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金京一
（延邊大學教授、博士生導師）
鎖定
金京一，男，理學博士，延邊大學化學系教授，博士研究生導師；中國化學會高級會員；吉林省高校實驗室安全專家委員會委員。
歷任延邊大學物理化學學科主任、國家級實驗教學示範中心副主任、延邊大學化學系主任；現任延邊大學化學生物學研究中心主任。
金京一人物經歷
金京一教育經歷
2003-2005年，北京大學化學與分子工程學院，博士後；
2002-2003年，韓國浦項工大化學科，研究員；
1999-2003年，延邊大學有機化學，理學博士；
1996-1999年，延邊大學有機化學，理學碩士；
金京一工作經歷
1993-1996年，吉林化學工業公司 技術員；
2005-2006年，延邊大學化學系無機化學專業，副教授；
2007-2008年，延邊大學化學系物理化學學科主任，延邊大學化學實驗教學示範中心副主任，副教授；
2009-2013年，延邊大學化學系物理化學學科主任，教授；
2010-2014年，吉林省化學會常務理事，副秘書長；
2014-2020年，延邊大學化學系主任，國家一流專業建設負責人（2019年）；
2014年-至今，延邊大學化學生物學研究中心主任；
金京一榮譽獎項
全國第七屆教育碩士優秀教師（2019年）；
電致發光材料的合成及性質研究，吉林省科技進步三等獎（2008年）；
金京一教學科研
金京一研究方向
主要從事化學生物學研究，以生物信號轉導過程為研究對象，以小分子探針為主要工具，研究生命體系信號轉導中重要分子事件的過程和機理，推動新藥、新靶標和新的藥物作用機制的發現，解決地區特色生物資源深度利用的基礎問題。
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金京一科研項目
2006年以來，課題組合同經費合計7603萬元，
- 面向內質網-線粒體互作的小分子熒光探針及其在藥物評價方面的應用，2024-2027，國家自然科學基金；
- 從次氯酸熒光探針到髓過氧化物酶的特異性熒光標記：機理和方法，2023-2026，國家自然科學基金；
- 基質金屬蛋白酶-7的近紅外探針的設計、合成及其應用，2018-2021，國家自然科學基金；
金京一講授課程
本科專業理論課程：有機化學、物理化學、儀器分析、無機化學、化學生物學導論等；
本科專業實驗課程：基礎化學實驗、綜合化學實驗、研究型實驗；
金京一論文專著
出版物：有機化學實驗
期刊論文：
自2003年以來，在Development Cell; Chem. Eng. J.; Sens Actuators B; J Mater Chem等國內外期刊發表SCI論文30餘篇，核心論文等20餘篇。
A single fluorescent probe to examine the dynamics of mitochondria-lysosome interplay and extracellular vesicle role in ferroptosis, Developmental Cell, 2024, 59, 1-12.（中科院一區Top期刊，IF 11.8）.
A triple-targeting fluorescent probe reveals the glutathione and viscosity crosstalk in mitochondria, endoplasmic reticulum, and nucleoli in cells during ferroptosis. Sens. Actuators B. Chem., 2024, 399, 134872.（中科院一區Top期刊，IF 8.4）.
A single fluorescent probe reveals changes in endoplasmic reticulum-mitochondria contact in hepatocytes during ferroptosis. Chem. Eng. J., 2023, 466, 143104.（中科院一區Top期刊，IF 16.744）
An aggregation-induced emission probe to detect the viscosity change in lipid droplets during ferroptosis. J. Fluores., 2023, 10.1007/s10895-023-03481-z. (IF 2.70)
Labelling matrix metalloproteinasses. Curr. Med. Chem., 2023, 30, 4569-4585.（中科院二區，IF 4.74）
Fluorescent probe disclosing hydroxyl radical generation in mitochondria and nucleoli of cells during ferroptosis. Sens. Actuators B. Chem., 2022, 373, 132707.（中科院一區Top期刊，IF 9.22）
Simultaneous imaging of hypochlorous acid and nitric oxide in live cells based on a dual-channel fluorescent probe. Anal. Chim. Acta, 2021, 1183, 338980（中科院一區Top期刊，IF 6.558）
Facile synthesis of pyronin-9-thione via a trisulfur radical anion mechanism. New J. Chem., 2021, 45, 19-22.
