郝愛軍

郝愛軍，畢業於山東醫科大學，獲醫學學士，醫學碩士學位；1993年至1999年在山東醫科大學醫學系組織學與胚胎學教研室任教。後赴新加坡國立大學攻讀博士學位，2002年畢業於新加坡國立大學醫學院神經科學專業，獲博士學位。同年進入新加坡國立分子生物學研究所做高級研究員。2004年作為高層次引進人才回山東大學醫學院組織學與胚胎學教研室擔任教授, 博士生導師。

1999/5 - 2002/5，新加坡國立大學，醫學院分子神經發育生物學實驗室，博士，導師：Ling Eng-ang

1990/9 - 1993/7，山東醫科大學，組織胚胎學教研室，碩士，導師：高英茂

1985/9 - 1990/7，山東醫科大學，醫學院，學士 ^[1] 

2004/5 - 至今，山東大學，醫學院組胚，教授

2002/07-2004/04，新加坡國立分子生物學研究院,細胞信號傳導實驗室, Research Fellow

1999/07-2002/06，新加坡國立大學,醫學院分子神經發育生物學實驗室，Teaching Assistant

1993/06-1999/06，山東醫科大學，組織胚胎學教研室，助教，講師 ^[1] 

在我國著名胚胎學家高英茂教授指導下，從事生長因子在胚胎細胞分化過程中作用的研究, 對與胚胎細胞分化發育密切相關的多種蛋白進行了系統的免疫組化和分子原位雜交研究。後在著名神經科學學家、新加坡科學院院士Eng Ang Ling （小膠質細胞的發現者）教授的指導下，從事膠質細胞的起源、功能和各種病理狀態下膠質細胞作用機制的研究。對於傳統的神經病理和神經發育生物學研究打下了深厚的理論和實驗基礎，建立了理想的動物模型，並在體外神經細胞的培養方面對膠質細胞的功能機制進行了深入的研究。期間還在神經發育生物學家S.T. Dheen的分子神經生物學實驗室，利用RT-PCR、microarray differential display等方法對神經發育疾病發生機制進行了更加深入的探索。應著名生物化學和分子生物學家、細胞信號傳導分子STAT3的主要研究者、新加坡科學技術委員會（A*STAR）首席科學家Xinmin Cao教授的邀請，進入到新加坡國立分子生物學研究所做高級研究員，並與之進行了合作研究。充分利用分子生物學和生物化學的高技術方法，如：分子克隆（Cloning）、基因剔除（Gene knock-out）、細胞轉染（Cell Transfection）、蛋白質分析技術等進一步做關於神經發育機制和功能方面的研究。主要以神經幹細胞和胚胎幹細胞的誘導分化, 信號傳導以及它們在臨牀疾病模型的應用研究作為自己的主要研究方向。

美國神經科學協會會員(The American Society for Neuroscience)；新加坡神經科學協會會員(Neuroscience Society of Singapore)；新加坡顯微技術協會會員(Microscopy Society of Singapore)。

中華醫學會細胞生物學會理事，山東省解剖學會副理事長，美國細胞生物學協會會員（The American Society for Cell Biology） ^[1]  。

教育部2004年度“新世紀優秀人才支持計劃”；山東省衞生系統第二批傑出學科帶頭人和中青年重點科技人才；山東省科學技術廳2004山東省優秀中青年科學家科研獎勵。

2011年2月10日政協省十屆十六次常委會議審議通過，增補為十屆山東省政協委員。

1. 國家自然科學基金，81771219，TOX3在原發性小頭畸形發生中的作用及機制研究，2018/1-2021/12，54萬，在研，主持

2. 山東省重點研發計劃, 2018GSF118076, TOX3在大腦皮層發育缺陷中的作用機制研究及對認知功能障礙的影響，2018/1-2019/12, 15 萬，在研，主持

