陳化蘭

1987年，考入甘肅農業大學獸醫系，1991年，獲學士學位後繼續在甘肅農業大學獸醫系獸醫病理專業，就讀研究生。1994年，碩士畢業後考入中國農業科學院研究生院 ^[7]  。

1997年，獲得傳染病與預防獸醫學專業博士學位，之後在中國農業科學院哈爾濱獸醫研究所擔任助理研究員。

1999年，前往美國疾病控制中心流感分中心進行博士後工作，進行禽流感合作研究。

2002年，回到中國，擔任中國農業科學院哈爾濱獸醫研究所研究員，並先後擔任農業部動物流感重點開放實驗室主任，國家禽流感參考實驗室主任。

2005年11月9日，獲得第二屆中國青年女科學家獎 ^[1]  。2006年，獲得中國青年五四獎章 ^[2]  。

2008年，擔任世界動物衞生組織禽流感參考實驗室主任。2008年，獲得國家傑出青年科學基金 ^[8]  。2009年，加入九三學社 ^[9]  。

2015年10月，獲得聯合國教科文組織-歐萊雅頒發的“世界傑出女科學家成就獎”，是第五位獲得此獎的中國人。同年被評為湯森路透“全球高被引科學家”之一 ^[3]  。

2016年6月，獲得全國傑出科技人才獎和中國優秀青年科技人才獎。

2017年11月，當選中國科學院院士 ^[10]  。

2018年3月至2023年3月，任政協第十三屆全國委員會農業和農村委員會委員。 ^{[11]  [39]} 

2018年11月，全國婦聯副主席（兼），中國農業科學院哈爾濱獸醫研究所研究員，農業農村部動物流感重點開放實驗室主任，中國科學院院士。 ^[13] 

2022年06月，任九三學社黑龍江省第九屆委員會副主任委員。 ^[33-34] 

2022年12月，九三學社第十五屆中央委員會常務委員。 ^[36] 

2023年10月，任全國婦聯第十三屆副主席（兼）。 ^[40] 

第十二、十三、第十四屆全國政協委員，第十三、十四屆全國政協農業和農村委員會委員 ^{[11-12]  [38-39]}  ，九三學社第十五屆中央委員會委員。 ^[37] 

陳化蘭 工作(3張)

陳化蘭主持國家禽流感參考實驗室，系統開展了中國禽流感流行病學監測和研究工作，取得了一系列重大進展和創造性研究成果，初步闡明有關禽流感病毒的分子遺傳、抗原變異及致病性演化規律，為疫情的預警預報、防制策略、診斷試劑及疫苗研製與使用提供了全面的科學依據。在防制禽流感期間，迅速準確確診來自全國各地的大量樣品，對疫情的及時有效控制起到了關鍵作用，她主持研製的有關禽流感滅活疫苗已累計推廣應用60億羽份以上，為防控禽流感疫情作出了重大貢獻 ^[14]  。

主持國家禽流感參考實驗室在動物流感尤其是禽流感的流行病學、診斷技術、新型疫苗研製、分子演變及分子致病機制等方面取得了一系列重大進展和創造性研究成果，研製成功了H5 亞型禽流感滅活疫苗和新型“禽流感、新城疫重組二聯活疫苗”，代表了禽流感疫苗研製的國際先進水平和發展趨勢，推廣應用後，極大地提高了中國乃至世界防控禽流感的能力，具有十分重要的社會經濟及公共衞生意義 ^[15]  。

2013年4月，陳化蘭和她的科研團隊發現，在中國導致人感染的新型H7N9流感病毒，與同一時期存在於活禽市場上的H7N9禽流感病毒高度同源，在國際上首次從病原學角度揭示了新型H7N9流感病毒的來源，為中國科學防控H7N9禽流感提供了重要依據。5月，她們又發現H5N1病毒確有可能通過與人流感病毒的基因重配，獲得在哺乳動物之間高效空氣傳播的能力，從而具備引起人間大流行的潛力，從全新的角度揭示了H5N1病毒對全球公共衞生構成的現實威脅 ^[16]  。7月，她和科研人員研究發現，H7N9病毒對禽類無致病力，但該病毒侵入人體發生突變後，對哺乳動物的致病力與水平傳播能力得到明顯增強，從而揭示了H7N9病毒存在較大人間大流行的風險。這些成果先後發表在《科學通報》英文版及《科學（SCIENCE）》雜誌上 ^[17-18]  。

