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田勇

（中國科學院生物物理研究所研究員）

鎖定
中國科學院生物物理研究所研究員，博士生導師。2012年起擔任中國科學院生物物理研究所動物實驗中心主任；中國科學院核酸生物學重點實驗室課題組組長。2015年起擔任中國科學院大學崗位教授。2016年起擔任中國科學院動物實驗平台工作委員會主任。2017年起先後擔任中國實驗動物學會第七屆理事會常務理事，《Animal Models and Experimental Medicine》雜誌副主編，《Mammalian Genome》雜誌編委，《生物化學與生物物理學進展》雜誌常務編委，全國實驗動物標準化技術委員會委員，北京市實驗動物專家委員會副主任。 [1] 
中文名
田勇
國    籍
中國
學    位
博士
性    別
男

目錄

  1. 1 研究方向
  2. 2 簡歷
  3. 3 研究組工作方向
  4. 4 代表性論文

田勇研究方向

研究組工作摘要
中國科學院生物物理研究所研究員，博士生導師。2012年起擔任中國科學院生物物理研究所動物實驗中心主任；中國科學院核酸生物學重點實驗室課題組組長。2015年起擔任中國科學院大學崗位教授。2016年起擔任中國科學院動物實驗平台工作委員會主任。2017年起先後擔任中國實驗動物學會第七屆理事會常務理事，《Animal Models and Experimental Medicine》雜誌副主編，《Mammalian Genome》雜誌編委，《生物化學與生物物理學進展》雜誌常務編委，全國實驗動物標準化技術委員會委員，北京市實驗動物專家委員會副主任。近五年以來以通訊作者/共通訊作者身份在Immunity (2022), Cell Research (2022, 2020) , Neuron (2022), Nature Immunology (2019, 2018, 2017, 2016), Nucleic Acids Research (2022), Molecular Cancer (2021)，Journal of Hepatology (2018), Nature Communications (2021, 2020, 2019, 2018, 2017), Cellular & Molecular Immunology (2022，2021), Journal of Experimental Medicine (2019a，2019b), The EMBO Journal (2020, 2019, 2018)，Cell Reports (2019)等國際一流學術刊物上發表多篇研究論文。 [1] 

田勇簡歷

1992-1997，北京醫科大學臨牀醫學學士
1997-2002，中國協和醫科大學理學博士
2002-2008，美國ST JUDE兒童研究醫院博士後
2009-今， 中國科學院生物物理研究所研究員 [1] 

田勇研究組工作方向

1. 圍繞消化道腫瘤、免疫性疾病和神經退行性疾病，利用基因編輯技術構建大小鼠實驗動物模型並開展發病機制研究； [1] 
2. 基因編輯技術（CRISPR/Cas9）在模式生物疾病動物模型研發中的應用研究； [1] 
3. 利用動物模型開展非編碼核酸（lncRNA）和環形RNA (circRNA) 在體功能的研究。 [1] 

