陳華兵

1997.09－2001.07 華中科技大學化學與化工學院，精細化工，本科；

2001.09－2004.07 華中科技大學化學與化工學院，無機化學，碩士；

2005.09－2008.07 華中科技大學生命科學與技術學院，生物製藥工程博士；

2008.08－2010.12 德克薩斯大學西南醫學中心Simmons腫瘤中心，博士後；

2010.12－2012.02 東京大學材料工程系Kataoka教授研究室，特任研究員；

2012.03－至今 蘇州大學藥學院，教授/特聘教授；

2018.09－至今 蘇州大學放射醫學與輻射防護國家重點實驗室，學術帶頭人 ^[1]  。

2022.01－至今 蘇州大學藥學院，副院長

2023年11月，全國納米技術標準化技術委員會納米生物醫藥標準化工作組委員兼副秘書長。 ^[2] 

1、腫瘤靶向納米藥物：構建多功能、靶向性、智能化納米載藥系統，通過增強藥物輸送效率、調控腫瘤微環境及免疫微環境、探索協同增效新機制等，實現腫瘤高效協同治療（如光治療與化療、免疫治療及放療等協同治療），為高致死、難治性腫瘤如胰腺癌等的高效治療提供新策略。

2、高性能納米影像探針：通過高分子載體的智能化和功能化設計，實現納米探針對腫瘤的超靈敏、高空間分辨的智能高對比度探測，為腫瘤早期發現及手術精準導航提供新手段。

3、新型納米制劑技術及臨牀轉化：構建具有臨牀應用前景的納米藥物載體（如單分子白蛋白納米粒、膠束、脂質體、納米晶及納米乳等）製備技術，開發高效、低毒的納米藥物新制劑，實現創新制劑產品的臨牀轉化。 ^[1] 

2012年回國後，建立了“納米藥物與分子影像”研究室，團隊現有教授3人、副教授4人及研究生20餘人。作為課題負責人，承擔了國家自然科學基金傑出青年科學基金（2021年）、優秀青年科學基金（2014年）、面上項目、青年基金、以及江蘇省“雙創計劃（2014年）”、“蘇州市高等院校、科研院所緊缺高層次人才引進資助計劃”、江蘇省333高層次人才培養工程（2018年）等國家及省市項目；2016年入選教育部“長江學者獎勵計劃”青年學者。作為核心成員，參與了放射醫學與輻射防護國家重點實驗室、“雙創計劃（團隊）”項目、江蘇省“特種醫學”優勢學科、“江蘇省重大神經精神疾病診療技術研究重點實驗室”等的建設。作為學術骨幹，曾參與了國家重大科學研究計劃、國家支撐計劃等重大項目的研究。在國外工作期間，分別參與了日本大型科研計劃FIRST項目和美國NIH納米醫學研究項目等。在教學方面，承擔了本科生專業課程《藥劑學》、《Pharmaceutics》（全英文）和專業前沿課程《納米技術與生物醫藥的變革》等的教學；牽頭建設的《藥劑學》在線課程被選為江蘇省一流課程。為研究生講授《藥學研究進展》、《Modern Pharmaceutics》（全英文）、《Modern Pharmaceutics and Drug Discovery》（全英文）等課程。

迄今為止，已發表SCI論文60餘篇，其中作為通訊作者在Adv. Mater., ACS Nano, Adv. Funct. Mater., Biomaterials, Theranostics, J. Control. Release等雜誌上發表論文30餘篇，其中影響因子大於10的論文近30篇，ESI高被引論文10餘篇。參編十三五規劃教材《藥劑學》(科學出版社，並列副主編)、以及《納米藥物》、《Bioinspired and Biomimetic Systems for Drug and Gene Delivery》、《Advances in Nanotheranostics II: Cancer Theranostic Nanomedicine》等中英文專著3本，獲授權中國發明專利10餘項、湖北省科技進步二等獎1項。擔任《藥學學報》、《Nanomaterials》、《Sci China Chem》、《Sci Bull》及《Asian J Pharm Sci》等期刊青年編委或客座編輯。被選為中國藥學會納米藥物專業委員會委員、中國抗癌協會納米腫瘤學專業委員會常務委員等。

