劉俊嶺

教育經歷：

1993年6月畢業於新疆醫學院藥學本科專業；

1995-1998年在新疆醫學院天然藥物化學教研室攻讀碩士學位，師從堵年生教授，課題內容為中草藥化學成分提取、分離以及結構鑑定，獲得天然藥物化學碩士學位；

1998-2001年在北京大學醫學部藥學院藥物化學系攻讀博士學位，師從彭師奇教授，課題內容為具有生物活性小分子化合物合成及其活性評價。

工作經歷：

2001-2006年在美國孟菲斯大學微生物及細胞分子生物學系進行博士後研究，主要從事血小板粘附受體及其介導信號在血栓性疾病中的作用研究；

2006-2008在美國伊利諾伊大學芝加哥分校醫學院藥理系任研究助理教授，從事血栓止血分子機制的研究。2008回國在上海交通大學醫學院任研究員，獲上海市浦江人才計劃支持。 ^[1] 

2008年9月回國在上海交通大學醫學院擔任課題組長 ^[3] 

2012年-2020年擔任上海交通大學基礎醫學院副院長 ^[3] 

政協上海市第十四屆委員會委員。 ^[2] 

長期從事血小板在心腦血管疾病、免疫相關疾病、腫瘤以及罕見病發生髮展中的作用機制研究，主要關注受體介導胞內信號途徑和線粒體代謝調控通路在血小板相關疾病發生髮展過程中的關鍵作用機制和干預靶點，研發相關新治療手段。 ^[3] 

先後主持國家自然科學基金重點項目、重大研究計劃集成和培育項目，科技部重大研究計劃和973計劃子課題等國家重大重點項目8項，總經費超過2500萬元。此外，還獲得教育部“新世紀優秀人才”和上海市“浦江人才“等人才項目支持。在Circulation、Blood、Cell Metabolism、Hepatology、JCI、Nat. Commun.等國際期刊發表研究論文多篇。獲得國家科學技術進步獎二等獎和教育部科學技術進步獎一等獎各1項。申請專利5項，獲得轉化資金超1.7億元。 ^[3] 

1.科技部國家重點研發計劃項目，2021YFA0804900，心腦跨器官代謝調控，2021-12至2026-11，192.82萬元

2.國家自然科學基金委員會，重點項目，82030004 , 糖代謝調控血小板生成和凋亡的作用機制研究, 2021-01-01至2025-12-31 , 297萬元

3.國家自然科學基金委員會，重點項目，31830050，代謝調控血小板衰老死亡的分子機制，2019-01至2023-12，288萬元

4.國家自然科學基金委員會，重大研究計劃集成項目，91739302，危重血管性疾病血栓事件的發生、發展及干預研究，2018-01至2020-12，210萬元

5.國家自然科學基金委員會，國家傑出青年科學基金，81525001，血小板活化的分子調控機制，2016-01至2020-12，400萬元

6.國家自然科學基金委員會，重大研究計劃培育項目，91439115，血小板內皮聚集受體1調控血管穩態作用機制研究，2015-01~2017-12，150萬元

7.國家自然科學基金委員會，面上項目，81170479，整合素αIIb亞基介導信號在血小板活化和血栓形成中的作用，2012-01至2015-12，60萬元

8.科技部973重大科學研究計劃，2012CB518000，重大心血管疾病相關GPCR新藥物靶點的基礎研究，2012-01至2016-12，290萬元

9.國家自然科學基金委員會，重點項目，81030039，血小板介導預轉移微環境的形成及其在肺癌轉移中的作用，2011-01至2014-12，200萬元 ^[3] 

2016年獲得教育部科技進步一等獎（排名第2） ^[3] 

2018年獲得國家科技進步二等獎（排名第2）

1. Cao Y, Sun Y, Deng Y, Wei G, Liu J, Jin S, Dong C, Kang X, Huo Y, Zhang J, Luo J. Defective VWF secretion due to the expression of MYH9-RD E1841K mutant in endothelial cells disrupts hemostasis. Blood Adv. 2022 Jun 28:bloodadvances.2022008011. doi: 10.1182/bloodadvances.2022008011.

