趙黎明

分別於無錫輕工大學、江南大學（原無錫輕工大學）食品學院獲得食品科學與工程專業工學學士（1999.6）、碩士（2001.12）、博士（2009.12）學位。

2002年5月至2010年5月，兼任上海市高校畢業生就業指導中心（現上海市學生事務中心）流動黨支部書記。

2002年3月至2004年10年月，任職於上海生遠食品科技有限公司。

2005年1月至2009年1月，任職於凱能高科技工程(上海)有限公司工業流體事業部。

2009年1月出任江蘇欣瑞食品科技發展有限公司總經理。

2010年4月調入華東理工大學生物工程學院任教，2011年9月晉升副教授，2013年3月至2014年3月在美國加州大學戴維斯分校農業與生物工程系做訪問學者，2015年9月破格晉升教授。

2016年3月至2019年11月任生物工程學院副院長；

2019年11月至2021年5月任生物工程學院黨委書記；

2021年5月任華東理工大學科學技術發展研究院院長。

中國輕工業生物基材料工程重點實驗室主任，發酵工業分離提取技術研發中心主任，華東理工大學—上海長征醫院特醫食品聯合研究中心主任。

中國食品科學技術學會理事、食品添加劑分會理事長、休閒食品加工技術分會副理事長、青年工作委員會副主任委員；中國生物發酵產業協會理事、益生製品分會副理事長；上海食品學會常務理事；上海市食品安全專家委員會委員、上海市食品安全風險評估專家委員會生物安全專業委員會委員。

國際期刊Food Bioengineering創刊主編，Food Science & Nutrition、Bioresources and Bioprocessing、《中國食品學報》、《食品工業科技》、《食品科學》、《生物技術進展》、《中國釀造》、《食品安全質量檢測學報》等國際國內學術期刊編委。

基於分離提取技術的食品藥品及材料工程。

主要研究興趣：

1. 糖生物工程（功能碳水化合物的綠色生物製造、分離純化及功能評價）；

2. 分離工程（膜和色譜分離技術及其在糖工程、生物製造中的應用）；

3. 生物基材料工程（新型生物基材料開發、納米生物基材料及其在食品醫藥應用）；

4. 特殊醫學用途全營養食品、發酵食品開發。

1. 《食品工程原理》，本科專業核心課程，上海市重點課程

2. 《生物分離工程》，本科專業核心課程，國家精品課程

3. 《食品工廠設計》，本科專業必修課程

4. 《食品過程工程》，研究生學位必修課程

近年來主持多項國家級和省部級課題，承擔了20餘項企業橫向課題研發和產業化推廣工作，具有豐富的工程實踐經驗。以第一完成人獲得省部級科技獎勵6項；申請發明專利60件、授權中國發明專利36件、美國發明專利1件；發表學術論文150餘篇；出版中、英文學術專著3部；主編教材2部。

榮獲“十三五”輕工行業科技創新先進個人、中國生物發酵行業30年協同創新獎（個人）、倫世儀教育基金傑出青年學者、寶鋼優秀教師、中國產學研合作創新獎（個人）、中國食品科學技術學會科技創新獎－傑出青年獎等榮譽。

