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金美花

天津医科大学教授，博士生导师

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天津医科大学教授，博士生导师，韩国岭南大学博士。

2012年入选“131”创新型人才培养工程第二层次人选培养计划和天津市“优秀青年教师资助计划”，2018年入选天津市教育系统党外人才325培养计划，2019年被评为天津市高校中青年骨干创新人才。共主持了6项科研项目（国家级2项、省部级4项），包括国家自然科学基金面上项目、国家自然科学基金青年项目、天津市科委自然科学基金一般项目、中国博士后科学基金、教育部高等学校博士学科点专项科研基金项目、留学回国人员科研启动基金等。相关研究成果发表论文共64篇，SCI收录55篇，其中以第一或者通讯作者身份发表SCI论文25篇。获得1项发明专利权，申请3项发明专利。^[1]

中文名: 金美花
国籍: 中国
民族: 朝鲜族
出生地: 吉林延边
出生日期: 1980年8月

毕业院校: 韩国岭南大学
学位/学历: 博士
职业: 教师
专业方向: 药理学
研究方向: 抗炎免疫机理研究，肿瘤免疫治疗
办公室: 天津医科大学药学院B楼303室

个人简介

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天津医科大学教授，博士生导师，韩国岭南大学博士。

工作经历

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2009.03-2011.02 韩国岭南大学药学院助教授

2011.01月-至今天津医科大学药学院副教授、教授^[1]

研究方向

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研究方向为肿瘤发生与发展的分子机理、肿瘤的免疫治疗；^[1]天然非甾体抗炎新药筛选及其抗炎免疫机理研究；免疫治疗药物的研发。

主要科研项目

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国家自然科学基金面上项目：通过IgE受体FcεRI激活的肥大细胞抑制乳腺癌生长的作用及机理研究，本人排名：课题负责人，本人可支配经费（万）：54，项目起止时间：2017-01;2020-12^[1]

1. 国家自然科学基金青年科学基金项目：以旋覆花内酯活性化合物为探针研究抗哮喘多重分子作用机制以及先导化合物的发现，项目编号：81202542，2013.01-2015.12，项目负责人

2. 天津市科委自然科学基金一般项目：以ABLOO为探针研究其抗哮喘多重分子机制及协同作用，项目编号：13JCYBJC24800，2013.04-2016.03，项目负责人

3. 高等学校博士学科点专项科研基金新教师类项目：以旋覆花内酯活性化合物为探针研究抗哮喘多重分子作用机制，项目编号：20121202120009，2013.01-2015.12，项目负责人

主要论文

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Xiaoqing Wang, Sheng-An Tang, Ran Wang, Yuling Qiu, Mei Hua Jin*(共同通讯作者), Dexin Kong*. Inhibitory effects of JEUD-38, a new sesquiterpene lactone from Inula japonica Thunb, on LPS-induced iNOS expression in RAW264.7 cells. Inflammation 2014

Mei Hua Jin, Qianxiang Zhou, Eunkyung Lee, Shingo Dan, Hong Quan Duan, and Dexin Kong.* AS252424, a PI3Kg Inhibitor, downregulates inflammatory responsiveness in mouse bone marrow-derived mast cells. Inflammation 2014, 37(4):1254-1260

Sheng-An Tang, Hong Zhu, Nan Qin, Jing-Ya Zhou, Eunkyung Lee, De-Xin Kong, Mei-Hua Jin* (共同通讯作者), Hong-Quan Duan*. Anti-inflammatory Terpenes from Flowers of Inula japonica. Planta Med. 2014,80(7):583-589

Meihua Jin, Wennan Zhao, Yanwen Zhang, Motomasa Kobayashi, Hongquan Duan,* and Dexin Kong*. Antiproliferative effect of aaptamine on human chronic myeloid leukemia K562 cells. Int. J. Mol. Sci. 2011,12(11):7352-7359

Meihua JIN, Kun Ho SON*, and Hyeun Wook CHANG*, Luteolin-7-O-glucoside suppresses leukotriene C4 production and degranulation by inhibiting the phosphorylation of mitogen activated protein kinases and phospholipase Cg 1 in activated mouse bone marrow-derived mast cells. Biol. Pharm. Bull. 2011, 34(7):1032—1036

Meihua Jin, Yue Lu, Ju Hye Yang, Tae Hyung Jo, Young In Park, Chong-Kil Lee, Sang-Jo Park, Kun Ho Son*, and Hyeun Wook Chang*. Anti-inflammatory activity of 6-Hydroxy-2,7-dimethoxy-1,4-henanthraquinone from tuberous roots of Yam (Dioscorea batatas) through inhibition of prostaglandin D2 and leukotriene C4 production in mouse bone marrow-derived mast cells. Arch. Pharm. Res. 2011, 34(9):1495-1501