2. Zhang X, Chen F, Chen X, Cheng Y, Fang M, Feng J, Fu H, Gao H, Han Y, He A, Hou M, Hu Y, Huang R, Huang W, Jing Z, Kong P, Liang A, Liang M, Liu D, Liu J, Liu L, Liu X, Ma L, Mei H, Ni H, Niu T, Peng J, Qiao J, Ren J, Song Y, Tang LV, Tong T, Wang S, Wang X, Wang Z, Wei H, Wu D, Wu G, Xu C, Xu X, Xu Y, Yang L, Yang R, Yang T, Yin C, Yu L, Zhang G, Zhang L, Zhang L, Zhang X, Zhao W, Zhao Y, Zhou D, Zhou H, Zhou Z, Zhu T, Wang J, Huang X. 2021 Chinese consensus on the diagnosis and management of primary immune thrombocytopenia in pregnancy. Chin Med J (Engl). 2022 Apr 20;135(8):887-889. doi: 10.1097/CM9.0000000000002043.

3. Fan X, Wang Y, Cai X, Shen Y, Xu T, Xu Y, Cheng J, Wang X, Zhang L, Dai J, Lin S, Liu J*. CPT2 K79 Acetylation Regulates Platelet Lifespan. Blood Adv. 2022 Jun 21:bloodadvances.2021006687. doi: 10.1182/bloodadvances.2021006687.

4. Xiang H, Tao Y, Jiang Z, Huang X, Wang H, Cao W, Li J, Ding R, Shen M, Feng R, Li L, Guan C, Liu J, Ni J, Chen L, Wang Z, Ye Y, Zhong Q, Liu J*, Zou Q*, Wu X*. Vps33B controls Treg cell suppressive function through inhibiting lysosomal nutrient sensing complex-mediated mTORC1 activation. Cell Rep. 2022 Jun 14;39(11):110943. doi: 10.1016/j.celrep.2022.110943.

5. Chen X, Xu Y, Chen Q, Zhang H, Zeng Y, Geng Y, Shen L, Li F, Chen L, Chen GQ, Huang C, Liu J*. The phosphatase PTEN links platelets with immune regulatory functions of mouse T follicular helper cells. Nat Commun. 2022 May 19;13(1):2762. doi: 10.1038/s41467-022-30444-y.

6. Ding N, Wang K, Jiang H, Yang M, Zhang L, Fan X, Zou Q, Yu J, Dong H, Cheng S, Xu Y, Liu J*. AGK regulates the progression to NASH by affecting mitochondria complex I function. Theranostics. 2022 Apr 4;12(7):3237-3250. doi: 10.7150/thno.69826. eCollection 2022.

7. Hu L, Jiang GY, Wang YP, Hu ZB, Zhou BY, Zhang L, Song NN, Huang Y, Chai GD, Chen JY, Lang B, Xu L, Liu JL, Li Y, Wang QX, Ding YQ. The role of PTEN in primary sensory neurons in processing itch and thermal information in mice. Cell Rep. 2022 Apr 19;39(3):110724. doi: 10.1016/j.celrep.2022.110724.

8. Chen Q, Xin M, Wang L, Li L, Shen Y, Geng Y, Jiang H, Wang Y, Zhang L, Xu Y, Hou Y, Liu J*, Fan X*. Inhibition of LDHA to induce eEF2 release enhances thrombocytopoiesis. Blood. 2022 May 12;139(19):2958-2971. doi: 10.1182/blood.2022015620.

9. Yu Z, Yang W, He X, Chen C, Li W, Zhao L, Liu L, Liu J, Xie L, Zhang Y, Zheng J. Endothelial cell-derived angiopoietin-like protein 2 supports hematopoietic stem cell activities in bone marrow niches. Blood. 2022 Mar 10;139(10):1529-1540. doi: 10.1182/blood.2021011644.

10. Yan P, Li Z, Xiong J, Geng Z, Wei W, Zhang Y, Wu G, Zhuang T, Tian X, Liu Z, Liu J, Sun K, Chen F, Zhang Y, Zeng C, Huang Y, Zhang B. LARP7 ameliorates cellular senescence and aging by allosterically enhancing SIRT1 deacetylase activity. Cell Rep. 2021 Nov 23;37(8):110038.

