曹日暉

1989.9—1993.6 湖南師範大學生命科學學院生物學系，學士；

1993.9—1996.6 武漢大學生命科學學院病毒學系，碩士；

2001.9—2004.6 中山大學生命科學學院生物化學系，博士。 ^[1] 

1996.7—2000.11 珠海金沙製藥有限公司藥物研究所；

2000.12—2001.3 深圳雲大科技實業開發有限公司技術部，項目經理；

2001.4—2001.8 深圳創新慧生物技術開發有限公司，項目經理；

2004.8—2007.11 中山大學化學學院/新疆華世丹藥業股份有限公司，博士後；

2007.12—至今 中山大學化學學院應用化學系，講師、副教授。 ^[1] 

1. 本科生 《化學生物學》、《基礎化學實驗（有機）》、《綜合化學實驗》；

2. 研究生 《生物有機化學》、《結構生物學》。 ^[1] 

1. 新型抗腫瘤藥物的設計、合成、篩選及分子機理研究；

2. 新型酪氨酸酶抑制劑的設計、合成、篩選及機制研究。 ^[1] 

1. 光甘草定合成工藝技術研究 (企業橫向課題 No. 20173100071020837, 2017.07—2018.06, 項目負責人)

2. 新型腫瘤血管靶向抑制劑雙β-咔啉鹼的結構優化、構效關係與作用機制研究 (廣東省自然科學基金 No. 2016A030313349, 2016.06—2019.06, 項目負責人)

3. 香豆素結構改造衍生物的構效關係研究 (企業橫向課題 No. 20153100071020799, 2015.01—2015.12，項目負責人)

4. HMD-332原料藥有機雜質分離與結構鑑定研究 (企業橫向課題 No. 20143100071020786, 2014.01—2014.12, 項目負責人)

5. 新型雙β-咔啉鹼的設計合成、抗腫瘤構效關係與作用機理研究 (國家自然科學基金主任基金 No. 21342010, 2014.01—2014.12, 項目負責人)

6. HMD-332原料藥的質量標準研究 (企業橫向課題 No. 20133100071020772, 2011.01—2011.12, 項目負責人)

7. 基於魚腥草素結構優化的候選藥物研究 (廣東省科技計劃項目 No. 2009310004202685，2009.12—2011.12, 項目負責人)

8. 新型雙β-咔啉鹼的設計合成、抗腫瘤構效關係與作用機理研究 (廣東省自然科學基金 No. S2013010012138, 2013.10—2015.10， 項目負責人)

9. β-咔啉鹼結構優化的抗腫瘤候選藥物研究 (國家重大科技專項“重大新藥創制”候選藥物研究課題 No. 2009ZX09103-015, 2009.01—2011.12, 項目負責人)

10. 基於拓撲異構酶I靶點的新型抗腫瘤化合物β-咔啉鹼優化設計、合成及構效關係研究 (教育部高等學校青年培育項目 No. 09lgpy12, 2009.12—2012.12, 項目負責人)

11. 新型拓撲異構酶I抑制劑β-咔啉鹼的分子設計與生物活性研究 (教育部博士點基金新教師基金 No. 20100171120011, 2011.1— 2013.12, 項目負責人)

12. 去氫駱駝蓬鹼結構改造與抗腫瘤構效關係研究 (企業橫向課題 No. 20083100071020421, 2008.01—2008.12, 項目負責人)

13. 去氫駱駝蓬鹼結構改造與抗腫瘤構效關係研究 (中國博士後科學基金 No. 粵博準字[05]214, 2005.10—2007.10, 項目負責人) ^[1] 

1. Zeyan Zhang, Xingpeng Xiao, Tong Su, Jinyi Wu, Jianwei Ren, Jiongchang Zhu, Xiaodong Zhang, Rihui Cao* and Runlei Du*, Synthesis, structure-activity relationships and preliminary mechanism of action of novel water-soluble 4-quinolone-3-carboxamides as antiproliferative agents, European Journal of Medicinal Chemistry, 2017, 140 (10): 239-251. (通訊作者,IF-2016: 4.519)

