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周立新

（暨南大學博士生導師）

鎖定
理學博士，暨南大學生命科學技術學院教授，博士生導師。現主要從事金屬離子與生物大分子活性位點的相互作用機制和選擇性研究；金屬抗癌藥物與DNA靶分子的相互作用機理研究和藥物分子設計；生物大分子的結構與功能關係研究；光、電、磁有機功能材料的分子設計、結構與性能關係研究；理論化學和計算化學研究。 [1] 
中文名
周立新
國    籍
中國
民    族
漢族
畢業院校
四川大學
職    業
教師
性    別
男
職    稱
教授

目錄

  1. 1 人物經歷
  2. 2 主講課程
  3. 3 主要貢獻

周立新人物經歷

1996年6月四川大學化學系物理化學專業博士研究生畢業；
1996年至2003年9月在福州大學化學系工作；
2001年7月破格晉升教授；
2003年5月獲得博士導師資格；
2003年10月調入暨南大學化學系。
現為生命科學技術學院教授，博士生導師。 [2] 

周立新主講課程

講授本科生《 結構化學 》，碩士研究生《 羣論 》、《 量子化學 》、《計算化學》和《計算機輔助藥物分子設計》，博士研究生《藥物與靶分子的相互識別與作用機制》、《量子藥物化學》等課程。 [2] 

周立新主要貢獻

發表論文70多篇（被SCI CDE和SCI Search收錄50多篇）、獲省部級三等獎（第一完成人）1項、研究成果已引起國內外同行專家的重視，先後有法國、美國、以色列、墨西哥、波蘭、西班牙、保加利亞等國和國內同行專家來函索要研究論文，發表論文被國外同行引用數十次，先後主持省部級科研項目4項和作為第二申請人蔘加國家重點實驗室科研項目4項，作為主要成員參加國家自然科學基金研究多項。現主持國家自然科學基金項目1項（20971056），作為學術骨幹參加973項目1項。
主要論文：
1.Lixin Zhou. Theoretical Analysis on the Transition State of the Anticancer Drug trans-[PtCl2(isopropylamine)2] and Its cis Isomer Binding to DNA Purine Bases. J. Phys. Chem. B, 2009, 113, 2110-2127.
2. Yan Gao, Lixin Zhou*.DNA Bindings of a Novel Anticancer Drugtrans-[PtCl2(isopropylamine)(3-picoline)] and Kinetic Competition of Purine Bases with Protein Residues in the Bifunctional Substitutions, a Theoretical DFT Study. Theor. Chem. Acc., 2009, 123 ,455-468.
3. Qinghui Yuan , Lixin Zhou* , Yan Gao. The Hydrolysis Mechanism of the Anticancer Agent trans-Dichloro(ammine)(quinoline)platinum Complex: A Theoretical Study. J. Theor. Comput. Chem. 2008,7,381-395.
4. Zhijuan Xu, Lixin Zhou*.A DFT Study of A Novel Oxime Anticancer Trans Platinum Complex: Monofunctional and Bifunctional Binding to Purine Bases. Int. J. Quantum Chem., 2011, 111, 1907-1920.
5. Xiang Chen, Lixin Zhou*.Titanocene(IV) binds to the purine bases and phosphate backbone of DNA: A theoretical calculation study. J. Mol. Struct.(Theochem), 2010, 940,45-49.
6. Chunqiang Deng, Lixin Zhou*. Binding of ansa- and non-ansa-titanocene anticancer drugs to DNA: a DFT study. 2010, Struct. Chem., 21,735-744.
7. Yanfang Wu, Lixin Zhou *. Binding to DNA purine bases and amino acid residues of a ruthenium(II)antitumor complex: A density functional study. Inorg. Chim. Acta, 2010, 363,3274-3281.
8. Dongdong Zhang, Xiuli Ren, Lixin Zhou*.Theoretical analysis of trans-[PtCl2(NH3)(thiazole)] and trans-[PtCl2(thiazole)2] binding to biological targets — Factors influence binding kinetics and adduct stability. Can. J. Chem., 2010, 88, 1240-1246.
9. Bo Jiang, Lixin Zhou*.Theoretical Study of Anticancer Drug cis-dichloro (pyridin-2-ylcarboxaldimine) -palladium(II) Compounds Containing Bulky Fluorinated Aryl Groups Binding to Purine Bases: The Activity of Three Isomers. Comput. Theor. Chem., 2011, 965,28-40.
10. Chunqiang Deng, Lixin Zhou*.Theoretical Study on the interaction of titanocene dichloride with deoxyguanosine monophosphate. Inorg. Chim. Acta, 2011, 370,70-75.
11. Dongdong Zhang, Lixin Zhou*. Theoretical Insight into [Pd(en)(H2O)2]2+ Binding to Guanine Form [{Pd(en)(guanine)}4]4+: Kinetic Control and Thermodynamic Control. Comput. Theor. Chem., 2011, 967,102-112.
12. Lixin Zhou*. Computational study on the mechanisms of action of the potential anticancer drug trans-isopropylaminedimethylaminedichloroplatinum (trans-IPADMADP) and its cis isomer with DNA purine bases. Inorg. Chim. Acta, 2011, 376: 44～56.
13. Bo Jiang, Lixin Zhou*. Theoretical study of anticancer drug trans-[Pd(dmnp)2Cl2] binding to DNA purine bases, phosphate group and amino acid residues. Struct. Chem., 2011, 22,1353-1364.
15. Hongli Zhao, Lixin Zhou*. A theoretical study on transition state of the antitumor drug: gold (III) dithiocarbamate derivative interaction with cysteine and DNA purine bases.Comput. Theor. Chem., 2012, 979,22-32.
16.Juan Li,* Qi Zhang, Lixin Zhou. Theoretical Studies on N−O or N−N Bond Formation from ArylAzide Catalyzed by Iron(II) Bromide Complex. J. Org. Chem. 2012, 77,2566-2570.
17. Qiulan Fu, Lixin Zhou*,Juan Li.Binding of anticancer drug Ru(η6-C6H5(CH2)2OH)Cl2(DAPTA) to DNA purine bases and amino acid residues: a theoretical study. Struct. Chem.,2012， DOI 10.1007/s11224-012-0003-5
18. Yaying Zhao, Lixin Zhou*. Computational study of Hydrogen-Bonded Complexes between the Most Stable Tautomers of L-Leucine and bases of RNA. Theor. Chem. Acc., 2005, 113,249-256.
19. Yaying Zhao, Lixin Zhou*.Computational study of hydrogen-bonded complexes of the pyrimidinic bases of RNA and L-leucine. J. Mol. Struct.(Theochem), 2005, 726,31-37.
20. Lixin Zhou*. Ab initio and density functional predictions of the structure, gas-phase acidity and aromaticity of 1,2-dithio-3,4-diselenosquaric acid. Chem. Phys. Lett., 2000,317, 330-337.
21. Lixin Zhou*, Chaoyong Mang, Yongfan Zhang, Shengchang Xiang, Zunxing Huang.Theoretical predictions of the structure, gas-phase acidity and aromaticity of tetrathiosquaric acid.Int. J. Quantum Chem., 2000, 78,443-449.
22. Lixin Zhou*. Theoretical predictions on the structure, gas-phase acidity and aromaticity of 1,2-diseleno-3,4-dithiosquaric acid. Theor. Chem. Acc., 2000, 105,86-92.
23. Lixin Zhou*, Yongfan Zhang, Liming Wu, Junqian Li. The gas-phase acidity and aromaticity of squaric acid:An ab initio and density functional study. J. Mol. Struct.(Theochem),2000,497,137-144 [2] 
參考資料