11. Ma J, Han M, Yang D, Zheng T, Hu R, Wang B, Ye Y, Liu J, Huang G. Vps33B in Dendritic Cells Regulates House Dust Mite-Induced Allergic Lung Inflammation. J Immunol. 2021 Dec 1;207(11):2649-2659.

12. Zhang Y, Long X, Ruan X, Wei Q, Zhang L, Wo L, Huang D, Lin L, Wang D, Xia L, Zhao Q, Liu J, Zhao Q, He M. SIRT2-mediated deacetylation and deubiquitination of C/EBPβ prevents ethanol-induced liver injury. Cell Discov. 2021 Oct 12;7(1):93.

13. Zhao J, Xu Y, Xie J, Liu J, Zhang R, Yan X. Roxadustat Does Not Affect Platelet Production, Activation, and Thrombosis Formation. Arterioscler Thromb Vasc Biol. 2021 Oct;41(10):2523-2537.

14. Fu KL, Chen P, Zhou YY, Jiang YM, Gao Y, Zhang HZ, Guan LH, Wang CH, Liu JL, Huang M, Bi HC. Hepatic Vps33b deficiency aggravates cholic acid-induced cholestatic liver injury in male mice. Acta Pharmacol Sin. 2021 Jul 12. doi: 10.1038/s41401-021-00723-3.

15. Guan C, Huang X, Yue J, Xiang H, Shaheen S, Jiang Z, Tao Y, Tu J, Liu Z, Yao Y, Yang W, Hou Z, Liu J, Yang XD, Zou Q, Su B, Liu Z, Ni J, Cheng J, Wu X. SIRT3-mediated deacetylation of NLRC4 promotes inflammasome activation. Theranostics. 2021 Feb 15;11(8):3981-3995.

16. Yu H, Zhang F, Yan P, Zhang S, Lou Y, Geng Z, Li Z, Zhang Y, Xu Y, Lu Y, Chen C, Wang D, Zhu W, Hu X, Wang J, Zhuang T, Zhang Y, Wu G, Liu J, Zeng C, Pu WT, Sun K, Zhang B. LARP7 Protects Against Heart Failure by Enhancing Mitochondrial Biogenesis. Circulation. 2021 May 18;143(20):2007-2022.

17. Zhang J, Zhang Y, Zheng S, Liu Y, Chang L, Pan G, Hu L, Zhang S, Liu J, Kim S, Dong J, Ding Z. PAK Membrane Translocation and Phosphorylation Regulate Platelet Aggregation Downstream of Gi and G12/13 Pathways. Thromb Haemost. 2020 Nov;120(11):1536-1547.

18. Jiang H, Yu Z, Ding N, Yang M, Zhang L, Fan X, Zhou Y, Zou Q, Hou J, Zheng J, Zhang L, Xu Y*, Liu J*. The role of AGK in thrombocytopoiesis and possible therapeutic strategies. Blood. 2020 Jul 2;136(1):119-129.

19. Xu Y, Jiang H, Li L, Chen F, Liu Y, Zhou M, Wang J, Jiang J, Li X, Fan X, Zhang L, Zhang J, Qiu J, Wu Y, Fang C, Sun H*, Liu J*. Branched-Chain Amino Acid Catabolism Promotes Thrombosis Risk by Enhancing Tropomodulin-3 Propionylation in Platelets. Circulation. 2020 Jul 7;142(1):49-64.

20. Yan Y, Yang H, Hu X, Zhang Z, Ge S, Xu Z, Gao J, Liu J, White GC, Ma YQ. Kindlin-3 in platelets and myeloid cells differentially regulates deep vein thrombosis in mice. Aging (Albany NY). 2019 Aug 31;11(17):6951-6959.

21. Zhu L, Xia C, Wu L, Zhang Y, Liu J, Chen Y, Liu J, Xiao Y, Nie K, Huang L, Qu N, Yu H. The critical role of RasGRP4 in the growth of diffuse large B cell lymphoma. Cell Commun Signal. 2019 Aug 13;17(1):92.