2. Xiaofei Zhang, Rongqin Sun, Yifan Jia, Qing Chen, Rongfu Tu, Keke Li, Xiaodong Zhang, Runlei Du* and Rihui Cao* Synthesis and mechanisms of action of novel harmine derivatives as potential antitumor agents, Scientific Reports, 2016, 6:33204. (通訊作者,IF-2016: 4.259)

3. Wei Chen, Guoxian Zhang, Liang Guo, Wenxi Fan, Qin Ma, Xiaodong Zhang, Runlei Du* and Rihui Cao*, Synthesis and biological evaluation of novel alkyl diamine linked bivalent β--carbolines as angiogenesis inhibitors, European Journal of Medicinal Chemistry, 2016, 124 (9):249-261. (通訊作者,IF-2016: 4.519)

4. Liang Guo, Wei Chen, Wenxi Fan, Qin Ma, Rongqin Song, Guang Shao* and Rihui Cao*, Synthesis and preliminary evaluation of novel alkyl diamine linked bivalent β-carbolines as angiogenesis inhibitors, Medicinal Chemistry Communication, 2016, 7, 2177-2183. (通訊作者,IF-2016: 2.608)

5. Qing Chen, Wei Chen, Liang Guo, Wenxi Fan, Qin Ma, Xiaodong Zhang, Runlei Du* and Rihui Cao*,Design, synthesis and biological evaluation of novel alkyl diamine linked bivalent β-carbolines as angiogenesis inhibitors, Bioorganic & Medicinal Chemistry Letters, 2016, 26(10): 5065-5068. (通訊作者,IF-2016: 2.454)

6. Rongqin Sun, Rui Liu, Chi Zhou, Zhenghua Ren, Liang Guo, Qin Ma, Wenxi Fan, Liqin Qiu, Huijuan Yu, Guang Shao* and Rihui Cao*, Synthesis and biological evaluation of piperazine group-linked bivalent β-carbolines as potential antitumor agents, Medicinal Chemistry Communication, 2015, 6 (12): 2170-2174. (通訊作者,IF-2016: 2.608)

7. Yuwei He, Chuyu Cheng, Bin Chen, Kun Duan, Yue Zhuang, Bo Yuan, Meisan Zhang, Yougui Zhou, Zihong Zhou, Yu-Jun, Rihui Cao , Liqin Qiu*, Highly enantioselective synthesis of 2,3-dihydro‑1H‑imidazo[2,1‑a]isoindol-5(9bH)‑ones via catalytic asymmetric intramolecular cascade imidization−nucleophilic addition−lactamization, Organic Letters. 2014, 16: 6366-6369.(IF-2016: 6.579)

8. Qing Li, Pin Wan, Yuwei He, Yougui Zhou, Lanning Li, Bin Chen, Kun Duan, Rihui Cao , Zhongyuan Zhou, Liqin Qiu *, Enantioselective hydrogenation of the double bond of exocyclic a,b-unsaturated carbonyl compounds catalyzed by iridium/H8-BINOL derived phosphine-oxazoline complexes, Asian Journal of Organic Chemistry, 2014, 3, 744-783. (IF-2016: 2.788)

9. Qifeng Wu, Zhushuang Bai, Qin Ma, Wenxi Fan, Liang Guo, Guoxian Zhang, Liqin Qiu, Huijuan Yu, Guang Shao*, Rihui Cao*, Synthesis and biological evaluation of novel bivalent β-carbolines as potential antitumor agents, Medicinal Chemistry Communication. 2014, 5: 953-957. (通訊作者,IF-2016: 2.608)

10. Guang Shao*, Huijuan Yu, Na Zhang, Yanjian He, Kejun Feng, Xin Yang, Rihui Cao*, Menglian Gong, Synthesis and photophysical properties of europium(III)-β-diketonate complexes applied in LEDs, Physical Chemistry Chemical Physics. 2014, 16: 695-702. (通訊作者,IF-2016: 4.123)

