孟豔

教育背景

2002-2006：日本信州大學生物機能工學專業，工學博士

1997-2000：安徽農業大學特種經濟動物飼養專業，農學碩士

1993-1997：安徽農業大學蠶學專業，農學學士

工作經歷

2009-至今： 安徽農業大學講席教授、教授

2009-2012：東京大學農學生命科學研究科，農學共同研究員

2007-2009：東京大學農學生命科學研究科，日本學術振興會外國人特別研究員

2006-2007：東京大學農學生命科學研究科，博士後

2000-2002：安徽農業大學蠶業絲綢系助教、講師

以第一作者和通訊作者在JBC、Genetics、BBA-GRM，以共同作者在 PNAS、JBC等國際權威刊物上發表了20多篇高水平SCI研究論文，影響因子總和超過70。

獲國家發明專利授權5項，其中第一發明人3項：

1. 孟豔，王敬，高俊山，王文靜，劉朝良. 一種從蠶體中提取純化高純度墨蝶呤的方法，專利號：ZL 201110387345.3

2. 孟豔，王文靜，王敬，高俊山，劉朝良. 一種從蠶體提取的墨蝶呤的鑑定方法，專利號：ZL 201210133303.1

3. 孟豔，李靜，高俊山，戴偉宏，張蕾. 桑螟β-呋喃果糖苷酶、編碼基因、基因載體、菌株及應用，專利號：ZL 201410031951.5

（#，通訊作者）

(32) Zhang, X.W., Yang, L.L., Gan, Q., Jiang, S., Liang, D., Gao, J.S., and Meng, Y.# (2023) BmTBP upregulates the transcription of BmSuc1 in silkworm (Bombyx mori) by binding to BmTfΙΙA-S. Insect Science, 2022 Dec. 31, doi: 10.1111/1744-7917.13168. Online ahead of print.

(31) Liang, D., Shu, R., Jiang, S., Gan, Q., Wu, S.J., Zhao, Y., Yang, L.L., Xu, M.J., Gao, J.S., and Meng, Y.# (2023) Expression of BmDHFR is up-regulated to trigger an increase in the BH4/BH2 ratio when the de novo synthesis of BH4 is blocked in silkworm, Bombyx mori. International Journal of Biological Macromolecules, 225, 625-633.

(30) Liang, D., Shu, R., Jiang, S., Xu, M.J., Cai, Y.Y., Qin, H.W., Zhang, D.B., Feng, M.W., Gao, J.S. #, and Meng, Y.# (2022) Exploring the mystery of the tetrahydrobiopterin synthetic defect lethal mutant lem^l from birth to death in the silkworm Bombyx mori. International Journal of Molecular Sciences, 23, 12083.

(29) Yang, L.L., Zhao, Y., Gan, Q., Liang, D., Shu, R., Jiang, S., Xie, R.P., and Meng, Y.# (2022) BmSuc1 affects silk properties by acting on sericin1 in Bombyx mori. International Journal of Molecular Sciences, 23, 9891 (doi: 10.3390/ijms23179891).

(28) Zhao, Y., Yang, L.L., Chen, Y., Zhang, X.W., Li, Jing., Liang, D., Jiang, S., Gao, J.S., and Meng, Y.# (2022) A comparative analysis of Bombyx mori (Lepidoptera: Bombycidae) β-fructofuranosidase homologs reveals different post-translational regulations in Glyphodes pyloalis walker (Lepidoptera: Pyralidae). Insects, 13, 410 (doi: 10.3390/insects13050410).

(27) Liang, D., Shu, R., Jiang, S., Yang, L.L., Wang, Y., Zhao, Y., Cai, Y.Y., Xie, R.P., and Meng, Y.# (2022) Identification and functional analysis of carbonyl reductases related to tetrahydrobiopterin synthesis in the silkworm, Bombyx mori. Insect Molecular Biology, DOI: 10.1111/imb.12768.

(26) Ye, C.J., Jiang, S., Gong, M.X., Min, Q., Fan, M.L., Gao, J.S., and Meng, Y.# (2020) Expressional localization and functionally identifying an RNA editing enzyme BmADARa of the silkworm Bombyx mori. Insects, 11, 523 (doi:10.3390/insects11080523).

(25) Gan, Q.*, Zhang, X.W.*, Zhang, D.B., Shi, L., Zhou, Y., Sun, T.T., Jiang, S., Gao, J.S., and Meng, Y.# (2018) BmSUC1 is essential for glycometabolism modulation in the silkworm, Bombyx mori. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms, 1861 (6), 543-553.

(24) Gan, Q., Li, X., Zhang, X.W., Wu,L.L., Ye, C.J., Wang, Y., Gao, J.S., and Meng, Y.# (2018) D181A site-mutagenesis enhances both the hydrolyzing and transfructosylating activities of BmSUC1, a novel β-fructofuranosidase in the silkworm Bombyx mori. International Journal of Molecular Sciences, 19 (3), 683 (doi: 10.3390/ijms19030683).

