胡鵬飛

2014年6月獲華東理工大學有機化學碩士學位，指導老師為童曉峯教授；

隨後加入Scott A. Snyder教授課題組，並於2019年8月獲芝加哥大學博士學位；

2019年9月至2021年3月作為Hewitt Foundation Fellow在Scripps研究所的Phil S. Baran課題組進行電合成化學博士後研究；

胡鵬飛博士於2021年4月全職加入西湖大學。 ^[1] 

胡鵬飛博士的研究集中在通過開發突破傳統觀念的合成策略和反應方法學高效地合成複雜天然產物分子。學術成果包括：

1. 利用串聯Heck反應和重排縮環策略，首次合成含有高張力的反式5-5並環的萜presilphiperfolan-8-ol；

2. 用季碳導向天然產物合成，將此傳統意義上的重大合成挑戰作為有利因素指導你合成分析，完成了6個conidiogenone家族天然產物的高效合成；

3. 發展了新的鈀催化的烯烴碳氧化反應，首次實現Pd(II)促進的非活化的C(sp3)–OAc的還原消除，並應用於botrydial家族天然產物的高效合成；

4. 發展了電驅動的酮-烯烴的還原偶聯反應，突破了傳統親電性的酮基自由基的反應性侷限，將分子間酮-烯烴的還原偶聯反應拓展到電中性烯烴。該反應有着廣泛的底物普適性，極大地簡化了天然產物（片段）和藥物分子的合成。 ^[1] 

· 國家優秀自費留學生獎學金(2020)

· Hewitt Foundation Fellowship for Medical Research (2020)

· Elizabeth R. Norton Prize for Excellence in Research in Chemistry (2019)

· Bristol-Myers Squibb Graduate Fellowship in Synthetic Organic Chemistry (2018)

· Morris Selig Kharasch Lecture Graduate Fellowship (2018)

· William Rainey Harper Dissertation Fellowship (2018)

· 華東理工大學成思危名譽校長獎學金(2014)  ^[1] 

1. Pengfei Hu, Byron K. Peters, Christian A. Malapit, Julien C. Vantourout, Pan Wang, Jinjun Li, Lucas Mele, Pierre-Georges Echeverria, Shelley D. Minteer, and Phil S. Baran. Electroreductive Olefin–Ketone Coupling. J. Am. Chem. Soc. 2020, 142, 20979.

· Highlighted in Nature Reviews Chemistry (Davey, S. G. Nat. Rev. Chem. 2021, 5, 75).

2. Pengfei Hu,^¶Hyung Min Chi,^¶ Kenneth C. DeBacker, Xu Gong, Jonathan H. Keim, Ian Tingyung Hsu, Scott A. Snyder. Quaternary Center-Guided Synthesis: Concise Preparations of Complex Polycyclic Terpenes. Nature 2019, 569, 703.

· Highlighted in UChicago News (https://news.uchicago.edu/story/scientists-design-better-method-build-molecules-could-be-drugs-half-steps).

· Highlighted in Synfacts (Carreira, E. M.; Gillespie, R. J. Synfacts 2019, 15, 970).

3. Heng Yi,^¶ Pengfei Hu^¶, Scott A. Snyder. Development and Elucidation of a Pd-based Cyclization/Oxygenation Sequence for Natural Product Synthesis. Angew. Chem. Int. Ed. 2020, 59, 2674. 

4. Pengfei Hu, Scott A. Snyder. Enantiospecific Total Synthesis of the Highly Strained (−)-Presilphiperfolan-8-ol via a Pd-Catalyzed Tandem Cyclization. J. Am. Chem. Soc. 2017, 139, 5007.

· Highlighted in the ACS Select Virtue Issue “Total Synthesis of Natural Products” (Baran, P. S. J. Am. Chem. Soc. 2018, 140, 4751).

· Highlighted in Synfacts (Carreira, E. M.; Richter, M. J. R. Synfacts 2017, 13, 564).

5. Yiting Gu,^¶Pengfei Hu,^¶ Chunjie Ni, Xiaofeng Tong. Phosphine-Catalyzed Addition/Cycloaddition Domino Reactions of β′-Acetoxy Allenoate: Highly Stereoselective Access to 2-Oxabicyclo[3.3.1]nonane and Cyclopenta[a]pyrrolizine. J. Am. Chem. Soc. 2015, 137, 6400. 

6. Pengfei Hu, Jian Hu, Jiajun Jiao, Xiaofeng Tong. Amine-Promoted Asymmetric (4 + 2) Annulations for the Enantioselective Synthesis of Tetrahydropyridines: A Traceless and Recoverable Auxiliary Strategy. Angew. Chem. Int. Ed. 2013, 52, 5319. ^[1]