Yue LU, Meihua JIN（共同第一作者）, Sang-Jo PARK, Kun Ho SON, Jong-Keun SON*, and Hyeun Wook CHANG*. Batatasin I, a naturally occurring phenanthrene derivative, isolated from tuberous roots of Dioscorea batatas suppresses eicosanoids generation and degranulation in bone marrow derived-mast cells. Biol. Pharm. Bull. 2011, 34(7): 1021—1025

Meihua Jin, Seok-Jong Suh, Ju Hye Yang, Yue Lu, Su Jeong Kim, Soonyoul Kwon, Tae Hyung Jo, Jin Wan Kim, Young In Park, Ghe Whan Ahn, Chong-Kil Lee, Cheorl-Ho Kim, Jong-Keun Son, Kun Ho Son*, Hyeun Wook Chang*. Anti-inflammatory activity of bark of Dioscorea batatas DECNE through the inhibition of iNOS and COX-2 expressions in RAW264.7 cells via NF-kB and ERK1/2 inactivation. Food Chem.Toxicol. 2010, 48(11): 3073-3079.

Meihua JIN, Eunkyung LEE, Ju Hye YANG, Yue LU, SangGu KANG, Young-Chae CHANG, Seung Ho LEE, Seok-Jong SUH, Cheorl-Ho KIM, and Hyeun Wook CHANG*. Deoxypodophyllotoxin inhibits the expression of intercellular adhesion molecule-1 induced by tumor necrosis factor-a in murine lung epithelial cells. Biol. Pharm. Bull. 2010, 33(1): 1-5.

Meihua JIN, Ju Hye YANG, Eunkyung LEE, Yue LU, Soonyoul KWON, Kun Ho SON, Jong Keun SON, and Hyeun Wook CHANG*. Antiasthmatic Activity of Luteolin-7-O- glucoside from Ailanthus altissima through the Down regulation of T Helper 2 Cytokine Expression and Inhibition of Prostaglandin E2 Production in an Ovalbumin-Induced Asthma Model. Biol. Pharm. Bull. 2009, 32(9): 1500-1503.

Meihua JIN, KiHwan BAE, Hyeun Wook CHANG*, and Jong Keun SON*. Anti- inflammatory Compounds from the Leaves of Ailanthus altissima. Biomol. Ther. 2009, 17(1): 86-91.

Meihua JIN, Tae Chul MOON, Zhejiu QUAN, Eunkyung LEE, Yun Kyung KIM, Ju Hae YANG, Seok-Jong SUH, Tae Cheon JEONG, Seung Ho LEE, Cheorl-Ho KIM*, and Hyeun Wook CHANG*. The naturally occurring flavolignan, deoxypodophyllotoxin, inhibits lipopolysaccharide-induced iNOS expression require inhibition of NF-κB activation in RAW264.7 macrophage cells. Biol. Pharm. Bull. 2008, 31(7): 1312-1315.(Highlighted paper selected by Editor-in-chief)

Jin Mei Hua, Tae Chul Moon,Tae Gyun Hong, Kyong Min Park, Jong Keun Son, and Hyeun Wook Chang*. 5-Methoxy-8-(2-hydroxy-3-buthoxy-3-methylbutyloxy)- psoralen Isolated from Angelica dahurica inhibits Cyclooxygenase-2 and 5-Lipoxygenase in Mouse Bone Marrow-Derived Mast Cells. Arch. Pharm. Res. 2008, 31(5): 617-621

Tae Chul Moon, Meihua Jin（共同第一作者）, Jong Keun Son, and Hyeun Wook Chang*. The Effects of Isoimperatorin Isolated from Angelica dahurica on Cyclooxygenase-2 and 5-Lipoxygenase in Mouse Bone Marrow-Derived Mast Cells. Arch. Pharm. Res. 2008, 31(2): 210-215.

Se Jong Kim, Meihua Jin（共同第一作者）, Eunkyung Lee, Tae Chul Moon, Zhejiu Quan, Kun Ho Son, Kil-Ung Kim, Jong Kun Son, Hyeun Wook Chang*. Effects of Methyl Gallate on Arachidonic Acid Metabolizing Enzymes: Cyclooxygenase-2 and 5-Lipoxygenase in Mouse Bone Marrow-Derived Mast Cells. Arch. Pharm. Res. 2006, 29 (10): 874-878.

Mei Hua JIN, Jumin YOOK, Eunkyung LEE, Chang Xin LIN, Zhejiu QUAN, Kun Ho SON, Ki Hwan BAE, Hyun Pyo KIM, Sam Sik KANG, and Hyeun Wook CHANG*. Anti-inflammatory activity of Ailanthus altissima in Ovalbumin-Induced Lung Inflammation. Biol. Pharm. Bull. 2006, 29(5): 884-888.

朱虹，唐生安，秦楠，段宏泉，金美花*. 旋覆花中化学成分及其活性研究。中国中药杂志 2014, 39(1):83-8

金美花，孔德新*. 分子靶向药物PI3K抑制剂的研究进展。药品评价2012, 9(5): 20-25