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胡煒

（中國科學院水生生物研究所副所長）

鎖定
胡煒，男，博士，研究員，博士生導師，魚類基因工程學科組組長，中國科學院水生生物研究所副所長。國家自然科學基金創新研究羣體學術帶頭人，湖北省自然科學基金創新羣體學術帶頭人。先後在南開大學和中國科學院研究生院獲學士、碩士和博士學位。 [3] 
現任中國科學院水生生物研究所副所長。 [4] 
中文名
胡煒
國    籍
中國
出生日期
1968年11月
畢業院校
南開大學
中國科學院研究生院 [3] 
職    業
教育科研工作者
主要成就
中國科學院水生生物研究所研究員
學    歷
研究生
職    稱
研究員
性    別
男

目錄

  1. 1 人物經歷
  2. ▪ 簡歷
  3. ▪ 學科組
  1. 2 研究方向
  2. 3 主要成就
  3. 4 社會任職
  1. 5 代表論著
  2. 6 發明專利

胡煒人物經歷

胡煒簡歷

1968年11月出生，博士，中國科學院水生生物研究所研究員，博士生導師，中國水產學會水產生物技術專業委員會委員，《農業生物技術學報》和《遺傳》編委。1991年畢業於南開大學生物系，獲理學學士學位；2002年獲中科院研究生院博士學位。主要從事魚類生殖發育調控、魚類基因工程育種、克隆胚胎再程序化機制等研究。主持國家自然科學基金重點項目、863項目、973課題及湖北省傑出青年人才基金等多項研究。
在Genetics，Endocrinology，Journal of Molecular Cell Biology，Journal of Neuroendocrinology，Biology of Reproduction，MarineBiotechnology等學術期刊上發表SCI論文80餘篇，其中封面論文4篇；參編國內外著作5本。獲美國發明專利3項，獲中國發明專利5項。 [1] 

胡煒學科組

魚類基因工程學科組
學科組長：胡煒
學科組成員：朱作言研究員、院士；胡煒研究員；陳尚萍高級實驗師
魚類基因工程學科組的研究工作發端於上世紀70年代末的魚類細胞核移植試驗：朱作言先生在著名實驗胚胎學家童第周先生的領導下，通過合作研究完成鯉鯽間的細胞核移植，首次實現脊椎動物的種間克隆。上世紀80年代，朱作言先生領導開創魚類基因轉移研究新領域，研製世界首批快速生長的轉基因魚。以上成果作為近代中國科技領域的兩大重要科研成就被載入《世界科學年史》（A. Hellemans & B. Bunch, 美國Simon & Schuster出版社）。 [2] 
合影 合影

胡煒研究方向

魚類基因工程與生殖發育調控 [1] 

胡煒主要成就

主持國家傑出青年基金、國家自然科學基金重點項目、863項目、國家重點研發計劃項目和湖北省傑出青年基金等研究。發現脊椎動物中樞神經系統中最主要的抑制性神經遞質GABA對生殖具有雙重調控作用，揭示了魚類生殖軸中重要信號分子在脊椎動物雌雄生殖中的不同功能及調控性腺發育的機理，發現了魚類生殖軸與生長軸間新的信號調控通路，發現魚類配子成熟需要RNA的m6A甲基化修飾，創建了魚類育性可控的生殖開關新策略。合作培育出具有優良養殖性狀的冠鯉和生殖發育可控的吉鯉，全面系統地評價了冠鯉的生態安全。首次報道了低溶氧耐受魚的成功研製。建立了黃鱔、鯉、鱘等重要養殖魚類高效特異的基因組編輯技術平台，並有效運用於遺傳育種和基因功能研究。建立模式動物斑馬魚的克隆技術，獲得斑馬魚體細胞再程序化機制及克隆胚發育機理研究的新發現。 [1] 

胡煒社會任職

國家水產原種和良種審定委員會委員，國家農業轉基因生物安全委員會委員，國家藍色糧倉科技創新重點專項總體專家組成員，中國水產學會淡水養殖分會副主任委員、水產生物技術專業委員會委員，中國動物學會比較內分泌分會理事。Comparative Biochemistry and Physiology、Frontiers in Endocrinology、水生生物學報、遺傳、農業生物技術學報、中國農業科技導報和水產學報等學術期刊編委。 [3] 