田勇代表性論文

1. Zhu P, Lu T, Chen Z, Liu B, Fan D, Li C, Wu J, He L, Zhu X, Du Y, Tian Y*, Fan Z*. 5-hydroxytryptamine produced by enteric serotonergic neurons initiates colorectal cancer stem cell self-renewal and tumorigenesis. Neuron. 2022 May 7;S0896-6273(22)00369-5. doi: 10.1016/j.neuron.2022.04.024. [1] 
2. Zhu P, Lu T, Wu J, Fan D, Liu B, Zhu X, Guo H, Du Y, Liu F, Tian Y*, Fan Z*. Gut microbiota drives macrophage-dependent self-renewal of intestinal stem cells via niche enteric serotonergic neurons. Cell Res. 2022 Apr 4. doi: 10.1038/s41422-022-00645-7. [1] 
3. Xiong Z, Zhu X, Geng J, Xu Y, Wu R, Li C, Fan D, Qin X, Du Y, Tian Y*, Fan Z*. Intestinal Tuft-2 cells exert antimicrobial immunity via sensing bacterial metabolite N-undecanoylglycine. Immunity. 2022 Apr 12;55(4):686-700.e7. doi: 10.1016/j.immuni.2022.03.001. [1] 
4. Ye B, Yang L, Liu B, Liu N, Fan D, Li H, Sun L, Du Y, Wang S, Tian Y*, Fan Z*. Induction of functional neutrophils from mouse fibroblasts by thymidine through enhancement of Tet3 activity. Cell Mol Immunol. 2022 May;19(5):619-633. doi: 10.1038/s41423-022-00842-9. [1] 
5. Song G, Zhang F, Tian C, Gao X, Zhu X, Fan D, Tian Y*. Discovery of potent and versatile CRISPR-Cas9 inhibitors engineered for chemically controllable genome editing. Nucleic Acids Res. 2022 Mar 21;50(5):2836-2853. doi: 10.1093/nar/gkac099. [1] 
6. Wang Y, Wang J, Li X, Xiong X, Wang J, Zhou Z, Zhu X, Gu Y, Dominissini D, He L, Tian Y*, Yi C*, Fan Z*. N1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism. Nat Commun. 2021 Nov 2;12(1):6314. doi: 10.1038/s41467-021-26718-6. [1] 
7. Gu Y, Wang Y, He L, Zhang J, Zhu X, Liu N, Wang J, Lu T, He L, Tian Y*, Fan Z*. Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling. Mol Cancer. 2021 Oct 14;20(1):132. doi: 10.1186/s12943-021-01435-2. [1] 
8. Liu B, Liu N, Zhu X, Yang L, Ye B, Li H, Zhu P, Lu T, Tian Y*, Fan Z*. Circular RNA circZbtb20 maintains ILC3 homeostasis and function via Alkbh5-dependent m6A demethylation of Nr4a1 mRNA. Cell Mol Immunol. 2021 Jun;18(6):1412-1424. doi: 10.1038/s41423-021-00680-1. [1] 
9. Su R, Fan LH, Cao C, Wang L, Du Z, Cai Z, Ouyang YC, Wang Y, Zhou Q, Wu L, Zhang N, Zhu X, Lei WL, Zhao H, Tian Y, He S, Wong CCL, Sun QY, Xue Y. Global profiling of RNA-binding protein target sites by LACE-seq. Nat Cell Biol. 2021 Jun;23(6):664-675. doi: 10.1038/s41556-021-00696-9. [1] 
10. Liu B, Ye B, Zhu X, Yang L, Li H, Liu N, Zhu P, Lu T, He L, Tian Y*, Fan Z*. An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution. Nat Commun. 2020 Aug 14;11(1):4076. doi: 10.1038/s41467-020-17944-5. [1] 
11 Ye B, Yang L, Qian G, Liu B, Zhu X, Zhu P, Ma J, Xie W, Li H, Lu T, Wang Y, Wang S, Du Y, Wang Z, Jiang J, Li J, Fan D, Meng S, Wu J, Tian Y*, Fan Z.*. The chromatin remodeler SRCAP promotes self-renewal of intestinal stem cells. EMBO J. 2020 Jul 1;39(13):e103786. doi: 10.15252/embj.2019103786. [1] 
