何祥久

2002年7月獲瀋陽藥科大學天然藥物化學專業博士學位。2003年2月至2005年2月, 暨南大學中藥及天然藥物研究所副教授、學術秘書。2005年3月至2007年2月，在康乃爾大學 (Cornell University) 進行天然抗癌和抗氧化活性成分研究。2007年3月至2008年2月，在普渡大學 (Purdue University) 進行從天然抗癌活性成分研究。2008年3月作為教授引進到武漢大學藥學院工作。

主要從事天然活性成分及其生物轉化研究

1. 天然活性化合物研究：從植物、海洋生物以及微生物中尋找活性天然產物，鑑定它們的化學結構，尋找活性先導化合物，闡明它們的作用機制。

2. 活性天然產物的生物轉化研究：利用微生物、植物細胞培養體系以及動物體內代謝等手段，研究天然活性化合物的生物轉化，尋找更多的活性先導化合物。

3. 中藥 (包括中藥複方) 物質作用基礎及中藥現代化研究。 ^[1] 

曾先後主持過國家自然科學基金、國家博士後基金及多項橫向開發等科研項目。

在國內外知名雜誌上發表論文30餘篇，其中SCI收載論文21篇。

1 Xiangjiu He, Rui Hai Liu. A novel sodium borohydride/chloranil based (SBC) assay for quantifying total flavonoids. Journal of Agricultural and Food Chemistry, 2008, 56: 9337-9344.

2 Xiangjiu He, Rui Hai Liu. Phytochemicals of Apple Peels: Isolation, Structure Elucidation, and Their Antiproliferative and Antioxidant Activities. Journal of Agricultural and Food Chemistry, 2008, 56: 9905-9910.

3 Xiangjiu He, Rui Hai Liu. Triterpenoids isolated from apple peels may be responsible for their anticancer activity. Journal of Agricultural and Food Chemistry, 2007, 55: 4366-4370.

4 Xiangjiu He, Rui Hai Liu. Cranberry Phytochemicals: Isolation, Structure Elucidation, and their Antiproliferative and Antioxidative Activities. Journal of Agricultural and Food Chemistry, 2006, 54: 7069 - 7074.

5 Xiangjiu He, Jinshan Tang, Aimin Qiao, Guanghui Wang, Miaomiao Jiang, Rui Hai Liu, Xinsheng Yao. Cytotoxic biotransformed products from cinobufagin by Mucor spinosus and Aspergillus niger. Steroids, 2006, 71: 392 - 402.

6 Xiangjiu He, Aimin Qiao, Bo Liu, Xinluan Wang, Guanghui Wang, Gexia Qu, Rui Hai Liu, Xinsheng Yao. Bioconversion of methyl protodioscin by Penicillium melinii cells. Enzyme and Microbial Technology, 2006, 38: 400 - 406.

7 Xiangjiu He, Bo Liu, Guanghui Wang, Xinluan Wang, Lina Su, Gexia Qu, Xinsheng Yao. Microbial metabolism of methyl protodioscin by Aspergillus niger culture—A new androstenedione producing way from steroid. Journal of Steroid Biochemistry & Molecular Biology, 2006, 100: 87 - 94.

8 Xiangjiu He, Aimin Qiao, Xinluan Wang, Bo Liu, Miaomiao Jiang, Lina Su, Xinsheng Yao. Structural identification of methyl protodioscin metabolites in rats’ urine and their antiproliferative activities against human tumor cell lines. Steroids, 2006, 71: 828 - 833.

9 Xiangjiu He, Xinluan Wang, Bo Liu, Lina Su, Guanghui Wang, Gexia Qu, Zhihong Yao, Rui Hai Liu, Xinsheng Yao. Microbial transformation of methyl protodioscin by Cunninghamella elegans. Journal of Molecular Catalysis B: Enzymatic, 2005,25: 33 - 40.

10 Xiangjiu He, Jiankuan Li, Hao Gao, Feng Qiu, Xiangmin Cui, Xinsheng Yao. Four New Andrographolide Metabolites in Rats. Tetrahedron. 2003, 59: 6603 - 6607.

11 Xiangjiu He, Jiankuan Li, Hao Gao, Feng Qiu, Ke Hu, Xiangmin Cui, Xinsheng Yao. Identification of a rare sulphonic acid type metabolite of andrographolide in rats. Drug Metabolism and Disposition. 2003, 31: 983 - 985.

12 Xiangjiu He, Jiankuan Li, Hao Gao, Feng Qiu, Xiangmin Cui, Xinsheng Yao. Six New Andrographolide Metabolites in Rats. Chem. Pharm. Bull. 2003, 51: 586 - 589. ^[1]