3. 國家自然科學基金，81571093，Sox19b在神經管發育缺陷中的新作用及機制研究，2016/1-2019/12，57萬，在研，主持

4. 國家自然科學基金（應急管理項目），31440056，小分子化合物對胚胎神經幹細胞作用的新發現及機制研究，2015/1-2015/12，15萬，已結題，主持

5. 國家自然科學基金（面上項目），31271289，DHHC16對胚胎端腦NSCs調控作用的研究， 2013/1-2016/12，80萬，已結題，主持

6. 國家自然科學基金（面上項目），81071057，G-CSF 對腦癱內源性NSCs的作用及作用機制研究，2011/1-2013/12，36 萬，已結題，主持

7. 國家自然科學基金（面上項目）, 30771142, 蛋白H 在神經發育中作用的研究, 2008/1-2010/12，27 萬，已結題，主持

8. 山東省傑出青年基金，JQ200823，Oct4 在NSCs正常及異常發生中的作用及其機制的研究，2008-2011，50 萬，已結題，主持

9. 國家自然科學基金（面上項目）, 30671105, 妊娠糖尿病致神經管畸形發生機理的研究, 2007/1-2009/12，30 萬，已結題，主持

10. 山東省自然科學基金重點項目, Z2007C11, 蛋白H在神經元蛋白棕櫚酰化中作用的研究，2007/12-2010/12, 10 萬，已結題，主持

11. 新世紀優秀人才支持計劃，2004年

12. 曾獲國際腦科學研究組織(The international Brain Research Organization),國際發育神經生物學學會(The International Society For Developmental)，歐洲健康和疾病研究會(European Society for cell Function in Health)和新加坡李氏基金(Lee Foundation, Singapore)的資助和獎勵。曾主持新加坡國立大學的重要科研項目Molecular and morphological analysis of Neural Tube Defects in Embryos of Diabetic and Retinoic Acid Treated Rats(R-181-000-027-112) 和新加坡醫學研究委員會重要科研項目Analysis of Regulatory Factor Involved in Neurdoxicing in Neurodegeneratine Disease(R-181-000-058-213) 。 ^[1] 

1. Li, Xian, Chen, Xueran, Zhou, Wenjuan, Ji, Shufang, Li,Xinyue, Li,Guanchong, Liu, Guowei, Wang, Fuwu, Hao, Aijun^(*), Effect of melatonin on neuronal differentiation requires CBP/p300-mediated acetylation of histone H3 lysine 14. Neuroscience. 2017 Aug 4. pii: S0306-4522(17)30550-X.

2. Chen, Xueran, Du, Zhaoxia, Li, Xian, Wang, Liyan, Wang, Fuwu, Shi, Wei, Hao, Aijun^(*), Protein Palmitoylation Regulates Neural Stem Cell Differentiation by Modulation of EID1 Activity. Molecular Neurobiology. 2016.10.01，53（8）：5722~5736

3. Shi Wei，Chen Xueran，Wang Fen，Gao Ming，Yang Yang，Du Zhaoxia，Wang Chen，Yao Yao，He Kun，Hao Aijun^(*), ZDHHC16 Modulates FGF/ERK Dependent Proliferation of Neural Stem/Progenitor Cells in the Zebrafish Telencephalo, Developmental Neurobiology，2016.9.3，76（9）：1014~1028

4. Du, Zhaoxia, Chen, Xueran^(*), Li, Xian, He, Kun, Ji, Shufang, Shi,Wei, Hao, Aijun^(*)，Protein palmitoylation activate zygotic gene expression during the maternal-to-zygotic transition. Biochemical and Biophysical Research Communications，2016.6.24，475：194~201

5. Guo Yuji, Liu Shangming, Zhang Xianghong, Wang Liyan, Gao Jiangang, Han Aiqing^(*), Hao Aijun ^(*), G-CSF promotes autophagy and reduces neural tissue damage after spinal cord injury in mice. Laboratory Investigation，2015.12.1，95：1439~1449

6. Wang Fen，Chen Xueran，Shi Wei，Yao Linli，Gao Ming，Yang Yang，Hao Aijun^(*)，Zdhhc15b Regulates Differentiation of Diencephalic Dopaminergic Neurons in Zebrafish. Journal of Cellular Biochemistry，2015.12.01，116：2980~2991

