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劉志剛

（西北農林科技大學教師）

鎖定
劉志剛，博士，教授，博士研究生導師，西北農林科技大學食品科學與工程學院食品營養與健康系副主任，食品營養與衞生教研室主任。研究方向：食品營養與人類健康。 [1] 
中文名
劉志剛
國    籍
中國
畢業院校
西北農林科技大學
學位/學歷
博士
職    業
教師
專業方向
食品科學
任職院校
西北農林科技大學
職    稱
教授

目錄

  1. 1 人物經歷
  2. 2 開設課程
  3. 3 研究方向
  1. 4 學術成果
  2. 5 科研項目
  3. 6 外文專著
  1. 7 代表論文
  2. 8 代表性專利
  3. 9 國際會議

劉志剛人物經歷

2020年1月－至今，西北農林科技大學食品科學與工程學院，教授；
2020年8月－至今，德國人類營養研究所，訪問研究員/洪堡學者；
2020年7月－至今，美國Cornell University，Department of Food Science，客座教授；
2017年2月－至今，西北農林科技大學食品科學與工程學院，副教授；
2019年7月－至今，美國康奈爾大學農業與生命科學學院食品科學系，客座副教授；
2015年9月－2017年1月，西北農林科技大學食品科學與工程學院，講師；
2013年8月－2015年8月，美國南加州大學藥學院，聯合培養博士；
2010年9月－2015年6月，西北農林科技大學食品科學與工程學院，食品科學，博士；
2006年9月－2010年6月，西北農林科技大學食品科學與工程學院，食品質量與安全，工學學士。 [1] 

劉志剛開設課程

本科課程：《食品營養學》、《食品化學安全性分析與控制教學實習》、《食品學科前沿討論課》
研究生課程：《高級食品化學》、《食品科學Seminar》 [1] 

劉志剛研究方向

主要從事食品營養與人類健康研究方向，包括：
1. 食品營養功能組分發掘與功效評價：結合我國特色食材資源和全民營養健康現狀，發掘果蔬、糧油等傳統食品原料中具有調節代謝、改善腦健康問題（情緒、社交、認知功能障礙等）等生理功能的可溶性膳食纖維、多酚和類胡蘿蔔素類功能成分；
2. 新型膳食模式對代謝綜合徵及神經退行性疾病的干預作用機制：利用多組學系統生物學研究方法探究限制性飲食模式對肥胖、糖尿病等代謝性疾病，以及衰老相關的阿爾茲海默症、帕金森症等神經退行性疾病的改善作用，揭示間歇性禁食、植物蛋白飲食、特殊氨基酸限制飲食通過調節“腸-肝-腦”軸調節機體微生態免疫平衡、干預系統性胰島素抵抗、改善與衰老相關的中樞神經系統功能紊亂的分子機制。 [1] 

劉志剛學術成果

研究發現了高脂高果糖等不合理膳食模式會誘導腦部胰島素抵抗及認知功能障礙，並嘗試探索了通過改變膳食結構和營養組分，干預由於遺傳、衰老、不合理飲食、社會壓力等因素引起的認知記憶功能紊亂及情緒變化。近年來在食品營養及生物化學領域共發表論文五十餘篇，主要成果發表在食品營養與生物化學領域等具有國際影響力的期刊上，論文總引次數超過800餘次，H-index 17，i10index 25。其中ESI前1%高被引論文3篇，封面文章1篇，參編英文專著1部。
近5年來主持包括國家自然科學基金面上項目、青年項目、陝西省重點研發計劃、中國博士後特別資助、企業橫向課題等科研項目10餘項，榮獲2018年陝西省科學技術進步獎二等獎（排名第二）及陝西省高等學校科學技術一等獎（排名第二）。目前任Frontiers in Aging Neuroscience審稿編輯，Free radical biology & medicine, Journal of Agricultural and Food Chemistry, Journal of Nutrition, Journal of Functional Foods等食品營養學雜誌審稿人。美國營養學會、歐洲自由基研究學會會員。多次受邀參與多個國際重要學術會議，包括美國營養學會（American Societyof Nutrition）、美國加州自由基協會（Oxygen California Club）以及戈登會議（Gordon Research Seminar & Gordon Research Conference）、國際脂質科學與健康研討會等國際會議並做學術報告。 [1] 

