韋祖樟

2008年畢業於中國農業科學院，獲博士學位。2008-2013年就職於中國農業科學院上海獸醫研究所，從事豬繁殖與呼吸綜合徵病毒致病機理和標記疫苗的研究。2016-2017年美國賓夕法尼亞大學訪問學者。2013年-至今在廣西大學從事教學、科研工作 ^[1]  。

1.廣西新發與再發傳染病學會副主任委員

2.廣西畜禽傳染病協會副秘書長

主講課程 1.本科生課程：動物傳染病學

2.碩士研究課程：動物免疫學研究進展

3.碩士研究生課程：動物微生物學研究進展

4.博士研究生課程：人獸共患傳染病學

5.博士研究生課程：新發動物疫病研究進展 ^[1] 

豬新發與再發傳染病遺傳變異與致病性研究；豬繁殖與呼吸綜合徵病毒複製轉錄機制研究；豬繁殖與呼吸綜合徵病毒基因工程標記疫苗的研究 ^[1]  ；

主持（或參與）的主要科研項目 主持和參與的課題

1. 主持人：國家自然科學基金面上項目“豬塞內卡病毒毒力上升的分子基礎”（31972666）（2020-2023年）

2. 主持人：國家自然科學基金地區科學基金項目“豬繁殖與呼吸綜合徵病毒基因組RNA衣殼化機制的研究”（31660716）（2017-2020年）

3. 主持人：國家自然科學基金面上項目“動脈炎病毒細胞嗜性蛋白的鑑定”（31372444）（2014-2017年）。

4. 主持人：國家自然科學基金青年科學基金項目“PRRSV程序性-1核糖體移碼信號的結構和功能研究”（30901078）（2010-2012年）。

5. 主持人：廣西自然科學基金項目重點項目”基於PRRSV感染性克隆創制新型疫苗的研究” （2018GXNSFDA281021）（2019-2022年）。

6. 主持人：廣西自然科學基金項目面上項目”豬繁殖與呼吸綜合徵病毒基因組RNA包裝機制的研究” （2016GXNSFAA380159）（2016-2019年）。

7. 主持人：廣西大學科研基金項目“PRRSV細胞受體結合蛋白的鑑定（XGZ130959）”（2013-2017年）。

8. 主持人：以馬動脈炎病毒為載體的豬繁殖與呼吸綜合徵疫苗（20151269）（2016-2018年）

9. 主要參加人：國家重點研發計劃“ 豬病原微生物持續感染的協同發病機制” (2018YFD0500104)（2018-2020年）。

10. 主要參加人：863“現代農業技術領域“ 家畜病毒病基因工程疫苗創制”子課題 (2011AA10A208)（2011-2015年）。

11. 主要參加人：歐盟“第七框架”項目“PoRRSCon-New tools and approaches to control Porcine Reproductive and Respiratory Syndrome (PRRS) in the EU and Asia”--“豬藍耳病綜合防控制劑的創制”（FP7-KBBF-2009-3）（2010-2014年）。

取得的主要成果 發表文章

1. Emergence and phylogenetic analysis of a novel Seneca Valley virus strain in the Guangxi Province of China. Hao Wang, Chenxia Niu, Zuorong Nong, Dongqun Quan, Ying Chen, Ouyang Kang, Weijian Huang, Zuzhang Wei*. Research in Veterinary Science 130 (2020) 207–211. *Corresponding author.

2. Pathogenic Characteristics of a Porcine Astrovirus Strain Isolated in China. Qingli Fang, Cui Wang, Huan Liu, Qingping Wu, Siying Liang, Minli Cen, Qinting Dong, Yingyi Wei, Ying Chen, Kang Ouyang, Zuzhang Wei * and Weijian Huang*. Viruses (2019). 11, 1156. *Corresponding author.

3. Genetic analysis of porcine circovirus type 2 (PCV2) strains between 2002 and 2016 reveals PCV2 mutant predominating in porcine population in Guangxi, China. Jing Yao, Yanran Qin, Yue Zeng, Kang Ouyang, Ying Chen, *Weijian Huang, Zuzhang Wei*. BMC Veterinary Research (2019) 15:118. *Corresponding author.

4. Genetic analysis of porcine productive and respiratory syndrome virus between 2013 and 2014 in Southern parts of China: identification of several novel strains with amino acid deletions or insertions in nsp2. Shaofeng Hong, Ying Wei, Siyuan Lin, Jiabing Huang, Wei He, Jing Yao, Ying Chen, Ouyang Kang, Weijian Huang* and Zuzhang Wei* .BMC Veterinary Research (2019) 15:171. *Corresponding author.