22. Zhang W, Ma Q, Siraj S, Ney PA, Liu J, Liao X, Yuan Y, Li W, Liu L, Chen Q. Nix-mediated mitophagy regulates platelet activation and life span. Blood Adv. 2019 Aug 13;3(15):2342-2354.

23. Hu Z, Qu G, Yu X, Jiang H, Teng XL, Ding L, Hu Q, Guo X, Zhou Y, Wang F, Li HB, Chen L, Jiang J, Su B*, Liu J*, Zou Q*. Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells. Cell Metab. 2019 Aug 6;30(2):290-302.e5.

24. Zhang K, Yang W, Zhang M, Sun Y, Zhang T, Liu J, Zhang J. Pretreatment with antiplatelet drugs improves the cardiac function after myocardial infarction without reperfusion in a mouse model. Cardiol J. 2021;28(1):118-128.

25. Fu K, Wang C, Gao Y, Fan S, Zhang H, Sun J, Jiang Y, Liu C, Guan L, Liu J, Huang M, Bi H. Metabolomics and Lipidomics Reveal the Effect of Hepatic Vps33b Deficiency on Bile Acids and Lipids Metabolism. Front Pharmacol. 2019 Mar 22;10:276.

26. Ma Q, Zhang W, Zhu C, Liu J, Chen Q. FUNDC2 regulates platelet activation through AKT/GSK-3β/cGMP axis. Cardiovasc Res. 2019 Sep 1;115(11):1672-1679.

27. Xu Y, Ouyang X, Yan L, Zhang M, Hu Z, Gu J, Fan X, Zhang L, Zhang J, Xue S, Chen G, Su B, Liu J*. Sin1 (Stress-Activated Protein Kinase-Interacting Protein) Regulates Ischemia-Induced Microthrombosis Through Integrin αIIbβ3-Mediated Outside-In Signaling and Hypoxia Responses in Platelets. Arterioscler Thromb Vasc Biol. 2018 Dec;38(12):2793-2805.

28. Qi Y, Chen W, Liang X, Xu K, Gu X, Wu F, Fan X, Ren S, Liu J, Zhang J, Li R, Liu J, Liang X. Novel antibodies against GPIbα inhibit pulmonary metastasis by affecting vWF-GPIbα interaction. J Hematol Oncol. 2018 Sep 17;11(1):117.

29. Fan X, Wang C, Shi P, Gao W, Gu J, Geng Y, Yang W, Wu N, Wang Y, Xu Y, Chen X, Zhang L, Wang K, Su B, Liu J*. Platelet MEKK3 regulates arterial thrombosis and myocardial infarct expansion in mice. Blood Adv. 2018 Jun 26;2(12):1439-1448.

30. Shen SM, Ji Y, Zhang C, Dong SS, Yang S, Xiong Z, Ge MK, Yu Y, Xia L, Guo M, Cheng JK, Liu JL, Yu JX, Chen GQ. Nuclear PTEN safeguards pre-mRNA splicing to link Golgi apparatus for its tumor suppressive role. Nat Commun. 2018 Jun 19;9(1):2392.

31. Ma Q, Zhu C, Zhang W, Ta N, Zhang R, Liu L, Feng D, Cheng H, Liu J, Chen Q. Mitochondrial PIP3-binding protein FUNDC2 supports platelet survival via AKT signaling pathway. Cell Death Differ. 2019 Jan;26(2):321-331.

32. Wang C, Cheng Y, Zhang X, Li N, Zhang L, Wang S, Tong X, Xu Y, Chen GQ, Cheng S, Fan X*, Liu J*. Vacuolar Protein Sorting 33B Is a Tumor Suppressor in Hepatocarcinogenesis. Hepatology. 2018 Dec;68(6):2239-2253.

33. Dang S, Bu D, Lu T, Wang Z, Liu J, Zhang W. Adamts18 deficiency increases arterial thrombus formation associated with vascular defects in mice. Biochem Biophys Res Commun. 2018 Feb 19;496(4):1362-1368.

34. Gao W, Wang K, Zhang L, Li J, Liu J, Chen X, Luo X. Pharmacological inhibition of S6K1 facilitates platelet activation by enhancing Akt phosphorylation. Platelets. 2019;30(2):241-250.

