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趙方慶
鎖定
趙方慶,中國科學院北京生命科學研究院研究員。
- 出生地
- 山東
- 畢業院校
- 中國科學院海洋研究所 [1]
- 主要成就
- 建立了一系列計算基因組學算法和工具
- 職 稱
- 研究員
趙方慶人物經歷
趙方慶,博士,研究員。
2006年獲中國科學院海洋研究所博士學位,研究方向為海洋微藻的進化基因組學。
2006年7月至2010年底在美國賓州州立大學比較基因組學和生物信息學研究中心,從事計算生物學和基因組學的研究工作。
2010年10月被中國科學院北京生命科學研究院聘為“百人計劃”研究員,研究方向為計算基因組學。現任中科院北京生科院科研部副主任、技術平台部主任,中國生物工程學會生物信息學與計算生物學專委會副主任。
在Briefings in Bioinformatics、Genomics,Proteomics & Bioinformatics、mLife、BMCEvolution and Ecology、Medicine in Microecology和Journal of Genetics and Genomics等國際學術刊物擔任副主編或編委。主要致力於建立高效的算法模型和實驗技術,探索人體微生物與非編碼RNA的結構組成與變化規律,以期解析它們與人類健康和疾病的關係。近年來,在Cell、Gut、Nature Biotechnology、Nature Computational Science和NatureCommunications等刊物上發表通訊作者論文60餘篇;總引用次數一萬餘次(H-index 45),其中十餘篇入選ESI高被引論文。
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趙方慶近期代表性論文
1. Li Z, Zhang B, Wang N, Zuo Z, Wei H & Zhao F*. Anovel peptide protects against diet-induced obesity by suppressing appetite andmodulating the gut microbiota. Gut, 2022 doi: 10.1136/gutjnl-2022-328035
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2. Xiao L, Zhang F & Zhao F*. Large-scale microbiomedata integration enables robust biomarker identification. NatureComputational Science, 2022, 2: 307-316.
3. Wu W, Zhang J, Cao X, Cai Z & Zhao F*. Exploringthe cellular landscape of circular RNAs using full-length single-cell RNAsequencing. Nature Communications, 2022, 13(1):3242.
4. Yang J, Hou L, Wang J, Xiao L, Zhang J, Yin N, Yao S, ChengK, Zhang W, Shi Z, Wang J, Jiang H, Huang N, You Y, Lin M, Shang R, Wei Y*,Zhao Y* & Zhao F*. Unfavourable intrauterine environment contributesto abnormal gut microbiome and metabolome in twins. Gut, 2022 doi: 10.1136/gutjnl-2021-326482
5. Chen S, Cao X, Zhang J, Wu W, Zhang B & Zhao F*.circVAMP3 drives CAPRIN1 phase separation and inhibits hepatocellular carcinomaby suppressing c-Myc translation. Advanced Science, 2022, 9(8):e2103817.
6. Yu Y, Zhang B, Ji P, Zuo Z, Huang Y, Wang N, Liu C, Liu SJ& Zhao F*. Changes to gut amino acid transporters andmicrobiome associated with increased E/I ratio in Chd8+/- mousemodel of ASD-like behavior. Nature Communications, 2022, 13(1):1151.
7. Zhang J, Hou L, Zuo Z, Zhang X, Xue Y & Zhao F*.Comprehensive profiling of circular RNAs with nanopore sequencing andCIRI-long. Nature Biotechnology, 2021, 39:836-845.
8. Xiao L, Wang J, Zheng J,Li X & Zhao F*. Deterministic transition of enterotypes shapes theinfant gut microbiome at an early age. Genome Biology, 2021,22:243.
9. Wang J, Li Z, Ma X, Du L, Jia Z, Cui X, Yu L, XiaoL, Zhang B, Fan H & ZhaoF*. Translocation of vaginalmicrobiota is involved in impairment and protection of uterine health. Nature Communications, 2021, 12:4191.