7. Liu, Shangming，Guo, Yuji，Yuan, Qiuhuan，Pan, Yan，Wang, Liyan，Liu, Qian，Wang, Fuwu，Wang, Jingjing^(*) , Hao, Aijun^(*)， Melatonin prevents neural tube defects in the offspring of diabetic pregnancy. Journal of Pineal Research，2015.11.01，59：508~517

8. Shi Wei，Wang Fen，Gao Ming，Yang Yang，Du Zhaoxia，Wang Chen，Yao Yao，He Kun，Chen Xueran^(*)，Hao Aijun^(*)， ZDHHC17 promotes axon outgrowth by regulating TrkA–tubulin complex formation，Molecular and Cellular Neuroscience，2015.9.01，68：194~202

9. Chen Wang，Xueran Chen，Wei Shi，Fen Wang，Zhaoxia Du，Xian Li，Yao Yao，Tong Liu，Tong Shao，Gang Li，Hao Aijun^(*)，2-Bromopalmitate impairs neural stem/progenitor cell proliferation, promotes cell apoptosis and induces malformation in zebrafish embryonic brain. Neurotoxicology and Teratology，2015.7.01，50：53~63

10. Wang, Fuwu，Zhou, Huaiyu，Du, Zhaoxia，Chen, Xueran，Zhu, Faliang，Wang, Zhen，Zhang, Yanmin，Lin, Lin，Qian, Mingyu，Zhang, Xianghong，Li, Xingang^(*), Hao, Aijun^(*)，Cytoprotective effect of melatonin against hypoxia/serum deprivation-induced cell death of bone marrow mesenchymal stem cells in vitro. European Journal of Pharmacology，2015.2.5，748：157~165

11. Zhang yanmin，Ni Shilei，Huang Bin，Wang Liyan，Zhang Xianghong，Li Xian，Wang Han，Liu Shuai，Hao Aijun^(*), Li Xingang^(*)， Overexpression of SCLIP promotes growth and motility in glioblastoma cells. Cancer Biol Ther.，2015.1.1，16：97~105

12. Chen X, Shi W, Wang F, Du Z, Yang Y, Gao M, Yao Y, He K, Wang C, Hao A*. Zinc finger DHHC-type containing 13 regulates fate specification of ectoderm and mesoderm cell lineages by modulating Smad6 activity. Stem Cells Dev, 2014, 23(16):1899-1909.

13.Chen X, Du Z, Shi W, Wang C1, Yang Y, Wang F, Yao Y, He K, Hao A*. 2-Bromopalmitate modulates neuronal differentiation through the regulation of histone acetylation. Stem Cell Res, 2014, 12(2):481–491.

14. Chen X, Li X, Du Z, Shi W, Yao Y, Wang C, He K, Hao A*. Melatonin promotes the acquisition of neural identity through extracellular-signal-regulated kinases 1/2 activation. Journal of Pineal Research, 2014, 57(2):168–176

15. Liu, D., Wang, Z., Zhan, J., Zhang, Q., Wang, J., Xian, X., Luan, Q., and Hao, A*. Hydrogen sulfide promotes proliferation and neuronal differentiation of neural stem cells and protects hypoxia-induced decrease in hippocampal neurogenesis. Pharmacol Biochem Behav ,2014,116, 55-63.

16. Wang, Z., Liu, D., Zhang, Q., Wang, J., Zhan, J., Xian, X., Du, Z., Wang, X., and Hao, A*.Palmitic acid affects proliferation and differentiation of neural stem cells in vitro. J Neurosci Res, 2014.

17. Zhang Y, Liu Q, Wang F, Ling EA, Liu S, Wang L, Yang Y, Yao L, Chen X, Wang F, Shi W, Gao M, Hao A*. Melatonin antagonizes hypoxia-mediated glioblastoma cell migration and invasion via inhibition of HIF-1α. J Pineal Res. 2013 Sep;55 (2):121-30. doi: 10.1111/jpi.12052. Epub 2013 Mar 29.