劉志剛科研項目

1. 國家自然科學麪上項目，No. 81871118，主持；
2. 國家自然科學基金青年項目，No. 81803231，主持；
3. 陝西省重點研發計劃，No. 2018NY-100，2018-2020，主持；
4. 中國博士後科學基金委特別資助，No. 2018T1104，2018-2020，主持；
5. 陝西省高校科協青年人才託舉計劃，No. 201770201，2017-2019，主持；
6. 國家“十三五”重點研發計劃，現代食品加工及糧食收儲運技術與裝備專項，項目子課題，No. 2017YFD0400200，2017-2021，子課題研究骨幹；
7. 中國博士後科學基金面上資助，No. 2016M602867，2016/01- 2018/12，主持；
8. 西北農林科技大學博士科研啓動基金，No. 2452015305，2015/9- 2018/9，主持。 [1] 

劉志剛外文專著

1. William Shang（向玉龍）, 劉志剛 《糖尿病自救攻略》Amazon KDP, 2020.（共同主編）
2. Zhigang Liu*, Harsh Sancheti, Enrique Cadenas*, and Fei Yin* (2015) Chapter 2: Energy-redox axis in mitochondria. Mitochondria in Liver Disease (Han, D. and Kaplowitz, N., Eds), pp. 29-43. CRC Press, Boca Raton. [1] 