12. Wang S, Qu Y, Xia P, Chen Y, Zhu X, Zhang J, Wang G, Tian Y*, Ying J*, Fan Z*. Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer. Cell Res. 2020 Jul;30(7):610-622. doi: 10.1038/s41422-020-0312-y. [1] 
13. Song G, Zhang F, Zhang X, Gao X, Zhu X, Fan D, Tian Y*. AcrIIA5 Inhibits a Broad Range of Cas9 Orthologs by Preventing DNA Target Cleavage. Cell Rep. 2019 Nov 26;29(9):2579-2589.e4. doi: 10.1016/j.celrep.2019.10.078. [1] 
14. Xiong Z, Xia P, Zhu X, Geng J, Wang S, Ye B, Qin X, Qu Y, He L, Fan D, Du Y, Tian Y*, Fan Z*. Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis. J Exp Med. 2020 Feb 3;217(2). pii: e20190974. doi: 10.1084/jem.20190974. [1] 
15. Liu B, Yang L, Zhu X, Li H, Zhu P, Wu J, Lu T, He L, Liu N, Meng S, Zhou L, Ye B, Tian Y*, Fan Z*. Yeats4 drives ILC lineage commitment via activation of Lmo4 transcription. J Exp Med. 2019 Nov 4;216(11):2653-2668. doi: 10.1084/jem.20182363. [1] 
16. Zhang F, Song G, Tian Y*. Anti-CRISPRs: The natural inhibitors for CRISPR-Cas systems. Animal Model Exp Med. 2019 May 29;2(2):69-75. doi: 10.1002/ame2.12069. [1] 
17. Wang Y, Zhu P, Luo J, Wang J, Liu Z, Wu W, Du Y, Ye B, Wang D, He L, Ren W, Wang J, Sun X, Chen R, Tian Y*, Fan Z*. LncRNA HAND2-AS1 promotes liver cancer stem cell self-renewal via BMP signaling. EMBO J. 2019 Sep 2;38(17):e101110. doi: 10.15252/embj.2018101110. [1] 
18. Zhu P, Zhu X, Wu J, He L, Lu T, Wang Y, Liu B, Ye B, Sun L, Fan D, Wang J, Yang L, Qin X, Du Y, Li C, He L, Ren W, Wu X, Tian Y*, Fan Z*. IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3. Nat Immunol. 2019 Feb;20(2):183-194. doi: 10.1038/s41590-018-0297-6. [1] 
19. Zhu P, Wu J, Wang Y, Zhu X, Lu T, Liu B, He L, Ye B, Wang S, Meng S, Fan D, Wang J, Yang L, Qin X, Du Y, Li C, He L, Ren W, Wu X, Tian Y*, Fan Z*. LncGata6 maintains stemness of intestinal stem cells and promotes intestinal tumorigenesis. Nat Cell Biol. 2018 Sep 17. doi: 10.1038/s41556-018-0194-0. [1] 
20. Wang Y, Zhu P, Wang J, Zhu X, Luo J, Meng S, Wu J, Ye B, He L, Du Y, He L, Chen R, Tian Y*, Fan Z*. Long noncoding RNA lncHand2 promotes liver repopulation via initiating Nkx1-2-induced c-Met signaling. J Hepatol. 2018 Oct; 69(4):861-872. doi: 10.1016/j.jhep.2018.03.029. [1] 
21. Gao L, Wu K, Liu Z, Yao X, Yuan S, Tao W, Yi L, Yu G, Hou Z, Fan D, Tian Y, Liu J, Chen ZJ, Liu J. Chromatin Accessibility Landscape in Human Early Embryos and Its Association with Evolution. Cell. 2018 Mar 22;173(1):248-259.e15. doi: 10.1016/j.cell.2018.02.028. [1] 
22. Ye B, Liu B, Hao L, Zhu X, Yang L, Wang S, Xia P, Du Y, Meng S, Huang G, Qin X, Wang Y, Yan X, Li C, Hao J, Zhu P, He L, Tian Y*, Fan Z*. Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice. Nat Commun. 2018 Mar 28;9(1):1261. doi: 10.1038/s41467-018-03008-2. [1] 
