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付向東
(西湖大學RNA生物學與再生醫學講席教授)
鎖定
付向東,男,1982年畢業於武漢大學,並獲得病毒學學士學位,1983年通過中美生物化學聯合招生(CUSBEA)計劃留學美國凱斯西儲大學,並於1988年獲得生物化學博士學位,1988年至1992年在哈佛大學生化與分子生物系完成博士後訓練。曾任美國加州大學聖地亞哥分校細胞與分子醫學系教授,獲Searle Scholar (1994)和 Leukemia and Lymphoma Society Scholar(1997)、武漢大學傑出校友(2003)、Ray Wu Society終身成就獎(2016)和柏林牆2020年度創新科學突破獎(2020)。2010年入選美國科學促進會成員(AAAS Fellow)。現為西湖大學生命科學院RNA生物學與再生醫學講席教授。
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付向東人物經歷
付向東學習經歷
1977-1982: 武大病毒系, 本科。
1983-1988: Case Western Reserve University, Biochemistry, 博士。
1988-1992: Harvard University, 博後。
付向東工作經歷
1992-1998 加州大學聖地亞哥分校(UCSD),細胞與分子醫學助理教授
1998-2002 加州大學聖地亞哥分校,細胞與分子醫學副教授
2002-2018 加州大學聖地亞哥分校,細胞與分子醫學教授
2018-2022 加州大學聖地亞哥分校,細胞與分子醫學傑出教授
主要社會兼職:
付向東研究方向
RNA processing and regulation
microRNA biogenesis and functions
Transcription and mRNA processing coupling
Functional genomics
Genetics and epigenetics regulation of gene expression
付向東實驗室將繼續關注RNA生物學及神經再生領域,致力於發育和疾病中RNA調節機制的探索,通過分子生物學、分子遺傳學、生物化學,基因組學,動物行為學、電生理學等多種實驗手段對疾病機理與干預展開研究。
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付向東主要貢獻
1. Qian, H., Kang, X.J., Hu, J., Zhang, D., Liang, Z., Meng, F., Zhang X., Xue, Y., Maion, R., Dowdy, S. F., Devaraj, N., Zhou, Z., Mobley, W. C., Cleveland, D. W., and Fu, X-D. (2020). Reversing a model of Parkinson’s disease with in situ converted nigral neurons. Nature 582:550-556.
2. Gou, L-T., Lim, D-H., Ma, W., Aubol, B. E., Hao, Y., Wang, X., Zhao, J., Liang, Z., Shao, C., Zhang, X., Li, H., Zhang, X., Xu, R., Li, D., Rosenfeld, M. G., Mellon, P. L., Adams, J. A., Liu, M-F., and Fu, X-D. (2020). Initiation of parental genome reprogramming in fertilized oocyte by splicing kinase SRPK1-catalyzed protamine phosphorylation. Cell 180:1212-1227.
3. Chen, L., Chen, J-Y., Huang, Y-J., Gu, Y., Qiu, J., Shao, C., Zhang, X., Hu, J., Li, H., He., S., Zhou, Y., Zhang, D-E., and Fu, X-D. (2018). The augmented R-loop is a unifying mechanism for Myelodyplastic Syndromes induced by high risk splicing factor mutations. Mol Cell 69:412-425.
4. Zhang, X., Zuo, X., Yang, B., Li, Z., Xue, Y., Zhou, Y., Huang, J., Zhao, X., Zhou, J., Yan, Y., Zhang, H., Guo, P., Sun, H., Guo, L., Zhang, Y., and Fu, X-D. (2014). microRNA directly enhances mitochondrial translation during muscle differentiation. Cell 158:607-619.
5. Xue, Y-C., Ouyang, K., Huang, J., Zhou, Y., Ouyang, H., Li, H., Wang, G., Wu, Q., Wei, C., Bi, Y., Jiang, L., Cai, Z., Sun, H., Zhang, K., Zhang, Y., Chen, J., and Fu, X-D. (2013) Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits. Cell 152:82-96.
6. Wang, D., Garcia-Bassets, I., Benner, C., Li, W., Su. X., Zhou, Y., Qiu, J., Liu, W., Kaikkonen, M. U., Ohgi, K.A. Glass, C. K., Rosenfeld, M. G., and Fu, X-D. (2011). Reprogramming transcription via distinct classes of enhancers functionally defined by eRNA. Nature 474:390-394.
7. Xu, X., Yang, D., Ding, J-H., Wang, W., Chu, P-H., Dalton, N. D., Wang, H-Y., Bermingham, Jr., J. R., Ye, Z., Liu, F., Rosenfeld, M. G., Manley, J. L., Ross Jr. J., Chen, J., Xiao, R-P., Cheng, H., and Fu, X-D. (2005). ASF/SF2-regulated postnatal reprogramming of CaMKIId alternative splicing modulates excitation-contraction coupling in cardiac muscle. Cell 120:59-72.
8. Gui, J-F., Lane, W. S., and Fu, X-D. (1994). A serine kinase regulates the intracellular localization of splicing factors during the cell cycle. Nature 369:678-682.
9. Fu, X-D. (1993). Specific commitment of different pre-mRNAs to splicing by single SR proteins. Nature 365:82-85.
10. Fu, X-D. and Maniatis, T. (1990). Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus. Nature 343:437-441.
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- 參考資料
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- 1. 華人學者付向東加入西湖大學因“中國行動計劃”辭去在美教職 .財新網.2023-03-22[引用日期2023-03-29]
- 2. 付向東博士 .西湖大學[引用日期2023-03-29]
- 3. 武大生科院知名教授最新Nature子刊文章:填補miRNA加工研究空白 - 生物通 .生物通.2017-08-30[引用日期2023-03-29]