1. 承擔國家重點研發計劃課題：水產活性組分高精度分離提取裝備與穩態化技術研發（2019YFD0901805）。

2. 主持國家重點研發計劃課題：低成本乳酸、丙交酯和聚乳酸製備關鍵技術及產業化研究（2017YFB0309302）(已結題)。

3. 主持國家高技術研究發展計劃（863）課題《利用生物基原料生產綠色尼龍聚丁內酰胺》（2014AA021202）(已結題)。

4. 主持工信部綠色製造系統集成項目：氨基葡萄糖生產綠色關鍵技術開發與系統集成項目(已結題)。

5. 主持國家自然科學基金項目：甲殼素加工廢水納濾傳質機理/膜分離特性和污染機理研究(已結題)。

6. 主持國家自然科學基金項目：納濾分離中單糖分子結構、極性和計算分子直徑對分離和傳質特性的影響和機理研究(已結題)。

7. 主持國家高技術研究發展計劃（863）課題《高效分離純化介質開發及應用》子課題《人用疫苗分離純化技術及裝備開發》（已結題）。

1. 趙黎明等，Method for preparing biobased nylon: polyactam，US10308764B2

2. 趙黎明等，一種氨糖的電場和流場耦合調控納濾分離方法，ZL201510273840X

3. 趙黎明等，一種低温殼聚糖酶及其編碼基因與應用，ZL2017101774291

4. 趙黎明等，一種氨基葡萄糖合成甲殼素及其衍生物的方法，ZL201510114679.1

1. Shumin Chen, Xiaoguo Ji, Mengyao Zhao, Jiayang Jin, Haiping Zhang*, Liming Zhao*, Construction of chitooligosaccharide-based nanoparticles of pH/redox cascade responsive for co-loading cyclosporin A and AZD9291. Carbohydrate Polymers.291 (2022) 119619.

2. Xiaoguo Ji, Liangliang Zhu, Kunlin Chang, Ran Zhang, Yijia Chen, Hao Yin, Jiayang Jin*, Liming Zhao*. Chitooligosaccahrides: digestion characterization and effect of the degree of polymerization on gut microorganisms to manage the metabolome functional diversity in vitro. Carbohydrate Polymers,275 (2022) 118716.

3. Yanying Hou, Lujie Liu, Qiaole He, Di Zhang, Jiayang Jin, Banghe Jiang, Liming Zhao*. Adsorption behaviors and kinetics studies 1 of chitooligosaccharides with specific degree of polymerization on a novel ion-exchange resin. Chemical Engineering Journal, 430 (2022) 132630.

4. Mai Chen, Jiayang Jin, Xiaoguo Ji, Kunlin Chang, Juan Li, Liming Zhao*. Pharmacokinetics, bioavailability and tissue distribution of chitobiose and chitotriose in rats. Bioresources and Bioprocessing.(2022) 9:13.

5. Xue Zhang, Chunyue Zhang, Mian Zhou, Quanming Xia, Liqiang Fan, Liming Zhao*. Enhanced bioproduction of chitin in engineered Pichia pastoris. Food Bioscience. 47 (2022) 101606.

6. Yanqiong Liu，Chunyue Zhang，Lujie Liu，Xingxing Zhang，Yanying Hou, Liming Zhao*. Characterization of Chitin-Glucan Complex of Ganoderma lucidum Extract and Its Application as Hemostatic Hydrogel. Waste and Biomass Valorization (2022).

7. Mengfeng Gao, Qiaole He, Huizhong Dong, Jiale Wang, Junfeng Shi, Chuanqi Xie, Lo Yangming Martin, Liming Zhao*. Identification of the coupled fouling mechanism involved in microfiltration of tobacco extracts liquid by multistage Hermia model. Journal of food process engineering (2022).

8. Wang Shumin, Ji Xiaoguo, Chen Shumin, Zhang Chunyue, Wang Yibin, Lin Haodong*, Zhao Liming*. Study of double bonded carboxymethyl chitosan/cysteamine-modified chondroitin sulfate composite dressing for hemostatic application. European Polymer Journal,(2021)110875.

9. Xin Shen,Xinyi Liang, Xiaoguo Ji, Jiangshan You, Xinye Zhuang, Yudong Song,Hao Yin, Mengyao Zhao* and Liming Zhao*. CD36 and DGAT2 facilitate the lipid-loweringeffect of chitooligosaccharides via fatty acidintake and triglyceride synthesis signaling.Food Functional,2021,12:8681-8693.

10. Mengyao Zhao，Linlin Deng，Xiaoxuan Lu，Liqiang Fan，Yang Zhu，Liming Zhao*. The involvement of oxidative stress, neuronal lesions, neurotransmission impairment, and neuroinflammation in acrylamide-induced neurotoxicity in C57/BL6 mice. Environmental Science and Pollution Research, (2022) 29:41151–41167.