主要承擔的科研及人才項目：

(1) 主持國家自然科學基金傑出青年科學基金項目“生物醫用高分子材料”（52125304），2022-2026年

(2) 主持國家自然科學基金面上項目“用於腫瘤光動力/光熱協同治療的低氧依賴性聚合物囊泡研究”（51873143），2019-2022年

(3) 主持國家自然科學基金面上項目“鉑類藥物蛋白納米粒的仿生合成及在耐藥腫瘤協同治療中的應用”（31671016），2017-2020年

(4) 江蘇省高等學校自然科學研究重大項目“鉑類藥物白蛋白納米粒的研究”（17KJA350003），2017-2020年

(5) 主持國家自然科學基金優秀青年科學基金項目“藥物載體”（31422021），2015-2017年

(6) 主持國家自然科學基金面上項目“用於腫瘤光熱/分子靶向雙向協同治療的聚合物膠束研究”（51473109），2015-2018年

(7) 主持江蘇省“雙創人才”項目，2015-2017年

(8) 主持國家自然科學基金青年科學基金項目“用於肝轉移瘤早期探測的可激活近紅外熒光納米探針研究”（81202472），2013-2015年

(9) 主持“蘇州市高等院校、科研院所緊缺高層次人才引進資助計劃”，2014-2018年

(10) 主持湖北省科技攻關項目“鬼臼毒素微乳凝膠劑的研製”(2005AA301B10), 2005-2007年

(11) 參與江蘇省“特種醫學”優勢學科項目（PAPD），2015-2018年

(12) 參與江蘇省“雙創計劃（團隊）”項目，2015-2017年

(13) 參與“江蘇省重大神經精神疾病診療技術研究重點實驗室”建設項目，2014-2016年

(14) 參與國家重大研究計劃課題“新型導向性納米藥物載體的構建及表徵” （2006CB933301），2006-2008年

主要論文：

66. B. Liu#, J Jiao#, W Xu, M Zhang, P Cui, Z Guo, Y Deng*, H Chen*, and W Sun*. Highly Efficient far-red/NIR-absorbing neutral Ir(III) complex micelles for potent photodynamic/photothermal therapy. Adv Mater, 2021, 33, 2100795.

65. Z Guo#, H He#, Y Zhang#, J Rao#, T Yang, T Li, L Wang, M Shi, M Wang, S Qiu, X Song, H Ke, and H Chen*. Heavy-atom-modulated supramolecular assembly increases antitumor potency against malignant breast tumors via tunable cooperativity, Adv Mater, 2021, 33, 2004225.

64. M He#, T Yang#, Y Wang, M Wang, X Chen, D Ding*, Y Zheng*, H Chen*, Immune checkpoint inhibitor-based strategies for synergistic cancer therapy, Adv Healthc Mater, 2021, 10, 2002104

63. Z Wang#, Y Wang#, Y Wang#, C Wei, Y Deng, H Chen, J Shen*, H Ke*. Biomineralized iron oxide–polydopamine hybrid nanodots for contrast-enhanced T1-weighted magnetic resonance imaging and photothermal tumor ablation, J. Mater. Chem. B, 2021, 9, 1781-1786.

62. H Iqbal, T Yang, T Li, M Zhang, H Ke, D Ding, Y Deng* H Chen*. Serum protein-based nanoparticles for cancer diagnosis and treatment., J Control Release, 2021, 329, 997-1022.

61. Y Zhang#, M Shi#, Z Yan#, S Zhang#, M Wang, H Xu, H Li, Y Ying, S Qiu, J Liu*, H Yang, H Chen, H He*, Z Guo*. Ultrastable near-infrared nonlinear organic chromophore nanoparticles with intramolecular charge transfer for dually photoinduced tumor ablation, Adv Healthc Mater, 2020, 9, 2001042.

60. Z Yan#, M Wang#, M Shi, Y He, Y Zhang, S Qiu, H Yang, H Chen, H He*, Z Guo*. Amphiphilic BODIPY dye aggregates in polymeric micelles for wavelength-dependent photo-induced cancer therapy, J Mater Chem B, 2020, 8, 6886-6897.

59. C Li#, J Wang*, Y Wang#, H Gao#, G Wei#, Y Huang#, H Yu#, Y Gan#, Y Wang#, L Mei#, H Chen#, H Hu#, Z Zhang#, Y Jin#. Recent progress in drug delivery, Acta Pharmaceutica Sinica B, 2019, 9, 1145-1162.

