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阮敏

(上海第九人民醫院主任醫師)

鎖定
阮敏,男,中共黨員,主任醫師,上海交通大學醫學院博士畢業。現為上海市口腔醫學會口腔頜面-頭頸腫瘤專業委員會委員。從事臨牀工作10餘年,擅長口腔頜面-頭頸腫瘤的外科治療。2013~2014年在美國紐約斯隆-凱特琳癌症中心(Sloan-Kettering Cancer Center)及德州大學MD安德森癌症中心(MD Anderson Cancer Center)進行為期一年的臨牀研修,學習並掌握了現代頭頸腫瘤外科的綜合治療新理念。主持國家級課題2項,入選全國優博提名及上海市浦江人才,累計發表學術論文30餘篇。
長期致力於口腔頜面腫瘤的基礎與臨牀研究,從事口腔頜面-頭頸腫瘤的外科治療工作近18年,帶領團隊累計完成口腔頜面腫瘤全麻手術近6000台,其中III-IV級手術2000餘台,修復重建手術1000餘台。依託國家口腔醫學中心和國家口腔疾病臨牀醫學中心,聚焦口腔鱗癌和腺樣囊性癌。 [1] 
中文名
阮敏
國    籍
中國
民    族
畢業院校
上海交通大學醫學院
學    歷
博士研究生
臨牀職稱
主任醫師
執業地點
上海交通大學醫學院附屬第九人民醫院 [2] 
專    業
口腔頜面-頭頸腫瘤的臨牀診治

阮敏研究方向

  1. 口腔黏膜上皮炎癌轉變的基礎與臨牀研究;
  2. 2.唾液腺腺樣囊性癌的基礎與臨牀研究

阮敏出診信息

專家門診:週三下午,週五上午

阮敏教育經歷

1997.9-2002.7:安徽醫科大學口腔醫學院(五年制本科);2002.9-2005.7:安徽醫科大學口腔醫學院(推免碩士);2005.9-2008.7:上海交通大學醫學院(口腔臨牀醫學博士)

阮敏工作經歷

阮敏科研成果

1.上海市優秀博士學位論文;2.全國優秀博士學位論文提名獎

阮敏科研項目

1. 國家自然科學基金面上項目,82072983,2021.1.1-2024.12.31 口腔鱗癌細胞趨化pDC促進淋巴結轉移前微環境形成的分子機制研究 55萬,在研,主持
2. 國家自然科學基金面上項目,81772870,2018.1.1-2021.12.31 TLR-9介導口腔粘膜癌變細胞抑制pDC免疫監控功能的分子機制研究 45萬,在研,主持
3. 上海市衞計委資助課題,201740186,2018.1.1-2020.12.31 口腔癌變細胞TLR-9過表達與腫瘤浸潤pDC細胞免疫功能下調的相關性研究,結題,主持
4. 國家自然科學基金面上項目,81472517,2015.1.1-2018.12.31 口腔粘膜上皮癌變過程中TLR-9基因過表達的轉錄調控機制研究 72萬,結題,主持
5. 國家自然科學基金青年項目,81104029,2012.1.1-2014.12.31 TLR-9活化AP-1促進口腔粘膜上皮癌變的分子機制研究 23萬,結題,主持 [1] 

阮敏學術兼職

美國紐約Memorial Sloan-Kettering Cancer Center和德州MD-Anderson Cancer Center訪問學者
中國抗癌協會頭頸腫瘤專委會常委
世界華人腫瘤醫師協會委員
上海市口腔醫學會口腔頜面-頭頸腫瘤專委會委員
上海市醫學會顯微外科專委會青年委員
教育部學位中心評審專家
上海市科技獎勵評審專家 [1] 

阮敏獲獎情況

  1. 上海九院“優青骨幹”;上海市浦江人才
  2. 曾獲全國優博提名、上海市優博、上海市“浦江人才”,上海市“醫苑新星”傑出青年醫學人才,上海市教委優秀青年骨幹教師、上海交通大學“晨星學者”、上海交通大學醫學院“新百人計劃”、上海交通大學醫學院“上藥杏林育才獎”、 上海九院“十佳教師”、上海九院優秀進修生帶教老師 [1] 

阮敏學術成就

以第一或通訊作者發表論文33篇,SCI收錄24篇,主編專著2部(《口腔頜面顯微外科的基本理論與操作教程》《旋髂淺動脈穿支皮瓣---口腔頜面部應用》),參編專著2部,獲實用新型專利3項,以第一負責人主持國家自然科學基金4項,上海市自然科學基金1項,其他各類基金6項。 [1] 

