王琛

王琛：博導、二級教授。1993年獲北京農業大學學士學位，1998年獲中科院上海生物化學研究所博士學位，1998年至2002年在美國德克薩斯西南醫學中心(UT Southwestern Medical Center)進行博士後訓練。2002年至2016年在中科院上海生命科學研究院生化與細胞所任課題組長、博導。曾擔任中科院分子細胞生物學重點實驗室副主任，生化與細胞所學術委員、民盟中科院上海分院副主委、上海市第十三、十四屆人大代表，第十一屆全國青年委員。2016年5月起任中國藥科大學生命科學與技術學院教授、博導、院長。 ^[1] 

曾獲得科技部“973”和“863”項目，國家基金委“傑出青年基金”、“重點項目”、“中加國際合作項目”、“創新研究羣體”、“面上項目”、中科院“百人計劃”、“分子細胞卓越中心”等支持。兼任Chemistry of Life、Chinese Journal of Cell Biology、Acta Biochimica et Biophysica Sinica等期刊編委。 ^[1] 

綜合運用分子細胞生物學、免疫學和疾病動物模型，聚焦在發現並解析宿主模式識別受體的特異性識別(TLRs、RLRs、cGAS-STING)、細胞信號轉導關鍵通路(NF-kB、IRF3)的組成與動態變化、早期免疫應答反應的時空特性，闡釋固有免疫與急性炎症相關的分子調控機制。特別關注泛素與類泛素化修飾(Ub、SUMO、ISG15、NEED8)調控固有免疫和炎症的新功能與新機制，並從天然小分子化合物庫中篩選並研究調控相關通路的先導化合物。以第一或通訊作者在Nature、Cell，Immunity、Nature Immunology、Journal of Cell Biology、PLOS Pathogens, Cell Research、Development、Journal of Immunology、Molecular and Cellular Biology、Molecular Biology of the Cell、Journal of Virology，Immunology、Cytokine & Growth Factors Review等雜誌發表論文50餘篇。 ^[1] 

1. Wei Chen, Senlin Li, Huansha Yu, Xing Liu, Lulu Huang, Qiang Wang, Heng Liu, Ye Cui, Yijun Tang, Peng Zhang, Chen Wang*(2016): Adaptor SCAP Translocates and Recruits IRF3 to Perinuclear Microsome Induced by Cytosolic Microbial DNAs. PLOS Pathogens.

2. Yi Zhou, Rui Ge, Rui Wang, Feng Liu, Yuefeng Huang, Heng Liu, Yan Hao, Qin Zhou*, ChenWang*(2015): UXT potentiates angiogenesis by attenuating Notch signaling. Development. Vol 142(3):1-13.

3.Qiang Wang, Xing Liu, Ye Cui, Yijun Tang, Wei Chen, Senlin Li, Huansha Yu, Youdong Pan, ChenWang*(2014): The E3 Ubiquitin Ligase AMFR and INSIG1 Bridge the Activation of TBK1 Kinase by Modifying the Adaptor STING. Immunity. Vol 41(6): 919-933.

4.Yue-feng Huang, Heng Liu, Sen-lin Li, Yi-jun Tang, Bo Wei, Huan-sha Yu, ChenWang* (2014): MAVS-MKK7-JNK2 Defines a Novel Apoptotic Signaling Pathway during Viral Infection. PLoS Pathogens. Vol 10(3): e1004020. doi: 10.1371/journal.ppat.1004020.

5.Xing Liu, Wei Chen, Qiang Wang, Li Li, ChenWang* (2013): Negative Regulation of TLR Inflammatory Signaling by the SUMO-deconjugating Enzyme SENP6. PLoS Pathogens. Vol 9(6): e1003480. doi: 10.1371/journal.ppat.1003480.

6.Yue-feng Huang, Heng Liu, Rui Ge, Yi Zhou, Xi-wen Lou, ChenWang* (2012): UXT-V1 facilitates the formation of MAVS antiviral signal some on mitochondria. JournalofImmunology. Vol188: 358-366.

7.He-Xin Shi, Xing Liu, Qiang Wang, Pei-Pei Tang, Xin-Yi Liu, Yu-Fei Shan, ChenWang* (2011): Mitochondrial ubiquitin ligase MARCH5 promotes TLR7 signaling by attenuating TANK action. PLOSPathogens. Vol 7(5): e1002057. doi:10.1371/journal.ppat.1002057.

8.Xin-Yi Liu, Bo Wei, He-Xin Shi, Yu-Fei Shan, ChenWang* (2010): Tom70 mediates activation of interferon regulatory factor 3 on mitochondria. Cell Research. Vol 20: 994-1011.

9.Shao gang Sun, Yujie Tang, Xiwen Lou, Lianhui Zhu, Kai Yang, Bianhong Zhang, Hexin Shi and ChenWang* (2007): UXT is a novel and essential co-factor in NF-kB transcriptional enhance some. JournalofCellBiology. Vol 178: 231-244.

10.Chen Wang, Li Deng, Mei Hong, Giridhr. Akkaraju, Jun-Ichiro Inoue, Zhijian J. Chen (2001): TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature. Vol 412: 346-351.

(*代表Corresponding Author 通訊作者) ^[1]