58. Q Guo, Q Zhu, T Miao, J Tao, X Ju, Z Sun, H Li, G Xu, H Chen, L Han*. LRP1-upregulated nanoparticles for efficiently conquering the blood-brain barrier and targetedly suppressing multifocal and infiltrative brain metastases, J Control Release, 2019, 303, 117-129.

57. W Ke#, J Li#, F Mohammed, Y Wang, K Tou, X Liu, P Wen, H Kinoh, Y Anraku, H Chen, K Kataoka, Z Ge*. Therapeutic Polymersome Nanoreactors with Tumor-Specific Activable Cascade Reactions for Cooperative Cancer Therapy, ACS Nano, 2019, 13, 2357-2369.

56. H Zhao#, J Xu, W Huang, G Zhan, Y Zhao*, H Chen*, X Yang*. Spatiotemporally light-activatable platinum nanocomplexes for selective and cooperative cancer therapy, ACS Nano, 2019, 13, 6647-6661.

55. H Chen#, Z Gu#, H An, C Chen, J Chen, R Cui, S Chen, W Chen, X Chen, X Chen, Z Chen, B Ding, Q Dong, Q Fan, T Fu, D Hou, Q Jiang, H Ke, X Jiang, G Liu, S Li, T Li, Z Liu, G Nie, M Ovais, D Pang, N Qiu, Y Shen, H Tian, C Wang, H Wang, Z Wang, H Xu, J Xu, X Yang, S Zhu, X Zheng, X Zhang, Y Zhao, W Tan*, X Zhang*, Y Zhao*. Precise nanomedicine for intelligent therapy of cancer, Sci China Chem, 2018, 61, 1503-1552.

54. X Lv, X Wang, T Li, C Wei, Y Tang, T, Yang, Q Wang, X Yang, H Chen, J Shen*, H Yang*, H Ke*. Rationally designed monodisperse Gd2O3/Bi2S3 hybrid nanodots for efficient cancer theranostics, Small, 2018, 14, 1802904.

53. S Ye, J Rao, S Qiu, J Zhao, H He*, Z Yan, T Yang, Y Deng, H Ke, H Yang, Y Zhao, Z Guo*, H Chen*. Rational design of conjugated photosensitizers with controllable photoconversion for dually cooperative phototherapy, Adv Mater, 2018, 30, 1801216.

52. Y Tang, T Yang, Q Wang, X Lv, X Song, H Ke, Z Guo, X Huang, J Hu, Z Li, P Yang*, X Yang*, H Chen*. Albumin-coordinated assembly of clearable platinum nanodots for photo-induced cancer theranostics, Biomaterials, 2018, 154, 248-260.

51. Y Wang, Y Deng, H Luo, A Zhu, H Ke, H Yang, H Chen*. Light-responsive nanoparticles for highly efficient cytoplasmic delivery of anticancer agents, ACS Nano, 2017, 11, 12134-12144.

50. T Yang, H Ke, Q Wang, Y Tang, Y Deng*, H Yang, X Yang, P Yang, D Ling, C Chen, Y Zhao, H Wu*, H Chen*. Bifunctional tellurium nanodots for photo-induced synergistic cancer therapy, ACS Nano, 2017, 11, 10012-10024.

49. H Luo, Q Wang, Y Deng, T Yang, H Ke, H Yang, H He, Z Guo, D Yu, H Wu, H Chen*. Mutually synergistic nanoparticles for effective thermo-molecularly targeted therapy, Adv Funct Mater, 2017, 27, 1702834.

48. J Li, K Wei, S Zuo, Y Xu, Z Zha, W Ke, H Chen*, Z Ge*. Light-triggered clustered vesicles with self-supplied oxygen and tissue penetrability for photodynamic therapy against hypoxic tumor, Adv Funct Mater, 2017, 27, 1702108.

47. R Wen, X Lv, T Yang, Y Li, Y Tang, X Bai, H Ke*, J Shen*, H Chen*. Albumin nanoreactor-templated synthesis of Gd2O3/CuS hybrid nanodots for cancer theranostics, Sci China Mater, 2017, 60, 554-562 (Invited paper).

46. T Yang, L Liu, Y Deng, Z Guo, G Zhang, Z Ge*, H Ke*, H Chen*. Ultrastable near-infrared conjugated polymer nanoparticles for dually photoactive tumor inhibition, Adv Mater, 2017, 29, 1700487.

