趙巖

2006 - 2010 德州學院物理系，獲學士學位

2010 - 2015 中國科學技術大學 & 中科院生物物理所，獲博士學位

2015 - 2019 美國俄勒岡健康與科學大學/霍華德·休斯醫學研究所博士後

2020 - 至今 中國科學院生物物理研究所，研究員 ^[1] 

膜蛋白在所有物種的生命活動中都起着至關重要的作用，幫助物質、能量以及信號實現跨生物膜的傳遞。在已知的基因組測序中，30%左右的基因負責編碼膜蛋白。大約50%的藥物分子靶向膜蛋白，這些都顯示出膜蛋白具有重要的生物學和醫學研究意義。本實驗室的研究方向是利用冷凍電子顯微術、電生理實驗以及其他生物化學手段研究神經系統中重要的膜蛋白複合物的三維結構，並闡明這些複合物工作的分子機制。 ^[1] 

1. Z. Zhang^#, H. Chen^#, Z. Geng^#, Z. Yu, H. Li, Y. Dong, H. Zhang, Z. Huang*, J. Jiang*, Y. Zhao*. Structural basis of ligand binding modes of human EAAT2. Nature Communications. 2022 Jun 9;13(1):3329.

2. Y. Dong^#, H. Li^#, A. Ilie^#, Y. Gao, A. Boucher, X. C. Zhang*, J. Orlowski*, Y. Zhao*. Structural basis of autoinhibition of the human NHE3-CHP1 complex. Science advances. 2022 May 27;8(21):eabn3925.

3. L. He^#, Z. Yu^#, Z. Geng^#, Z. Huang^#, C. Zhang, Y. Dong, Q. Chen, L. Sun, X. Ma, B. Huang, X. Wang, Y. Zhao*. Structure, gating and pharmacology of human CaV3.3 channel. Nature Communications. 2022 Apr 19;13(1):2084.

4. X. Li^#, F. Xu^#, H. Xu^#, S. Zhang, Y. Gao, H. Zhang, Y. Dong, Y. Zheng, B. Yang, J. Sun, X. C. Zhang, Y. Zhao*, D. Jiang*. Structural basis for modulations of human NaV by clinical drug and selective antagonist. Nature Communications. 2022 Mar 11;13(1):1286.

5. H. Zhang^#, J. Su^#, B. Li^#, Y. Gao, M. Liu, L. He, H. Xu, X. C. Zhang, Y. Zhao*. Structure of human glycosylphosphatidylinositol transamidase. Nature Structural & Molecular Biology. 2022: 1-7

6. Yanli Dong^#, Yiwei Gao^#, Shuai Xu^# Yuhang Wang, Zhuoya Yu, Yue Li, Bin Li, Bei Yang, Xuejun Cai Zhang, Daohua Jiang*, Zhuo Huang*, Y. Zhao*. Closed-state inactivation and pore-blocker modulation mechanisms of human CaV2.2. Cell Reports. 2021. 37, 109931.

7. Lingli He^#, Jiahui Sun^#, Yiwei Gao^#, Bin Li, Yuhang Wang, Yanli Dong, Weidong An, Hang Li, Bei Yang, Yuhan Ge, Xuejun Cai Zhang*, Yun Stone Shi* & Y. Zhao*. Kainate receptor modulation by NETO2. Nature. 2021.

8. Yanli Dong^#, Yiwei Gao^#, Alina Ilie, DuSik Kim, Annie Boucher, Bin Li, Xuejun C. Zhang*, John Orlowski* & Y. Zhao*. Structure and mechanism of the human NHE1-CHP1 complex. Nature Communications. 2021. 9;12(1):3474.

9. Rong Y, Jiang J.H, Gao Y.W, Guo J.L, Song D.F, Liu W.H, Zhang M.M, Zhao Y*, Xiao B.L*, Liu Z.F*. TMEM120A contains a specific coenzyme A-binding site and might not mediate poking- or stretch-induced channel activities in cells. Elife. 2021.10, e71474.