胡煒代表論著

1.Chen Ji.Cui Xiaojuan, Jia Shaoting, Luo Daji, Cao Mengxi, Zhang Yunsheng, Hu Hongling, Huang Kaiyao, Zhu Zuoyan &Hu Wei.Disruption ofdmc1produces abnormal sperm in medaka (Oryzias latipes).ScientificReports,2016,6, 30912; doi: 10.1038/srep30912.
2.Mikwar M, Navarro-Martin L, Volkoff H,Hu Weiand Trudeau V.L. Stimulatory effect of the secretogranin-ll derived peptide secretoneurin on food intake and locomotion in female goldfish(Carassius auratus), Peptides, 2016 Apr;78:42-50.
3.Peng Wei, Cao Mengxi, Chen Ji, Li Yongming, Wang Yaping, Zhu Zuoyan,Hu Wei. GnIH plays a negative role in regulating GtH expression in the common carp,Cyprinus carpioL. General and Comparative Endocrinology, 2016, 235 :18–28.
4.Shu Yuqin, Lou Qiyong, Dai Ziru, Dai Xiangyan, He Jiangyan,Hu Wei& Yin Zhan, The basal function of teleost prolactin as a key regulator on ion uptake identified with zebrafish knockout models.ScientificReports,2016, 6:18597, DOI: 10.1038/srep18597.
5.Zhou Y,Wang M,Jiang M,Peng L,Wan C,Liu J,Liu W,Zhao R,Zhao X,Hu W,Liu S,Xiao Y.Autotetraploid cell line induced by SP600125 from crucian carp and its developmental potentiality.ScientificReports, 2016, 6:21814. doi: 10.1038/srep21814.
6.Zhu T. B, Zhang L. H,Zhang T. L, WangY. P,Hu W, Ringø E. and Zhu Z. Y.Effects of sustained predation by fast-growing transgenic common carp (Cyprinus carpioLinnaeus, 1758) on gastropods in artificial environments.J. Appl. Ichthyol.2016; DOI:10.1111/jai.13130
7.胡煒，朱作言。美國轉基因大西洋鮭產業化對我國的啓示。中國工程科學，2016，18（3）：105-109。
8.Zhang Yunsheng,Chen Ji,Cui Xiaojuan,Luo Daji, XiaHui,Dai Jun,Zhu Zuoyan,Hu Wei. A controllable on-off strategy for the reproductive containment of fish. Scientific Reports, 2015,5,7614; DOI:10.1038/srep07614. [1] 
9.Song Yanlong, DuanXiaohai, Chen Ji, Zhu Zuoyan,Hu Wei. The distribution of Kiss1- and Kiss2-positive neurones and their connections with GnRH3 neurones in the zebrafish brain. Journal of Neuroendocrinology, 2015, 27(3): 198–211.
10.Tang Haipei, Liu Yun, Luo Daji, Ogawa Satoshi, Yin Yike, Li Shuisheng, Zhang Yong,Hu Wei, Parhar Ishwar S, Lin Haoran, Liu Xiaochun, Cheng Christopher H.K.. The kiss/kissr systems are dispensable for zebrafish reproduction: evidence from gene knockout studies，Endocrinology, 2015, 156:589-599.
11.Chu Lianhe, Li Jianzhen, Liu Yun,Hu Wei, Cheng Christopher H.K..Targeted gene disruption in zebrafish reveals noncanonical functions of Lh signaling in reproduction. Molecular Endocrinology,2014, 28(11):1785-95.
12.Cao Mengxi, Chen Ji, Peng Wei, Wang Yaping, Liao Lanjie, Li Yongming, Trudeau Vance L., Zhu Zuoyan,Hu Wei.Effects of growth hormone over-expression on reproduction in the common carpCyprinus carpioL.General and Comparative Endocrinology, 2014, 195:47-57.
13.Garcia-ReyeroNatàlia, Tingaud-SequeiraAngèle, Cao Mengxi, Zhu Zuoyan, Perkins Edward,Hu Wei. Endocrinology: Advances through omics and related technologies, General and Comparative Endocrinology, 2014, 203:262-273.(Invited review)
14.Liu Y, Luo D, Lei Y, Zhao H,Hu W, Cheng HK, A highly effective TALEN-mediated approach for targeted gene disruption inXenopus tropicalisand zebrafish,Methods, 2014, 69: 58–66.
15.Qiu Chao, Cheng Bin, Zhang Yunsheng, Huang Rong, Liao Lanjie, Luo Daji,Hu Wei, Wang Yaping. Efficient Knockout of Transplanted Green Fluorescent Protein Gene in Medaka using TALENs. Marine Biotechnology. 2014, DOI 10.1007/s10126-014-9584-x
16.Zhong C, Song Y, Wang Y, Zhang T, Duan M, Li Y, Liao L, Zhu Z,Hu W.Increased food intake in growth hormone-transgenic common carp (Cyprinus carpioL.) may be mediated by upregulating Agouti-related protein (AgRP). General and Comparative Endocrinology，2013，192, 81-88.
17.Chen Ji,HU Wei& ZHU ZuoYan. Progress in studies of fish reproductive development regulation. Chinese Science Bulletin, 2013,58:7-16.陳戟，胡煒，朱作言，魚類生殖發育調控研究進展。科學通報，2013,58:103-114.
18.LianHao,Hu Wei, Huang Rong, Du Fukuan, Liao Lanjie, Zhu Zuoyan, Wang Yaping. Transgenic Common Carp Do Not Have the Ability to Expand Populations. PLoS ONE, 2013, 8(6): e65506. [1] 
19. Liu Yun, Luo Daji, Zhao Hui, Zhu Zuoyan,Hu Wei,Cheng Christopher H. K..Inheritable and Precise Large Genomic Deletions of Non-Coding RNA Genes in Zebrafish Using TALENs.PLoS ONE, 2013,8(10): e76387.
20.Zhong Chengrong, Song Yanlong, Wang Yaping, Li Yongming, Liao Lanjie, XieShouqi, Zhu Zuoyan,Hu Wei. Growth hormone transgene effects on growth performance are inconsistent among offspring derived from different homozygous transgenic common carp (Cyprinus carpioL.). Aquaculture, 2012, 356–357: 404–411.