11. Linlin Deng, Mengyao Zhao*, Yanan Cui, Quanming Xia, Lihua Jiang, Hao Yin & Liming Zhao*. Acrylamide induces intrinsic apoptosis and inhibits protective autophagy via the ROS mediated mitochondrial dysfunction pathway in U87-MG cells, Drug and Chemical Toxicology, (2021):DOI: 10.1080/01480545.2021.1979030.

12. Ling Xie, Jun Yi, Yongjia Song, Mengyao Zhao, Liqiang Fan*, Liming Zhao*. Suppression of GOLM1 by EGCG through HGF/HGFR/AKT/GSK-3β/ β-catenin/c-Myc signaling pathway inhibits cell migration of MDA-MB-231. Food and Chemical Toxicology, 2021, (157):112574.

13. Qu Tianle, Zhang Chunyue, Qin Zhen, Fan Liqiang*, Jiang Lihua* and Zhao Liming*. A Novel GH Family 20 β-N-acetylhexosaminidase With Both Chitosanase and Chitinase Activity From Aspergillus oryzae. Frontiers in Molecular Biosciences (Front. Mol. Biosci). (2021) 8:684086.

14. Xiao-Guo Ji, Kun-Lin Chang, Mai Chen, Liang-Liang Zhu, Arwa Osman, Hao Yin*, Li-Ming Zhao*. In vitro fermentation of chitooligosaccharides and their effects on human fecal microbial community structure and metabolites, LWT - Food Science and Technology, 144 (2021) 111224.

15. Mengyao Zhao, Shumin Chen, Xiaoguo Ji, Xin Shen, Jiangshan You, Xinyi Liang, Hao Yin*, Liming Zhao*. Nutraceuticals and functional foods for intervention of non-alcoholic fatty liver disease, Pharmacological Research, 166 (2021) 105517.

16. Xiaoguo Ji, Mai Chen, Mengyao Zhao, Yudong Song, Yong Lin, Hao Yin*, Liming Zhao*. Effects of chitooligosaccharides on the rebalance of gut microorganisms and their metabolites in patients with nonalcoholic fatty liver disease, Journal of Functional Foods, 77 (2021) 104333.

17. Chunfeng Zhu, Mengyao Zhao*, Liqiang Fan, Xuni Cao, Quanming Xia, Jiachun Zhou, Hao Yinand Liming Zhao*.Chitopentaose inhibits hepatocellularcarcinoma by inducing mitochondrialmediated apoptosis and suppressing protectiveautophagy. Bioresources and Bioprocessing. (2021) 8:4.

18. Yani Wang, Zhen Qin, Liqiang Fan, Liming Zhao*. Structure–function analysis of Gynuella sunshinyii chitosanase uncovers the mechanism of substrate binding in GH family 46 members. International Journal of Biological Macromolecules. 165 (2020) 2038–2048.

19. Xiaochao Hu^#, Shumin Chen^#, Hao Yin, QiWang, Yourong Duan, Lihua Jiang*, Liming Zhao*，Chitooligosaccharides-modified PLGA nanoparticles enhance the antitumor efficacy of AZD9291 (Osimertinib) by promoting apoptosis. International Journal of Biological Macromolecules.162 (2020) 262–272.

20. Qiao-Le He, Eric von Lieres, Zhaoxi Sun, Liming Zhao*，Model-based process design of a ternary protein separation using multi-step gradient ion-exchange SMB chromatography，Computers and Chemical Engineering，138 (2020) 106851.

21. Qiao-Le He, Liming Zhao*，Bayesian inference based process design and uncertainty analysis of simulated moving bed chromatographic systems，Separation and Purification Technology，246 (2020) 116856.

22. Sa Luo, Zhen Qin*, Qiming Chen, Liqiang Fan, Lihua Jiang, Liming Zhao* ,High level production of a Bacillusamlyoliquefaciens chitosanase in Pichia pastoris suitable for chitooligosaccharides preparation, International Journal of Biological Macromolecules, 149 (2020) :1034–1041.