11. Guoxian Zhang, Rihui Cao*, Liang Guo, Qin Ma, Wenxi Fan, Xuemei Chen, Jianru Li, Guang Shao, Liqin Qiu, Zhenghua Ren*, Synthesis and structure–activity relationships of N2-alkylated quaternary β-carbolines as novel antitumor agents, European Journal of Medicinal Chemistry. 2013, 65 (7) 21-31. (通訊作者,IF-2016: 4.519)

12. Qing Li, Pin Wan, Shouliang Wang, Yue Zhuang, Lanning Li, Yougui Zhou, Yuwei He, Rihui Cao , Liqin Qiu*, Zhongyuan Zhou, Synthesis of a class of new phosphine-oxazoline ligands and their applications in palladium-catalyzed asymmetric addition of arylboronic acids to isatins, Applied Catalysis A: General, 2013, 458(10) 201-206. (IF-2016: 4.339)

13. Liang Guo, Wenxi Fan, Xuemei Chen, Qin Ma and Rihui Cao*, Synthesis and antitumor activities of β-carboline derivatives, Chinese Journal of Organic Chemistry, 2013, 33: 332-338. (通訊作者,IF-2016: 1.010)

14. Guang Shao*, Na Zhang, Duan Lin, Kenjun Feng, Rihui Cao*, Menglian Gong, A neweuropium(III)-β-diketonatecomplexbasedondiphenylethyne as red phosphors applied in LED, Journal of Luminescence. 2013, 138 (7) 195-200. (通訊作者, IF-2016: 2.686)

15. Buxi Shi, Rihui Cao*, Wenxi Fan, Liang Guo, Qin Ma, Xuemei Chen, Guoxian Zhang, Liqin Qiu, Huacan Song*, Design, synthesis and in vitro and in vivo antitumor activities of novel bivalent β-carbolines. European Journal of Medicinal Chemistry. 2013, 60(2) 10-22. (通訊作者,IF-2016: 4.519)

16. Rihui Cao*, Wenxi Fan, Liang Guo, Qin Ma, Guoxian Zhang, Jianru Li, Xuemei Chen, Zhenghua Ren*, Liqin Qiu, Synthesis and structure-activity relationships of harmine derivatives as potential antitumor agents. European Journal of Medicinal Chemistry, 2013, 60(2) 135-143. (通訊作者,IF-2016: 4.519)

17. Xiaomin Han, Jing Zhang, Liang Guo, Rihui Cao, Yongzhen Li, Ni Li, Qin Ma, Jialin Wu, Yanchang Wang, Shuyi Si*. A series of beta-carboline derivatives inhibit the Kinase activity of PLKs. PLoS ONE, 2012, 7 (10) 1-11. (IF-2016: 2.806)

18. Shuang Li, Huan Li, Li Li, Ningqi Luo, Rihui Cao , Dihu Chen, Yuanzhi Shao. Mesoporous silica nanoparticles encapsulating Gd(2)O(3) as a highly efficient magnetic resonance imaging contrast agent. Applied Physics Letters. 2011, 98(9):093704. (IF-2016: 3.411)

19. Zhiyong Chen, Rihui Cao*, Buxi Shi, Liang Guo, Jie Sun, Qin Ma, Wenxi Fan, Huacan Song. Synthesis and biological evaluation of 1,9-disubstituted β-carbolines as potent DNA intercalating and cytotoxic agents. European Journal of Medicinal Chemistry. 2011, 46 (10), 5127-5137. (通訊作者,IF-2016: 4.519)

20. Chunming Ma, Rihui Cao*, Buxi Shi, Xiantai Zhou, Qin Ma, Jie Sun, Liang Guo, Wei Yi, Zhiyong Chen, Huacan Song*. Synthesis and cytotoxic evaluation of 1-carboxamide and 1-amino side chain substituted β-carbolines. European Journal of Medicinal Chemistry. 2010, 45(11), 5513-5519. (通訊作者, IF-2016: 4.519)

21. Zhiyong Chen, Rihui Cao*, Liang Yu, Buxi Shi, Jie Sun, Liang Guo, Qin Ma, Wei Yi, Xiao Song, Huacan Song*. Synthesis, cytotoxic activities and DNA binding properties of β-carboline derivatives. European Journal of Medicinal Chemistry. 2010, 45(11), 4740-4745. (通訊作者, IF-2016: 4.519)

