魏煒

1，生物體內微量金屬元素和無機多聚物的代謝機制及調控功能：

微量金屬元素和無機多聚物在生命過程中有着一系列其他物質所不能替代的特殊作用。這些物質在體內的代謝水平紊亂，會導致多種疾病,包括癌症、神經退行性疾病、中風、腦出血、創傷性腦損傷等。為了研究其在生物體內的代謝機制及調控功能，我們將運用化學生物學，生物無機化學，微生物學，合成生物學和蛋白質組學等多學科交叉的研究方法，相關的主要課題包括：

(1)細胞鐵死亡相關金屬蛋白的作用機制;

(2)多聚磷酸鹽在原核及真核系統中的生物學功能。

2，基於光電驅動的新型半人工光合作用：

半人工光合作用系統是通過將具有光電催化功能的材料與具有生物活性的酶/微生物細胞複合構建的雜化系統，是合成生物學，化學生物學和材料科學等學科國際學者共同關注的熱點。設計開發新型的半人工光合系統並應用到醫藥和生物技術研究中將具有重要的科研價值和巨大的社會效益。相關的主要課題包括：

(1)光電驅動的微生物“非天然”生物合成。

3，無機二維材料和金屬介導的免疫調控與干預。 ^[1] 

南京大學“仲英青年學者”2019年度南京大學魅力導師獎2018年度南京大學本科教學實踐優秀教師國際基因工程機器大賽金牌(2015,2016,2018)國際基因工程機器大賽最佳能源項目單項獎(2016) ^[1] 

代表性論文、論著：W. Wei(#); P. Sun; Z. Li; K. Song; W. Su; B. Wang; Y. Liu; J. Zhao(*), A surface-display biohybrid approach to light-driven hydrogen production in air, Science Advances, 2018.2.21, 4(2) IF：12.804 Mo Jianbin(#); Xie Qingyun; W. Wei(*); Zhao Jing(*), Revealing the immune perturbation of black phosphorus nanomaterials to macrophages by understanding the protein corona, Nature Communications, 2018.06.26, 9(1): 2480 IF：11.878 Yan Li(#); Sun Peiqing; Xu Yun; Xu Yun; W.Wei(*); Zhao Jing(*), Integration of a Gold-Specific Whole E. coli Cell Sensing and Adsorption Based on BioBrick, International Journal of Molecular Sciences, 2018, 19(12) IF：4.183 X. Wang(#); M. Zhu; F. Gao; W. Wei; Y. Qian; H.-K. Liu(*); J. Zhao(*), Imaging of a clickable anticancer iridium catalyst, Journal of Inorganic Biochemistry, 2017.12.29, 180: 179~185 IF：3.224 X. Wang(#); X. Wang; K. Hui; W. Wei; W. Zhang; A. Miao; L. Xiao; L. Yang, Highly Effective Polyphosphate Synthesis, Phosphate Removal, and Concentration Using Engineered Environmental Bacteria Based on a Simple Solo Medium-Copy Plasmid Strategy, Environmental Science & Technology, 2017, 52(1): 214~222 IF：7.149 S. Cai(#); Y. Shen; Y. Zou; P. Sun; W. Wei(*); J. Zhao(*); C. Zhang(*), Engineering highly sensitive whole-cell mercury biosensors based on positive feedback loops from quorum-sensing systems, Analyst, 2017.12.11, 143(3): 630~634 IF：4.019 F. Xiong(#); L. Lu; T.-Y. Sun; Q. Wu; D. Yan; Y. Chen; X. Zhang; W. Wei; Y. Lu; W.-Y. Sun; J. J. Li; J. Zhao(*), A bioinspired and biocompatible ortho-sulfiliminyl phenol synthesis, Nature Communications, 2017.1.19, 8 IF：11.878 Q. Wu(#); D. Yan(#); Y. Chen(#); T. Wang; F. Xiong; W. Wei; Y. Lu; W.-Y. Sun; J. J. Li; J. Zhao(*), A redox-neutral catechol synthesis, Nature Communications, 2017.1.27, 8: 14227~14227 IF：11.878 W. Wei(#); Y. Sun(#); M. Zhu; X. Liu; P. Sun; F. Wang; Q. Gui; W. Meng; Y. Cao(*); J. Zhao(*), Structural Insights and the Surprisingly Low Mechanical Stability of the Au–S Bond in the Gold-Specific Protein GolB, Journal of the American Chemical Society, 2015, 137(49): 15358~15361 IF：14.695 Wei, Wei(#); Liu, Xiangzhi; Sun, Peiqing; Wang, Xin; Zhu, Hong; Hong, Mei; Mao, Zong-Wan(*); Zhao, Jing(*), Simple Whole-Cell Biodetection and Bioremediation of Heavy Metals Based on an Engineered Lead-Specific Operon, Environmental Science & Technology, 2014.3.18, 48(6): 3363~3371 IF：7.149 Yang, Maiyun(#); Jalloh, Abubakar S.; Wei, Wei; Zhao, Jing(*); Wu, Peng(*); Chen, Peng R.(*), Biocompatible click chemistry enabled compartment-specific pH measurement inside E-coli, Nature Communications, 2014.9, 5: 4981 IF：11.878 Wang, Dongqi(#); Cai, Sheng; Ben, Rong; Zhou, Yang; Li, Xingwei; Zhao, Jing; Wei, Wei(*); Qian, Yong(*), Direct Access to Isoindolinone Derivatives by Palladium-Catalyzed C-H Activation and Isocyanide Insertion by Using Molecular Oxygen as the Sole Oxidant, Synthesis, 2014.8, 46(15): 2045~2050 IF：2.867 Yan, Li(#); Yan, Yiyong; Pei, Lei; Wei, Wei(*); Zhao, Jing(*), A G-quadruplex DNA-based, Label-Free and Ultrasensitive Strategy for microRNA Detection., Scientific Reports, 2014, 4: 7400~7400 IF：4.011 Yang, Hualin(#); Cui, Hanli; Wang, Longgang; Yan, Li; Qian, Yong; Zheng, Xi Emily; Wei, Wei(*); Zhao, Jing(*), A label-free G-quadruplex DNA-based fluorescence method for highly sensitive, direct detection of cisplatin, Sensors and Actuators B: Chemical, 2014.10, 202: 714~720 IF：6.393 Wei, Wei(#); Zhu, Tianze; Wang, Yue; Yang, Hualin; Hao, Ziyang; Chen, Peng R.(*); Zhao, Jing(*), Engineering a gold-specific regulon for cell-based visual detection and recovery of gold, Chemical Science, 2012, 3(6): 1780~1784 IF：9.556 Wei, Wei(#); Yang, Chun; Luo, Jun; Lu, Changmei; Wu, Yajun; Yuan, Sheng(*), Synergism between cucumber alpha-expansin, fungal endoglucanase and pectin lyase, Journal of Plant Physiology, 2010, 167(14): 1204~1210 IF：2.825 ^[1]