18. Li, L., Wang, J., Chau, J.F., Liu, H., Li, B., Hao, A., and Li, J*. Smad1 stabilization and delocalization in response to the blockade of BMP activity. Cell Mol Biol Lett,2013 ,18, 340-354.

19. Liu, Q., Wang, L., Wang, Z., Yang, Y., Tian, J., Liu, G., Guan, D., Cao, X., Zhang, Y*., and Hao, A. GRIM-19 opposes reprogramming of glioblastoma cell metabolism via HIF1alpha destabilization. Carcinogenesis, 2013, 34, 1728-1736.

20. Wang, L., Liu, Q., Zhao, H., Cui, K*., Yao, L., Nie, F., Jin, G., Hao, A*., and Wong, S.T.. Differential effects of low- and high-dose GW2974, a dual epidermal growth factor receptor and HER2 kinase inhibitor, on glioblastoma multiforme invasion. J Neurosci Res ,2013a, 91, 128-137.

21. Wang, Z., Liu, D., Zhan, J., Xie, K., Wang, X., Xian, X., Gu, J., Chen, W., and Hao, A*. Melatonin improves short and long-term neurobehavioral deficits and attenuates hippocampal impairments after hypoxia in neonatal mice. Pharmacol Res ,2013b, 76, 84-97.

22. Yao, L., Cao, Q., Wu, C., Kaur, C., Hao, A., and Ling, E.A*. Notch signaling in the central nervous system with special reference to its expression in microglia. CNS Neurol Disord Drug Targets ,2013a ,12, 807-814.

23. Yao, L., Kan, E.M., Kaur, C., Dheen, S.T., Hao, A., Lu, J., and Ling, E.A*. Notch-1 Signaling Regulates Microglia Activation via NF-kappaB Pathway after Hypoxic Exposure In Vivo and In Vitro. PLoS One, 2013b, 8, e78439.

24. Yao, L., Kan, E.M., Lu, J., Hao, A., Dheen, S.T., Kaur, C*., and Ling, E.A*. Toll-like receptor 4 mediates microglial activation and production of inflammatory mediators in neonatal rat brain following hypoxia: role of TLR4 in hypoxic microglia. J Neuroinflammation, 2013c, 10, 23.

25. Yuan, Q., Zhao, S., Liu, S., Zhang, Y., Fu, J., Wang, F., Liu, Q., Ling, E.A., and Hao, A*. Folic acid supplementation changes the fate of neural progenitors in mouse embryos of hyperglycemic and diabetic pregnancy. J Nutr Biochem, 2013a, 24, 1202-1212.

26. Yuan, Q., Zhao, S., Wang, F., Zhang, H., Chen, Z.J., Wang, J., Wang, Z., Du, Z., Ling, E.A., Liu, Q*., Hao, A*. Palmitic acid increases apoptosis of neural stem cells via activating c-Jun N-terminal kinase. Stem Cell Res ,2013b, 10, 257-266.

27. Chen, Y., Lu, H., Liu, Q., Huang, G., Lim, C.P., Zhang, L., Hao, A*., and Cao, X*. Function of GRIM-19, a mitochondrial respiratory chain complex I protein, in innate immunity. J Biol Chem ,2012, 287, 27227-27235.

28. Ma, G., Li, L., Hu, Y., Chau, J.F., Au, B.J., Jia, D., Liu, H., Yeh, J., He, L., Hao, A*., and Li, B*. Atypical Atm-p53 genetic interaction in osteogenesis is mediated by Smad1 signaling. J Mol Cell Biol ,2012, 4, 118-120.

29. Wang, J., Hao, H., Yao, L., Zhang, X., Zhao, S., Ling, E.A., Hao, A*, and Li, G*. Melatonin suppresses migration and invasion via inhibition of oxidative stress pathway in glioma cells. J Pineal Res, 2012a, 53, 180-187.

30. Wang, J., Yao, L., Zhao, S., Zhang, X., Yin, J., Zhang, Y., Chen, X., Gao, M., Ling, E.A., Hao, A*, Li, G*. Granulocyte-colony stimulating factor promotes proliferation, migration and invasion in glioma cells. Cancer Biol Ther, 2012b, 13, 389-400.