劉志剛代表論文

1. Zhigang Liu*#; Xiaoshuang Dai#; Hongbo Zhang; Renjie Shi; Yan Hui; Xin Jin; Wentong Zhang;Luanfeng Wang;Qianxu Wang; Danna Wang; Jia Wang; Xintong Tan; Bo Ren; Xiaoning Liu; Tong Zhao; Jiamin Wang; Junru Pan; Tian Yuan; Chuanqi Chu; Lei Lan; Fei Yin; Enrique Cadenas; Lin Shi*; Shancen Zhao*; Xuebo Liu*. Gut microbiota mediates intermittent-fasting alleviation of diabetes-induced cognitive impairment.Nature Communications 2020;11(1):855.
2. Xin Zhang; Qianhui Zou; Beita Zhao; Jingwen Zhang; Weiyang Zhao; Yitong Li; Ruihai Liu; Xuebo Liu;Zhigang Liu*. Effects of alternate-day fasting, time-restricted fasting and intermittent energy restriction DSS-induced on colitis and behavioral disorders.Redox Biology 2020;32:101535.
3. Zhigang Liu#; Ling Li#; Shaobo Ma; Jin Ye; Hongbo Zhang; Yitong Li; Ali Tahir Sair; Junru Pan; Xiaoning Liu; Xiang Li; Shikai Yan; Xuebo Liu*. High-Dietary Fiber Intake Alleviates Antenatal Obesity-Induced Postpartum Depression: Roles of Gut Microbiota and Microbial Metabolite Short-chain Fatty Acid Involved. Journal of Agricultural and Food Chemistry2020;68(47):13697-13710.
4. Hongbo Zhang; Wentong Zhang; Duo Yun; Ling Li; Weiyang Zhao; Yitong Li; Xuebo Liu*;Zhigang Liu*. Alternate-day fasting alleviates diabetes-induced glycolipid metabolism disorders: Roles of FGF21 and bile acids. Journal of Nutritional Biochemistry 2020;83:108403.
5. Qianhui Zou; Xin Zhang; Xiaoshuang Liu; Yitong Li; Qiaoli Tan; Qin Dan;Tian Yuan; Xuebo Liu; Ruihai Liu; Zhigang Liu*. Ficus carica polysaccharide attenuates DSS-induced ulcerative colitis in C57BL/6 mice. Food & Function 2020;11(7):6666-6679.
6. Luanfeng Wang; Bo Ren; Qian Zhang; Chuanqi Chu; Zhenting Zhao; Jianbin Wu; Weiyang Zhao; Zhigang Liu*, Xuebo Liu*. Methionine Restriction Alleviates High-Fat Diet-induced Obesity: Involvement of Diurnal Metabolism of Lipids and Bile Acids.Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease2020;1866(11):165908.
7. Luanfeng Wang; Bo Ren; Yan Hui; Chuanqi Chu; Zhenting Zhao; Yuyu Zhang; Beita Zhao; Renjie Shi; Junli Ren; Xiaoshuang Dai; Zhigang Liu*; Xuebo Liu*. Methionine Restriction Regulates Cognitive Function in High-Fat Diet-Fed Mice: Roles of Diurnal Rhythms of SCFAs Producing-and Inflammation-related Microbes.Molecular Nutrition & Food Research 2020;64(17):2000190.
8. Jia Wang; TonghuiGeng; Qianhui Zou; Ningru Yang; Weiyang Zhao; Yitong Li; Xintong Tan; Tian Yuan; Xuebo Liu, and Zhigang Liu*. Lycopene prevents lipid accumulation in hepatocytes by stimulating PPARα and improving mitochondrial function. Journal of Functional Foods 2020;67:103857.
9. Bo Ren; Tian Yuan; Xinglin Zhang; Luanfeng Wang; Junru Pan; Yan Liu; Beita Zhao; Weiyang Zhao; Zhigang Liu*; Xuebo Liu*. Protective Effects of Sesamol on Systemic Inflammation and Cognitive Impairment in Aging Mice. Journal of Agricultural and Food Chemistry 2020;68(10):3099-3111.
10. AiziguliMulati; Shaobo Ma; Hongbo Zhang; Bo Ren; Beita Zhao; Luanfeng Wang; Xiaoning Liu; Tong Zhao; Svetlana Kamanova; Ali Tahir Sair; Zhigang Liu*; Xuebo Liu*. Sea-Buckthorn Flavonoids Alleviate High-Fat and High-Fructose Diet-Induced Cognitive Impairment by Inhibiting Insulin Resistance and Neuroinflammation. Journal of Agricultural and Food Chemistry 2020;68(21):5835-5846.
11. Shikai Yan; Renjie Shi; Ling Li; Shaobo Ma; Hongbo Zhang; Jin Ye; Jiamin Wang; Junru Pan; Qianxu Wang; Xiang Jin; Xuebo Liu; Zhigang Liu*. Mannan Oligosaccharide Suppresses Lipid Accumulation and Appetite in Western-Diet-Induced Obese Mice Via Reshaping Gut Microbiome and Enhancing Short-Chain Fatty Acids Production. Molecular Nutrition & Food Research 2019;63(23):e1900521.
12. Xintong Tan; Ling Li; Jia Wang; Beita Zhao; Junru Pan; Leran Wang; Xiao Liu; Xuebo Liu; Zhigang Liu*. Resveratrol Prevents Acrylamide-Induced Mitochondrial Dysfunction and Inflammatory Responses via Targeting Circadian Regulator Bmal1 and Cry1 in Hepatocytes. Journal of Agricultural and Food Chemistry 2019;67(31):8510-8519.
13. Cover Article: Qianxu Wang; Mengzhen Jia; Yihang Zhao; Yan Hui; Junru Pan; Hongfei Yu; Shikai Yan; Xiaoshuang Dai; Xuebo Liu; Zhigang Liu*. Supplementation of Sesamin Alleviates Stress-Induced Behavioral and Psychological Disorders via Reshaping the Gut Microbiota Structure. Journal of Agricultural and Food Chemistry 2019;67(45):12441-12451.
14. Yihang Zhao; Qianxu Wang; Mengzhen Jia; Shangchen Fu; Junru Pan; Chuanqi Chu; Xiaoning Liu; Xuebo Liu; Zhigang Liu*. (+)-Sesamin Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-Like Behaviors and Memory Deficits via Suppression of Neuroinflammation. Journal of Nutritional Biochemistry 2019;64:61-71.
15. Tian Yuan; Chuanqi Chu; Rubing Shi; Tianlin Cui; Xinglin Zhang; Yihang Zhao; Xu Shi; Yan Hui; Junru Pan; Rui Qian; Xiaoshuang Dai; Zhigang Liu*; XueboLiu*. ApoE-Dependent Protective Effects of Sesamol on High-Fat Diet-Induced Behavioral Disorders: Regulation of the Microbiome-Gut-Brain Axis. Journal of Agricultural and Food Chemistry 2019;67(22):6190-6201.