5. Wei He, Ying Wei, Jing Yao, Xin Xie, Jiabin Huang, Siyuan Lin ,Kang Ouyang ,Ying Chen, Weijian Huang*，Zuzhang Wei*. Effect of an 88‑amino‑acid deletion in nsp2 of porcine reproductive and respiratory syndrome virus on virus replication and cytokine responses in vitro. Archives of Virology.2018. 2018. 163:1489–1501. *Corresponding author.

6. Yifeng Qin, Qingli Fang, Huan Liu, Chengyuan Ji,Ying Chen, Kang Ouyang, Zuzhang Wei*, Weijian Huang*. Construction of a reverse genetic system for porcine astrovirus. Archives of Virology. 2018. 163:1511–1518 *Corresponding author.

7. Zuzhang Wei, Tao Lin, Lichang Sun, Yanhua Li, Xiaoming Wang, Fei Gao, Runxia Liu, Feifei Tan,Jiaqi Lu, Ping Liu, Chunyan Chen, Hongbiao Zhang, Guangzhi Tong*, Shishan Yuan*. N-linked Glycosylation of GP5 of Porcine Reproductive and Respiratory Syndrome Virus is Critically Important for Virus Replication in vivo. Journal of virology 2012 Sep;86 (18):9941-51.

8. Zuzhang Wei, Debin Tian, Lichang Sun, TaoLin, Fei Gao, Yanhua Li, Jiaqi Lu, Ping Liu, Rong Zhang, Chunyan Chen, Runxia Liu, Guangzhi Tong*, Shishan Yuan*. Influence of N-linked Glycosylation of Minor Proteins of Porcine Reproductive and Respiratory Syndrome Virus on Infectious Virus Recovery and Receptor Interaction. Virology. 2012 Jul 20;429(1):1-11.

9. Zuzhang Wei, Jianwu Zhang, Jinshan Zhuang, Zhi Sun,Fei Gao, Shishan Yuan*. Immunization of pigs with a type 2 modified live PRRSV vaccine prevents the development of a deadly long lasting hyperpyrexia in a challenge study with highly pathogenic PRRSV JX143. Vaccine. 2013 Apr 12;31(16):2062-6.

10. Xiaomin Wang, Lichang Sun, Yanhua Li, Tao Lin, Fei Gao, Huochun Yao, Kongwang He, Guangzhi Tong*, Zuzhang Wei*,Shishan Yuan. Development of a differentiable virus via a spontaneous deletion in the nsp2 region associated with cell adaptation of porcine reproductive and respiratory syndrome virus. Virus research 2013 Jan;171(1):150-60. *Corresponding author.

11. Lichang Sun, Yanhua Li, Runxia Liu, Xiaomin Wang, Fei Gao, Tao Lin, Ting Huang , Huochun Yao, Guangzhi Tong, Hongjie Fan*, Zuzhang Wei*, Shishan Yuan. Porcine Reproductive and Respiratory Syndrome Virus ORF5a Protein is Essential for Virus Viability. Virus research (2013) Jan;171(1):178-85. *Corresponding author.

12. Shao Lun Zhai, Jin Xue Long, Wen Kang Wei , Qin-Ling Chen, ManLin Luo, DianHong Lv, DaCheng Wu, Fei Gao, ShiShan Yuan, GuangZhi Tong, ZuZhang Wei* ,High prevalence of torque teno sus virus in China and genetic diversity of the 5' non-coding region. Archives of virology. 2013 Jul;158(7):1567-73. *Corresponding author.

13. Haihong Zheng, Keyu Zhang, Xing-Quan Zhu, Changlong Liu, Jiaqi Lu, Fei Gao ,Yan Zhou, Hao Zheng , Tao Lin , Liwei Li ,Guangzhi Tong , Zuzhang Wei* ,Shishan Yuan*. Genetic manipulation of a transcription-regulating sequence of porcine reproductive and respiratory syndrome virus reveals key nucleotides determining its activity. Archives of virology. 2014 Aug;159(8):1927-40. *Corresponding author.

14. Lichang Sun, Yan Zhou, Runxia Liu, Yanhua Li, Fei Gao, Xiaomin Wang, Hongjie Fan, Shishan Yuan, Zuzhang Wei* ,Guangzhi Tong*. Cysteine residues of the Porcine Reproductive and Respiratory Syndrome Virus ORF5a Protein are not essential for virus viability. Virus research 2015 Feb 2;197:17-25 *Corresponding author.