23. Ye B, Liu B, Yang L, Zhu X, Zhang D, Wu W, Zhu P, Wang Y, Wang S, Xia P, Du Y, Meng S, Huang G, Wu J, Chen R*, Tian Y*, Fan Z*. LncKdm2b controls self-renewal of embryonic stem cells via activating expression of transcription factor Zbtb3. EMBO J. 2018 Mar 13. pii: e97174. doi: 10.15252/embj.201797174. [1] 
24. Xia P, Wang S, Xiong Z, Zhu X, Ye B, Du Y, Meng S, Qu Y, Liu J, Gao G, Tian Y*, Fan Z*. The ER membrane adaptor ERAdP senses the bacterial second messenger c-di-AMP and initiates anti-bacterial immunity. Nat Immunol. 2018 Jan 1. doi: 10.1038/s41590-017-0014-x. [1] 
25. Liu B, Ye B, Zhu X, Huang G, Zhu P, Yang L, Du Y, Wu J, Meng S, Tian Y*, Fan Z*. IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development. Nat Commun. 2017 Aug 10. doi:10.1038/s41467-017-00235-x. [1] 
26. Liu B, Ye B, Yang L, Zhu X, Huang G, Zhu P, Du Y, Wu J, Qin X, Chen R*, Tian Y*, Fan Z*. Long noncoding RNA lncKdm2b is required for ILC3 maintenance by initiation of Zfp292 expression. Nat Immunol. 2017 Mar 20. doi: 10.1038/ni.3712. [1] 
27. Xia P, Ye B, Wang S, Zhu X, Du Y, Xiong Z, Tian Y*, Fan Z*. Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity. Nat Immunol. 2016 Feb 1. doi: 10.1038/ni.3356. [1] 
28. Wang Y, He L, Du Y, Zhu P, Huang G, Luo J, Yan X, Ye B, Li C, Xia P, Zhang G, Tian Y, Chen R, Fan Z. The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling. Cell Stem Cell. 2015 Apr 2;16(4):413-25. doi: 10.1016/j.stem.2015.03.003. [1] 
29. Chen J, Hao L, Li C, Ye B, Du Y, Zhang H, Long B, Zhu P, Liu B, Yang L, Li P, Tian Y*, Fan Z*. The endoplasmic reticulum adaptor protein ERAdP initiates NK cell activation via the Ubc13-mediated NF-κB pathway. J Immunol. 2015 Feb 1;194(3):1292-303. doi: 10.4049/jimmunol.1402593. [1] 
30. Ye B, Li C, Yang Z, Wang Y, Hao J, Wang L, Li Y, Du Y, Hao L, Liu B, Wang S, Xia P, Huang G, Sun L, Tian Y*, Fan Z*. Cytosolic carboxypeptidase CCP6 is required for megakaryopoiesis by modulating Mad2 polyglutamylation. J Exp Med. 2014 Nov 17;211(12):2439-54. doi: 10.1084/jem.20141123. [1] 
31. Zhu X, Xu Y, Yu S, Lu L, Ding M, Cheng J, Song G, Gao X, Yao L, Fan D, Meng S, Zhang X, Hu S*, Tian Y*. An efficient genotyping method for genome-modified animals and human cells generated with CRISPR/Cas9 system. Sci Rep. 2014 Sep 19;4:6420. doi: 10.1038/srep06420. [1] 
32. Li G, Ci W, Karmakar S, Chen K, Dhar R, Fan Z, Guo Z, Zhang J, Ke Y, Wang L, Zhuang M, Hu S, Li X, Zhou L, Li X, Calabrese MF, Watson ER, Prasad SM, Rinker-Schaeffer C, Eggener SE, Stricker T, Tian Y, Schulman BA, Liu J, White KP. SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer. Cancer Cell. 2014 Apr 14;25(4):455-68. doi: 10.1016/j.ccr.2014.02.007. [1] 
33. Han J, Li J, Jia W, Yao L, Li X, Jiang L*, Tian Y*. Photothermal therapy of cancer cells using novel hollow gold nanoflowers. Int J Nanomedicine. 2014 Jan 16;9:517-26. doi: 10.2147/IJN.S55800. [1] 
參考資料