2019年11月20日，中國農業科學院發佈了10項能夠充分代表2018年我國農業科技前沿研究水平、取得重大突破性進展的基礎科學研究成果，其中包括：H7N9高致病性禽流感病毒的快速進化及其成功防控。該研究由中國農科院哈爾濱獸醫研究所陳化蘭院士團隊主導，通過對家禽禽流感病毒進行大規模監測，對分離的H7N9高致病性禽流感病毒進行系統研究，成功研發了H5、H7二價禽流感滅活疫苗，監測結果顯示疫苗免疫後有效阻斷了H7N9病毒在家禽中的流行，在阻斷人感染H7N9病毒方面也取得了“立竿見影”的效果。 ^[19] 

1994年以來，陳化蘭一直從事禽流感及豬流感相關基礎研究和應用研究，先後主持國家“攻關”、“863”、“973”、國家自然科學基金等科研項目20多項。

截止到2014年，陳化蘭在國際重要學術雜誌發表禽流感研究相關SCI論文50多篇；已獲得6個禽流感疫苗新獸藥證書，其中3個為基因工程疫苗；獲得7項國家發明專利 ^[23]  。

1. Yanbing Li, Liling Liu, Yi Zhang, Zhenhua Duan, Guobin Tian, Xianying Zeng, Jianzhong Shi, Licheng Zhang, Hualan Chen*. New lineage of H5N1 influenza virus detected in wild birds in Qinghai, western China. Emerging Infectious Disease, 2010, in press.

2. Ying Chen, Gongxun Zhong, Guojun Wang, Guohua Deng, Yanbing Li, Jianzhong Shi, Zhuo Zhang, Yuntao Guan, Yongping Jiang, Zhigao Bu, Yoshihiro Kawaoka, Hualan Chen*. Dogs are highly susceptible to H5N1 avian influenza virus. Virology. 2010, 405, 15-19, on-line, June 25.

3. Lihong Tao, Jinying Ge, Xijun Wang, Hongyue Zhai, Tao Hua, Bolin Zhao, Dongni Kong, Chinglai Yang, Hualan Chen*, and Zhigao Bu*. Molecular Basis of Neurovirulence of Flury Rabies Virus Vaccine Strains: Importance of the Polymerase and the Glycoprotein R333Q Mutation. Journal of Virology. 2010, 84 (17), 8926-8936. on-line, June 10

4. Yanbing Li, Jianzhong Shi, Gongxun Zhong, Guohua Deng, Guobin Tian, Jinying Ge, Xianying Zeng, Jiasheng Song, Dongming Zhao, Liling Liu, Yongping Jiang, Yuntao Guan, Zhigao Bu, Hualan Chen*. Continued evolution of H5N1 influenza viruses in wild birds, domestic poultry and humans in China from 2004 to 2009. Journal of Virology. 2010, 84(17), 8389-8379. On-line, June 10.

5. Yujie Tang, Gongxun Zhong, Lianhui Zhu, Xing Liu, Yufei Shan, Huapeng Feng, Zhigao Bu, Hualan Chen*, and Chen Wang. Herc5 Attenuates Influenza A Virus by Catalyzing ISGylation of Viral NS1 Protein. Journal of Immunology, 2010, 184, 5777-5790

6. Bo Wah Leung, Hualan Chen, George G. Brownlee. Correlation between polymerase activity and pathogenicity in two duck H5N1 influenza viruses suggests that the polymerase contributes to pathogenicity. Virology, 2010, 401：96-106.

7. Yuwei Gao, Ying Zhang, Kyoko Shinya, Guohua Deng, Yongping Jiang, Zejun Li, Yutao Guan, Guobin Tian, Yanbing Li, Jianzhong Shi, Liling Liu, Xianying Zeng, Zhigao Bu, Xianzhu Xia, Yoshihiro Kawaoka, Hualan Chen*. Identification of Amino Acids in HA and PB2 Critical for the Transmission of H5N1 Avian Influenza Viruses in a Mammalian Host. PLoS Pathogens, 2009, 5(12): e1000709.

8. Yongping Jiang, Hongbo Zhang, Guojun Wang, Pingjing Zhang, Guobin Tian, Zhigao Bu, and Hualan Chen*. Protective Efficacy of H7 Subtype Avian Influenza DNA Vaccine. Avian Disease, 2010, 54(S1), 294-296.

