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蔡超

（中國海洋大學教授）

鎖定
中國海洋大學 醫藥學院 教授 博士生導師
中文名
蔡超
國    籍
中國
民    族
漢族
畢業院校
山東大學
中國科學院生態環境研究中心
職    稱
教授
蔡超，博士，教授。中國海洋大學“青年英才工程”計劃資助獲得者。
2007年畢業於山東大學，並先後獲得學士、碩士學位；2011年畢業於中國科學院生態環境研究中心，獲博士學位；2011至2014年在美國倫斯勒理工學院（RPI）化學生物學系Robert J. Linhardt教授課題組從事博士後研究工作；2014年底經中國海洋大學“青年英才工程”計劃引進在醫藥學院工作。主要從事化學與酶法定向合成海洋來源糖類化合物和糖胺聚糖類寡糖，開發新穎的糖聚合物合成方法並應用於活性多糖模擬物的製備，特徵糖類化合物的活性評價及糖類藥物研發工作。近年來在Chem. Rev., Nat. Chem. Biol., Org. Lett.,ACS Macro Lett., Biomacromolecules等雜誌發表SCI論文50餘篇。主持國家自然科學基金、山東省重點研發計劃以及參與國家重點研發計劃、國家重大新藥創制等多項國家及省部級課題。
研究方向及內容：
1. 海洋來源和糖胺聚糖類特徵寡糖的化學及酶法合成研究
2. 基於海洋活性多糖的糖聚合物合成研究
3. 海洋糖類藥物研發
代表性論文：
  1. ChendongYang#, Lei Gao#, Meng Shao, Chao Cai*,Lihao Wang, Yifan Chen, Jianghua Li, Fei Fan, Yubing Han, Ming Liu*, Robert J. Linhardt and Guangli Yu*. End-functionalised glycopolymers asglycosaminoglycan mimetics inhibit HeLa cell proliferation. Polym. Chem., 2020, 11, 4714-4722.
  2. Jianghua Li#, Yang Zhang#, Chao Cai*, Xiaozhi Rong, Meng Shao, Jiarui Li, Chendong Yang, Guangli Yu*. Collaborative assembly of doxorubicin and galactosyl diblock glycopolymer for targeted delivery of hepatocellular carcinoma. Biomater. Sci., 2020, 8, 189–200.
  3. Jia Li, Feifei Gu, Chao Cai*, Minghua Hu, Luodi Fan, Jiejie Hao*, Guangli Yu*. Purification, structural characterization, and immunomodulatory activity of the polysaccharides from Ganoderma lucidum. Int. J. Biol. Macromol., 2020, 143，806-813.
  4. Xueliang Wang, Zimei Yang, Xu Xu, Hao Jiang*, Chao Cai*, Guangli Yu*. Odd-numbered agaro-oligosaccharides alleviate type 2 diabetes mellitus and related colonic microbiota dysbiosis in mice. Carbohyd. Polym., 2020, 240, 116261.
  5. Jun Li, Chao Cai*, Lihao Wang, Chendong Yang, Hao Jiang, Miaomiao Li, Ding Xu, Guoyun Li, Chunxia Li, Guangli Yu*. Chemoenzymatic synthesis of heparan sulfate mimetic glycopolymers and their interactions with the receptor for advanced glycation end-product. ACS Macro Lett., 2019, 8, 1570-1574.
  6. Fei Fan, Ping Zhang, Lihao Wang, Tiantian Sun, Chao Cai*, Guangli Yu*. Synthesis and properties of functional glycomimetics through click grafting of fucose onto chondroitin sulfates. Biomacromolecules, 2019, 20, 3798-3808.
  7. Jun Li, Jiarui Li, Tiantian Sun, Chao Cai*, Meng Shao, Guangli Yu*. Concise chemoenzymatic synthesis of heparan sulfate analogues as potent BACE-1 inhibitors. Carbohyd. Polym., 2019, 217, 232-239.
  8. Jun Li, Chao Cai*, Chendong Yang, Jianghua Li, Tiantian Sun, Guangli Yu. Recent advances in pharmaceutical potential of brown algal polysaccharides and their derivatives. Curr. Pharm. Design, 2019, 25, 1290-1311.
  9. Jia Li, Chao Cai*, Mengmeng Zheng, Jiejie Hao, Ya Wang, Minghua Hu, Luodi Fan, Guangli Yu*. Alkaline extraction, structural characterization, and bioactivities of (1→6)-β-d-glucan from Lentinus edodes. Molecules, 2019, 24, 1610.
  10. Brady F. Cress, Ujjwal Bhaskar, Deepika Vaidyanathan, Asher Williams, Chao Cai, Xinyue Liu, Li Fu, Vandhana M-Chari, Fuming Zhang, Shaker A. Mousa, Jonathan S. Dordick, Mattheos A. G. Koffas, Robert J. Linhardt*. Heavy heparin: a stable isotope‐enriched, chemoenzymatically‐synthesized, poly‐component drug. Angew. Chem. Int. Ed., 2019, 58, 5962 –5966.
  11. Fei Fan, Chao Cai*, Wei Wang, Lei Gao, Jun Li, Jia Li, Feifei Gu, Tiantian Sun, Jianghua Li, Chunxia Li, and Guangli Yu*. Synthesis of fucoidan-mimetic glycopolymers with well-defined sulfation patterns via emulsion ring-opening metathesis polymerization. ACS Macro Lett., 2018, 7, 330-335.
