黃文

1999–2002，四川大學，博士 ^[1] 

2002–2004，北京大學，博士後

2004–2006，北京中醫藥大學，藥學院

2006–2009，四川大學，生物治療國家重點實驗室

2009–至今，四川大學，華西醫院中藥藥理實驗室主任 ^[1] 

四川省學術帶頭人；聯合國人居署“SCP” 項目中方專家；中國—歐盟“EMCP”國際合作項目中方專家；國家中醫藥管理局項目評委；國家自然科學基金項目評審專家。 ^[1] 

天然藥物和傳統藥物藥理學，天然藥物及中藥新藥臨牀前研究與評價 ^[1] 

1. Bcl-xL調控mtDNA/P選擇素在糖尿病血瘀證發病中的作用及薯蕷皂苷的干預機制（國家自然科學基金，2017-2020，負責人）

2. 環戊烷並多氫菲類化合物抗新生血管新藥臨牀前基礎研究與評價（企業合作項目，2015-2020，負責人）

3. 環境有害化合物毒理及其生物降解研究（國家“十二五”科技支撐，2011-2015，負責人）

4. 一種新型高效單寧酰基水解酶的晶體結構及其催化機制（國家自然科學基金，2010-2012，負責人）

5. 靶向治療心血管疾病的薯蕷皂苷納米脂質載藥體系製備技術研究（四川省科技支撐，2008-2010，負責人）

6. 黃姜資源高值產品的開發和利用技術研究（國家“十一五”科技支撐，2006-2009，負責人）

7. 食品添加劑叔丁基對苯二酚（TBHQ）體內代謝及其檢測技術研究（國家“十五”科技攻關，2003-2005，負責人）

1. pH-Responsive nanoparticles based on ibuprofen prodrug as drug carriers for inhibition of primary tumor growth and metastasis. J Mat Chem B 2017, 5(33): 6860-6868.(IF 4.543，通訊作者)

2. Xanthohumol isolated from Humulus lupulus prevents thrombosis without increased bleeding risk by inhibiting platelet activation and mtDNA release. Free Radic Biol Med 2017, 108: 247-257. (IF 5.6059，通訊作者)

3. Deoxyarbutin displays antitumour activity against melanoma in vitro and in vivo through a p38-mediated mitochondria associated apoptotic pathway. Scientific reports 2017, 7: 12. (IF 4.2589，通訊作者)

4. Synthesis, characterization, and biological studies of diosgenyl analogs. Journal of Asian Natural Products Research 2017, 19(3): 272-298. (通訊作者)

5. Preventive effect of a novel diosgenin derivative on arterial and venous thrombosis in vivo. Bioorganic & Medicinal Chemistry Letters 2016, 26(14): 3364-3369. (通訊作者)

6. One compound of saponins from Disocorea zingiberensis protected against experimental acute pancreatitis by preventing mitochondria-mediated necrosis. Scientific reports 2016, 6: 35965. (IF 4.2589，通訊作者)

7. Metformin Uniquely Prevents Thrombosis by Inhibiting Platelet Activation and mtDNA Release. Scientific reports 2016, 6: 36222. (通訊作者)

8. Synthesis, characterization, and biological studies of diosgenyl analogs. J Asian Nat Prod Res 2016: 1-27. (通訊作者)

9. 9,10-Dihydrophenanthrene derivatives and one 1,4-anthraquinone firstly isolated from Dioscorea zingiberensis C. H. Wright and their biological activities. Fitoterapia 2016, 109: 20-24. (通訊作者)

10. Novel polyacetylenes from Coreopsis tinctoria Nutt. Journal of Asian Natural Products Research 2015, 17(7): 744-749. (通訊作者)

11. Reference Intervals for Hemoglobin and Age- and Gender-Related Trends in the Population of Southwest China. Clinical Laboratory 2015, 61(12): 1831-1836. (通訊作者)