21.Cao Mengxi, DuanJundan, Cheng Nana, ZhongXueping, Wang Zequn,Hu Wei, Zhao Haobin. Sexually dimorphic and ontogenetic expression of dmrt1, cyp19a1a and cyp19a1b inGobiocypris rarus. Comparative Biochemistry and Physiology, Part A, 2012, 162: 303–309.
22. Cao Mengxi, Yang Yuhui, Xu Hongyan, DuanJundan, Cheng Nana, Wang Jialin,Hu Wei, Zhao Haobin. Germ cell specific expression of Vasa in rare minnow,Gobiocypris rarus,Comparative Biochemistry and Physiology, Part A, 2012, 162:163–170. [1] 
23. Guan Bo, Ma Hong, Wang Yaping, Hu Yuanlei, Lin Zhongping, Zhu Zuoyan,Hu Wei. Vitreoscilla Hemoglobin (VHb) Overexpression Increases Hypoxia Tolerance in Zebrafish (Danio rerio). Marine Biotechnology, 2011, 13（2）: 336-344. (cover paper)
24. Li Deliang, FU Cuizhang, Wang Yaping, Zhu Zuoyan,Hu Wei. The hematological response to exhaustive exercise in ‘all-fish’ growth hormone transgenic common carp (Cyprinus carpioL.). Aquaculture, 2011,311:263-268.
25. Luo Daji,Hu Wei, Chen Shangping, Zhu Zuoyan. Critical Developmental Stages For The Efficiency Of Somatic Cell Nuclear Transfer In Zebrafish.International Journal of Biological Sciences, 2011,7: 476-486.
26. Xu Jing, Huang Wei, ZhongChengrong, Luo Daji, Li Shuangfei, Zhu Zuoyan andHu Wei, Defining Global Gene Expression Changes of the Hypothalamic-Pituitary-Gonadal Axis in Female sGnRH-Antisense Transgenic Common Carp (Cyprinus carpio). PLoS One, 2011, 6(6): e21057. [1] 
27. Xu Zhuwei, Li Qi, Wang Yun, Song Chaojun, Zhang Tao, Chen Lihua, JiJianguo, Yang Angang, Zhu Zuoyan,Hu Wei, Jin Boquan. Production, characterization, and applications of mouse monoclonal antibodies against gonadotropin, somatolactin, and prolactin from common carp (Cyprinus carpio). General and Comparative Endocrinology, 2010, 167:373-378.
28. Tang Bin,Hu Wei, Hao Jun and Zhu Zuoyan. Developmental expression of steroidogenic factor-1, cyp19a1a and cyp19a1b from common carp (Cyprinus carpio). General and Comparative Endocrinology, 2010,167:408-416.
29. Dai J, Cui X, Zhu Z,Hu W. Non-Homologous End Joining Plays a Key Role in Transgene Concatemer Formation in Transgenic Zebrafish Embryos. International Journal of Biological Sciences, 2010; 6:756-768.
30. Duan M., Zhang T.,Hu W., Guan B., Wang Y., Li Z. & Zhu Z.. Increased mortality of “all-fish” growth hormone transgenic common carp (Cyprinus carpioL.) under a short-term risk of predation. Journal of Applied Ichthyology, 2010,26:908–912.
31. Guan Bo,HU Wei, ZHANG Tanglin, DUAN Ming, LI Deliang, WANG Yaping, ZHU Zuoyan. Acute and chronic un-ionized ammonia toxicity to ‘all-fish’ growth hormone transgenic common carp (Cyprinus carpioL.). Chinese Science Bulletin, 2010, 55: 4032-4036. [1] 
32.Hu Weiand Zhu Zuoyan. Integration mechanisms of transgenes and population fitness of GH transgenic fish. Science in China Ser C-Life Sci, 2010, 53:401-408.
33. Luo Yu-Shan,Hu Wei, Liu Xiao-Chun, Lin Hao-Ran, Zhu Zuo-Yan. Molecular cloning and mRNA expression pattern of Sox9 during sex reversal in orange-spotted grouper (Epinephelus coioides). Aquaculture, 2010,306:322-328.
34.Luo D,Hu W, Chen S, Xiao Y, Sun Y, Zhu Z. Identification of Differentially Expressed Genes Between Cloned and Zygote-Developing Zebrafish (Danio rerio) Embryos at the Dome Stage Using Suppression Subtractive Hybridization. Biology of Reproduction, 2009，80：674-684.
35. Guan B,Hu W, Zhang T, Wang Y, Zhu Z. Metabolism traits of 'all-fish' growth hormone transgenic common carp (Cyprinus carpioL.). Aquaculture 2008; 284: 217-223. [1] 
36.Hu Wei, Li Shuangfei, Tang Bin, Wang Yaping, Lin Haoran，Liu Xiaochun, Zou Jun & Zhu Zuoyan. Antisense for gonadotropin-releasing hormone reduces gonadotropin synthesis and gonadal development in transgenic common carp (Cyprinus carpio). Aquaculture, 2007, 271: 498–506.
37.Hu Wei, Wang Yaping& Zhu Zuoyan. Progress in the evaluation of transgenic fish for possible ecological risk and its containment strategies. Science in China Ser C-Life Sci. 2007, 50:573-579.胡煒，汪亞平，朱作言。轉基因魚生態風險評價及其對策研究進展。中國科學C輯：（生命科學），2007,37:377-381。
38. Wang Yun,Hu Wei, Liu Weiyi, Wang Yaping, Zhu Zuoyan. Identification and characterization of a novel alternative splicing transcript of gonadotropin alpha subunit in the common carp (Cyprinus Carpio). Journal of Fish Biology, 2007, 71: 1082–1094.
39.Hu Wei, Wang Yaping and Zhu Zuoyan. Perspective of fish gonad manipulation for biotechnical applications. Chinese Science Bulletin 2006,51(18):1-7.胡煒，汪亞平，朱作言。魚類性腺發育調控的生物技術前景分析。科學通報，2005,50:2689-2694.
40.Hu W, Wang Y, Chen S and Zhu Z. Nuclear transplantation in different strains of zebrafish, Chinese Science Bulletin,2002, 47(15):1277-1280. [2] 

