the disruption of Ca2+ homeostasis. Cancer Chemotherapy and Pharmacology, 2005,55⑴,79-90.
3. Liu MJ,Wang Z,Ju Y(巨勇),Zhou JB,Wang Y,Wong RNS,The Mitotic-Arresting and Apoptosis-Inducing Effects of Diosgenyl Saponins on Human Leukemia Cell Lines. Biological & Pharmaceutical Bulletin. 2004,27 ⑺1059-1065.
4. Li HY,Byeon IJL,Ju Y(巨勇),Tsai MD,Structure of human Ki67 FHA domain and its binding to a phosphoprotein fragment from hNIFK reveal unique recognition sites and new views to the structural basis of FHA domain functions,Journal of Molecular Biology,2004,335⑴,371-381.
5. Tan B,Lee MC,Cui M,Liu T,Chen ZZ,Li YM,Ju Y(巨勇),Zhao YF,Chen KX,Jiang HL,A common intermediate for prebiotic synthesis of proteins and nucleosides: a density functional theory (DFT) study on the formation of penta-coordinate phosphorus carboxylic–phosphoric mixed anhydride from N-phosphoryl amino acids,Journal of Molecular Structure (Theochem) 2004,672,51–60.
6. Xiao Q,Sun J,Sun Q,Ju Y(巨勇),Zhao YF,Cui YX,Synthesis of AZT 5’-O-Hydrogen phospholipid and their derivatives,Synthesis-Stuttgart,2003,⑴,107-111.
7. Xiao Q,Ju Y(巨勇),Yang XP,Zhao YF,Electrospray ionization mass spectrometry of AZT H-phosphonates conjugated with steroids,Rapid Communications in Mass Spectrometry,2003,17⒀,1405–1410
8. Wang SF,Ju Y(巨勇),Chen XG,Hu ZD,Separation and determination of coumarins in the root bark of three Citrus plants by micellar electrokinetic capillary chromatography,Planta Medica,2003,69⑸,483-486
9. Xiao Q,Ju Y(巨勇),Zhao YF,A facile approach to phosphonic acid diesters,Heteroatom Chemistry,2003,14⑶,208-210.
10. Qin ZH,Lin CX,Ju Y(巨勇),Zhao YF,Synthesis of serine/alanine conjugated 3’,5’- TpT,Nucleosides,Nucleotides & Nucleic Acids,2003,22⑴,63-69.
11. Xiao Q,Sun J,Ju Y(巨勇),Zhao YF,Cui YX,Facile synthesis of 3β-cholesterol H-phosphonates,Chemistry Letters,2003,32⑹,522-523.
12. Xiao Q,Ju Y(巨勇),Zhao YF,One-pot Synthesis of the H-phosphonate of AZT and diosgenin,Chemical Journal of Chinese Universities,2003,24⑻,1427-1429 (in Chinese).
13. Xiao Q,Ju Y(巨勇),Zhao YF,A convenient route to symmetric phosphate,phosphorothioate and phosphoroselenoate of AZT and D4T,Synthetic Communications,2003,33(23),4157-4162.
14. Xiao Q,Sun J,Ju Y(巨勇),Zhao YF,Cui YX,Facile synthesis of bivalent ligand-based phosphoramidates of AZT,Journal of Chemical Research,2003,⑸,262-263.
15. Xiao Q,Ju Y(巨勇),Zhao YF,Cui YX,Characteristic fragmentation behavior of phosphoamino acid conjugates with 3’-azido-3’ -deoxythymidine by electrospray ionization tandem mass spectrometry,Rapid Communications in Mass Spectrometry,2003,17⒇,2273-2278.
16. Wang SF,Chen XG,Hu ZD,Ju Y(巨勇),Analysis of three effective components in Fructus corni and its preparations by micellar electrokinetic capillary chromatography,Biomedical Chromatography,2003,17⑸,306-311.
17. Wang SF,Wu YQ,Ju Y(巨勇),Chen XG,Zheng WJ,Hu ZD,On-line concentration by field-enhanced sample injection with reverse migrating micelles in micellar electrokinetic capillary chromatography for the analysis of flavonoids in Epimedium brevicornum Maxim,Journal of Chromatography A,2003,1017 (1-2),27-34.
18. Qin DY,Lee H,Yuan CH,Ju Y(巨勇),Tsai MD,Identification of Potential Binding Sites for the FHA Domain of Human Chk2 by in vitro Binding Studies,Biochemical & Biophysical Research Communications,2003,311 ⑷,803-808.
19. Xiao Q,Sun J,Ju Y(巨勇),Zhao YF,Cui YX,Novel approach to the synthesis of AZT 5’-O-hydrogen phospholipids,Tetrahedron Letters,2002,43(30),5281-5283.
20. Qin ZH,Lin CX,Chen Y,Ju Y(巨勇),Zhao YF,Electrospray ionization mass spectrometry of serine/alanine conjugated 5’-UMP and 3’,5’-dithymidine phosphoramidates,Rapid Communications in Mass Spectrometry,2002,16,1997-2002.
21. Cai J,Liu MJ,Wang Z,Ju Y(巨勇),Apoptosis induced by dioscin in hela cells,Biological Pharmaceutical Bulletin,2002,25⑵,193-196.
22. Ju Y(巨勇),Still CC,Sacalis JN,Li J and Ho CT,Cytotoxic coumarins and lignans from extracts of the northern prickly ash,Phytotherapy Research,2001,15,441-443.
23. Hu JJ,Ju Y(巨勇),Zhao Y F,Stereo effect of the peptide formation reaction of N- (O,O-diisopropyl) phosphoryl serine,Chemical Journal Chinese Universities,2001,22⑶,399-402 (in Chinese).
24. Wang Z,Zhou JB,Ju Y(巨勇),Zhang H,Liu MJ,Li X,Effects of two saponins extracted from the Polygonatum zanlanscianense on the human leukemia (HL-60) cells,Biological Pharmaceutical Bulletin,2001,24⑵,159-162.
25. Ju Y(巨勇),Hu JJ,Zhao YF,Reaction of carbohydrates and pentacoordinate oxaphosphorane and their biomimetic mechanism,Phosphorus,Sulfur,Silicon and other Element,2000,167,93-100.
26. Hu JJ,Ju Y(巨勇),Zhao YF,Novel synthesis of tri- and penta-coordinate phosphorous saccharides,Synthetic Communication,2000,30 (22),4087-4092.
27. Hu JJ,Ju Y(巨勇),Zhao YF,LC-MS analysis of the formed peptides from N- (O,O-diisoprpyl) phosphoryl aspartic acid,Chinese Journal of Chemistry,2000,18⑹,932-935.
28. Hu JJ,Ju Y(巨勇),Zhao YF,Studies on reaction of between N-phosphoryl amino acids and ribotides,Chemical Journal of Chinese Universities,2000,21⑾,1667-1670 (in Chinese).
參考資料