22. Liang Yu, Rihui Cao , Wei Yi, Qin Yan, Zhiyong Chen, Lin Ma, Huacan Song. Design, synthesis and evaluation of difunctionalized 4-hydroxybenzaldehyde derivatives as novel cholinesterase inhibitors. Chemical & Pharmaceutical Bulletin. 2010, 58 (9), 1216-1220. (IF-2016: 1.133)

23. Zhiyong Chen, Rihui Cao*, Buxi Shi, Wei Yi, Liang Yu, Huacan Song, Zhenhua Ren, Wenlie Peng. Synthesis of novel β-carbolines with efficient DNA-binding capacity and potent cytotoxicity. Bioorganic & Medicinal Chemistry Letters. 2010, 20 (13), 3876-3879. (通訊作者, IF-2016: 2.454)

24. Yuanzhi Shao, Lizhi Liu, Shuqin Song, Rihui Cao , Huan Liu, Chunyan Cui, Xing Li, Mengjie Bie, Li Li. A novel one-step synthesis of Gd incorporated mesoporous nanoparticles for use as an efficient MRI contrast agent. Contrast Media & Molecular Imaging. 2010, 5(12), 110-118. (IF-2016: 3.307)

25. Liang Yu, Rihui Cao , Wei Yi, Qin Yan, Zhiyong Chen, Lin Ma, Wenlie Peng, Huacan Song. Synthesis of 4-[(diethylamino)methyl]-phenol derivatives as novel cholinesterase inhibitors with selectivity towards butyrylcholinesterase. Bioorganic & Medicinal Chemistry Letters. 2010, 20(11), 3254-3258. (IF-2016: 2.454)

26. Wei Yi, Rihui Cao , Zhiyong Chen, Liang Yu, Huan Wen, Qin Yan, Lin Ma and Huacan Song. Rational Design and Synthesis of 4-O-Substituted Phenylmethylene-thiosemicarbazones as Novel Tyrosinase Inhibitors. Chemical Pharmaceutical Bulletin. 2010, 58(5), 752-754. (IF-2016: 1.133)

27. Zhiyong Chen, Rihui Cao , Buxi Shi, Wei Yi, Liang Yu, Huacan Song, Zhenhua Ren. Synthesis and Biological Evaluation of Novel β-Carbolines as Potent Cytotoxic and DNA Intercalating Agents. Chemical Pharmaceutical Bulletin. 2010, 58 (7), 901-907. (IF-2016: 1.133)

28. Rihui Cao*, Xiangdong Guan, Buxi Shi, Zhiyong Chen, Zhenhua Ren, Wenlie Peng, Huacan Song. Design, synthesis and 3D-QSAR of β-carboline derivatives as potent antitumor agents. European Journal of Medicinal Chemistry. 2010, 45 (6) 2503-2515. (通訊作者, IF-2016: 4.519)

29. Chunming Ma, Rihui Cao*, Buxi Shi, Shaoxue Li, Zhiyong Chen, Wei Yi, Wenlie Peng, Zhenhua Ren, Huacan Song*. Synthesis and cytotoxic evaluation of N2-benzylated quaternary β-carboline amino acid ester conjugates. European Journal of Medicinal Chemistry. 2010, 45 (4)：1515-1523. ( 通訊作者, IF-2016: 4.519 )

30. Wei Yi, Rihui Cao*, Wenlie Peng, Huan Wen, Qin Yan, Binhua Zhou, Lin Ma, Huacan Song*. Synthesis and biological evaluation of novel 4-hydroxybenzaldehyde derivatives as tyrosinase inhibitors. European Journal of Medicinal Chemistry. 2010, 45 (2)，639-646. (通訊作者, IF-2016: 4.519)

31. Wei Yi, Rihui Cao , Zhiyong Chen, Liang Yu, Lin Ma, Huacan Song. Design, synthesis and biological evaluation of hydroxy- or methoxy-substituted enylmethylenethiosemicarbazones as tyrosinase inhibitors. Chemical Pharmaceutical Bulletin. 2009, 57 (11), 1273-1277. (IF-2016: 1.133 )