23. Jiayi Chen, Qiming Chen, Chuanqi Xie, Waheed Ahmad, Lihua Jiang, Hongfang Ji, Liming Zhao*. Effects of simulated gastric and intestinal digestion on chitooligosaccharides in two in vitro models. International Journal of Food Science & Technology. 2020, 55, 1881–1890.

24. Mengyao Zhao, Liming Gu, Yun Li, Shumin Chen, Jiangshan You, Liqiang Fan, Yudong Wang, Liming Zhao*. Chitooligosaccharides display anti-tumor effects against human cervical cancer cells via the apoptotic and autophagic pathways. Carbohydrate Polymers. 2019, 224：115171.

25. Zhen Qin^#, Si Lin^#, Yongjun Qiu, Qiming Chen, Yin Zhang, Jiachun Zhou, Liming Zhao*. One-step immobilization-purification of enzymes by carbohydrate-binding module family 56 tag fusion[J]. Food Chemistry, 2019, 299(30):125037.

26. Si Lin^#, Zhen Qin^#, Qiming Chen, Liqiang Fan, Jiachun Zhou, Liming Zhao*. Efficient immobilization of bacterial GH family 46 chitosanase by carbohydrate-binding module fusion for the controllable preparation of chitooligosaccharides[J]. Journal of Agricultural and Food Chemistry, 2019, 67(24): 6847-6855.

27. Jun Lu^#, Qiming Chen^#, Bolin Pan, Zhen Qin, Liqiang Fan, Quanming Xia, Liming Zhao*. Efficient inhibition of Cronobacter biofilms by chitooligosaccharides of specific molecular weight[J]. World Journal of Microbiology and Biotechnology, 2019, 35(6): 87.

28. Qiming Chen, Lu Jun, Yongjun Qiu, Liming Zhao*. Bioinformatics-based mining of novel gene targets for identification of Cronobacter turicensis using PCR[J]. Journal of Dairy Science, 2019, 102(7): 6023-6026.

29. Sijing Jiang, Liqiang Fan*, Mengyao Zhao, Yongjun Qiu, Liming Zhao*. Enhanced Low Molecular Weight Poly-γ-Glutamic Acid Production in Recombinant Bacillus subtilis 1A751 with Zinc Ion[J]. Applied Biochemistry and Biotechnology, 2019,189:411–423.

30. Ping Chen, Mengyao Zhao, Qiming Chen, Liqiang Fan, Feng Gao, and Liming Zhao*，Absorption Characteristics of Chitobiose and Chitopentaose in the Human Intestinal Cell Line Caco-2 and Everted Gut Sacs，Journal of Agricultural and Food Chemistry ，2019 ，67 (16)：4513-4523.

31. Mengyao Zhao, Xin Shen, Xiaodan Li, Baoli Chen, Liqiang Fan, Quanming Xia, Liming Zhao*，Chitooligosaccharide supplementation prevents the development of high fat diet-induced non-alcoholic fatty liver disease (NAFLD) in mice via the inhibition of cluster of differentiation 36 (CD36)，Journal of Functional Foods, 57 (2019):7–18.

32. Yang Zhang, Liqiang Fan, Mengyao Zhao, Qiming Chen, Zhen Qin, Zhihang Feng, Toru Fujiwara, Liming Zhao*. Chitooligosaccharide plays essential roles in regulating proline metabolism and cold stress tolerance in rice seedlings[J]. Acta Physiologiae Plantarum, 2019, 41(6): 77.

33. Jiachun Zhou，Qiao Chen, Yang Zhang, Liqiang Fan, Zhen Qin,Qiming Chen, Yongjun Qiu, Lihua Jiang and Liming Zhao*，Chitooligosaccharides enhance cold tolerance by repairing photodamaged PS II in rice，The Journal of Agricultural Science，2018,156, 888–899.