Matrix metalloproteinases (MMPs) in targeted drug delivery: synthesis of a potent and highly selective inhibitor against matrix metalloproteinase-7. Cur. Top. Med. Chem., 2020, 20, 2459-2471.
A Quninolylthiazole Derivatives as an ICT-Based Fluorescent Probe of Hg(II) and its Application in Ratiometric Imaging in Live HeLa Cells. J. Fluores., 2018, 28, 795-800.
2-Pyridylthiazole derivative as ICT-based ratiometric fluorescent sensor for Fe(III). Tetrahedron Lett., 2016, 57, 2399-2402.
Fluorescence-enhanced sensing of hypochlorous acid based on 2-pyridylthiazole unit. J. Fluores., 2016, 26, 593-598.
Fluorescent sensing of both Fe(III) and pH based on 4-phenyl-2-(2-pyridyl)thiazole and construction of OR logic Function. J. Fluores., 2016, 26, 1653-1657.
Nitro-based selective inhibitors against matrix metalloproteinase-7 over matrix metalloproteinase-1. RSC Adv., 2015, 5, 104725-104732.
Ratiometrically Fluorescent Sensing of Zn(II) Based on Dual-emission of 2-Pyridylthiazole Derivatives. J. Fluores., 2015, 25, 1831-1834.
Molecular Keypad Locks Based on Gated Photochromism and Enhanced Fluorescence by Protonation Effects. J. Fluores., 2014, 24, 1169-1176.
Digital pH fluorescent sensing shown by small organic molecules. J. Fluores., 2012, 22, 1421-1424.
Photo-isomerization of Aromtic α-Hydroxy Hydrazone. Chem. Res. Chinese Universities，2012，28（5），886-890.
Nitro-based inhibitors against thermolysin. Med. Chem. Comm., 2011, 2, 698.
Optical 2-benzyl-5-hydroxy-4-oxopentanoic acids against carboxypeptidase A: synthesis, kinetic evaluation and X-ray crystallographic study. Chin. Chem. Lett. 2010, 21, 159-162.
Isophorone-based analogues with A-π-D-π-A structure for red organic light emitting devices. Synth. Metals 2009, 159, 401.
Characterization of α-nitromethyl ketone as a new zinc-binding group based on structural analysis of its complex with carboxypeptidase A. Bioorg. Med. Chem. Lett., 2009, 19, 5009-5011.
Nitro as a novel zinc-binding group in the inhibition of carboxypeptidase A. Bioorg. Med. Chem., 2008, 16, 3596-3601.
Synthesis and evaluation of optical 2-benzyl-5-bromo-4-oxopentanoic acids as transition-state analog inhibitors against carboxypeptidase A. Chin. J. Chem., 2008, 26, 153-157.
Synthesis of a solvent-sensitive highly fluorescent derivative of perfluorocyclopentene. Tetrahedron Lett., 2007, 48, 7675-7679.
Optical sensors based on functionalized mesoporoius silica SBA-15 for the detection of multianalytes (H+ and Cu2+) in water. J. Mater. Chem., 2007, 17, 4492-4498.
Design and synthesis of 1,4-bis[4-(1,1-dicyanovinyl)styryl]-2,5-biso(alkoxy)benzenes as red organic electroluminescent PPV analogs. Polymer, 2007, 48, 4028-4033.
A new series of fluorescent 5-methoxy-2-pyridylthaizoles with a pH-sensitive dual-emission. New. J. Chem., 2006, 30, 1192-1196.
Thermal Arndt-Eistert reaction of N-tosyl cyclic α-amino acids. Syn. Commun., 2005, 35, 2535-2542.
Stereoselective synthesis of (2S,8S)-2-benzyl hexahydro-pyrrolidizin-3-one starting from (L)-proline based on stereoselective benzylation. Syn. Commun., 2004, 34, 3191-3196.
Optically active 2-benzyl-3-methanesulfinylpropanoic acid: synthesis and evuluation as inhibitors for carboxypeptidase A. Bioorg. Med. Chem., 2003, 11, 4377-4382.
硝基二肽類嗜熱菌蛋白酶抑制劑的分子動力學研究，分子科學學報，2015，31，516-520.