45. M Zhang, L Xing, H Ke, Y He, P Cui, Y Zhu, G Jiang, J Qiao, N Lu, H Chen*, H Jiang*. MnO2-based nanoplatform serves as drug vehicle and MRI contrast agent for cancer theranostics, ACS Appl Mater Interfaces, 2017, 9, 11337-11344.

44. H He, S Ji, Y He, A Zhu, Y Zou, Y Deng, H Ke, H Yang, Y Zhao*, Z Guo*, H Chen*. Photoconversion-tunable fluorophore vesicles for wavelength-dependent photo-induced cancer therapy, Adv Mater, 2017, 29, 1606690.

43. T Yang, Y Tang, L Liu, X Lv, Q Wang, H Ke, Y Deng, H Yang, X Yang, G Liu, Y Zhao, H Chen*. Size-dependent Ag2S nanodots for second near-infrared fluorescence/photoacoustics imaging and simultaneous photothermal therapy. ACS Nano, 2017, 11, 1848–1857.

42. L Zhou, T Yang, J Wang, Q Wang, X Lv, H Ke, Z Guo, J Shen, Y Wang*, C Xing*, H Chen*. Size-tunable Gd2O3@albumin nanoparticles conjugating Chlorin e6 for magnetic resonance imaging-guided photo-induced therapy. Theranostics, 2017, 7, 764-774.

41. Y Deng, L Huang, H Yang*, H Ke, H He, Z Guo, T Yang, A Zhu, H. Wu*, H Chen*. Cyanine-anchored silica nanochannels for light-driven synergistic thermo-chemotherapy. Small, 2017, 13, 1602747.

40. J Li, X He, Y Zou, D Chen, L Yang, J Rao, H Chen, M Chan, L Li, Z Guo, L Zhang*, C Chen. Mitochondria-targeted platinum(II) complexes: dual inhibitory activities on tumor cell proliferation and migration/invasion via intracellular trafficking of beta-catenin. METALLOMICS, 2017, 9, 726-733.

39. S Song, H Shen*, T Yang, L Wang, H Fu, H Chen, Z Zhang*. Indocyanine green loaded Magnetic Carbon Nanoparticles for Near Infrared Fluorescence/Magnetic Resonance Dual-modal imaging and photothermal therapy of tumor. ACS Appl Mater Interfaces, 2017, 9, 9484-9495.

38. Z Guo, Y Zou, H He, J Rao, S Ji, X Cui, H Ke, Y Deng, H Yang, C Chen, Y Zhao, H Chen*. Bifunctional platinated nanoparticles for photo-induced tumor ablation. Adv Mater, 2016, 28, 10155-10164.

37. T Yang, Y Wang, H Ke, Q Wang, X Lv, H Wu, Y Tang, X Yang, C Chen, Y Zhao, H Chen*. Protein nanoreactor-assisted synthesis of semiconductor nanocrystals for efficient cancer theranostics. Adv Mater, 2016, 28, 5923-5930.

36. X An, A Zhu, H Luo, H Ke, H Chen*, Y Zhao*. Rational design of multi-stimuli-responsive nanoparticles for precise cancer therapy. ACS Nano, 2016, 10, 5947-5958.

35. Y Ma, J Huang, S Song, H Chen*, Z Zhang*. Cancer-targeted nanotheranostics: recent advances and perspectives. Small, 2016, 12, 4936-4954.

34. X Ai, C Ho, J Aw, A Attia, J Mu, Y Wang, X Wang, Y Wang, X Liu, H Chen, M Gao, X Chen, E Yeow, G Liu, M Olivo, B Xing*. In vivo covalent cross-linking of photo-converted rare-earth nanostructures for tumor localization and theranostics. Nat Commun, 2016, 7, 10432.

33. Y Li, Y Deng, X Tian, H Ke*, M Guo, A Zhu, T Yang, Z Guo, Z Ge, X Yang, H Chen*. Multi-pronged design of light-triggered nanoparticles to overcome cisplatin resistance for efficient ablation of resistant tumor. ACS Nano, 2015, 9, 9626-9637.

32. A Zhu, K Miao, Y Deng, H Ke, H He, T Yang, M Guo, Y Li, Z Guo, Y Wang, X Yang, Y Zhao*, H Chen*. Dually pH/reduction-responsive vesicles for ultrahigh-contrast fluorescence imaging and thermo-chemotherapy-synergized tumor ablation. ACS Nano, 2015, 9,7874-7885.