34. Wei Li，Mengyao Zhao，Zhen Qin，Qiming Chen，Liqiang Fan，Jiachun Zhou， Liming Zhao*，Inhibitory effect of chitooligosaccharides on retinol metabolism and bioavailability in mice，J Food Biochem. 2019，43（3）:1-10.

35. Lei Yao, Zhen Qin, Qiming Chen, Mengyao Zhao, Hefei Zhao, Waheed Ahmad, Liqiang Fan, Liming Zhao*, Insights into the nanofiltration separation mechanism of monosaccharides by molecular dynamics simulation, Separation and Purification Technology ,205 (2018): 48–57.

36. Xiaodan Li^#, Mengyao Zhao^#, Liqiang Fan, Xuni Cao, Liehuan Chen, Junhui Chen, Y. Martin Lo, Liming Zhao*, Chitobiose alleviates oleic acid-induced lipid accumulation by decreasing fatty acid uptake and triglyceride synthesis in HepG2 cells, Journal of Functional Foods, 46 (2018): 202-211.

37. Zhen Qin, Sa Luo, Yun Li, Qiming Chen, Yongjun Qiu, Liming Zhao*, Lihua Jiang, Jiachun Zhou, Biochemical properties of anovelchitosanase from Bacillus amyloliquefaciens and its use in membrane reactor. LWT - Food Science and Technology, 97 (2018): 9-16.

38. Xiaoxing Yang, Jiachun Zhou, Liqiang Fan, Zhen Qin, Qiming Chen, Liming Zhao*. Antioxidant properties of a vegetable–fruit beverage fermented with two Lactobacillus plantarum strains. Food Science and Biotechnology, (2018) 27(6): 1719-1726.

39. Li-Qiang Fan*, Ming-Wei Li, Yong-jun Qiu, Qi-ming Chen, Si-Jing Jiang, Yu-Jie Shang, Li-Ming Zhao*, Increasing thermal stability of glutamate decarboxylase from Escherichia. coli by site-directed saturation mutagenesis and its application in GABA production. Journal of Biotechnology, 278 (2018):1-9.

40. Zhen Qin, Qiming Chen，Si Lin，Sa Luo，Yongjun Qiu，Liming Zhao*. Expression and characterization of a novel cold‑adapted chitosanase suitable for chitooligosaccharides controllable preparation. Food Chemistry, 253 (2018):139-147.

41. Sha Huang, Liming Zhao*, Qiming Chen, Zhen Qin, Jiachun Zhou, Yongjun Qiu, Yin Zhang, Mingyue Ma, Physicochemical Characteristics of Edible Bird’s Nest Proteins and Their Cooking Processing Properties. International Journal of Food Engineering.2018;20170152.

42. Qiming CHEN, Yang ZHU, Zhen QIN, Yongjun QIU, Liming ZHAO*, Cronobacter spp., foodborne pathogens threatening neonates and infants, Front. Agr. Sci. Eng. 2018, 5 (3): 330-339.

43. 曾貝迪，陳濤^*，趙黎明^*．聚丁內酰胺/殼聚糖電紡納米蛛網複合纖維膜的製備及性能．功能高分子學報. 10.14133/j.cnki.1008-9357.20210603001

44. 劉洋,張洋,範立強,趙夢瑤,趙黎明^*. N-乙酰氨基葡萄糖對水稻的抗寒作用研究. 南方農業學報. 2021，52（6）:1576-1586

45. 馬冰清,張忠,吳迪,範立強,張春月,周峯,楊焱^*,趙黎明^*.香菇菌糠高温高壓－複合酶降解工藝優化及提取物的生物活性.食用菌學報.2021,28(04):27-38

46. 鄭安娜,趙夢瑤,遊江珊,潘小旭,趙黎明^*.殼三糖胍鹽酸鹽對胰島素抵抗細胞模型的改善作用．食品工業科技.

