胡奇

2002至2008年就讀於北京大學醫學部藥學院，先後獲得藥學學士和藥物化學碩士學位；

2014年畢業於清華大學生命學院，獲生物學博士學位；

2015年至今，在加州大學舊金山分校Kevan Shokat教授實驗室進行博士後研究，得到Damon Runyon癌症研究基金會博士後獎學金支持。

2019年加入西湖大學任研究員。主要研究細胞信號轉導的分子機理，以第一作者或通訊作者身份在Cell、Nature、PNAS、Cell Research等期刊發表多篇研究文章。

1.Hu, Q., Shokat, K. (2018). Disease-causing mutations in the G protein Gαs subvert the roles of GDP and GTP.Cell173, 1254–1264.

2. Li, Y.#, Zhou, M.#,Hu, Q.#, Bai, X.-C., Huang, W., Scheres, S.H.W., and Shi, Y. (2017). Mechanistic insights into caspase-9 activation by the structure of the apoptosome holoenzyme.Proc Natl Acad Sci U S A114, 1542–1547. (# co-first author)

3. Zhou, M., Li, Y.,Hu, Q., Bai, X.-C., Huang, W., Yan, C., Scheres, S.H.W., and Shi, Y. (2015). Atomic structure of the apoptosome: mechanism of cytochrome c- and dATP-mediated activation of Apaf-1.Genes Dev29, 2349–2361

4. Wang, J., Yan, C., Li, Y., Hirata, K., Yamamoto, M., Yan, N.*, andHu, Q.* (2014). Crystal structure of a bacterial homologue of SWEET transporters.Cell Res24, 1486-1489. (* co-corresponding author)

5.Hu, Q.#, Wu, D.#, Chen, W., Yan, Z., Yan, C., He, T., Liang, Q., and Shi, Y. (2014). Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome.Proc Natl Acad Sci U S A111, 16254-16261. (# co-first author)

6.Hu, Q.#, Wu, D.#, Chen, W., Yan, Z., and Shi, Y. (2013). Proteolytic processing of the caspase-9 zymogen is required for apoptosome-mediated activation of caspase-9.J Biol Chem288, 15142-15147. (# co-first author)

7. Wu, D.#,Hu, Q..#, Yan, Z.#, Chen, W., Yan, C., Huang, X., Zhang, J., Yang, P., Deng, H., and Wang, J., et al. (2012). Structural basis of ultraviolet-B perception by UVR8.Nature484, 214-219. (# co-first author)

8.Hu, Q., Nie, A., Welsh, K., Pinacho, C.F., Zhu, X., Li, Z., An, J., Reed, J.C., Zhang, L., and Huang, Z. (2011). Novel X-linked inhibitor of apoptosis protein inhibitors as probes of apoptosis in biology and medicine.Exp Biol Med (Maywood)236, 247-251.

9. Wang, F., Mei, Z., Qi, Y., Yan, C.,Hu, Q., Wang, J., and Shi, Y. (2011). Structure and mechanism of the hexameric MecA-ClpC molecular machine.Nature471, 331-335.

10. Qi, S., Pang, Y.,Hu, Q., Liu, Q., Li, H., Zhou, Y., He, T., Liang, Q., Liu, Y., and Yuan, X., et al. (2010). Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4.Cell141, 446-457. ^[1]