31. Y Wang, T Yang, H Ke, A Zhu, Y Wang, J Wang, J Shen, G Liu, C Chen, Y Zhao, H Chen*. Smart albumin-biomineralized nanocomposites for multimodal imaging and photothermal tumor ablation. Adv Mater, 2015, 27, 3874-3882.

30. J Huang, M Guo, H Ke, C Zong, B Ren*, G Liu, H Shen, Y Ma, X Wang, H Zhang, Z Deng, H Chen*, Z Zhang*. Rational design and synthesis of γFe2O3@Au magnetic gold nanoflowers for efficient cancer theranostics. Adv Mater, 2015, 27, 5049-5056.

29. M Guo, J Huang, Y Deng, H Shen, Y Ma, M Zhang, A Zhu, Y Li, H He, Y Wang, X Yang, Z Zhang*, H Chen*. pH-responsive cyanine-grafted graphene oxide for fluorescence resonance energy transfer-enhanced photothermal therapy. Adv Funct Mater, 2015, 25, 59-67.

28. J Li, Z Lyv, Y Li, H Liu, J Wang, W Zhan, H Chen*, H Chen*, X Li*. A theranostic prodrug delivery system based on Pt(IV) conjugated nano-graphene oxide with synergistic effect to enhance the therapeutic efficacy of Pt drug. Biomaterials, 2015, 51, 12-21.

27. H Chen, L Xiao, Y Anraku, P Mi, X Liu,H Cabral, A Inoue, T Nomoto, A Kishimura*, N Nishiyama*, K Kataoka*. Polyion complex vesicles for photo-induced intracellular delivery of amphiphilic photosensitizer. J Am Chem Soc, 2014, 136, 157-163.

26. M Guo, H Mao, Y Li, A Zhu, H He, H Yang, Y Wang, X Tian, C Ge, Q Peng, X Wang, X Yang, X Chen, G Liu*, H Chen*. Dual imaging-guided photothermal/photodynamic therapy using micelles. Biomaterials, 2014, 35, 4656-4666.

25. Z Wan, H Mao, M Guo, Y Li, A Zhu, H Yang, H He, J Shen, L Zhou, Z Jiang, C Ge, X Chen, X Yang, G Liu, H Chen*. Highly efficient hierarchical micelles integrating photothermal therapy and singlet oxygen-synergized chemotherapy for cancer eradication. Theranostics, 2014, 4, 399-411.

24. H Liu#, Y Li#, Z Lyu#, Y Wan, X Li, H Chen, H Chen, X Li*. Enzyme-triggered supramolecular self-assembly of platinum prodrug with enhanced tumor-selective accumulation and reduced systemic toxicity. J Mater Chem B, 2014, 2, 8303-8309.

23. H Yang, H Mao, Z Wan, A Zhu, M Guo, Y Li, X Li, J Wan, X Yang, X Shuai, H Chen*. Micelles assembled with carbocyanine dyes for theranostic near-infrared fluorescent cancer imaging and photothermal therapy. Biomaterials, 2013, 34, 9124-9133.

22. G Huang#, H Chen#, Y Dong#, X Luo, H. Yu, ZMoore, E Bey, D Boothman*, J Gao*. Superparamagnetic iron oxide nanoparticles: amplifying ROS stress to improve anticancer drug efficacy. Theranostics, 2013, 3,116-126.

21. H Zhu, J Hao, H Chen, S Jiang, M Liu, H Sun, H Xu, J Zhang, X Yang*. Nanovesicles system for rapid-onset sublingual delivery containing sodium tanshinone IIA sulfonate: In vitro and in vivo evaluation. J Pharm Sci-us, 2013, 102,2332-2340.

20. H Chen, H Zhu, J Hu, Y Zhao, Q Wang, J Wan, Y Yang, H Xu, X Yang*. Highly compressed assembly of deformable nanogels into nanoscale suprastructures and their application in nanomedicine. ACS Nano, 2011, 5, 2671-2680.

19. H Chen, C Khemtong, X Yang, X Chang, J Gao*. Nanonization strategies for poorly water-soluble drugs. Drug Discov Today, 2011, 16, 354-360.

18. D Mou, H Chen, J Wan, H Xu, X Yang*. Potent dried drug nanosuspensions for oral bioavailability enhancement of poorly soluble drugs with pH-dependent solubility. Int J Pharm, 2011, 413, 237-224.