阮敏著作譯作

1. Han N, Li X, Wang Y, Wang L, Zhang C, Zhang Z*, Ruan M*, Zhang C. Increased tumor-infiltrating plasmacytoid dendritic cells promote cancer cell proliferation and invasion via TNF-α/NF-κB/CXCR-4 pathway in oral squamous cell carcinoma. J Cancer. 2021 Mar 19;12(10):3045-3056.
2. Wang Y, Wang L, Li X, Qu X, Han N*, Ruan M*, Zhang C. Decreased CSTA expression promotes lymphatic metastasis and predicts poor survival in oral squamous cell carcinoma. Arch Oral Biol. 2021 Mar 31;126:105116.
3. Han J, Han N, Xu Z, Zhang C, Liu J*, Ruan M*. Expression profile of circular RNA and construction of circular RNA-Micro RNA network in salivary adenoid cystic carcinoma. Cancer Cell Int. 2021 Jan 7;21(1):28.
4. Wang L, Wang Y, Han N, Wang X*, Ruan M*. HPRT promotes proliferation and metastasis in head and neck squamous cell carcinoma through direct interaction with STAT3. Exp Cell Res. 2021 Feb 1;399(1):112424.
5. Yang W, Jiang C, Xia W, Ju H, Jin S, Liu S, Zhang L, Ren G, Ma H*, Ruan M*, Hu J*. Blocking autophagy flux promotes interferon-alpha-mediated apoptosis in head and neck squamous cell carcinoma. Cancer Lett. 2019 Jun 1;451:34-47.
6. Ju H, Mao L, Zhang L, Liu S, Wu Y, Ruan M*, Hu J*, Ren G*. Ultrasound hyperthermia enhances chemo-sensitivity in oral squamous cell carcinoma by TRIF-mediated pathway. J Oral Pathol Med. 2018 Nov;47(10):964-971. IF=2.237
7. Ju H, Zhang L, Mao L, Liu S, Xia W, Hu J*, Ruan M*, Ren G*. Altered expression pattern of circular RNAs in metastatic oral mucosal melanoma. Am J Cancer Res. 2018 Sep 1;8(9):1788-1800.IF=3.998
8. Han N, Lu H, Zhang Z*, Ruan M*, Yang W, Zhang C. Comprehensive and in-depth analysis of microRNA and mRNA expression profile in salivary adenoid cystic carcinoma. Gene. 2018 Dec 15;678:349-360.
9. 韓楠男,劉勝文,阮敏*,楊雯君,孫堅,張陳平. 腺體保存術在下頜下腺良性腫瘤治療中的應用,口腔醫學 2017 ,37 (2 ):126-130.
10. 張煦,許恩馨,阮敏*. Toll樣受體9與頭頸部鱗狀細胞癌關係的研究進展,國際口腔醫學雜誌 2017,44(5):596-601.
11. Ju H, Zhang L, Mao L, Wu Y, Liu S, Ruan M*, Hu J*, Ren G*. A comprehensive genome-wide analysis of the long noncoding RNA expression profile in metastatic lymph nodes of oral mucosal melanoma. Gene. 2018 Oct 30;675:44-53. pii: S0378-1119(18)30720-0. doi: 10.1016/j.gene.2018.06.064.
12. Han N, Zhang Z, Jv H, Hu J*, Min Ruan*, Zhang C. Culture supernatants of oral cancer cells induce impaired IFN-α production of pDCs partly through the down-regulation of TLR-9 expression. Arch Oral Biol. 2018 Jun 5;93:141-148.
13. Nannan Han, Zun Zhang, Shengwen Liu, Andrew Ow*, Min Ruan*, Wenjun Yang, Chenping Zhang. Increased Tumor-Infiltrating Plasmacytoid Dendritic Cells Predicts Poor Prognosis in Oral Squamous Cell Carcinoma,Archives of Oral Biology 2017 Jun;78:129-134.
DOI:doi.org/10.1016/j.archoralbio.2017.02.012.
14. Nannan Han, Huishan Ong, Zhihui Liu*, Min Ruan*,Wenjun Yang, Chenping Zhang,Lymph node involvement predicts poor prognosis in primary tongue adenoid cystic carcinoma: A preliminary study of 54 cases,Journal of Cranio-Maxillo-Facial Surgery 2017, 45(4):589-594. DOI:doi.org/10.1016/j.jcms.2017.01.012.
15. 黃擎,韓楠男,劉勝文,王麗珍,阮敏*,楊雯君,張陳平,唾液腺腺樣囊性癌頸淋巴結轉移規律的臨牀研究,中國腫瘤臨牀,2016.12.30,(24):1094~1098
16. Liu, S, Ow, A, *Ruan, M, Yang, W, Zhang, C, Wang, L, Zhang, C, Prognostic factors in primary salivary gland mucoepidermoid carcinoma: an analysis of 376 cases in an Eastern Chinese population,International Journal of Oral and Maxillofacial Surgery,2014.6.01,43(6):667~673.