16. Guoyuan Qi; Yashi Mi; Rong Fan; Zhigang Liu*; Xuebo Liu*. Nobiletin Protects against Systemic Inflammation-Stimulated Memory Impairment via MAPK and NF-κB Signaling Pathways. Journal of Agricultural and Food Chemistry 2019;67(18):5122-5134.
17. Zhigang Liu#; Xiaoning Liu#; Shunyi Luo; Chuanqi Chu; Dandan Wu; Runhua Liu; Lei Wang; Jiamin Wang; Xuebo Liu*. Extract of Sesame Cake and Sesamol Alleviate Chronic Unpredictable Mild Stress-Induced Depressive-Like Behaviors and Memory Deficits. Journal of Functional Foods 2018;42:237-247.
18. Beita Zhao; Hua Liu; Jiamin Wang; Pujie Liu; Xintong Tan; Bo Ren; Zhigang Liu*; Xuebo Liu*. Lycopene Supplementation Attenuates Oxidative Stress, Neuroinflammation, and Cognitive Impairment in Aged CD-1 Mice. Journal of Agricultural and Food Chemistry 2018;66(12):3127-3136.
19. Rui Guo; Beita Zhao; Yijie Wang; Dandan Wu; Yutang Wang; Yafan Yu; Yuchen Yan; Wentong Zhang; Zhigang Liu*; Xuebo Liu*. Cichoric Acid Prevents Free-Fatty-Acid-Induced Lipid Metabolism Disorders via Regulating Bmal1 in HepG2 Cells. Journal of Agricultural and Food Chemistry 2018;66(37):9667-9678.
20. Jia Wang; Zhuo Wang; Bing Li; Yu Qiang; Tian Yuan; Xintong Tan; Zihan Wang; Zhigang Liu*; Xuebo Liu*. Lycopene Attenuates Western-Diet Induced Cognitive Deficits via Improving Glycolipid Metabolism Dysfunction and Inflammatory Responses in Gut-Liver-Brain Axis. International Journal of Obesity 2018;43(9):1735-1746.
21. Jia Wang; Lixia Li; Zhuo Wang; Yifan Cui; Xintong Tan; Tian Yuan; Qian Liu; Zhigang Liu*; Xuebo Liu*.Supplementation of Lycopene Attenuates Lipopolysaccharide-Induced Amyloidogenesis and Cognitive Impairments via Mediating Neuroinflammation and Oxidative Stress. Journal of Nutritional Biochemistry 2018;56:16-25.
22. Front Cover Article: Zhigang Liu#; Yuwei Chen#; QinglianQiao; Yali Sun; Qian Liu; Bo Ren; Xuebo Liu*. Sesamol Supplementation Prevents Systemic Inflammation-Induced Memory Impairment and Amyloidogenesis via Inhibition of Nuclear Factor KappaB. Molecular Nutrition & Food Research 2017;61(5):10.
23. 劉學波; 劉小寧; 原田; 劉志剛* 芝麻酚的神經保護作用及分子機制《中國食品學報》2017;17(10):1-7.
24. Zhigang Liu#; Yali Sun#; QinglianQiao; Tong Zhao; Wentong Zhang; Bo Ren; Qian Liu; Xuebo Liu*. Sesamol Ameliorates High-Fat and High-Fructose Induced Cognitive Defects via Improving Insulin Signaling Disruption in the Central Nervous System. Food & Function 2017;8(2):710-719.
25. Zhigang Liu; Patil Ishan; Sancheti Harsh; Yin Fei; Cadenas Enrique*. Effects of Lipoic Acid on High-Fat Diet-Induced Alteration of Synaptic Plasticity and Brain Glucose Metabolism: A PET/CT and13C-NMR Study. Scientific Reports 2017;7(1):5391.
26. Qian Liu; Yaya Hu; Youfang Cao; Ge Song; Zhigang Liu*; Xuebo Liu*. Chicoric Acid Ameliorates Lipopolysaccharide-Induced Oxidative Stress via Promoting the Keap1/Nrf2 Transcriptional Signaling Pathway in BV-2 Microglial Cells and Mouse Brain. Journal of Agricultural and Food Chemistry 2017;65(2):338-347.
27. Zhigang Liu; Bo Ren; Yihui Wang; Chen Zou; QinglianQiao; Zhijun Diao; Yashi Mi; Di Zhu; Xuebo Liu*. Sesamol Induces Human Hepatocellular Carcinoma Cells Apoptosis by Impairing Mitochondrial Function and Suppressing Autophagy. Scientific Reports 2017;7:45728.
28. Ge Song#; Zhigang Liu#; Luanfeng Wang; Renjie Shi; Chuanqi Chu; Man Xiang; Qi Tian; Xuebo Liu*. Protective Effects of Lipoic Acid Against Acrylamide-Induced Neurotoxicity: Involvement of Mitochondrial Energy Metabolism and Autophagy. Food &Function2017;8:4657-4667.
29. Guoyuan Qi#; Zhigang Liu#; Rong Fan; Ziru Yin; Yashi Mi; Bo Ren; Xuebo Liu*. Athyrium multidentatum (Doll.) Ching extract induce apoptosis via mitochondrial dysfunction and oxidative stress in HepG2 cells. Scientific Reports 2017;7(1):2275.
30. Qian Liu; Yuwei Chen; Chun Shen; Yating Xiao; Yutang Wang; Zhigang Liu*; Xuebo Liu*. Chicoric acid supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of NF-κB. FASEB Journal 2017;31(4):1494-1507.
31. Zhigang Liu; Qinglian Qiao; Yali Sun; Yuwei Chen; Bo Ren; Xuebo Liu*. Sesamol Ameliorates Diet-Induced Obesity in C57BL/6J Mice and Suppresses Adipogenesis in 3T3-L1 Cells via Regulating Mitochondria-Lipid Metabolism. Molecular Nutrition & Food Research 2017; 63(8):e1600717
32. 劉學波，張文彤，郭瑞，劉志剛 高脂高果糖膳食影響腦認知功能的分子機制與研究進展《中國食品學報》 2016;16(10):1-9. EI
33. Zhigang Liu; Ge Song; Chen Zou; Gongguan Liu; Wanqiang Wu; Tian Yuan; Xuebo Liu. Acrylamide Induces Mitochondrial Dysfunction and Apoptosis in BV-2 Microglial Cells. Free Radical Biology & Medicine 2015;84:42-53.
34. Zhigang Liu; Ishan Y Patil; Tianyi Jiang; Harsh Sancheti; John P Walsh; Bangyan L Stiles; Fei Yin; Enrique Cadenas. High-Fat Diet Induces Hepatic Insulin Resistance and Impairment of Synaptic Plasticity. PLoS One 2015;10(5):e0128274.
35. 劉學波，劉志剛 線粒體介導食品功能因子活性與食品危害物毒性的分子機制《中國食品學報》2015;15(10):1-8. EI
36. Zhigang Liu; Qisen Xiang; Lihui Du; Ge Song; Yutang Wang; Xuebo Liu*. The Interaction of Sesamol with DNA and Cytotoxicity, Apoptosis, and Localization in HepG2 Cells. Food Chemistry 2013;141(1):289-296.