(23) Gao, J.S., Wu, F.F., Shen, Z.L., Meng, Y., Cai, Y.P., and Lin, Y. (2016) A putative molybdate transporter LjMOT1 is required for molybdenum transport in Lotus japonicus. Physiologia Plantarum, 158, 331–340.

(22) Li, W.T., Gong, M.X., Shu, R., Li, X., Gao, J.S., and Meng, Y.# (2015) Molecular and enzymatic characterization of two enzymes BmPCD and BmDHPR involving

in the regeneration pathway of tetrahydrobiopterin from the silkworm Bombyx mori. Comparative Biochemistry and Physiology-Part B, 186，20-27.

(21) Gao, J.S., Hu, L., Xie, P., Meng, Y., Cai, Y.P., and Lin, Y. (2014) Isolation and molecular characterization of an ethylene response factor NtERF1-1 in Nicotiana tabacum cv. Xanthi. Journal of Biosciences, 39, 887-897.

(20) Gao, J.S., Wang, J., Wang, W.J., Liu, C.L.#, and Meng, Y.# (2013) Isolation, purification and identification of an important pigment sepiapterin from integument of the lemon mutant of silkworm, Bombyx mori. Journal of Insect Science, 13, 118.

(19) Hirayama, C., Ono, H., Meng, Y., Shimada, T., and Daimon, T. (2013) Flavonoids from the cocoon of Rondotia menciana. Phytochemistry, 94, 108-112.

(18) Lin, Y.*, Meng, Y.*, Wang, Y.X.*, Luo, J., Katsuma, S., Yang, C.W., Banno, Y., Kusakabe, T., Shimada, T., and Xia, Q.Y. (2013) Vitellogenin receptor mutation leads to the oogenesis mutant phenotype ‘scanty vitellin’ of the silkworm, Bombyx mori. Journal of Biological Chemistry, 288，13345-13355. (*co-first author)

(17) Wang, W.J., Gao, J.S., Wang, J., Liu, C.L.#, and Meng, Y.# (2012) Cloning, expression and enzymatic properties analysis of dihydrofolate reductase gene from the silkworm, Bombyx mori. Molecular Biology Reports, 39, 10285–10291.

(16) Qian, C., Liu, C.L., Zhu, B.J., Meng Y., and Wei, G.Q. (2011) Identification and expression analysis of vitellogenin from silk-producing insect, Actias selene Hubner. African Journal of Biotechnology, 10, 999-1010.

(15) Gao, J.S., Meng, Y., Sasaki, N., Kanegae, H., Hayashi, N., and Nyunoya, H. (2010) Characterization and cloning of TMV resistance gene N homologues from Nicotiana tabacum. African Journal of Biotechnology, 9, 7998-8006.

(14) Daimon, T., Hirayama, C., Kanai, M., Ruike, Y., Meng, Y., Kosegawa, E., Nakamura, M., Tsujimoto, M., Katsuma, S., and Shimada, T. (2010) The silkworm Green b locus encodes a quercetin 5-O-glucosyltransferase that produces green cocoons with UV-shielding properties. Proceedings of the National Academy of Sciences USA, 107, 11471-11476.

(13) Meng, Y., Katsuma, S., Daimon, T., Banno, Y., Uchino, K., Sezutsu, H., Tamura, T., Mita, K., and Shimada, T. (2009) The silkworm mutant lemon (lemon lethal) is a potential insect model for human Sepiapterin reductase deficiency. Journal of Biological Chemistry, 284, 11698-11705.

(12) Meng, Y., Katsuma, S., Mita, K., and Shimada, T. (2009) Abnormal red body coloration of the silkworm, Bombyx mori, is caused by a mutation in a novel kynureninase. Genes to Cells, 14, 129-40.

(11) Kawaoka, S., Katsuma, S., Meng, Y., Hayashi, N., Mita, K., and Shimada, T. (2009) Identification and characterization of globin genes from two lepidopteran insects, Bombyx mori and Samia cynthia ricini. Gene, 431, 33-38.

(10) Daimon, T., Taguchi, T., Meng, Y., Katsuma, S., Mita, K., and Shimada, T. (2008) Beta-fructofuranosidase genes of the silkworm, Bombyx mori: Insight into enzymatic adaptation of B. mori to toxic alkaloids in mulberry latex. Journal of Biological Chemistry, 283, 15271-15279.

(9) Futahashi, R*., Sato, J*., Meng, Y*., Okamoto, S., Daimon, T., Yamamoto, K., Suetsugu, Y., Narukawa, J., Takahashi, H., Banno, Y., Katsuma, S., Shimada, T., Mita, K., and Fujiwara, H. (2008) yellow and ebony are the responsible genes for the larval color mutants of the silkworm Bombyx mori. Genetics, 180, 1995-2005. (*co-first author).

(8) Meng, Y., Omuro, N., Funaguma, S., Daimon, T., Kawaoka, S., Katsuma, S., and Shimada, T. (2008) Prominent down-regulation of storage protein genes after bacterial challenge in eri-silkworm, Samia cynthia ricini. Archives of Insect Biochemistry and Physiology, 67, 9-19.