10. Jia N, Wang J, Shi W, Du L,Sun Y, et al., Tick Genome and Microbiome Consortium, Zhao F* & Cao WC*. Large-scale comparative analysesof tick genomes elucidate their genetic diversity and vector capacities. Cell,2020, 182(5):1328-1340
11. Zhang J, Chen S, YangJ & Zhao F*. Accuratequantification of circular RNAs identifies extensive circular isoform switchingevents. Nature Communications, 2020, 11:90.
12. Wu W, Ji P & Zhao F*. CircAltas: An integrated resource of one millionhighly confident circular RNAs from 1,070 transcriptomes of vertebrates. GenomeBiology, 2020, 21:101.
13. Wang J, Jia Z, Zhang B,Peng L & Zhao F*. Tracing the accumulation of in vivohuman oral microbiota elucidates microbial community dynamics at the gateway tothe GI tract. Gut, 2020, 69:1355-1356.
14. Ji P, Wu W, Chen S, etal, Zhao F*. Expandedexpression landscape and prioritization of circular RNAs in mammals. CellReports, 2019, 26 (12), 3444-3460.
15. Wang J, Zheng J, Shi W, Du N, XuX, Zhang Y, Ji P, Zhang F, Jia Z, Wang Y, Zheng Z, Zhang H& Zhao F*. Dysbiosis of maternal andneonatal microbiota associated with gestational diabetes mellitus. Gut,2018, 67:1614-1625.
16. Ji P, Zhang Y, Wang J& Zhao F*. MetaSort untanglesmetagenome assembly by reducing microbial community complexity. NatureCommunications, 2017, 8:14306.
17. Shi W, Ji P & Zhao F*. The combination of directand paired link graphs boosts repetitive genome assembly. NucleicAcids Res 2017, 45 (6): e43.
18. Gao Y, Zhang J & Zhao F*. Circular RNA identificationbased on multiple seed matching. Briefingsin Bioinformatics 2018, 19(5):803-810.
19. Peng G, Ji P & Zhao F*. A novel codon-based de Bruijn graph algorithm for geneconstruction from unassembled transcriptomes. Genome Biology 2016,17:232.
20. Gao Y, Wang J, ZhengY, Zhang J, Chen S & Zhao F*. Comprehensive identification of internal structureand alternative splicing events in circular RNAs. Nature Communications 2016,7:12060.
21. Gao Y, Wang J & Zhao F*. CIRI: an efficient andunbiased algorithm for de novo circular RNA identification. GenomeBiology. 2015, 16:4.Ye N*, Zhang X, Miao M, Fan X, Zheng Y, XuD, Wang J, Zhou L, Wang D, Gao Y, Wang Y, Shi W, Ji P,Li D, Guan Z, Shao C, Zhuang Z, Gao Z, Qi J* & Zhao F*. Saccharina genomes provide novel insight into kelp biology. NatureCommunications. 2015, 6: 6986
趙方慶所獲榮譽
2022年,入選國家傑出青年科學基金專家評審組
先後4次榮獲“中國科學院優秀導師獎”(2017, 2018, 2019, 2021);承擔的《生物信息學》先後入選“國家精品在線開放課程”(2018)和“國家級一流本科課程”(2020);培養的研究生已有6人次獲得“中國科學院院長獎” (包括特別獎和優秀獎)和“中國科學院優秀博士學位論文”
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- 參考資料
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- 1. 研究人員 .中國科學院北京生命科學研究院[引用日期2016-05-06]
- 2. 86人!基金委生命學部公佈傑青、創新羣體項目評審專家名單 .中國科學報[引用日期2022-07-01]
- 3. 北京大學生命科學學院 .生物大數據挖掘的新技術和新方法[引用日期2022-07-05]
- 4. Zhao F[Author]-National Library of Medicine .National Library of Medicine[引用日期2022-07-08]
- 5. 趙方慶-中國科學院大學-UCAS .中國科學院大學[引用日期2022-07-11]
- 6. 趙方慶-國科大杭州高等研究院 .國科大杭州高等研究院[引用日期2022-07-11]
- 7. 關於2021年度中國科學院大學必和必拓獎學金評選結果公示的通知-中國科學院大學 .中國科學院大學[引用日期2022-07-13]