35. Shi P, Zhang L, Zhang M, Yang W, Wang K, Zhang J, Otsu K, Huang G, Fan X, Liu J*. Platelet-Specific p38α Deficiency Improved Cardiac Function After Myocardial Infarction in Mice. Arterioscler Thromb Vasc Biol. 2017 Dec;37(12):e185-e196.

36. Gao W, Shi P, Chen X, Zhang L, Liu J, Fan X, Luo X. Clathrin-mediated integrin αIIbβ3 trafficking controls platelet spreading. Platelets. 2018 Sep;29(6):610-621.

37. Wang Y, Jiang L, Mo X, Lan Y, Yang X, Liu X, Zhang J, Zhu L, Liu J, Wu X. Megakaryocytic Smad4 Regulates Platelet Function through Syk and ROCK2 Expression. Mol Pharmacol. 2017 Sep;92(3):285-296.

38. Zhou J, Wu Y, Chen F, Wang L, Rauova L, Hayes VM, Poncz M, Li H, Liu T, Liu J, Essex DW. The disulfide isomerase ERp72 supports arterial thrombosis in mice. Blood. 2017 Aug 10;130(6):817-828.

39. Lai W, Cai Y, Zhou J, Chen S, Qin C, Yang C, Liu J, Xie X, Du C. Deficiency of the G protein Gαq ameliorates experimental autoimmune encephalomyelitis with impaired DC-derived IL-6 production and Th17 differentiation. Cell Mol Immunol. 2017 Jun;14(6):557-567.

40. Zhang W, Ren H, Xu C, Zhu C, Wu H, Liu D, Wang J, Liu L, Li W, Ma Q, Du L, Zheng M, Zhang C, Liu J, Chen Q. Hypoxic mitophagy regulates mitochondrial quality and platelet activation and determines severity of I/R heart injury. Elife. 2016 Dec 20;5:e21407.

41. Zhang J, Li Z, Hu X, Su Q, He C, Liu J, Ren H, Qian M, Liu J, Cui S, Jiang W. Knockout of P2Y12 aggravates experimental autoimmune encephalomyelitis in mice via increasing of IL-23 production and Th17 cell differentiation by dendritic cells. Brain Behav Immun. 2017 May;62:245-255.

42. Chen X, Fan X, Tan J, Shi P, Wang X, Wang J, Kuang Y, Fei J, Liu J, Dang S, Wang Z. Palladin is involved in platelet activation and arterial thrombosis. Thromb Res. 2017 Jan;149:1-8.

43. Chen Y, Yang W, Guo L, Wu X, Zhang T, Liu J, Zhang J. Atractylodes lactone compounds inhibit platelet activation. Platelets. 2017 Mar;28(2):194-202.

44. Zhang WM, Liu Y, Li TT, Piao CM, Liu O, Liu JL, Qi YF, Jia LX, Du J. Sustained activation of ADP/P2ry12 signaling induces SMC senescence contributing to thoracic aortic aneurysm/dissection. J Mol Cell Cardiol. 2016 Oct;99:76-86.

45. Dai J, Lu Y, Wang C, Chen X, Fan X, Gu H, Wu X, Wang K, Gartner TK, Zheng J, Chen G, Wang X*, Liu J*. Vps33b regulates Vwf-positive vesicular trafficking in megakaryocytes. J Pathol. 2016 Sep;240(1):108-19.

46. Cheng Z, Liu J*. Receptor-mediated inhibitory mechanisms and the regulation of platelet function. Sci China Life Sci. 2015 Dec;58(12):1299-301.

47. Zhi H, Dai J, Liu J, Zhu J, Newman DK, Gao C, Newman PJ. Platelet Activation and Thrombus Formation over IgG Immune Complexes Requires Integrin αIIbβ3 and Lyn Kinase. PLoS One. 2015 Aug 20;10(8):e0135738.

48. Liang Y, Fu Y, Qi R, Wang M, Yang N, He L, Yu F, Zhang J, Yun CH, Wang X, Liu J, Kong W. Cartilage oligomeric matrix protein is a natural inhibitor of thrombin. Blood. 2015 Aug 13;126(7):905-14.