胡煒發明專利

1. Hu Wei, Zhang Yunsheng, Dai Jun and Zhu Zuoyan. Controllable on-off method for fish reproduction. United States Patent and Trademark Office,2015年獲美國發明專利，專利號：US 9,187,764 B2
2. Hu Wei,Zhu Z, Ma H, Guan B, Lin Z, and Hu R.Recombinant gene which enhances the ability of fish to tolerate low dissolved oxygen stress and the use thereof.United States Patent and Trademark Office, 2013年獲美國發明專利，專利號：US8, 546, 644B2. [1] 
3. Hu Wei, Zhu Zuoyan, Wang Yaping and Li Shuangfei. Method for preparing a sterile transgenic carp. United States Patent and Trademark Office,2007年獲美國發明專利，專利號：US7,230,156B2.
4. 胡煒，馮科，陳戟，朱作言。一種黃鱔基因編輯的方法。中國發明專利，2016年8月10日受理，申請號：201610651812.1
5. 胡煒，湯斌，汪亞平，朱作言，一種雌性鯉魚性逆轉為雄性鯉魚的培育方法，2012年獲中國發明專利，專利號：ZL201110186519.X
6. 胡煒，張運生，戴軍，朱作言，一種控制魚類生殖的方法。2013年獲中國發明專利，專利號：ZL201310049161.5 [1] 
7. 胡煒，朱作言，汪亞平，黎雙飛。不育轉基因魚的製備方法，2007年獲中國發明專利授權，專利號：ZL031254551。
8. 胡煒，朱作言，黎雙飛，汪亞平。一種殼聚糖甲基睾酮緩釋藥條的製備方法，2007年獲中國發明專利授權，專利號：ZL200510018148.9。 [1] 
9. 吳玉萍，朱作言，胡煒，徐安龍。魚類基因原位修飾育種的方法，2006年獲中國發明專利授權，專利號：ZL200410015247.7 [1] 
10.朱作言，鍾家玉。一種魚類電脈衝精子轉基因方法，中國發明專利，2004，專利號：ZL01114202.2 [2] 
參考資料