10. Y. Zhao, S. Chen, A. C. Swensen, W. J. Qian, E. Gouaux. Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM. Science. 2019. 364, 355-362.

11. Y. Xin, Y. Zhao, J. Zheng, H. Zhou, X. C. Zhang, C. Tian, & Y. Huang. Structure of YidC from Thermotoga maritima and its implications for YidC-mediated membrane protein insertion. The FASEB Journal. 2018. 32(5), 2411-2421.

12. S. Chen^#, Y. Zhao^#, Y. Wang, M. Shekhar, E. Tajkhorshid and E. Gouaux. Activation and desensitization mechanism of AMPA receptor - TARP complex by cryo-EM. Cell. 2017.170, 1234-1246.

13. Y. Zhao^#, S. Chen^#, C. Yoshioka, I. Baconguis, E. Gouaux. Architecture of fully occupied GluA2 AMPA receptor-TARP complex elucidated by cryo-EM. Nature. 2016.536(7614): 108-111.　　

14. G. Mao^#, Y. Zhao^#, X. Kang, Z. Li, Y. Zhang, X. Wang, F. Sun, K. Sankaran and XC. Zhang. Crystal structure of E. coli lipoprotein diacylglyceryl transferase. Nature communications. 2016.7: 10198.　　

15. J. Heng, Y. Zhao, M. Liu, Y. Liu, J. Fan, X. Wang, Y. Zhao, and XC. Zhang. Substrate-bound structure of the E. coli multidrug resistance transporter MdfA. Cell research. 2015.25(9): 1060. 　　

16. X.C. Zhang, Y. Zhao, J. Heng, D. Jiang. Energy coupling mechanisms of MFS transporters. Protein Science. 2015.24(10): 1560-1579.　

17. Y. Zhao^#, G. Mao^#, M. Liu, L. Zhang, X. Wang, X.C. Zhang. Crystal structure of the E. coli peptide transporter YbgH. Structure. 2014.22(8): 1152-1160.　　

18. B. Cao^#, Y. Zhao^#, Y. Kou, D. Ni, X.C. Zhang and Y. Huang. Structure of the nonameric bacterial amyloid secretion channel. Proceedings of the National Academy of Sciences. 2014.111(50): E5439-E5444.　　　

19. D. Jiang^#, Y. Zhao^#, J. Fan, X. Liu, Y. Wu, W. Feng, X.C. Zhang. Atomic resolution structure of the E. coli YajR transporter YAM domain. Biochemical and biophysical research communications. 2014.450(2): 929-935.　　

20. S. Qiao, Q. Luo, Y. Zhao, X.C. Zhang, Y. Huang. Structural basis for lipopolysaccharide insertion in the bacterial outer membrane. Nature. 2014.511(7507): 108.

21. J. Fan, D. Jiang, Y. Zhao, J. Liu, and X.C. Zhang. Crystal structure of lipid phosphatase Escherichia coli phosphatidylglycerophosphate phosphatase B. Proceedings of the National Academy of Sciences. 2014.111(21): 7636-7640. 　　

22. D. Jiang^#, Y. Zhao^#, X. Wang^#, J. Fan, J. Heng, X. Liu, W. Feng, X. Kang, B. Huang, J. Liu and X.C. Zhang. Structure of the YajR transporter suggests a transport mechanism based on the conserved motif A. Proceedings of the National Academy of Sciences. 2014.110(36): 14664-14669.　　

23. W. Zhang, F. Zeng, Y. Liu, Y. Zhao, H. Lv, L. Niu, M. Teng and X. Li (2013). Crystal Structures and RNA-Binding Properties of the RRMs of hnRNP-L: Insights into Its Roles in Alternative-splicing Regulation. Journal of Biological Chemistry. 2014 288(31), 22636-22649. ^[1]