32. Wei Yi, Rihui Cao*, Huan Wen, Qin Yan, Binhua Zhou, Lin Ma, Huacan Song. Discovery of 4-functionalized phenyl-O-β-D-glycosides as a new class of mushroom tyrosinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 2009, 19 (21), 6157-6160. (通訊作者, IF-2016: 2.454)

33. Qin Yan, Rihui Cao*, Wei Yi, Liang Yu, Zhiyong Chen, Lin Ma, Huacan Song*. Synthesis and evaluation of 5-benzylidene(thio)barbiturate-β-D-glycosides as mushroom tyrosinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 2009, 19 (15), 4055-4058. (通訊作者, IF-2016: 2.454)

34. Qin Yan, Rihui Cao*, Wei Yi, Zhiyong Chen, Huan Wen, Lin Ma, Huacan Song*. Inhibitory effects of 5-benzylidene barbiturate derivatives on mushroom tyrosinase and their antibacterial activities. European Journal of Medicinal Chemistry. 2009, 44 (10), 4235-4243. (通訊作者, IF-2016: 4.519)

35. Yi Wei, Xiaoqin Wu, Rihui Cao , Huacan Song, Lin Ma. Biological evaluations of novel vitamin C esters as mushroom tyrosinase inhibitors and antioxidants. Food Chemistry. 2009, 117 (3), 381-386. (IF-2016: 4.529)

36. Jinbing Liu, Rihui Cao*, Wei Yi, Chunming Ma, Yiqian Wan, Binhua Zhou, Lin Ma, Huacan Song*. A class of potent tyrosinase inhibitors: Alkylidenethiosemicarbazide compounds. European Journal of Medicinal Chemistry. 2009, 44(4): 1773-1778. (通訊作者, IF-2016: 4.519)

37. Jinbing Liu, Rihui Cao , Qifeng Wu, Chunming Ma, Zihou Wang, Wenlie Peng, Huacan Song*. Synthesis and antibacterial evaluation of novel 4-alkyl substituted phenyl β-aldehyde ketone derivatives. European Journal of Medicinal Chemistry. 2009, 44 (4): 1737-1744. (IF-2016: 4.519)

38. Qifeng Wu, Rihui Cao*, Manxiu Feng, Xiangdong Guan, Chunming Ma, Jinbing Liu, Huacan Song, Wenlie Peng*. Synthesis and in vitro cytotoxic evaluation of novel 3,4,5-trimethoxyphenyl substituted β-carboline derivatives. European Journal of Medicinal Chemistry. 2009, 44 (2), 533-540. (通訊作者，IF-2016: 4.519)

39. Jing Zhang, Yan Li, Liang Guo, Rihui Cao , Pei Zhao, Wei Jiang, Qin Ma, Hong Yi, Zhuorong Li, Jiandong Jiang, Jialin Wu, Yanchang Wang, Shuyi Si. DH166, a beta-carboline derivative, inhibits the kinase activity of PLK1. Cancer Biology & Therapy. 2009, 8: 2374-2383. (IF-2016: 3.294)

40. Rihui Cao*, Wei Yi, Qifeng Wu, Xiangdong Guan, Manxiu, Feng, Chunming Ma, Zhiyong Chen, Huacan Song, Wenlie Peng*. Synthesis and cytotoxic activities of 1-benzylidine substituted β-carboline derivatives. iBoorganic & Medicinal Chemistry Letters. 2008, 18 (24) : 6558-6561. (通訊作者, IF-2016: 2.454)

41. Wei Yi, Rihui Cao*, Huan Wen, Qin Yan, Binhua Zhou, Yiqian Wan, Lin Ma, Huacan Song*. Synthesis and biological evaluation of helicid analogues as mushroom tyrosinase inhibitors. Bioorganic & Medicinal Chemistry Letters. 2008, 18 (24): 6490-6493. (通訊作者, IF-2016: 2.454)