9. Jinying Ge, Guobin Tian, Xianying Zeng, Yongping Jiang, Hualan Chen and Zhigao Bu*. Generation and Evaluation of a Newcastle Disease Virus-Based H9 Avian Influenza Live Vaccine. Avian Disease, 2010, 54(S1), 290-293.

10. Guobin Tian, Xianying Zeng, Yanbing Li, Jianzhong Shi, Hualan Chen*. Protective Efficacy of the H5 Inactivated Vaccine against Different Highly Pathogenic H5N1 Avian Influenza Viruses Isolated in China and Vietnam. Avian Disease, 2010, 54(S1), 287-289.

11. Neumann G, Chen H, Gao GF, Shu Y, Kawaoka Y. H5N1 influenza viruses: outbreaks and biological properties. Cell Research, 2010, 20(1):51-61

12. Qimeng Tao , Xiurong Wang, Hongmei Bao, Jianan Wu , Lin Shi, Yanbing Li, Chuanling Qiao , Yakovlevich SA, Mikhaylovna PN, Hualan Chen. Detection and differentiation of four poultry diseases using asymmetric reverse transcription polymerase chain reaction in combination with oligonucleotide microarrays. J Vet Diagn Invest. 2009;21(5):623-632

13. Chuantian Xu, Qiyun Zhu, Huanliang Yang, Xiumei Zhang, Chuanling Qiao, Yan Chen, Xiaoguang Xin, Hualan Chen*. Two genotypes of H1N2 influenza viruses appeared among pigs in China. Journal of Clinical Virology. 2009, 46: 192-195.

14. Hualan Chen, Zhigao Bu. Development and application of avian influenza vaccines in China. Current Topics in Microbiology and Immunology. 2009;333:153-62 (Review)

15. Hualan Chen. Avian influenza vaccination: the experience in China. Rev Sci Tech. 2009, 28(1): 267-74 (Review)

16. Jiyong Zhou, Wenbo Sun, Junhua Wang, Junqing Guo, Wei Yin, Nanping Wu, Lanjuan Li, Yan Yan, Ming Liao, Yu Huang, Kaijian Luo, Xuetao Jiang, Hualan Chen. Characterization of the H5N1 Highly Pathogenic Avian Influenza Virus derived from Wild Pikas in China. J Virol. 2009, 83: 8957-8964

17. Hualan Chen. H5N1 avian influenza in China. Sci China C Life Sci. 2009, 52(5):419-27. (Review)

18. Szretter KJ, Gangappa S, Belser JA, Zeng H, Chen H, Matsuoka Y, Sambhara S, Swayne DE, Tumpey TM, Katz JM. Early Control of H5N1 Influenza Virus Replication by the Type I Interferon Response in Mice. J Virol. 2009 83(11): 5825-34

19. Kashiwagi T, Leung BW, Deng T, Chen H, Brownlee GG.. The N-terminal region of the PA subunit of the RNA polymerase of influenza A/HongKong/156/97 (H5N1) influences promoter binding. PLoS ONE. 2009; 4(5):e5473.

20. Shufang Fan, Yuwei Gao, Kyoko Shinya, Chris K-F. Li, Yanbing Li, Jianzhong Shi, Yongping Jiang, Yongbing Suo, Tiegang Tong, Gongxun Zhong, Jiasheng Song, Ying Zhang, Guobin Tian, Yuntao Guan, Xiaoning Xu, Zhigao Bu, Yoshihiro Kawaoka , Hualan Chen. Immunogenicity and protective efficacy of a live attenuated H5N1 vaccine in nonhuman primates. PLoS Pathogens, 2009, 5(5), e1000409

21. Chuanling Qiao, Yongping Jiang, Guobin Tian, Xiurong Wang, Chengjun Li, Xiaoguang Xin, Hualan Chen, Kangzhen Yu. Recombinant Fowlpox Virus Vector-based Vaccine Completely Protects Chickens from H5N1 Avian Influenza Virus. Antiviral Research, 2009, 81(3):234-8

22. Shufang Fan, Guohua Deng, Jiasheng Song, Guobin Tian, Yongbing Suo, Yongping Jiang, Yuntao Guan, Zhigao Bu, Yoshihiro Kawaoka, Hualan Chen. Two amino acid residues in the matrix protein M1 contribute to the virulence difference of H5N1 avian influenza viruses in mice. Virology, 2009, 384: 29-32

