裴新海

曾任蘭州大學附屬一院住院醫師,主治醫師;美國北卡羅來納大學 (University of North Carolina at Chapel Hill) 博士後，研究助理教授; 美國邁阿密大學 (University of Miami) 終身軌助理教授，副教授。 ^[1] 

主要從事細胞增殖和分化與疾病,及基因工程小鼠的的研究工作。 ^[1] 

共發表SCI期刊收錄論文43篇，累計影響因子255分，第一作者發表論文最高影響因子25.3分。通訊作者發表論文最高影響因子9.3分。

代表性科研項目

Representative Grants and Contracts completed in USA (4 out of 17, Total $2,836,798):

1. Title: BRCA1 controls mammary stem/progenitor differentiation and proliferation, epithelial-mesenchymal transition and tumorigenesis

PI: Pei XH

Agency: Breast Cancer Research Program (BCRP)

Type: Idea Award (W81XWH-10-1-0302)

Amount: $554,491

Period: 4/15/2010 – 5/14/2012

2. Title: Adult stem cell cycle control and tumorigenesis

PI: Pei XH

Agency: University of Miami, Startup Funding

Amount: $978,522

Period:11/1/2010 – 5/31/2013

3. Title: The Role of BRCA1 in Suppressing Epithelial-Mesenchymal Transition in Mammary Gland and Tumor Development

PI: Pei XH

Agency: Breast Cancer Research Program (BCRP)

Type: Idea Expansion Award (W81XWH1310282)

Amount: $537,779

Period:9/1/2013 – 8/31/2016

4. Title: Targeting BRCA1 deficient breast cancers

PI: Pei XH

Agency:Florida Department of Health (Bankhead Coley Cancer Research Grant Award - 7BC07)

Amount: $97,880

Period: 3/1/17 - 2/28/18

代表性成果

· Wang C, Bai F, Zhang LH, Scott A, Li E, Pei XH. (2018) Estrogen promotes estrogen receptor negative BRCA1-deficient tumor initiation and progression. Breast Cancer Research. 20(1);74:1-17.

· Bai F, Chan HL, Scott A, Smith MD, Fan C, Herschkowitz JI, Perou, CM, Livingstone AS, Robbins DJ, Capobianco AJ, Pei XH. (2014) BRCA1 suppresses epithelial-to-mesenchymal transition and stem cell dedifferentiation during mammary and tumor development. Cancer Research. 74(21):6161-6172.

· Bai F, Smith MD, Chan HL, Pei XH. (2013) Germline mutation of Brca1 alters the fate of mammary luminal cells and causes luminal-to-basal mammary tumor transformation. Oncogene. 30;32(22): 2715-2725. Featured Article.

Commentary in Oncogene: BRCA1 mutations and luminal-basal transformation. Ng T, Irshad S, Stebbing J. 2013 May 30;32(22):2712-2714.

· Pei XH, Bai F, Li Z, Smith MD, Whitewolf G, Jin R, and Xiong Y. (2011) Cytoplasmic CUL9/PARC ubiquitin ligase is a tumor suppressor and promotes p53-dependent apoptosis. Cancer Research. 71, 2969-2977.

· Pei XH*, Bai F*, Smith MD, Usary J, Fan C, Pai SY, Ho IC, Perou CM, Xiong Y. (2009) CDK inhibitor p18INK4c is a downstream target of GATA3 and controls mammary luminal progenitor cell proliferation and tumorigenesis. Cancer Cell, 15, 389-401. *equal contribution. ^[1]