劉志剛代表性專利

1. 一種具有改善和緩解壓力作用的芝麻木酚素咀嚼片；已授權；專利授權國：中國；專利號：2017102429392；
2. 一種抗疲勞的苣蕒菜運動飲料；已授權；專利授權國：中國；專利號：201710219898.5。 [1] 

劉志剛國際會議

1. Intermittent Fasting Alleviates Diabetes-induced Cognitive Decline via Gut Microbiota-metabolites-brain Axis, American Society of Nutrition; Baltimore, Maryland, United States,2019 (Selected Oral Presentation).
2. The neuroprotective effects of sesamol and underlying molecular mechanisms. 3rdInternational Symposium of Food Science and Human Wellness; Changchun, Jilin, China, 2017 (Selected Oral Presentation).
3.芝麻酚改善認知記憶損傷的功能與分子機制探索，第三屆中國食品科學青年論壇，中國·上海 (Speaker).
4.Liu, Z., Liu, X.*The neuroprotective effects of sesamol. 3rdChinese Institute of Food Science Youth Forum; Shanghai, China, 2017 (Selected Oral Presentation).
5.Liu, Z., Liu, X.*The Glorious history of sesame food，2017 Industry Conference of White Sesame in Pingyu Country; Pingyu, Henan, China, 2017 (Invited Speaker).
6.Liu, Z., Chen, Y., and Liu, X.*Sesamol supplementation prevents systemic inflammation-induced memory impairment and amyloidogenesis via inhibition of nuclear factor kappaB. International Conference on Aging Research; Hangzhou, Zhejiang, China, 2016 (Poster).
7.Liu, Z., Cadenas, E.*, Effect of lipoic acid on high-fat diet-induced alteration of synaptic plasticity and brain glucose metabolism. Gordon Research Conference: Oxidative Stress & Disease; Ventura, California, United States. 2015.3 (Selected Oral Presentation).
8.Liu, Z., Cadenas, E.*,High-fat diet induces a systemic insulin resistance that impairs synaptic Plasticity. Oxygen Club of California (OCC) World Congress; UC Davis, Davis, California, United States. 2014.5 (Poster). [1] 
參考資料
  • 1.    教師  ．西北農林科技大學[引用日期2019-11-10]