(7) Meng, Y., Liu, C.L., Shiomi, K., Nakagaki, M., and Kajiura, Z. (2008) Purification and cDNA cloning of vitellogenin of the wild silkworm, Saturnia japonica (Lepidoptera: Saturniidae). Journal of Insect Biotechnology and Sericology, 77, 35-44.

(6) Miao, Y.G., Zhang, Y.S., Nakagaki, K., Zhao, T.F., Zhao, A.C., Meng, Y., Nakagaki, M., Park, E.Y, and Maenaka, K. (2006) Expression of spider flagelliform silk protein in Bombyx mori cell line by a novel Bac-to-Bac/BmNPV baculovirus expression system. Applied Microbiology and Biotechnology, 71, 192–199.

(5) Miao, Y.G., Zhao, A.C., Zhang, Y.S., Nakagaki, K., Meng, Y., Zhao, T.F., and Nakagaki, M. (2006) Silkworm, Bombyx mori larvae expressed the spider silk protein through a novel Bac-to-Bac/BmNPV baculovirus. Journal of Applied Entomology, 130, 297–301.

(4) Meng, Y., Liu, C.L., Shiomi, K., Nakagaki, M., Banno, Y., and Kajiura, Z. (2006) Genetic variations in the vitellogenin of Japanese populations of the wild silkworm, Bombyx mandarina. Journal of Insect Biotechnology and Sericology, 75, 127–134.

(3) Meng, Y., Liu, C.L., Zhao, A.C., Shiomi, K., Nakagaki, M., and Kajiura, Z. (2006) Vitellogenin gene organization of Antheraea yamamai and promoter analysis. International Journal of Wild Silkworm & Silk, 11, 29–40.

(2) 孟豔，徐厚鎔，趙正龍，魯成，向仲懷. 氮離子束注入家蠶卵的生化效應及其RAPD分析.蠶業科學，2001,27, 227–231.

(1) 孟豔，徐厚鎔，趙正龍，姚建銘. 氮離子束注入家蠶卵對血液SOD 活性的影響. 蠶業科學，2000,26, 271–273.

主講《養蠶學》、《繭絲學》、《細胞生物學》、《昆蟲生物化學》、《分子生物學》等研究生和本科生課程。

以鱗翅目模式昆蟲家蠶為研究對象，主要從事昆蟲生理生化學、分子生物學與遺傳學等方面的課題研究。在後基因組時代利用家蠶全基因組信息及豐富的突變體遺傳資源，定位克隆控制家蠶重要品質性狀基因、研究基因功能，開發家蠶蠶絲以外具有重要應用前景的研究領域具有學術專長並取得較好的研究進展。主要研究方向：

（1）定位克隆調控家蠶內源性體表色素形成的重要功能性基因，闡明其在昆蟲氨基酸等物質代謝中的作用機制，探索利用家蠶突變體作為藥用前體物質合成及人類疾病模型的應用價值；

（2）研究家蠶糖營養代謝過程中特異性蔗糖水解酶同源基因在不同鱗翅目昆蟲中的進化特徵、表達模式及其表達調控分子機制，從昆蟲中腸消化酶的角度揭示植食性昆蟲-寄主植物的互作規律與協同進化關係；

（3）以家蠶為模式，通過對主要卵黃蛋白受體基因的克隆與功能鑑定，研究鱗翅目昆蟲受精卵形成前及胚胎髮育過程中卵黃蛋白的內吞作用機理，為防治農林害蟲尋求新靶標、提供新策略。 ^[1] 

1. 苯丙酮尿症等疾病模型用家蠶種質資源的引進與創新利用，安徽省重點研究與開發計劃（2022h11020020，2022-2024），主持。

2. β-呋喃果糖苷酶調控家蠶前中部絲腺糖代謝的作用機理研究，國家自然科學基金（31872423，2019-2022），主持。

3. 家蠶BH4選擇性合成途徑的分子調控機制研究，國家自然科學基金（31572468，2016-2019），主持。

4. BH4/多巴胺缺陷型疾病模型的建模關鍵技術研發，安徽省國際科技合作項目（1503062033，2015-2017），主持。

5. 家蠶關鍵品質性狀分子解析及分子育種基礎研究，國家973計劃項目（2012CB114600，2012-2016），子課題負責人。

6. 家蠶β-FFase 同源基因的表達差異與昆蟲食性相關的功能研究，國家自然科學基金（31172270，2012-2015），主持。

7. 四氫生物蝶呤缺陷型家蠶突變體的研究，教育部留學回國人員科研啓動基金（2011-1586），主持。

8. 家蠶重要體表色素墨蝶呤的提取與應用研究，安徽省優秀青年科技基金項目（10040606Y16，2010-2011），主持。

9. 家蠶黃體色突變體作為人SPR缺陷型疾病模型的研究，安徽農業大學引進人才資助項目（yj2009-17），主持。

10. 利用家蠶體色突變系解明昆蟲體表色素形成機制，日本學術振興會特別研究員項目（19-07427），主持。

11. 家蠶抗病毒病基礎與品質培育新品系，國家863計劃項目（2011AA100306-3），第二參加人。

12. 天蠶卵黃原蛋白基因解析及生物反應器應用的研究，國家自然科學基金（30371088），第四參加人。