42. Huan Wen, Chonglan Lin, Ling Que, Hui Ge, Lin Ma, Rihui Cao, Yiqian Wan, Wenlie Peng, Zihou Wang, Huacan Song. Synthesis and biological evaluation of helicid analogues as novel acetylcholinesterase inhibitors. European Journal of Medicinal Chemistry, 2008, 43(1): 166-173. (IF-2016: 4.519)

43. Yan Li, Fengshan Liang, Wei Jiang, Fusheng Yu, Rihui Cao, Qinghe Ma, Xiuyong Dai, Jiandong Jiang, Yanchang Wang*, Shuyi Si*. DH334, a β-carboline anti-cancer drug, inhibits the CDK activity of budding yeast. Cancer Biology & Therapy. 2007, 6: 1193-1199. (IF-2016: 3.294)

44. Rihui Cao, Wenlie Peng, Zihou Wang，Anlong Xu*. β-Carboline alkaloids: Biochemical and pharmacological functions. Current Medicinal Chemistry. 2007, 14 (4) : 479-500. (IF-2016: 3.249)

45. Huaji Guan, Hongsheng Chen, Wenlie Peng, Yan Ma, Rihui Cao, Xiaodong Liu, Anlong Xu*. Design of β-carboline derivatives as DNA-targeting antitumor agents. European Journal of Medicinal Chemistry. 2006, 41(10):1167-1179. (IF-2016: 4.519)

46. Rihui Cao, Wenlie Peng, Hongsheng Chen，Yan Ma, Xiaodong Liu, Xuerui Hou, Huaji Guan, Wenlie Peng, Anlong Xu*. DNA binding properties of 9-substituted harmine derivatives. Biochemical and Biophysical Research Communication. 2005, 338 (3): 1157-1563. (IF-2016: 2.466)

47. Rihui Cao, Wenlie Peng, Hongsheng Chen, Xuerui Hou, Huaji Guan, Qi Chen, Yan Ma, Anlong Xu*. Synthesis and in vitro cytotoxic evaluation of 1,3-bisubstituted and 1,3,9-trisubstituted β-carboline derivatives. European Journal of Medicinal Chemistry. 2005, 40 (3): 249 -257. (IF-2016: 4.519)

48. Rihui Cao, Hongsheng Chen, Wenlie Peng, Yan Ma, Xuerui Hou, Huaji Guan, Xiaodong Liu, Anlong Xu*. Design, synthesis and in vitro and in vivo antitumor activities of novel β-carboline derivatives. European Journal of Medicinal Chemistry. 2005, 40 (10): 991-1001. (IF-2016: 4.519)

49. Huaji Guan, Xiaodong Liu, Wenlie Peng, Rihui Cao, Yan Ma, Hongsheng Chen, Anlong Xu*. β-carboline derivatives－Novel photosensitizers that intercalate into DNA to cause direct DNA damage in photodynamic therapy. Biochemical and Biophysical Research Communication. 2005, 342 (3): 894-901. (IF-2016: 2.466)

50. Qi Chen, Rihui Chao, Hongsheng Chen, Xuerui Hou, Huifang Yan, Shufeng Zhou, Wenlie Peng, Anlong Xu*. Antitumor and neurotoxic effects of novel harmine derivatives and structure-activity relationship analysis. International Journal of Cancer, 2004, 114 (8): 675-682 (並列第一作者, IF-2016: 6.513)

51. Rihui Cao, Qi Chen, Xuerui Hou, Hongsheng Chen, Huaji Guan, Yan Ma, Wenlie Peng, Anlong Xu. Synthesis, acute toxicities and antitumor effects of novel 9-substituted β-carboline derivatives. Bioorganic & Medicinal Chemistry. 2004, 12 (17): 4613- 4623. (IF-2016: 2.93)

52. Xue-rui HOU, Qi CHEN, Ri-hui CAO, Wen-lie PENG, An-long XU*. A comparative molecular field analysis of cytotoxic beta-carboline analogs. Acta Pharmacologica Sinica. 2004, 25 (7): 959-965. (IF-2016: 3.223) ^[1]