47. 周衞強,李娟,沈雪梅,彭超,陳博,晏禮明,趙黎明^*,李義,佟毅.基於紫外檢測器的殼寡糖色譜分析與比較.理化檢驗(化學分冊). 2021,57(08):698-702

48. 張春月，金佳楊，邱勇雋，範立強，趙黎明^*. 傳統與未來的碰撞：食品發酵工程技術與應用進展. 生物技術進展, 2021, 11(4):418-429

49. 陳靚，劉佳，王樂軍，陳濤，陳啓明，趙黎明^*．聚丁內酰胺的熱性能改性．高分子材料科學與工程，2021,37(2):1-6.

50. 張迪，張紫薇，李春蕊，劉佳，陳濤，趙黎明^*．聚丁內酰胺的生物降解性研究進展．包裝工程. 2021,42(13):136-142

51. 謝玲，益鈞，宋永佳，李卓渝，範立強^*，趙黎明^*．基於網絡藥理學探究EGCG干預MDA-MB-231 細胞的潛在分子機制．華東理工大學學報(自然科學版). Doi：10.14135/j.cnki.1006-3080.20201126003

52. 馬佳菲,秦臻,範立強,趙黎明^*，蔣麗華^*. Cyclobacterium qasimii脱乙酰酶的異源表達及酶學性質[J]. 食品科學技術學報,2020, 38(6):39-46.

53. 沈欣，趙夢瑤，邱勇雋，夏泉鳴，趙黎明^*，殼寡糖對體外誘導的非酒精性脂肪肝細胞模型的降脂機理研究，食品科學技術學報，2020,38(5):41-47．

54. 張添添，陳啓明，趙黎明^*，姜舒文，陳濤，生物基聚丁內酰胺腸衣膜的性能分析，食品科學，2021, 42（03）：236-242

55. 馬佳菲,秦臻,範立強,趙黎明^*，蔣麗華^*. Cyclobacterium qasimii脱乙酰酶的異源表達及酶學性質[J]. 食品科學技術學報,2020, 38(6):39-46.

56. 沈欣，趙夢瑤，邱勇雋，夏泉鳴，趙黎明*，殼寡糖對體外誘導的非酒精性脂肪肝細胞模型的降脂機理研究，食品科學技術學報，2020,38(5):41-47．

57. 張添添，陳啓明，趙黎明*，姜舒文，陳濤，生物基聚丁內酰胺腸衣膜的性能分析，食品科學，20200303

58. 周衞強，沈雪梅，彭超，陳博，盧宗梅，周勇，李義，趙黎明*，佟毅，單一聚合度殼寡糖色譜分離技術的應用，化學分析計量，2020，29(4): 135–139.

59. 陳倩倩，邱勇雋，夏泉鳴，秦臻，趙黎明*．特定聚合度區間殼寡糖的膜分離製備技術[J/OL]．食品工業科技.20190625

60. 陳寶莉，秦臻，趙黎明*，糞腸球菌β-N-乙酰氨基葡萄糖苷酶基因的克隆表達及酶學性質表徵. 生物技術進展. 2019,9 (3):296-302

61. 陳寶莉，秦臻，趙黎明*．解澱粉芽孢桿菌β-N-乙酰氨基葡萄糖苷酶的克隆表達及酶學表徵[J/OL]．食品科學. 2020，41（8）：123-129

62. 李允，秦臻，張崟，陳啓明，邱勇雋，趙黎明*．酶膜耦合法制備高聚合度殼寡糖[J/OL]．食品工業科技. 20190505

63. 吳德，唐亮琛，唐頌超，錢軍，魏傑*，趙黎明*，生物基丁內酰胺及聚丁內酰胺的合成及性能，功能高分子學報．2019,32(1):110-116

1. 主編：《生物基可降解材料的研究與應用》，上海科學技術出版社，2022

2. 編著：《Oligosaccharides of Chitin and Chitosan: Bio-manufacture and Applications》，Springer Nature, 2019

2. 主編：《膜分離技術在食品發酵工業中的應用》，中國紡織出版社，2011

1. 主編：《食品過程工程》，中國輕工業出版社，2020

2. 主編：《食品工程原理》，中國紡織出版社，2013.9(2018.9再版)