23. Murakami S, Horimoto T, Mai le Q, Nidom CA, Chen H, Muramoto Y, Yamada S, Iwasa A, Iwatsuki-Horimoto K, Shimojima M, Iwata A, Kawaoka Y. Growth determinants for H5N1 influenza vaccine seed viruses in MDCK cells. Journal of Virology, 2008, 82: 10502-9

24. Beibei Jia, Jianzhong Shi, Yanbing Li, Kyoko Shinya, Yukiko Muramoto, Xianying Zeng, Guobin Tian, Yoshihiro Kawaoka, Hualan Chen. Pathogenicity of Chinese H5N1 Highly Pathogenic Avian Influenza Viruses in Pigeons. Archives of Virology, 2008, 153: 1821-1826

25. Chengjun Li, Jihui Ping, Bo Jing, Guohua Deng, Yongping Jiang, Yanbing Li, Guobin Tian, Kangzhen Yu, Zhigao Bu, Hualan Chen. H5N1 influenza marker vaccine for serological differentiation between vaccinated and infected chickens. Biochemical and Biophysical Research Communications, 2008, 372(2): 293-7

26. Kiyoko Iwatsuki-Horimoto, Yasuko Hatta, Masato Hatta, Yukiko Muramoto, Hualan Chen, Yoshihiro Kawaoka, Taisuke Horimoto. Limited compatibility between the RNA polymerase components of influenza virus type A and B. Virus Research, 2008, 135(1): 161-5

27. Jihui Ping, Chengjun Li, Guohua Deng, Yongping Jiang, Guobin Tian, Shuxia Zhang, Zhigao Bu and Hualan Chen. Single-amino-acid mutation in the HA alters the recognition of H9N2 influenza virus by a monoclonal antibody. Biochemical and Biophysical Research Communications, 2008, 371(1): 168-371

28. Peirong Jiao, Guobin Tian, Yanbing Li, Guohua Deng, Yongping Jiang, Chang Liu, Weilong Liu, Zhigao Bu, Yoshihiro Kawaoka, Hualan Chen. A single amino acid substitution in the NS1 protein changes the pathogenicity of H5N1 avian influenza viruses in mice. Journal of Virology, 2008, 82 (3): 1146–1154.

Comment in Journal of Virology: Single-Amino-Acid Substitution Changes the Virulence of H5N1 Influenza Viruses. Journal of Virology, 2008, 82 (3): 1065

Comment in Microbe: Single-Amino-Acid Substitution Changes the Virulence of H5N1 Influenza Viruses.

29. Qiyun Zhu, Huangliang Yang, Weiye Chen, Wenyan Cao, Gongxun Zhong, Peirong Jiao, Guohua Deng, Kangzhen Yu, Chinglai Yang, Zhigao Bu, Yoshihiro Kawaoka, Hualan Chen. A naturally occurring deletion in its NS gene contributes to attenuation of an H5N1 swine influenza virus in chickens. Journal of Virology, 2008, 82 (1):220–228.

30. Hualan Chen, Rick Bright, Kanta Subbarao, Catherine Smith, Nancy Cox, Jacqueline M. Katz, and Yumiko Matsuoka. Polygenic virulence factors involved in pathogenesis of 1997 Hong Kong H5N1 influenza viruses in mice. Virus Research, 2007, 128(1-2):159-63.

31. Yongping Jiang, Kangzhen Yu, Hongbo Zhang, Pingjing Zhang, Chenjun Li, Guobin Tian, Yanbing Li, Xijun Wang, Zhigao Bu, Hualan Chen. Enhanced protective efficacy of H5 subtype avian influenza DNA vaccine with codon optimized HA gene in a pCAGG plasmid vector. Antiviral Research, 2007, 75: 234-241.

32. Jinying Ge, Guohua Deng, Zhiyuan Wen, Guobing Tian, Yong Wang, Jianzhong Shi, Xijun Wang, Yanbing Li, Sen Hu, Yongping Jiang, Chinglai Yang, Kangzhen Yu, Zhigao Bu, Hualan Chen. Newcastle disease virus-based live attenuated vaccine completely protects chickens and mice from lethal challenge of homologous and heterologous H5N1 avian influenza viruses. Journal of Virology, 2007, 81, 150－158.

