凌俊傑

合成生物學 ^[1] 

1.生命起源過程中，核酶（ribozyme）起着十分重要的作用，本實驗室計劃利用體外進化和體內篩選技術獲得新的核酶，藉以探索生命由RNA world向protein world演化過程中核酶所扮演的角色，同時計劃將新型核酶應用到作物基因編輯中，為農作物的分子改造提供幫助。

2. 植物的信號轉導系統異常複雜且精密，本實驗室計劃改造植物的主要信號轉導系統，一方面構建合成生物學相關的篩選平台，另一方面，為實現植物DNA的信息存儲和邏輯門（logic gate）改造奠定基礎。 ^[1] 

1. Jun-Jie Ling#, Chuyao Fan#, Hong Qin, Min Wang, Ji Chen, Pernilla Wittung-Stafshede, Ting F. Zhu (2020). Mirror-Image 5S Ribonucleoprotein Complexes. Angewandte Chemie International Edition 59(9): 3724-3731. （IF：15.34）

2. Li J, Terzaghi W, Gong Y, Li C, Jun-Jie Ling,, Fan Y, Qin N, Gong X, Zhu D, Deng XW (2020). Modulation of BIN2 kinase activity by HY5 controls hypocotyl elongation in the light. Nature Communication 11(1):1592

3. Wang, M., W. J. Jiang, X. Y. Liu, J. X. Wang, B. C. Zhang, C. Y. Fan, L. Liu, G. Pena-Alcantara, Jun-Jie Ling, J. Chen and T. F. Zhu (2019). "Mirror-Image Gene Transcription and Reverse Transcription." Chem 5(4): 848-857.

4. Jun-Jie Ling#, J. Li#, D. M. Zhu and X. W. Deng (2017). "Noncanonical role of Arabidopsis COP1/SPA complex in repressing BIN2-mediated PIF3 phosphorylation and degradation in darkness." Proceedings of the National Academy of Sciences of the United States of America 114(13): 3539-3544.

5. Xu, D. Q., F. Lin, Y. Jiang, Jun-Jie Ling, C. Hettiarachchi, C. Tellgren-Roth, M. Holm, N. Wei and X. W. Deng (2015). "Arabidopsis COP1 SUPPRESSOR 2 Represses COP1 E3 Ubiquitin Ligase Activity through Their Coiled-Coil Domains Association." Plos Genetics 11(12)

6. Xu, D. Q., F. Lin, Y. Jiang, X. Huang, J. G. Li, Jun-Jie Ling, C. Hettiarachchi, C. Tellgren-Roth, M. Holm and X. W. Deng (2014). "The RING-Finger E3 Ubiquitin Ligase COP1 SUPPRESSOR1 Negatively Regulates COP1 Abundance in Maintaining COP1 Homeostasis in Dark-Grown Arabidopsis Seedlings." The Plant Cell 26(5): 1981-1991. ^[1]