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錢鋒
(清華大學藥學院院長)
鎖定
- 中文名
- 錢鋒
- 國 籍
- 中國
- 畢業院校
- 清華大學
錢鋒人物履歷
錢鋒本科、碩士畢業於清華大學材料科學與工程系,2003年於美國Case Western Reserve University獲得生物醫學工程博士學位後,就職於美國Bristol-Myers Squibb Company(百時美-施貴寶公司),從事藥劑學科研和新藥開發工作。2012年回國加入清華大學藥學院,主要從事針對癌症和眼科疾病的新型藥物治療,以及各類藥物的遞送技術研究。
曾任清華大學藥學院教授,副院長。
現任清華大學藥學院院長。
錢鋒研究方向
1. 針對癌症、眼科疾病的藥物遞送:
2. 物理藥劑學:
在化學藥物和多肽藥物領域,本實驗室長期研究新型製劑的設計策略,用於提高不符合“rule of five”的新藥分子的口服生物利用度。在蛋白藥物領域,本課題組的研究興趣為研究設計用於皮下和局部注射用的高濃度蛋白製劑。
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錢鋒人物貢獻
錢鋒個人榮譽
清華大學-楊森研究員(Janssen-Tsinghua Investigator)
錢鋒代表性論文
1. Dou L, Liu H., Wang K, Liu J, Liu L, Ye J, Wang R, Deng H, Qian F.*; Albumin binding revitalizes NQO1 bioactivatable drugs as novel therapeutics for pancreatic cancer, Journal of Controlled Release, 2022 Aug 4;349:876-889. doi: 10.1016/j.jconrel.2022.07.033.
2. Kong W, Liu Z, Sun M, Liu H, Kong C, Ma J, Wang R, Qian F.*; Synergistic Autophagy Blockade and VDR Signaling Activation Enhance Stellate Cell Reprogramming in Pancreatic Ductal Adenocarcinoma, Cancer Letters. 2022 Jul 28;539:215718. doi: 10.1016/j.canlet.2022.215718. Epub 2022 May 5.
3. Fang Yuan, Mengnan Sun, Zhengsheng Liu, Huiqin Liu, Weijian Kong, Rui Wang, Qian F*, Macropinocytic dextran facilitates KRAS-targeted delivery while reducing drug-induced tumor immunity depletion in pancreatic cancer. Theranostics. 2022; 12(3): 1061-1073. doi: 10.7150/thno.65299
4. Liu H; Yu S; Qian F*, Opportunities and delusions regarding drug delivery targeting pancreatic cancer-associated fibroblasts, Advanced Drug Delivery Reviews, 2021 May;172:37-51. https://doi.org/10.1016/j.addr.2021.02.012
5. Zhou T,; Qian F.*; Adenosine Triphosphate-Induced Rapid Liquid–Liquid Phase Separation of a Model IgG1 mAb, Mol. Pharmaceutics. 2021 18 (1), 267-274, DOI: 10.1021/acs.molpharmaceut.0c00905
6. Mi W; Chen H; Zhu A, Zhang T, Qian F*, Melting point prediction of organic molecules by deciphering the chemical structure into a natural language, Chemical Communications, 2021, 57, 2633 – 2636
7. Yuan F; Sun M; Liu H; Qian, F.*, Albumin-conjugated drug is irresistible by single gene mutation of endocytic system: verification by genome-wide CRISPR-Cas9 loss-of function screens, Journal of Controlled Release, Vol 323, 10 July 2020, Pages 311-320
8. Hu C.; Liu Z.; Liu C.; Zhang Y.; Fan H.; Qian F.*; Improvement of Antialveolar Echinococcosis Efficacy of Albendazole by a Novel Nanocrystalline Formulation with Enhanced Oral Bioavailability, ACS Infect. Dis. 2020, 6, 5, 802–810
9. Kong C; Li Y; Liu Z; Ye J; Wang Z; Zhang L; Kong W.; Liu H.; Liu C.; Pang H.; Hu Z.; Gao J.; and Qian, F*, Targeting the Oncogene KRAS Mutant Pancreatic Cancer by Synergistic Blocking of Lysosomal Acidification and Rapid Drug Release, ACS Nano, DOI: 10.1021/acsnano.8b08246, March 26, 2019.
10. Liu H; Sun M; Liu Z; Kong C; Kong W; Ye J; Gong J; Huang D; Qian, F.*, KRAS-enhanced macropinocytosis and reduced FcRn-mediated recycling sensitize pancreatic cancer to albumin-conjugated drugs, Journal of Controlled Release, Vol 296, 28 February 2019, Pages 40-53.
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錢鋒社會任職
錢鋒職務任免
- 參考資料
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- 1. 錢鋒任清華大學藥學院院長,首任院長丁勝任職近8年後卸任 .澎湃新聞.2022-07-27[引用日期2022-07-27]
- 2. 錢鋒, PhD-清華大學藥學院 .清華大學藥學院[引用日期2023-07-25]