49. Di C, Lin X, Zhang Y, Zhong W, Yuan Y, Zhou T, Liu J, Xia Z. Basophil-associated OX40 ligand participates in the initiation of Th2 responses during airway inflammation. J Biol Chem. 2015 May 15;290(20):12523-36.

50. Yao T, Ying X, Zhao Y, Yuan A, He Q, Tong H, Ding S, Liu J, Peng X, Gao E, Pu J, He B. Vitamin D receptor activation protects against myocardial reperfusion injury through inhibition of apoptosis and modulation of autophagy. Antioxid Redox Signal. 2015 Mar 10;22(8):633-50.

51. Delaney MK, Liu J, Kim K, Shen B, Stojanovic-Terpo A, Zheng Y, Cho J, Du X. Agonist-induced platelet procoagulant activity requires shear and a Rac1-dependent signaling mechanism. Blood. 2014 Sep 18;124(12):1957-67.

52. Fan X, Shi P, Dai J, Lu Y, Chen X, Liu X, Zhang K, Wu X, Sun Y, Wang K, Zhu L, Zhang CC, Zhang J, Chen GQ, Zheng J, Liu J*. Paired immunoglobulin-like receptor B regulates platelet activation. Blood. 2014 Oct 9;124(15):2421-30.

53. Xu Z, Chen X, Zhi H, Gao J, Bialkowska K, Byzova TV, Pluskota E, White GC 2nd, Liu J, Plow EF, Ma YQ. Direct interaction of kindlin-3 with integrin αIIbβ3 in platelets is required for supporting arterial thrombosis in mice. Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):1961-7.

54. Wang Y, Sun Y, Li D, Zhang L, Wang K, Zuo Y, Gartner TK, Liu J*. Platelet P2Y12 is involved in murine pulmonary metastasis. PLoS One. 2013 Nov 13;8(11):e80780.

55. Chen X, Zhang Y, Wang Y, Li D, Zhang L, Wang K, Luo X, Yang Z, Wu Y, Liu J*. PDK1 regulates platelet activation and arterial thrombosis. Blood. 2013 May 2;121(18):3718-26.

56. Niu H, Chen X, Gruppo RA, Li D, Wang Y, Zhang L, Wang K, Chai W, Sun Y, Ding Z, Gartner TK, Liu J*. Integrin αIIb-mediated PI3K/Akt activation in platelets. PLoS One. 2012;7(10):e47356.

57. Li D, Wang Y, Zhang L, Luo X, Li J, Chen X, Niu H, Wang K, Sun Y, Wang X, Yan Y, Chai W, Gartner TK, Liu J*. Roles of purinergic receptor P2Y, G protein- coupled 12 in the development of atherosclerosis in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):e81-9.

58. Niu H, Xu Z, Li D, Zhang L, Wang K, Taylor DB, Liu J*, Gartner TK*. Peptide LSARLAF induces integrin β3 dependent outside-in signaling in platelets. Thromb Res. 2012 Aug;130(2):203-9.

59. Zhang S, Hu L, Du H, Guo Y, Zhang Y, Niu H, Jin J, Zhang J, Liu J, Zhang X, Kunapuli SP, Ding Z. BF0801, a novel adenine derivative, inhibits platelet activation via phosphodiesterase inhibition and P2Y12 antagonism. Thromb Haemost. 2010 Oct;104(4):845-57.

60. Weng Z, Li D, Zhang L, Chen J, Ruan C, Chen G, Gartner TK, Liu J*. PTEN regulates collagen-induced platelet activation. Blood. 2010 Oct 7;116(14):2579-81.

61. Xiang B, Zhang G, Liu J, Morris AJ, Smyth SS, Gartner TK, Li Z. A G(i) -independent mechanism mediating Akt phosphorylation in platelets. J Thromb Haemost. 2010 Sep;8(9):2032-41.

62. Li Z, Zhang G, Liu J, Stojanovic A, Ruan C, Lowell CA, Du X. An important role of the SRC family kinase Lyn in stimulating platelet granule secretion. J Biol Chem. 2010 Apr 23;285(17):12559-70.