17. W Xiong, W Wang, Y Wang, Y Zhao*, H Chen, H Xu, X Yang. Dual temperature/pH-sensitive drug delivery of poly(N-isopropylacrylamide-co-acrylic acid) nanogels conjugated with doxorubicin for potential application in tumor hyperthermia therapy. Colloids Surf B, 2011, 84, 447-453.

16. L Xiao, X Xiong, X Sun, Y Zhu, H Yang, H Chen, L Gan*, H Xu, X Yang*. Role of cellular uptake in the reversal of multidrug resistance by PEG-b-PLA polymeric micelles. Biomaterials, 2011, 32, 447-453.

15. H Chen, L Xiao, D Du, D Mou, H Xu, X Yang*. A facile construction strategy of highly stable nanoparticles for drug delivery using a hydrogel-thickened microemulsion system as a template. Nanotechnology, 2010, 21, 5148-5157.

14. C Mao, J Wan, H Chen, H Xu, X Yang*. The composition of oil phase modulates venous irritation of lipid emulsion-loaded diallyl trisulfide. Drug Development and Industrial Pharmacy, 2010, 36, 698-704.

13. E Blanco, E A Bey, C Khemtong, S-G Yang, J Setti-Guthi, H Chen, C W Kessinger, K A Carnevale，W G Bornmann*, D A Boothman, J Gao*. β-Lapachone micellar nanotherapeutics for non–small cell lung cancer therapy. Cancer Res, 2010, 70, 3896-3904.

12. H Chen, H Zhu, J Zheng, D Mou, J Wan, J Zhang, T Shi, Y Zhao, H Xu, X Yang*. The iontophoresis-driven penetration of lecithin-based nanovesicles through microneedle-induced skin microchannels for transdermal delivery of insulin. J Control Release, 2009, 139, 63-72.

11. C Mao, J Wan, H Chen, H Xu, X Yang*. Emulsifiers’ composition modulates venous irritation of the nanoemulsions as a lipophilic and venous irritant drug delivery system. AAPS PharmSciTech, 2009, 10, 1058.

10. H Chen, J Wan, Y Wan, D Mou, H Liu, H Xu, X Yang*. A facile nanoaggregation strategy for oral delivery of hydrophobic drug by utilizing acid-base neutralization reaction. Nanotechnology, 2008, 19, 375104.

9. L Xu, H Chen, H Xu, X Yang*. Anti-tumour and immuno-modulation effects of triptolide-loaded polymeric micelles. Eur J Pharm Biopharm, 2008, 70, 741-748.

8. D Mou, H Chen*, D Du, C Mao, J Wan, H Xu, X Yang*. Hydrogel-thickened nanoemulsion system for topical delivery of lipophilic drugs. Int J Pharm, 2008, 353, 270-276.

7. H Chen, D Mou, D Du, X Chang, D Zhu, J Liu, H Xu, X Yang*. Hydrogel-thickened microemulsion for topical administration of drug molecule at an extremely low concentration. Int J Pharm, 2007, 341, 78-84.

6. J Liu, W Hu, H Chen, Q Ni, H Xu, X Yang*. Isotretinoin-loaded solid lipid nanoparticles with skin targeting for topical delivery. Int J Pharm, 2007, 328, 191-195.

5. H Chen, X Chang, D Du, W Liu, J Liu, T Weng, Y Yang, H Xu, X Yang*. Podophyllotoxin-loaded Solid lipid nanoparticles for epidermal targeting. J Control Release, 2006, 110, 296-306.

4. H Chen, X Chang, D Du, J Li, H Xu, X Yang*. Microemulsion-based hydrogel formulation of ibuprofen for topical delivery. Int J Pharm, 2006, 315, 52-58.

3. X Chang, H Chen, X Zhao, Z Gao, H Xu, X Yang*. High-performance liquid chromatography determination of triptolide in vitro permeation studies. Analytica Chimica Acta, 2005, 534, 215-221.

2. H Chen, X Chang, T Weng, X Zhao, Z Gao,Y Yang, H Xu, X Yang*. A study of microemulsion systems for transdermal delivery of triptolide. J Control Release, 2004, 98, 427-436.

1. Solid lipid nanoparticle and microemulsion for topical delivery of triptolide. Eur J Pharm Biopharm, 2003, 56, 189-196. ^[1]