17. Li Siyi,Liu Shengwen,Ruan Min(*),Yang Wenjun,Wang Lizheng,Zhang Chenping,Increased expression of MUC-1 has close relation with patient survivor in high-grade salivary gland mucoepidermoid carcinoma,Journal of Oral Pathology & Medicine,2014.9.01,43(8):579~584.
18. Liu, Shengwen, Ruan, Min*, Li, Siyi,Wang, Lizheng,Yang, Wenjun,Increased expression of MUC1 predicts poor survival in salivary gland mucoepidermoid carcinoma.,J Craniomaxillofac Surg,2014.12.01,42(8):1891~1896.
19. *Ruan, Min; Thorn, Katherine; Liu, Shengwen; Li, Siyi; Yang, Wenjun; Zhang, Chunye; Zhang, Chenping,The secretion of IL-6 by CpG-ODN-treated cancer cells promotes T-cell immune responses partly through the TLR-9/AP-1 pathway in oral squamous cell carcinoma,International Journal of Oncology,2014.6.01,44(6):2103~2110
20. *Ruan, Min; Zhang, Zun; Li, Siyi; Yan, Min; Liu, Shengwen; Yang, Wenjun; Wang, Lizheng; Zhang, Chenping,Activation of Toll-Like Receptor-9 Promotes Cellular Migration via Up-Regulating MMP-2 Expression in Oral Squamous Cell Carcinoma,PLos One,2014.3.21,9(3):e92748
21. * Ruan, Min,Toll-like receptor-9 agonists increase cyclin D1 expression partly through activation of activator protein-1 in human oral squamous cell carcinoma cells.,Cancer Science,2012.09.14,103(11):1938~1945
22. Ruan Min; Zhang Zun; Li Siyi; Yang Wenjun; Wang Lizheng; *Zhang Chenping,Increased expression of Toll-like receptor-9 has close relation with tumour cell proliferation in oral squamous cell carcinoma,Archives of Oral Biology,2011.9.01,56(9):877~884
23. Ruan, M.,Ji, T.,Wu, Z.,Zhou, J.,Zhang, C.,Evaluation of expression of midkine in oral squamous cell carcinoma and its correlation with tumour angiogenesis,International Journal of Oral and Maxillofacial Surgery,2007.2.01,36(2):159~164
24. Ruan Min; Ji Tong; Yang Wenjun; Duan Wenhu; Zhou Xiaojian; He Jiacai; Zhou Jian; Chen Wantao; Zhang Chenping,Growth inhibition and induction of apoptosis in human oral squamous cell carcinoma Tca-8113 cell lines by Shikonin was partly through the inactivation of NF-kappa B pathway,Phytotherapy Research,2008.3.01,22(3):407~415
25. Ruan Min; Zhang Zun; Wang Lizheng; Dong Minjun; Liu Shengwen; *Yang Wenjun; Zhang Chenping,Oral and maxillofacial desmoid-type fibromatoses in an eastern Chinese population: a report of 20 cases,Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology,2011.3.01,111(3):340~345
26. Ruan Min; Zhang Zun; *Li Siyi; Yang Wenjun; Sun Jian; Zhang Chenping,Gland-preserving surgery can effectively preserve gland function without increased recurrence in treatment of benign submandibular gland tumour,British Journal of Oral and Maxillofacial Surgery,2013.10.01,51(7):615~619
27. Min, R.; Zun, Z.; Min, Y.; Wenhu, D.; Wenjun, Y.; *Chenping, Z.,Shikonin inhibits tumor invasion via down-regulation of NF-kappa B-mediated MMP-9 expression in human ACC-M cells,Oral Diseases,2011.5.01,17(4):362~369
28. Min, R.; Siyi, L.; *Wenjun, Y.; Ow, A.; Lizheng, W.; Minjun, D.; Chenping, Z.,Salivary gland adenoid cystic carcinoma with cervical lymph node metastasis: a preliminary study of 62 cases,International Journal of Oral and Maxillofacial Surgery,2012.8.01,41(8):952~957
29. *Zhang Chenping; Ruan Min#; Xu Liqun; Hu Yongjie; Yang Wenjun; Ji Tong; Qv Xingzhou; Li Siyi; Ow, Andrew; Ma Jizhuang; Wu Yiqun,Dental Implant Distractor Combined With Free Fibular Flap: A New Design for Simultaneous Functional Mandibular Reconstruction,Journal of Oral and Maxillofacial Surgery,2012.11.01,70(11):2687~2700 [1] 
參考資料