63. Guerrero JA, Kyei M, Russell S, Liu J, Gartner TK, Storrie B, Ware J. Visualizing the von Willebrand factor/glycoprotein Ib-IX axis with a platelet-type von Willebrand disease mutation. Blood. 2009 Dec 24;114(27):5541-6.

64. Flevaris P, Li Z, Zhang G, Zheng Y, Liu J, Du X. Two distinct roles of mitogen-activated protein kinases in platelets and a novel Rac1-MAPK-dependent integrin outside-in retractile signaling pathway. Blood. 2009 Jan 22;113(4):893-901.

65. Yin H, Liu J, Li Z, Berndt MC, Lowell CA, Du X. Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway. Blood. 2008 Aug 15;112(4):1139-46.

66. Liu J, Joglekar M, Ware J, Fitzgerald ME, Lowell CA, Berndt MC, Gartner TK. Evaluation of the physiological significance of botrocetin/ von Willebrand factor in vitro signaling. J Thromb Haemost. 2008 Nov;6(11):1915-22.

67. Liu J, Jackson CW, Gartner TK. The Src requirement for washed platelet aggregation and dense granule secretion in response to stimulation by a low level gamma-thrombin. J Thromb Haemost. 2008 Jun;6(6):1035-7.

68. Guerrero JA, Shafirstein G, Russell S, Varughese KI, Kanaji T, Liu J, Gartner TK, Bäumler W, Jarvis GE, Ware J. In vivo relevance for platelet glycoprotein Ibalpha residue Tyr276 in thrombus formation. J Thromb Haemost. 2008 Apr;6(4):684-91

69. Jain S, Zuka M, Liu J, Russell S, Dent J, Guerrero JA, Forsyth J, Maruszak B, Gartner TK, Felding-Habermann B, Ware J. Platelet glycoprotein Ib alpha supports experimental lung metastasis. Proc Natl Acad Sci U S A. 2007 May 22;104(21):9024-8.

70. Liu J, Ware J, Jackson CW, Gartner TK. FcRgamma-chain-dependent alphaIIbeta3 elicited outside-in signaling. J Thromb Haemost. 2007 Feb;5(2):426-8.

71. Liu J, Ware J, Jackson CW, Gartner TK. FcRgamma-chain signals in the absence of glycoprotein VI. J Thromb Haemost. 2007 Jan;5(1):201-3.

72. Liu J, Fitzgerald ME, Berndt MC, Jackson CW, Gartner TK. Bruton tyrosine kinase is essential for botrocetin/VWF-induced signaling and GPIb-dependent thrombus formation in vivo. Blood. 2006 Oct 15;108(8):2596-603.

73. Liu J, Pestina TI, Berndt MC, Jackson CW, Gartner TK. Botrocetin/VWF-induced signaling through GPIb-IX-V produces TxA2 in an alphaIIbbeta3- and aggregation-independent manner. Blood. 2005 Oct 15;106(8):2750-6.

74. Liu J, Jackson CW, Gruppo RA, Jennings LK, Gartner TK. The beta3 subunit of the integrin alphaIIbbeta3 regulates alphaIIb-mediated outside-in signaling. Blood. 2005 Jun 1;105(11):4345-52.

75. Liu J, Pestina TI, Berndt MC, Steward SA, Jackson CW, Gartner TK. The roles of ADP and TXA in botrocetin/VWF-induced aggregation of washed platelets. J Thromb Haemost. 2004 Dec;2(12):2213-22.

76. Cho MJ, Liu J, Pestina TI, Steward SA, Jackson CW, Gartner TK. LSARLAF utilizes ADP and thromboxane A2 receptors to cause alpha-granule secretion by platelets. J Thromb Haemost. 2003 Feb;1(2):363-73.

77. Cho MJ, Liu J, Pestina TI, Steward SA, Thomas DW, Coffman TM, Wang D, Jackson CW, Gartner TK. The roles of alpha IIb beta 3-mediated outside-in signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregation. Blood. 2003 Apr 1;101(7):2646-51.

78. Liu J, Zhao M, Wang C, Peng S. Synthesis and bioactivities of nitronyl nitroxide and RGD containing pseudopeptides. Bioorg Med Chem Lett. 2003 Nov 17;13(22):4065-9. ^[3]