  12. Lihao Wang, Fei Fan, Haotian Wu, Lei Gao, Ping Zhang, Tiantian Sun, Chendong Yang, Guangli Yu, Chao Cai*. Effect of anomeric configuration on stereocontrolled α-glycosylation of L-Fucose. Synlett, 2018, 29, 2701-2706.
  13. Jianghua Li, Chao Cai*, Jiarui Li, Jun Li, Jia Li, Tiantian Sun, Lihao Wang, Haotian Wu, Guangli Yu. Chitosan-based nanomaterials for drug delivery. Molecules, 2018, 23, 2661.
  14. Fei Fan,Chao Cai*, Lei Gao, Jun Li, Ping Zhang, Guoyun Li, Chunxia Li, and Guangli Yu*. Microwave-assisted synthesis of glycopolymers by ring-opening metathesis polymerization (ROMP) in an emulsion system. Polym. Chem., 2017, 8, 6709-6719.
  15. Lang Ding, Xindi Shan, Xiaoliang Zhao, Hualian Zha, Xiaoyu Chen, Jianjun Wang, Chao Cai*, Xiaojiang Wang, Guoyun Li, Jiejie Hao, Guangli Yu*. Spongy bilayer dressing composed of chitosan-Ag nanoparticles and chitosan-Bletilla striata polysaccharide for wound healing applications. Carbohyd. Polym., 2017, 157, 1538-1547.
  16. Angeles Farrán, Chao Cai, Manuel Sandoval, Yongmei Xu, Jian Liu, María J. Hernáiz*, and Robert J. Linhardt*. Green solvents in carbohydrate chemistry: from raw materials to fine chemicals. Chem. Rev., 2015, 115, 6811-6853.
  17. Sashka Dimitrievska, Chao Cai, Amanda Weyers, Jenna L. Balestrini, Tylee Lin, Sumati Sundaram, Go Hatachi, David A. Spiegel, Themis R. Kyriakides, Jianjun Miao, Guoyun Li, Laura E. Niklason, Robert J. Linhardt*. Click-coated, heparinized, decellularized vascular grafts. Acta Biomater.,2015, 13, 177-187.
  18. Chao Cai, Demetria M. Dickinson, Lingyun Li, Sayaka Masuko, Matt Suflita, Victor Schultz, Shawn D. Nelson, Ujjwal Bhaskar, Jian Liu & Robert J. Linhardt*. Fluorous-assisted chemoenzymatic synthesis of heparan sulfate oligosaccharides. Org. Lett., 2014, 16, 2240-2243.
  19. Yongmei Xu, Chao Cai, Kasemsiri Chandarajoti, Po-Hung Hsieh, Lingyun Li, Truong Q. Pham, Erica M. Sparkenbaugh, Juzheng Sheng, Nigel S. Key, Rafal Pawlinski, Edward N. Harris, Robert J. Linhardt* and Jian Liu*. Homogeneous low-molecular-weight heparins with reversible anticoagulant activity. Nat. Chem. Biol., 2014, 10, 248-250.
  20. Chao Cai, Lingyun Li, Cate Harvey, Jian Liu, Robert J. Linhardt*. Towards the chemoenzymatic synthesis of heparan sulfate oligosaccharides: Oxidative cleavage of p-nitrophenyl group with ceric ammonium salts. Tetrahedron Lett., 2013, 54, 4471-4474.
  21. Chao Cai, Kristi Edgar, Jian Liu, Robert J. Linhardt*. Preparation and application of a “clickable” acceptor for enzymatic synthesis of heparin oligosaccharides. Carbohyd. Res., 2013, 372, 30-34.
  22. Chao Cai, Kemal Solakyildirim, Bo Yang, Julie M. Beaudet, Amanda Weyers, Robert J. Linhardt, Fuming Zhang*. Semi-synthesis of chondroitin sulfate-E from chondroitin sulfate-A. Carbohyd. Polym., 2011, 87, 822-829.
論著：
  1. Chao Cai, Jun Li, Fei Fan, Guoyun Li, Chunxia Li, Guangli Yu. Synthesis of marine polysaccharides/oligosaccharides and their derivatives (Chapter 12), Royal Society of Chemistry, 2019, Wanyi Guan, Lei Li, Peng George Wang, Synthetic Glycomes.
專利：
  1. 蔡超，於廣利，凡飛，李國雲. 聚降冰片烯骨架糖聚合物的製備方法及其在巖藻聚糖硫酸酯模擬物合成中的應用，2020.03.27. 中國，201810126793.X.
  2. 於廣利, 張曉, 李國雲, 蔡超, 李芹英. 一種低抗凝肝素、其低聚糖及其製備方法和在製備抗阿爾茲海默症的藥物中的應用, 2017.11.01, 中國, 201510933082.X.
  3. 李國雲, 李芹英, 於廣利, 蔡超, 郝傑傑, 蔣昊. 一種巖藻糖化硫痠軟骨素FCShm及其製備方法和應用, 2019.12.05, 中國, 201710564187.1.
  4. 於廣利, 趙小亮, 李國雲, 蔡超. 一種透明質酸奇數寡糖單體及其製備方法, 2018.04.03, 中國, 201510921459.X.
  5. 於廣利, 李芹英, 李國雲, 尚慶森, 趙小亮,蔡超, 郝傑傑. 一種高硫酸化硫酸角質素及其製備方法和應用, 2019.09.03, 中國, 201611102103.4.
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