31. Wang, L., Zhao, H., Cui, K*., Yao, L., Ren, M., Hao, A., Smollen, P., Nie, F., Jin, G., Liu, Q*., Wong , ST. Identification of novel small-molecule inhibitors of glioblastoma cell growth and invasion by high-throughput screening. Biosci Trends, 2012c, 6, 192-200.

32. Wang, Z., Liu, D., Wang, F., Liu, S., Zhao, S., Ling, E.A., and Hao, A*. Saturated fatty acids activate microglia via Toll-like receptor 4/NF-kappaB signalling. Br J Nutr, 2012d, 107, 229-241.

33. Wang, Z., Liu, D., Wang, J., Liu, S., Gao, M., Ling, E.A., and Hao, A*. Cytoprotective effects of melatonin on astroglial cells subjected to palmitic acid treatment in vitro. J Pineal Res, 2012e, 52, 253-264.

34. Liu, D., Wang, Z., Liu, S., Wang, F., Zhao, S., and Hao, A* Anti-inflammatory effects of fluoxetine in lipopolysaccharide(LPS)-stimulated microglial cells. Neuropharmacology, 2011a, 61, 592-599.

35. Liu, S., Yuan, Q., Zhao, S., Wang, J., Guo, Y., Wang, F., Zhang, Y., Liu, Q., Zhang, S., Ling, E.A., Hao, A*. High glucose induces apoptosis in embryonic neural progenitor cells by a pathway involving protein PKCdelta. Cell Signal, 2011b, 23, 1366-1374.

36. Ren, S., Wang, X., Ma, B*., Yuan, Q., Zhang, H., Yu, X., and Hao, A. Arnebia preventing the expression of Muc1 protein decrease results in anti-implantation in early pregnant mice. Contraception, 2011, 83, 378-384.

37. Shidou Zhao^（#）, Qiuhuan Yuan^（#）, Hongbo Hao, Yuji Guo, Shangming Liu, Yanmin Zhang, Jianli Wang, Huijuan Liu, Fuwu Wang, Kai Liu, Eng-Ang Ling, and Aijun Hao^（*）, Expression of OCT4 pseudogenes in human tumours: lessons from glioma and breast carcinoma, J Pathol, 2011, 223: 672-682。

38. Yuji Guo^（#）, Shangming Liu^（#）, Ping Wang, Shidou Zhao, Fuwu Wang, Lujun Bing, Yanmin Zhang, Eng-Ang Ling, Jiangang Gao^（*） and Aijun Hao^（*）, Expression profile of embryonic stem cell-associated genes Oct4, Sox2 and Nanog in human gliomas, Histopathology, 2011, 59: 763-775。

39. Yanmin Zhang^（#）, Hongbo Hao^（#）, Shidou Zhao, Qian Liu, Qiuhuan Yuan, Shilei Ni, Fuwu Wang, Shangming Liu, Liyan Wang, and Aijun Hao^（*）, Downregulation of GRIM-19 promotes growth and migration of human glioma cells, Cancer Sci, 2011, 102: 1991-1999。

40. Fu-wu Wang^（#）, Hong-bo Hao, Shi-dou Zhao, Yan-min Zhang, Qian Liu, Hui-juan Liu, Shang-ming Liu, Qiu-huan Yuan, Lu-jun Bing, Eng-Ang Ling, Ai-jun Hao, Roles of activated astrocyte in neural stem cell proliferation and differentiation, Stem Cell Res. 2011 Jul;7(1):41-53.

41. Jie Fu^（#）, Shi-Dou Zhao, Hui-Juan Liu, Qiu-Huan Yuan, Shang-Ming Liu, Yan-Min Zhang, Eng-Ang Ling, Ai-Jun Hao, Melatonin promotes proliferation and differentiation of neural stem cells subjected to hypoxia in vitro. J Pineal Res. 2011 Aug;51(1):104-12. ^[1]