12. Haloemodin as Novel Antibacterial Agent Inhibiting DNA Gyrase and Bacterial Topoisomerase I. Journal of Medicinal Chemistry 2014, 57(9): 3707-3714. (IF 6.2589，通訊作者)

13. Micro-flowers changing to nano-bundle aggregates by translocation of the sugar moiety in Janus TA nucleosides. Chemical Communications 2013, 49(36): 3742-3744. (IF6.3189，通訊作者)

14. Anti-thrombosis effect of diosgenyl saponins in vitro and in vivo. Steroids 2013, 78(11): 1064-1070. (通訊作者)

15. Synthesis of Diosgenin-Ibuprofen Derivatives and Their Activities against Insulin-Dependent Diabetes Mellitus. Chemical & Pharmaceutical Bulletin 2013, 61(5): 532-538. (通訊作者)

16. Determination of deltonin in rat plasma by using HPLC-MS/MS and the application of this method in pharmacokinetic studies. Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences 2013, 931: 1-5. (通訊作者)

17. Cytotoxicity and apoptosis-inducing effect of steroidal saponins from Dioscorea zingiberensis Wright against cancer cells. Steroids 2012, 77(12): 1219-1227. (通訊作者)

18. Ultrasonic and fermented pretreatment technology for diosgenin production from Diosorea zingiberensis CH Wright. Chemical Engineering Research & Design 2011, 89(2A): 239-247. (通訊作者)

19. Anti-thrombosis effect of diosgenin extract from Dioscorea zingiberensis CH Wright in vitro and in vivo. Phytomedicine 2011, 18(6): 458-463. (通訊作者)

20. Anti-thrombotic activity and chemical characterization of steroidal saponins from Dioscorea zingiberensis C.H. Wright. Fitoterapia 2010, 81(8): 1147-1156. (通訊作者)

21. Robinetinidol-(4beta--＞8)-epigallocatechin 3-O-gallate, a galloyl dimer prorobinetinidin from Acacia mearnsii De Wild, effectively protects human neuroblastoma SH-SY5Y cells against acrolein-induced oxidative damage. J Alzheimers Dis 2010, 21(2): 493-506.（第一作者）

22. Rutin inhibits hydrogen peroxide-induced apoptosis through regulating reactive oxygen species mediated mitochondrial dysfunction pathway in human umbilical vein endothelial cells. Eur J Pharmacol 2010, 628(1-3): 27-35. (通訊作者)

23. Optimised ultrasonic-assisted extraction of flavonoids from Folium eucommiae and evaluation of antioxidant activity in multi-test systems in vitro. Food Chemistry 2009, 114: 1147-1154.（第一作者）

24. The best utilization of D. zingiberensis C.H. Wright by an eco-friendly process. Bioresource Technology 2008, 99(15): 7407-7411.（第一作者）

25. Ellagic acid from acorn fringe by enzymatic hydrolysis and combined effects of operational variables and enzymes on yield of the production. Bioresource Technology 2008, 99(6): 1518-1525.（第一作者）

26. Optimization of ellagic acid production from ellagitannins by co-culture and correlation between its yield and activities of relevant enzymes. Bioresource Technology 2008, 99(4): 769-775.（第一作者）

27. Bioactivity of Solanesol Extracted from Tobacco Leaves with Carbon Dioxide-Ethanol Fluids. Biochemical Engineering Journal 2008, 42: 92-96.（第一作者）

28. Utilization of acorn fringe for ellagic acid production by Aspergillus oryzae and Endomyces fibuliger. Bioresource Technology 2008, 99(9): 3552-3558.（第一作者）

29. Optimization of operating parameters of supercritical carbon dioxide extraction for lycopene production and extract antioxidant activity by response surface methodology. Journal of Food Engineering 2008, 89: 298-302.（第一作者）

30. Effect of ellagitanin acyl hydrolase, xylanase and cellulase on ellagic acid production from cups extract of valonia acorns. Process Biochemistry 2007, 42: 1291-1295.（第一作者） ^[1]