15. Liwei Li, Zuzhang Wei, Yanjun Zhou, Fei Gao, Yifeng Jiang, Lingxue Yu, Hao Zheng, Wu Tong Shen, Yang Haihong Zheng, Tongling Shan ,Fei Liu, Tianqi Xia, Guangzhi Tong. Host miR-26a suppresses replication of porcine reproductive and respiratory syndrome virus by upregulating type I interferons Virus research . 2014 Sep 16;195C:86-94

16. Debin Tian, Zuzhang Wei, Jessika C. Zevenhoven-Dobbe, Runxia Liu, Guangzhi Tong, Eric J. Snijder*, Shishan Yuan*.Arterivirus minor envelope proteins are a major determinant of viral tropism in cell culture. Journal of virology. 2012 Apr;86(7):3701-12.

17. ShiShan Yuan, ZuZhang Wei. Construction of infectious cDNA clones of PRRSV: Separation of coding regions for nonstructural and structural proteins. 2008. Sci China Ser C-Life Sci. 51(NO. 2):1-10.

18. FeiFei Tan, Zuzhang Wei, YanhuaLi, Rong Zhang, JinshanZhuang, ZhiSun, ShishanYuan. Identification of non-essential regions in nucleocapsid protein of porcine reproductive and respiratory syndrome virus for replication in cell culture. Virus Research . 2011 Jun;158(1-2):62-71

19. Jiaqi Lu, Fei Gao, Zuzhang Wei, Ping Liu, Changlong Li, Haihong Zheng, Yanhua Li, Tao Lin and Shishan Yuan. A 5'-proximal Stem-loop Structure of 5' Untranslated Region of Porcine Reproductive and Respiratory Syndrome Virus Genome Is Key for Virus Replication. Virology Journal. 2011, 8:172

20. Shaolun Zhai, Cheng Yue, Zuzhang Wei, Jinxue Long, Duoliang Ran, Tao Lin, Yu Deng, Lv Huang, Lichang Sun, Haihong Zheng, Fei Gao, Hao Zheng, Shengnan Chen, Shishan Yuan.. High prevalence of a novel porcine bocavirus in weanling piglets with respiratory tract symptoms in China. Arch Virol. 2010 Aug;155(8):1313-7

21. ShaoLun Zhai, ShengNan Chen, Zuzhang Wei ,ShiShan Yuan , WenKang Wei ,JinXue Long. Co-existence of multiple strains of porcine circovirus type 2 in the same pig from China. Virology Journal. 2011 Nov 13;8:517

22. Fei Gao, Jiaqi Lu, Huochun Yao, Zuzhang Wei, Qian Yang, Shishan Yuan, Cis- Acting Structural Element in 5’ UTR Is Essential for Replication of Porcine Reproductive and Respiratory Syndrome Virus. Virus Research, 2012 Jan;163(1):108-19

23. Fei Gao, Huochun Yao, Jiaqi Lu, Zuzhang Wei, Haihong Zhen, Jinshan Zhuang,GuangzhiTong,* Shishan Yuan,*. Replacement of the heterologous 5’ untranslated region allows preservation of the fully functional activities of type 2 porcine reproductive and respiratory syndrome virus. Virology. 2013 Apr 25;439(1):1-12

24. Tao Lin, Xiangrui Li, Huochun Yao, Zuzhang Wei, Feifei Tan, Runxia Liu, Lichang Sun, Rong Zhang, Wenliang Li, Jiaqi Lu, Guangzhi Tong, Shishan Yuan. Use of reverse genetics to develop a novel marker porcine reproductive and respiratory syndrome virus. Virus Genes (2012) 45:548–555

申請專利：

1. 韋祖樟，王玉旭，賀微，李清清，謝欣，覃念，王豪，林思遠，黃加濱，陳櫻，歐陽康，黃偉堅. 豬繁殖與呼吸綜合徵病毒及其克隆載體和插入基因方法.專利號：202010081921.0.2020年

2. 韋祖樟，王豪，謝欣，任同偉，王玉旭，賀微，陳櫻，歐陽康，黃偉堅.豬繁殖與呼吸綜合徵病毒雙熒光標記基因重組毒株的構建方法.專利號: 202010081916.X, 2020年、 ^[1]