趙剛

1980年和1987年曾分別就讀於四川大學化學系和蘭州大學化學系,1999年在香港中文大學獲博士學位。1987年至1996年在四川大學任教。1999年赴法國在法國國家科學研究中心從事博士後研究。2000年任美國俄亥俄州立大學研究員助理。2003年在世界500強企業之一的日東電工集團生物製藥部任技術總監。 ^[1] 

多年來一直致力於有機合成、有機合成方法學、藥用高分子材料等領域的研究工作，近年來在不對稱有機合成、核糖核酸和脱氧核糖核酸的合成、金屬有機化學、配位化學、晶體學、生物學等領域也有重要的研究成果 ^[1] 

曾在《Nature》《J. Am. Chem. Soc.》《Chemistry & Biology》《Molecular Microbiology》《Chem. Eur. J.》《Organic Letters》《Organometallics》等上發表論文近五十篇，引用次數超過800次。並申請美國、歐洲專利六十項。

作為主要參加者在《Nature》雜誌、作為共同第一作者在《Chemistry & Biology》雜誌上發表了關於新型氨基酸吡咯賴氨酸的全合成與生物活性研究的文章，這兩篇文章被國際著名雜誌和媒體廣泛報道。被譽為解決了近半個多世紀以來遺傳基因編碼中的一個難題並擴展了遺傳基因編碼的規則。作為項目技術負責人承擔了加州大學重大科研項目和抗腫瘤藥物重大國際合作項目。2011年作為“四川省百人計劃”入選者和“四川省特聘專家”到四川大學從事製藥工程領域的研究與開發工作。 ^[1] 

1.Zhao, Gang, Kitaura, Chieko, Liu, Jian, Yu, LeiPeptide nucleic acid based guanidinium compounds, US7700565 B22010

2.Zhao, Gang, Yu, Lei, Liu, Jian,Kitaura, Chieko, Wang, Xinghe, Castello, ChrisGuanidinium delivery carriers, US7687603 B22010

3.Zhao, Gang, Fu, Xiaoli, Yu, LeiBiodegradable cationic polymers,US7700542 B22010

4.Niitsu, Yoshiro, Yu, Lei, Liu, Jian,Zhao, Gang, Ma, Nianchun, Van, SangDrug carriers, US8003621 B22011

5.Ravikumar, Vasulinga, Kumar, Raju K., Mori, Kenjirou, Konishi, Tatsuya, Matsunawa, Ayako, Matsumura, Takeo, Kitaura, Cheiko,Zhao, GangPolymeric beads for oligomer synthesis, US7348391 B22011

6.Yu, Lei,Zhao, Gang, Van, Sang, Das, Sanjib Kumar, Feng, Zhongling, Fu, Xiaoli, Wang, Xinghe Polyglutamate-amino acid conjugates and methods EP2206736 B12012

7.Zhao, Gang, Fu, Xiaoli, Yu, Lei,Biodegradable Cationic Polymers, EP1799748 B12012

8.Yu, Lei,Zhao, Gang, Van, Sang, Das, Sanjib Kumar, Feng, Zhongling, Fu, Xiaoli, Wang, Xinghe,Polyglutamate-Amino Acid Conjugates and Methods, EP1969031 B12012 ^[1] 

1.Zhongling Feng,Gang Zhao, Lei Yu, David Gough, Stephen B. Howell,“Preclinical efficacy studies of a novel nanoparticle-based formulation of paclitaxel that out-performs Abraxane”,Cancer Chemotherapy and Pharmacology, 2010, 65, 923-930.

2.Xinghe Wang,Gang Zhao, Sang Van, Lei Yu, David Vera, Stephen B. Howell, “Pharmacokineticsand tissue distribution of PGGA-paclitaxel, a novel macromolecular formulation of paclitaxel, in nu/nu mice bearing NCI-460 lung cancer xenografts”,Cancer Chemotherapy and Pharmacology, 2010, 65, 515-526.

3.Changxing Liu,Gang Zhao, Jian Liu, Nianchun Ma, Zongyou Chen, David Gough, and Lei Yu, “Novel biodegradable lipid nano complex for siRNA delivery significantly improvingthechemosensitivity of human colon cancer stem cells to paclitaxel”J. Controlled Release, 2009, 140(3), 277-283.

4.Wen-Tai Li, Anirban Mahapatra, David G. Longstaff, Jonathan Bechte,Gang Zhao, Patrick T. Kang, Michael K. Chan and Joseph A. Krzycki, “Specificity of Pyrrolysyl-tRNA Synthetase for Pyrrolysine and Pyrrolysine Analogs”,J. Mol. Biol.2009,385, 1156–1164.

5.Zhongling Feng,Gang Zhaoand Lei Yu, “Neural Stem Cells and Alzheimer's Disease: Challenges and Hope”,Am J Alzheimers Dis Other Demen.2009; 24; 52. (Invited review)

6.Mahapatra, A, Srinivasan, G, Richter, KB, Meyer, A, Lienard, T, Zhang, JK,Zhao, G, Kang, PT, Chan, M, Gottschalk, G, Metcalf, WW, Krzycki, JA, “Class I and class II lysyl-tRNA synthetase mutants and the genetic encoding of pyrrolysine in Methanosarcina spp.”Molecular Microbiology2007,5, 1306-1318.

7.Carine Bughin,Gang Zhao, Hugues Bienaym , Jieping Zhu, “5-Aminooxazole as an Internal Traceless Activator of C-Terminal Carboxylic Acid: Rapid Access to Diversely Functionalized Cyclodepsipeptides”,Chem. Eur. J.2006,4, 1174-1184.

8.Sherry K. Blight, Ross C. Larue, Anirban Mahapatra, David G. Longstaff, Edward Chang,Gang Zhao, Patrick T. Kang, Kari B. Green-Church, Michael K. Chan and Joseph A. Krzycki, “Direct charging of tRNA_CUAwith pyrrolysinein vitroandin vivo”,Nature(London, United Kingdom),2004, 431 (7006), 333-335.

9.Bing Hao,Gang Zhao, Patrick T. Kang, Jitesh A. Soares, Tsuneo K. Ferguson, Judith Gallucci, Joseph A. Krzycki, Michael K. Chan,”Reactivity and chemical synthesis of L-pyrrolysine - the 22(nd) genetically encoded amino acid”,Chemistry & Biology2004,11 (9): 1317-1324.

10.Gang Zhao, Xiaowen Sun, Hugues Bienaymé, and Jieping Zhu, “Activation of a Terminal Carboxylic Acid by an Internal Oxazole: A Novel Synthesis of Macrocyclodepsipeptide”,J. Am. Chem. Soc.,2001,123, 6700.

11.Xiaowen Sun, Pierre Janvier,Gang Zhao, Hugues Bienaymé, and Jieping Zhu, “A Novel Multicomponent Synthesis of Polysubstituted 5-Aminooxazole and Its New Scaffold-Generating Reaction to Pyrrolo[3,4-b]pyridine”,Organic Letters, 2001,6, 877.

12.Gang Zhao, Qingchuan Yang, and Thomas C. W. Mak, "Cyclic ether induced asymmetric cyclopalladation: synthesis, structural determination and alkyne insertion reaction of enantiopure planar chiral cyclopalladated derivatives of ferrocenylimines",Organometallics,1999,18, 3626. ^[1]