33. Chuanling Qiao, Guobin Tian, Yongping Jiang, Yanbing Li, Jianzhong Shi, Kangzhen Yu, Hualan Chen. Vaccines Developed for H5 Highly Pathogenic Avian Influenza in China. Ann. N.Y. Acad. Sci. 2006, 1081: 182–192

34. Zejun Li, Yongping Jiang, Peirong Jiao, Aiqin Wang, Fengju Zhao, Guobin Tian, Xijun Wang, Kangzhen Yu, Zhigao Bu and Hualan Chen. The NS1 Gene Contributes to the Virulence of H5N1 Avian Influenza Viruses. Journal of Virology, 2006, 80：11115-11123.

35. Taronna R. Maines, Li-Mei Chen, Yumiko Matsuoka, Hualan Chen, Thomas Rowe, Juan Ortin, Ana Falco’n, Nguyen Tran Hien, Le Quynh Mai, Endang R. Sedyaningsih, Syahrial Harun, Terrence M. Tumpey, Ruben O. Donis, Nancy J. Cox, Kanta Subbarao, and Jacqueline M. Katz. Lack of transmission of H5N1 avian–human reassortant influenza viruses in a ferret model. Proc. Natl. Acad. Sci. USA, 2006, 103(32): 12121-12126

36. Hualan Chen, Yanbing Li, Zejun Li, Jianzhong Shi, Kyoko Shinya, Guohua Deng, Qiaoling Qi, Guobin Tian, Shufang Fan, Haidan Zhao, Yingxiang Sun, Yoshihiro Kawaoka. Properties and dissemination of H5N1 viruses isolated during an influenza outbreak in migratory waterfowl in western China. Journal of Virology, 2006, 80(12):5976-83.

37. Yanbing Li, Chengjun Li, Liling Liu, Hongwei Wang, Chuanbin Wang, Guobing Tian, Robert. G. Webster, Kangzhen Yu, Hualan Chen. Characterization of an avian influenza virus of subtype H7N2 isolated from chickens in northern China. Virus Genes, 2006, 33:117-122

38. Yanbing Li, Zhixiong Lin, Jianzhong Shi, Qiaoling Qi, Guohua Deng, Zejun Li, Xiurong Wang, Guobin Tian, Hualan Chen. Detection of Hong Kong 97-like H5N1 influenza viruses from eggs of Vietnamese waterfowl. Archives of Virology. 2006, 151: 1615-1624

39. Yu H, Shu Y, Hu S, Zhang H, Gao Z, Chen H, Dong J, Xu C, Zhang Y, Xiang N, Wang M, Guo Y, Cox N, Lim W, Li D, Wang Y, Yang W. The first confirmed human case of avian influenza A (H5N1) in Chinese mainland. Lancet. 2006, 7: 367(9504):84.

40. Zejun Li, Hualan Chen, Peirong Jiao, Guohua Deng, Guobin Tian, Yanbing Li, Erich Hoffmann, Robert G. Webster, Yumiko Matsuoka, Kangzhen Yu. Molecular basis associated with replication of duck H5N1 influenza viruses in a mammalian mouse model. Journal of Virology, 2005, 79: 12058–12064

41. Guobin Tian, Suhua Zhang, Yanbing Li, Zhigao Bu, Peihong Liu, Jinping Zhou, Chengjun Li, Jianzhong Shi, Kangzhen Yu, Hualan Chen. Protective efficacy in chickens, geese and ducks of an H5N1 inactivated vaccine developed by reverse genetics. Virology, 2005, 341: 153 – 162

42. Chengjun Li, Kangzhen Yu, Guobin Tian, Dandan Yu, Liling Liu, Bo Jing, Jihui Ping, and Hualan Chen. Evolution of H9N2 influenza viruses from domestic poultry in Chinese mainland. Virology, 2005, 340: 70 – 83

43. K. M. Sturm-Ramirez, D. J. Hulse-Post, E. A. Govorkova, J. Humberd, P. Seiler, P. Puthavathana, C. Buranathai, T. D. Nguyen, A. Chaisingh, H. T. Long, T. S. P. Naipospos, H. Chen, T. M. Ellis, Y. Guan, J. S. M. Peiris, and R. G. Webster. Are Ducks Contributing to the Endemicity of Highly Pathogenic H5N1 Influenza Virus in Asia. Journal of Virology, 2005, 79(17): 11269-11279

44. D. J. Hulse-Post, K. M. Sturm-Ramirez, J. Humberd, P. Seiler, E. A. Govorkova, S. Krauss, C. Scholtissek, P. Puthavathana, C. Buranathai, T. D. Nguyen, H. T. Long, T. S. P. Naipospos, H. Chen, T. M. Ellis, Y. Guan, J. S. M. Peiris and R. G. Webster. Role of domestic ducks in the propagation and biological evolution of highly pathogenic H5N1 influenza viruses in Asia. Proc. Natl. Acad. Sci. USA, 2005, 102: 10682-10687

45. H. Chen，G. Deng，Z. Li，G. Tian，Y. Li，P. Jiao, L. Zhang, Z. Liu, R. G. Webster, K. Yu. The evolution of H5N1 influenza viruses in ducks in Southern China. Proc. Natl. Acad. Sci. USA, 2004, 101(28): 10452-10457

Comments in Nature: Increasing virulence of bird flu threatens mammals. Nature, 2004, 431, July 1, 4.

46. Hualan Chen, Yumiko Matsuoka, David Swayne, Qi Chen, Nancy Cox, Brain R. Murphy and Kanta Subbarao. Generation and Characterization of an H9N2 Cold-Adapted Reassortant as a Vaccine Candidate, Avian Diseases 2003, 47, 1127-1130

47. Yumiko Matsuoka, Hualan Chen, David Swayne, Safety Evaluation in Chickens of Candidate Human Vaccines against Potential Pandemic Strains of Influenza Avian Diseases, 2003, 47, 926-930

48. Hualan Chen, Yumiko Matsuoka, David Swayne, Qi Chen, Nancy Cox, Brain R. Murphy and Kanta Subbarao. Generation and characterization of a cold-adapted influenza A H9N2 reassortant as a live pandemic influenza vaccine candidate. Vaccine, 2003, 21(27-28): 4430-4436

49. Hualan Chen, Kanta Subbarao, David Swayne, Qi Chen, Xiuhua Lu, Jacqueline Katz, Nancy Cox and Yumiko Matsuoka, Generation and evaluation of a high-growth reassortant H9N2 influenza A virus as a pandemic vaccine candidate. Vaccine 2003, 21(17): 1974-1979

50. Kanta Subbarao, Hualan Chen, David Swayne, Louise Mingay, Ervin Fodor, George Brownlee, Xiyan Xu, Xiuhua Lu, Jacqueline Katz, Nancy Cox and Yumiko Matsuoka. Evaluation of a genetically modified reassortant H5N1 influenza A virus vaccine candidate generated by plasmid-based reverse genetics. Virology, 2003, 1.Jan 5, 305(1): 192-200

Book Chapters:

1. Hualan Chen, Zhigao Bu, Jingfei Wang. Epidemiology and Control of H5N1 Avian Influenza in China. Klenk H-D, Matrosovich MN, Stech J (eds): Avian Influenza. Monogr Virol. Basel, Karger, 2008, vol 27, 27-40

2004年至2017年期間，陳化蘭直接指導、聯合執導50名碩士、16名博士。根據中國科學技術信息研究所、國家工程技術數字研究館信息、全國圖書館參考諮詢聯盟：陳化蘭培養學生情況如下 ^[24]  ：

2008年，擔任世界動物衞生組織（OIE）禽流感參考實驗室主任，她也是OIE最高技術決策機構－生物標準委員會6名委員之一，OIE/國際糧農組織（FAO）流感專家委員會（OFFLU）5名執委之一。

2012年5月，當選世界動物衞生組織生物標準委員會副主席。

2017年12月7日，當選為九三學社第十四屆中央委員會委員 ^[30]  。

2022年12月，九三學社第十二次全國代表大會代表。 ^[35] 

陳化蘭是中國最早禽流感病毒基因工程疫苗分子診斷及分子流行病學的研究者之一。她在動物流感，尤其禽流感的流行病學、診斷技術、新型疫苗研製、分子演變及分子致病機制等方面取得了一系列重大進展和創造性研究成果，併產生了巨大社會經濟效益 ^[10]  。（九三學社黑龍江省委員會評）

2015年，陳化蘭為“甘肅農業大學盛彤笙科技創新基金”捐款，表達了她對母校的熱愛和感恩之情，對科研事業的摯愛和對科研工作者的寄望 ^[31]  。

2016年10月，陳化蘭用她獲得的“世界傑出女科學家獎”獎金的一部分，在甘肅農業大學70華誕之際，向母校捐贈20萬元，學校配套30萬，設立未來女科學家獎，用於獎勵和資助優秀女研究生及青年女教師。